Artificial intelligence (AI) is transforming healthcare, yet little is known about how consumers experience and make decisions regarding follow-up care with medical AI. We take an interdisciplinary approach combining behavioral research and neuroscience to examine how anthropomorphism and personalization influence well-being and follow-up decisions. Study 1 found that consumers felt well-being after interacting with a highly personalized interaction, whether human or AI doctor. However, they preferred follow-up visits with the human doctor. Empathy mediated these effects. Study 2 used fMRI to show that the anterior cingulate cortex had greater activation when interacting with the human doctor, indicating more emotional processing and conflict resolution. These findings suggest that medical AI cannot currently replace human doctors, who remain vital for actual medical consultations and treatment. However, consumers viewed AI doctors positively and expressed a belief that AI will enhance well-being. By integrating neuroscience, this research provides biological evidence complementing behavioral findings.

The purpose of this study is to investigate the effects of oxides (caryophyllene oxide, eucalyptol and linalool oxide), one of the major ingredients of essential oils, on odor intensity, electroencephalography (EEG) response and emotional response. The subjects were women in their twenties. Inhalation concentrations of oxides were varied from 0.01 to 10%, and EEGs were collected by Quantitative EEG. The odor intensity and average preference index (API) of the oxides were ranked in the order of eucalyptol > linalool oxide > caryophyllene oxide. Eucalyptol is a refreshing and pleasant substance that activates the brain (activation of β and γ waves and spectral edge frequencies (SEF50 and SEF90)). Linalool oxide has a calm and soft substance (activation of θ, inactivation of α, β, and γ waves) at a low concentration (<0.1%), and a fresh smell at high concentration (inactivation β and activation of θ and γ). Caryophyllene oxides were evaluated as a substance that is comfortable, soft, calm and sedating, which deactivates the brain (activation of α, inactivation of β and γ). Oxide materials showed a positive correlation between the odor intensity and the SEFs. Each of the oxides showed unique characteristics in the areas of odor intensity, emotional response, API, and EEG. These results give us a better understanding of the properties of the pure materials that make up a fragrance, and provide useful information for the manufacture of fragrance products or aroma oil blends with enhanced specific functions.

Human body and head lice are obligatory human ectoparasites. Although both body and head lice belong to a single species, Pediculus humanus, only body lice are known to be a vector of several bacterial diseases. The higher vector competence of body lice is assumed to be due to their weaker immune response than that of head lice. To test this hypothesis, immune reactions were compared between body and head lice following infections by two model bacteria, Staphylococcus aureus and Escherichia coli, and a human pathogen, Bartonella quintana. Following dermal or oral challenge, the number of these bacteria increased both in hemocoel and alimentary tract of body lice but not in head lice and the viability of the B. quintana was significantly higher in body louse feces, the major route of infection to human. In addition, body lice showed the lower basal/induced transcription level of major immune genes, cytotoxic reactive oxygen species and phagocytosis activity compared with head lice. These findings suggest that a reduced immune response may be responsible, in part, for the increased proliferation and excretion of viable bacteria which are associated with the high level of human infectivity seen in body versus head lice.

Glucosamine is commonly taken by the elderly without prescription as a nutritional supplement to attenuate the progression or symptoms of osteoarthritis. Previous studies demonstrated that glucosamine shows anti-inflammatory effects in tissues such as blood vessels and the heart. However, there have been few reports about the effects of glucosamine on oral inflammatory diseases. Therefore, in this study, the effects of glucosamine on lipopolysaccharide (LPS)-induced inflammatory responses were investigated using human periodontal ligament fibroblasts (HPDLFs). HPDLFs were incubated in the presence and absence of glucosamine (10 mM) for 24 h, followed by treatment with E. coli LPS (100 ng/ml) or vehicle. Quantitative RT-PCR and ELISA results showed that LPS exposure significantly increased the levels of IL-6 and IL-8 mRNA and protein, while the effect was significantly suppressed by glucosamine treatment. Glucosamine did not attenuate, but slightly increased, the LPS-induced activation of mitogen activated kinases (ERK, p38, JNK). However, it suppressed the LPS-induced increase in the DNA binding affinity and transcriptional activity of NF-κB. These results suggest that glucosamine exerts anti-inflammatory effects on HPDLFs exposed to LPS via inhibition of NF-κB activity, necessitating further studies using animal periodontitis models.

