목적 : 근시 어린이를 대상으로 2년 동안 OK-렌즈 착용자의 근시 감소에 대한 효능을 평가하고자 하였다. 방법 : OK-렌즈 그룹은 OK 렌즈 착용 기준에 부합하는 30명의 대상자로 구성되었고, 단초점 안경을 착용한 대조군에는 31명이 포함되었다. 이 연구에 사용된 OK-렌즈는 CRT였고, 굴절이상 측정은 조절마비제 사용없이 자 동굴절검사기와 자각적 굴절검사를 통하여 이루어졌다. 결과 : 총 61명(OK-렌즈 그룹과 대조군은 각각 30명, 31명)의 대상자가 2년 동안의 검사를 완료했다. 연구 초 기의 OK-렌즈군과 대조군의 평균 연령±SD는 각각 10.13±1.81세와 10.32±1.73세였고, 등가구면굴절력은 OK-렌즈군에서 –2.53±0.96 D, 대조군에서 -2.56±1.10 D로 두 그룹 간 유의미한 차이는 없었다. 2년 동안 등 가구면굴절력의 증가는 OK-렌즈군과 대조군에서 각각 –0.70±0.56 D, -1.27±0.78 D였으며, 그 차이는 통계적 으로 유의한 차이가 있었다(p<0.001). 결론 : OK-렌즈 치료는 학령기 어린이의 근시 진행을 늦추는 데 도움이 될 수 있다.

The purpose of this study was to provide basic data for evaluating the reproductive health of bivalves using intersexuality. We analyzed purplish bifurcate mussel Mytilisepta virgata (n = 67, shell height 37.1±8.3 mm), Manila clam Ruditapes philippinarum (n = 288, shell length 28.6±4.2 mm) collected from coastal water near Yeosu, Korea. The sex ratio (female:male) of M. virgata and R. philippinarum were 1:1.5 and 1:0.8, respectively, and showed differences depending on the collection area. The total intersexuality of M. virgata was 20.9%. The intersexuality in female (33.3%) was higher than in male (12.5%), and the regional intersexuality was 72.7% in Sogyeongdo, 20.0% in Oesamdo and 5.6% in Jungsamdo with the highest in Sogyeongdo. The total intersexuality of R. philippinarum was 11.8%. The intersexuality in female (17.5%) was higher than in male (4.7%), and regional intersexuality was 20.0% in Neungchodo, 13.0% in Dokdo, 2.8% in Samdo, 5.9% in Orando, 19.6% in Oesamdo with the highest in Neungchodo. The incidence of intersexuality according to distance from cities and ports each sampling area showed no clear tendency. Intersex specimens were showed histological structure changes of digestive gland, such as digestive tubule disruption and necrosis of epithelial cells, accumulation of eosinophilic granules in lumen of tubule, necrosis of connective tissue. These results suggest that not only the histological structure of the digestive gland but also intersexuality should be used as important biomarker for toxicity assessment of pollutants.

이 연구는 다목적 선박(MPV)의 공기역학적 구조물 설계, 분석 및 향상을 통해 그린 워터 압력에 의한 구조적 안전을 보장하고, 탈탄소화 및 에너지 효율성에 이바지하는 방법을 기술하였다. 유한 요소 분석(FEA)을 통한 초기 평가에서 좌굴 발생에 대한 잠재적인 취약점 이 있음을 확인하였다. 이러한 문제를 해결하기 위해 보강재(Carling stiffener)와 두께 증가를 통하여 응력을 재분배하고 국부적인 좌굴 발생의 위험을 최소화하였다. 보강 후 분석 결과, 한국선급(KR)의 안전 기준인 항복 강도, 미국 선급(ABS) 좌굴 강도 및 노르웨이 표준(NORSOK) 변 위 기준을 모두 충족하는 것이 확인되었다. 결과적으로 고유치 좌굴 해석 결과가 안전 기준을 초과하고 최대 변위가 허용 한계 내에 있는 등 중요한 개선이 이루어졌다. 이러한 개선은 극한의 해양 조건에서 운영 신뢰성을 보장할 수 있다. 이 연구는 공기역학적 항력 감소와 구조적 안전성의 이중적인 이점을 강조하며, 국제 해사 기구(IMO)의 2050 탈탄소화 목표에 부합하는 연료 효율성 및 온실가스 배출 감소에 이바지할 수 있다. 연구 결과는 다양한 선박 유형에 걸쳐 항력 감소 기술을 확장하기 위한 기초 자료를 제공하며, 지속 가능하고 탄력적인 해양 운영을 위한 대안을 제시하였다. 향후 연구는 구조적 안전 평가를 가속할 수 있는 단순화된 모델링 기술 개발에 집중할 것이다.

아토피 피부염은 만성 염증을 동반한 알레르기성 질환 이며, 일반적으로 Type 2 염증 반응과 관련이 깊다고 알 려져 있다. Corchorus olitorius (C. olitorius)의 아토피 피 부염 치료 효과를 확인하기 위하여 2,4-dinitrochlorbenzene 로 아토피 피부염 모델을 유도한 BALB/c 마우스를 대상 으로 피부 염증 개선도를 육안으로 확인하였으며, 질환 관 련 IgE와 사이토카인(IL-4, IFN-γ and TNF-α)의 수준을 측정 하였다. 7일간의 투여기간동안 양성대조약물인 Dexamethasone 투여군의 체중은 감소하였던 반면에 모든 C. olitorius 투 여군의 체중은 꾸준히 증가하였다. 이와 같은 결과는 C. olitorius이 동물에 위해한 영향이 없었다는 것을 의미한다. C. olitorius 200 mg/kg/day 투여군의 치료 효과가 가장 뛰 어났으며, 모든 C. olitorius 투여군의 염증 관련 면역글로 불린과 사이토카인의 수준은 감소하였다. 따라서, C. olitorius 는 아토피 치료제로 충분히 활용될 수 있다고 판단된다.

