In Korea, extensive industry-academia-research research has already established many facilities and technologies for materials and chemical experiments on non-radioactive substances. However, few facilities have been built to analyze the physical and chemical properties of substances irradiated through neutron irradiation. Korea is planning to decommission Kori-1 and Wolsong-1 in 2027. Extensive analysis of low-level and intermediate-level materials is required to begin decommissioning these nuclear power plants. The material’s composition and level can be identified by analyzing the structure’s characteristics, and a cutting and decontamination plan can be established based on this. In addition, by conducting a nuclide analysis on the waste generated after cutting, suitability for disposal can be secured, and stable treatment can be performed. Accordingly, the Korea Decommissioning Research Institute (KRID) plans to secure infrastructure (hot cells) to analyze the characteristics of intermediate-level decommissioning waste. The goal is to secure high-dose/high-radiation decommissioning waste processing technology through Korea’s first intermediate-level hot cell, support domestic nuclear power plant decommissioning projects, and secure and verify procedures related to nuclide analysis of intermediate-level using hot cells. In addition, by possessing these material properties and nuclide analysis technology, KRID can have a foundation to conduct continuous research on low- and intermediate-level radioactive materials and decommissioning. The purpose of KRID’s establishment is to use this foundation in the future to improve the technological level of the nuclear industry as a whole through linkage between industry, academia, and research institutes.

Recently, the nuclear decommissioning and environmental restoration industries has significantly attracted as a new industry field due to the decision to decommission the KORI#1 and WOLSONG #1 nuclear power plant. In order to dispose of the decommissioning radioactive wastes generated during nuclear decommissioning, proper analysis is required, and disposal decisions are determined based on the analysis results. When dismantling a nuclear power plant, a few thousand of tons decommissioning waste are produced, so these require analysis for proper disposal. Therefore, a radionuclide facility for decommissioning waste analysis is essential for the disposal of the large quantities of decommissioning waste generated during nuclear power plant decommissioning. Korea Research Institute of Decommissioning (KRID) was established radionuclide analysis facilities to address above issues and support nuclear power plant decommissioning projects. The plan is to perform classification by type and radionuclide for all waste produced during nuclear power plant decommissioning and to support the disposal of radioactive wastes. In addition, we plan to establish validation methods for samples where verification methods are not established, in order to conduct efficient analysis and management. In this presentation, we will introduce the radionuclide facility currently under construction at KRID and present the space design, equipment layout, and utilization plans.

In this study, the regression equation was suggested to predict of the shot ball velocity according to blade shapes based on discrete element (DE) analysis. First, the flat type blade DE model was used in the analysis, the validity of the DE model was verified by giving that the velocity of the shot ball almost equal to the theoretical one. Next, the DE analyses for curved and combined blade models was accomplished, and their analytical velocities of shot ball were compared with the theoretical one. The velocity of combined blade model was greatest. From this, the regression equation for velocity of shot ball according to the blade shape based on the DE analysis was derived. Additionally, the wind speed measurement experiment was carried out, and the experimental result and analytical one were the same. Ultimately, it was confirmed that the prediction method of the velocity of shot ball based on DE analysis was effective.

Fe2O3 coated plate mica(Fe2O3/mica) for infrared reflectance red pigment was prepared under hydrothermal treatment. Fe2O3 was perfectly coated on mica via the difference of surface charge between Fe2O3 and mica particles at pH 3. Fe2O3/mica was then calcined at 800 oC to stabilize the coated layer on mica. The infrare (IR) reflectance pigments were characterized by X-ray diffraction, FE-SEM, zeta potential, and a UV-Vis-NIR spectrophotometer. In particular, the CIE color coordinate and IR reflectance properties of Fe2O3/mica pigments were investigated in relation to the thickness variation of the Fe2O3 layer coated on mica of various lateral sizes. The isolation-heat red paints containing the pigments were prepared and optimized with a thinner, settling agent, and dispersant. Then, the films were made. The thermal property of isolation-heat on these films was observed through the relationship of the IR reflectance value, which was based on the variation of the Fe2O3 layer’s thickness coated on mica and mica’s lateral size as IR reflectance pigment. With an increase in IR reflectance on these films, the thermal property of isolation-heat was effectively enhanced.