Biodiversity encompasses species diversity, which includes species richness and species evenness. High species diversity is known to contribute to community stability and the potential for maintaining healthy ecosystem functioning. However, the most commonly used species diversity indices have some limitations, as they require species-specific abundance data for each community. In contrast, phylogenetic diversity measures the evolutionary distances between species within a community, reflecting ecological and/or evolutionary divergences and niche differences, without requiring abundance data. This study assessed biodiversity by calculating phylogenetic diversity indices for freshwater fishes (19 species) and aquatic insects (49 species) at three sites within Seoraksan and Odaesan National Parks. The aquatic insects studied belong to the EPT group (Ephemeroptera, Plecoptera, and Trichoptera), which are widely used as bioindicators of aquatic ecosystems. Two mitochondrial DNA genes were used as molecular markers: COI and cyt b for fish, and COI and 16S rRNA for the EPT - group. Overall, Odaesan National Park exhibited higher phylogenetic diversity in both fishes and aquatic insects compared to Seoraksan National Park, although this difference was not statistically significant. The highest phylogenetic and species diversity were observed for fish at the OD2 site (Woljeong District) and for the EPT group at the OD1 (Gyebangsan) and SA2 (Jangsudae) sites. Correlation analysis revealed that phylogenetic diversity indices were more positively associated with species richness than species diversity indices. This study serves as a pilot project for establishing standardized methods for assessing biodiversity in national park habitats using phylogenetic diversity. It also aims to inform various policies, such as the development of biodiversity assessment systems and the prioritization of protected areas within national parks.

This study conducted an acute toxicity assessment using Daphnia magna to evaluate the potential for increased toxicity when pharmaceuticals persist in aquatic environments not as single substances but in mixed forms. In single-substance toxicity tests, the antibiotics clarithromycin and sulfamethoxazole showed EC50 values of 22.3 mg L-1 and 61.05 mg L-1, respectively. However, the EC50 for the mixture of the two substances was determined to be 31.1 mg L-1. Based on these findings, applying the Similar Mode of Action (MOA) equation from the QSAR Toolbox, as recommended by OECD non-testing methods, produced an estimated EC50 of 33.7 mg L-1 for the mixture, showing a difference of 8.5% compared to the experimental value. This study confirms that combined exposure to pharmaceuticals can increase toxicity due to synergistic effects, indicating a significant potential risk to aquatic ecosystems. According to the UN-GHS classification criteria, clarithromycin, sulfamethoxazole, and their mixture were all classified as Category 3, indicating potential toxicity to aquatic organisms. These results emphasize the importance of toxicity assessments that consider interactions between multiple contaminants in real environmental settings, contributing to the development of effective toxicity evaluation and management strategies for the protection of aquatic ecosystems.

This study evaluated the feasibility of integrating the carbon storage of grasslands in Gangwon province into the InVEST carbon storage and sequestration model using large-scale digital land cover maps. Land cover maps from 1980, 1990, 2000, and 2010, obtained from the Environmental Geographic Information Service, were analyzed, with 28 maps examined for each year. Grassland carbon storage in Gangwon province was estimated through the InVEST software. The findings indicated that the grassland area showed an increase in 1990, followed by a declining trend, contrasting with the continuous reduction observed in actual managed grassland areas. Discrepancies between mapped and managed grassland areas were attributed to the classification criteria of the land cover maps, which included non-forage land uses such as golf courses, ski resorts, and green spaces, resulting in overestimations of grassland areas. To enhance accuracy, the adoption of land cover maps with refined grassland classification criteria is necessary. Accurate representation of grassland areas in land cover maps is critical for reliable estimation of grassland carbon storage using the InVEST software.

This study is about the evaluation for shock-proof performance of the system, elastically support the low accumulator of the naval artillery against underwater explosion, using DDAM. For the evaluation, the shock analysis procedure using DDAM, supported by MSC/NASTRAN, was briefly described. In addition, in order to perform the shock analysis, the elastic support system was modeled as a finite element. The shock analysis of the elastic support system was performed by selecting the analysis frequency range so that reliable results can be obtained. Finally, the shock-proof performance of the system was evaluated by comparing the shock analysis results with the properties of the elastic support system.

Evaluating the performance of asphalt concrete using CT scanning has become an essential area of research due to its potential to revolutionize the way we assess road materials. Traditional methods often require destructive sampling, which can damage infrastructure and offer limited insight into the material's internal structure. In contrast, CT scanning provides a non-destructive, highly detailed analysis of asphalt's internal features, such as air voids, aggregate distribution, and binder coverage, all of which are critical to its durability and performance. Additionally, the ability to create 3D models from CT scans allows for deeper insights into factors like void connectivity and aggregate bonding, which directly affect the lifespan of pavements. By combining CT imaging with advanced data processing techniques, such as deep learning, this research offers more accurate and reliable methods for optimizing asphalt mix designs, ultimately leading to longer-lasting roads, reduced maintenance costs, and more sustainable construction practices.