CMP(Chemical Mechanical Polishing) Processes have been used to improve the planarization of the wafers in the semiconductor manufacturing industry. Polishing performance of CMP Process is determined by the chemical reaction of the liquid sol containing abrasive, pressure of the head portion and rotational speed of the polishing pad. However, frictional heat generated during the CMP process causes agglomeration of the particles and the liquidity degradation, resulting in a non-uniform of surface roughness and surface scratch. To overcome this chronic problem, herein, we introduced NaCl salt as an additive into silica sol for elimination the generation of frictional heat. The added NaCl reduced the zata potential of silica sol and increased the contact surface of silica particles onto the sapphire wafer, resulting in increase of the removal rate up to 17 %. Additionally, it seems that the silica particles adsorbed on the polishing pad decreased the contact area between the sapphire water and polishing pad, which suppressed the generation of frictional heat.

본 논문에서는 난류 강도가 풍력발전기 후류에 미치는 영향을 살펴보기 위하여 축소된 풍력발전기 모델을 이용하여 풍동실험을 수행하였다. 실험 결과 측정 위치에 따라 풍력발전기가 가지는 특성에 따라 후류의 형태가 달라지며, 난류 강도에 따른 영향이 반드시 고려되어야 하는 것으로 나타났다. 난류 강도만을 일부 고려한 격자 난류 조건에서 등류 조건보다 기존의 후류 모델과 보다 더 잘 일치하는 경향을 보이고 있으며, 측정된 난류 강도 값을 바탕으로 수정된 후류 모델을 제안하였다. 향후 다양한 난류 특성이 고려된 합리적인 모델이 필요하다고 판단된다.

Genus Litochila Momoi belonging to the tribe Hemigasterini is represented by eight species from Korea, China, Japan, Taiwan and India. Modern taxonomic revision of this genus was carried out by Kaur (1988). He and Chen (1996) enlarged the genus by adding one species, L. guizhouensis He & Chen from the oriental part of China. They provided a key to Chinese species and descriptions without including L. sinensis Kaur which was previously reported from Fujian, China by Kaur (1988). As a part of a large revisionary work of the subfamily Cryptinae, four species, L. nohirai (Uchida), L. carbonaria (Smith), L. jezonica (Uchida) and L. sinensis, are recognized from Korea. L. carbonaria. L. sinensis and L. jezonica are reported from Korea for the first time. The species L. guizhouensis is synonymized with L. sinensis. The distinction of females of two closely resembling species, L. carbonaria and L. jezonica, is possible by the number of flagellar segments, the shape of mesopleurum and second tergite, but males are difficult to identify. Momoi and Okamoto (1965) relied on the number of tyloids to identify them, and Kaur (1988) used the shape of postpetiole except for such character. However, our observations revealed these characters are not useful in relating these males, because many variations were found in these characters. Therefore, further DNA studies will be required to resolve this controversy.

Xylitol is a sugar alcohol with a variety of functions including bactericidal and anticariogenic effects. However, the cellular mechanisms underlying the role of xylitol in bone metabolism are not yet clarified. In our present study, we exploited the physiological role of xylitol on osteoclast dif-ferentiation in a co-culture system of osteoblastic and RAW 264.7 cells. Xylitol treatment of these co-cultures reduced the number of tartrate-resistant acid phosphatase (TRAP)- positive multinucleated cells induced by 10 nM 1α,25(OH)2 D3 in a dose‐dependent manner. A cell viability test revea-led no marked cellular damage by up to 100 mM of xylitol. Exposure of osteoblastic cells to xylitol decreased RANKL, but not OPG, mRNA expression in the presence of 10-8 M 1α,25(OH)2D3 in a dose‐dependent manner. Furthermore, bone resorption activity, assessed on bone slices in the co- culture system, was found to be dramatically decreased with increasing xylitol concentrations. RANKL and OPG proteins were assayed by ELISA and the soluble RANKL (sRANKL) concentration was decreased with an increased xylitol con-centration. In contrast, OPG was unaltered by any xylitol con-centration in this assay. These results indicate that xylitol inhibits 1α,25(OH)2D3-induced osteoclastogenesis by reducing the sRANKL/OPG expression ratio in osteoblastic cells.

This study was designed to evaluate a repeated oral dose toxicity and immunomodulating activity of Pulsatilla koreana and Artemisiae annuae in Sprague-Dawley rats. The female rats were treated with Pulsatilla koreana and Artemisiae annuae of control group, low group (0.5 ml/kg), medium group (1 ml/kg), high group (2 ml/ kg) for distilled water, intragastrically for 4 weeks, respectively. To ensure the safety of Pulsatilla koreana and Artemisiae annuae such as the following were observed and tested. We examined the body weight, the feed intake, the clinical signs, the ophthalmological test, the hematological and the serum biochemical analysis. We also observed the histopathological changes of liver and kidney in rats. Hematological results were the increase of neutrophils, lymphocytes and monocytes in the high dose group of Pulsatilla koreana. The increase immune cells in the high dose group of Pulsatilla koreana might immunomodulating activity. No significant differences in body weight, feed intake, serum biochemical analysis and histopathological between control and fed group were found. In conclusion, Pulsatilla koreana and Artemisiae annuae is physiologically safe and improve immunomodulating activity.

본 연구는 8주령 Sprague-Dawley계통의 암컷 랫드에서 제독유황을 반복경구투여 독성평가를 하기위해 시행하였다. 랫드에 처치한 물질은 사료섭취량의 0.2%, 1%, 5% 제독유황과 사료섭취량의 1% 유황으로 13주 경구투여를 하였다. 제독유황의 안전성을 확인하기 위해 다음과 같은 관찰 및 검사를 하였다. 검사항목으로는 체중과 사료 섭취를 측정하였고 임상증상, 안과학적 검사, 혈액학적 검사, 혈청 생화학적 검사를 관찰하였다. 또한 랫드에 간과 신장에서 의 병리조직학적 변화를 관찰하였다. 그 결과 체중, 사료섭 취량, 혈액학적 및 병리조직검사 소견에서 대조군과 제독 유황 그룹 간의 유의적인 차이가 보이지 않았다. 혈청생화 학적 검사소견에서는 0.2% 및 1% 투여군에서는 대조군과 비교시 용량의존적으로 유의적인 차이를 보이는 항목은 보이지 않았으나, 고용량군에서는 glucose 감소에 의한 저칼 륨혈증, 인슐린 과잉분비의 독성을 의심할 수 있었으며, 또 한 ALT와 ALP의 증가는 간 독성이나 간암, 황달의 유발이 의심되었다. 한편, 병리조직학적인 검사에서는 시험 전체군에서 대조군과 비교시 유의할만한 병리조직이상이 관 찰되지 않았다. 따라서 본 연구에서는 사료섭취량 1%의 제독유황까지 투여는 랫드에서 독성을 나타내지 않는 것으로 사료된다.

본 연구는 항암, 항균, 항산화 등의 기능을 나타내는 식물성 플라보노이드인 naringin이 암컷 SD rat의 지질대사와 혈액 생화학적 지표에 미치는 영향을 살펴보기 위해 수행되었다. 실험은 5주령의 암컷 SD rat를 대상으로 일주일에 3번, 총 5주 동안 naringin을 경구투여하여 지질대사와 항혈전능에 미치는 영향을 비교 분석하였으며, 실험군은 대조군(non naringin group), 저용량 naringin 투여군(0.2 g/kg), 고용량 naringin 투여군(0.5 g/kg)으로 구분하였다. 실험결과 랫드의 체중증가량과 상대장기중량에서는 통계학적으로 유의적인 변화가 관찰되지 않았다. 체중증가량에서 3주차 이후에 용량에 비례하지는 않지만 대조군에 비하여 naringin 투여군의 체중 증가율이 적은 것을 관찰 할 수 있었다. 사료섭취량과 체중증가량을 이용하여 각 군의 5주간 식이효율을 구해보았을 때, 군간에 통계학적으로 유의적인 차이는 없었으며, 장기와 조직의 상대장기중량은 간을 비롯하여 신장, 비장 모두 naringin 투여군과 대조군 간에 통계학적으로 유의적인 차이가 없었다. 혈청 중 Triglyceride, free fatty acid, total lipid, glucose의 수치는 대조군에 비해 naringin 투여군에서 유의적으로 감소하였다. 혈청 total cholesterol과 HDL-cholesterol의 수치를 이용한 Atherogenic index 즉, 동맥경화지수는 대조군에 비하여 고용량군이 유의적으로 감소하였다. 항혈전능 실험결과에서는 고용량 naringin 투여군이 대조군에 비해 유의적으로 높은 수치가 관찰되었다. 이상의 결과를 종합해 볼때 암컷 SD rat에서 naringin은 체중감소에 대한 효과는 관찰되지 않았지만, 지질저하 효과, 항산화 효과 등의 면에서 모두 우수하였다. 따라서 우리나라에서 자생하는 천연물 소재에 널리 분포된 naringin은 고혈압과 당뇨병에 효능이 있는 것으로 추측되며 동맥경화에도 효과가 있는 것으로 보여 건강기능 식품 소재로 이용될 수 있는 적절한 물질이라 판단된다.

To deterrnine the effects of insulin-like growth factor system in the aging process of the rat submandibular gland, expression pattems of 19f-1, 19f-2 and 19f-1 receptor were investigated by immunohistochem엽따. 1n addition, age-related changes of 19f-1 and 19f-2 concentrations in serum were deterrnined by radioimmunoassay 19f-1, 19f-2 and 19f-1 receptor were principally expressed 띠 the duct cells. 19f-1 receptors were strongly expre잃ed in 2-week-old group but were gradually decreased with advancing age. 19f-1 expressions were the strongest in the excretory and striated ducts of 7-month-old and 17-month-old groups. 19f-1 expressions, however, were weakiy expressed in the cells of granular convoluted tubules of 7-month잉ld ， 17-month-old and 27-month-old groups. 19f-2 expressions were found in some cells around duαs of 2-week-old group but were persisted relatively weak. The concentrations of 19f-1 and 1향2 in serum were the highest in 2-week-old group but were decreased and maintained at low level with advancing age. These results show that all components of 19f system were expressed in the rat submandibular giand in an age-related manner. Serum concentrations of all components of 19f system were not dosely related with the intra-밍and비ar expresslon patterns 까lerefore ， 1양 systerns may play important roles in the aging process of the rat submandibular gland in an autocrine/paracrine manner

본 연구는 순환골재를 사용한 콘크리트의 활용증대 방안으로 철근콘크리트 구조물의 노후화와 내구성 저하 시 보수․보강으로 사용되는 FRP (AFRP, CFRP) 판으로 보강된 순환골재 고강도콘크리트(40MPa, 60MPa) 보를 제작하여 순환골재 철근콘크리트 보의 휨 보강에 대한 적용성을 평가하고자 한다 기존의 표면매입보강에 따른 에폭시와 FRP 판의 부착력을 고려하지 않기 위해 콘크리트 타설 전 FRP 보강판을 거푸집에 미리 설치하였으며, 순환골재 치환율(30%), 콘크리트 강도(40MPa, 60MPa), 이형철근(D10, D13), FRP 판의 종류(AFRP 판, CFRP 판)를 변수로 12개 실험체를 제작하여, FRP 판과 순환골재 치환율에 따른 휨 성능을 분석하였다. 그 결과 FRP 판으로 보강한 실험체는 무보강 실험체에 비해 최대 17% 증가하는 경향을 나타내었으며 AFRP 판에 비해 CFRP 판의 보강 성능이 우수한 것으로 나타났다. 또한 순환골재 치환율에 따른 보강 성능의 차이는 없는 것으로 나타났다. 실험에 의해 측정된 균열모멘트는 파괴계수를 이용한 결과 기준식과 비슷한 값을 나타났으며 휨 모멘트는 FRP 판을 보강한 일부 시험체가 KCI 2012와 ACI 440-2R에서 제시한 기준을 만족하지 못하는 것으로 나타났다.