본 연구에서는 LED 면조명을 이용한 감성조명시스템의 인체 생리학적 반응을 검증하였다. 실험은 시각 질환이 없는 건강한 20대 남성 10명을 대상으로 LED 면조명의 색상에 따른 인체의 반응을 평가하였다. LED 조명은 빨간색, 주황색, 노란색, 초록색, 파란색, 보라색, 무채색(하얀색)을 사용하여 5분간 조명 자극을 주었다. 평가 방 법으로 심리적 상태를 분석하기 위하여 뇌파와 심박변이도를 평가하였고 피부의 온도 변화를 살펴보기 위해 체 열을 평가하였다. 분석 결과 뇌파의 경우 무채색, 빨간색, 주황색 LED 면조명 자극 시 α파 비율이 감소하였다. 또한 무채색, 빨간색, 주황색, 노란색 LED 면조명 자극을 받을 때 부교감신경에 비하여 교감신경이 활성화되고, 체열이 증가하였다. 이에 비해 초록색, 파란색, 보라색 LED 면조명 자극을 받을 때에는 α파 비율의 증가와 교감 신경에 비하여 부교감신경의 활성화가 발생하였고 체열이 감소하였다. 향후 각 색상을 조합하여 상황별 모드를 구성한 실험과 시각적 자극 외에 아로마와 같은 후각 자극, 음악과 자연의 소리를 이용한 청각 자극 등을 이용한 복합한 시너지 효과에 대한 연구가 필요할 것으로 사료된다.

Job stress weakens physical ability causing the diseases related to working condition, decreases a production level, and increases mistakes and accidents. This study examined the relationship between job stress and human error, and focused on the moderating effect of age and maintenance type on the relationship between job stress and human error. The study used a quantitative design based on the 450 questionnaires of maintenance personnel in the Air force. The results of multiple regression analysis showed that physiological and psychological stress responses have positively related with human error. In moderating effect test, age appeared to impact on the relationship between physiological/behavioral stress and human error.

This paper reviewed the relationship between job stress and human error, and the moderating effect of age and maintenance type on the relationship between job stress and human error in maintenance personnel. Based on the responses from 450 maintenance personnels, the results of multiple regression analysis showed that physiological and psychological stress responses have positively related with human error. In moderating effect test, age appeared to impact on the relationship between physiological/behavioral stress and human error.

The purpose of this study was to evaluate the biological characteristic of deproteinized freeze dried bovine bone(DFDBB) through grafting to maxillary sinus as following time lapsed. Nine patients who were needed of sinus elevation procedure because of severe resorption of maxillary edentulous alveolar bone were selected. patients were divided into three group. Firstly sinus lifting procedure was performed and then the implantation procedure was performed after 6 months in first group, 12 months in second group and 18 months in third group and simutaneously tissues of sinus were obtained by trephine. 18 sections are made from every obtained tissue. 9 sections were stained by Masson's trichrome method and were taken a photo at 100 times of magnification. Relative area of newly formed bone were obtained by IPTK(image processing tool kit) version 5.0 program and mean values and standard deviations were produced from obtained data by using SPSS version 17 program and significance tests were conducted by ANOVA method. This study revealed that DFDBB stimulated new bone formation in maxillary sinus and did not have osteoinductive capacity but osteoconductive capacity, and DFDBB was exceedingly slowly resorbed.

여름철 에너지 절약, 온실가스 줄이기, 직장인의 건강증진 등을 위한 쿨맵시 캠페인에 대하여 범국민 인식 및 실천의 필요를 바탕으로, 본 연구는 착의실험을 통해 클맵시 권장복장 착용시의 생리적 반응 및 주관적 감각에 대해 분석하였다. 1차 실험은 두 복장, 즉 일반복장, 쿨맵시 권장복장에 대한 생리적 반응의 측정으로서, 두 환경기온 25℃와 27℃, 상대습도 50%R.H.에서 20대 성인남성 4명을 대상으로 실험을 행하였다. 일반복장은 긴팔 셔츠 정장바지 차림이었고 쿨맵시 권장복장은 넥타이 없이 반팔셔츠에 정장바지 차림이었다. 피험자는 30분간의 안정기를 가진 후 60분 동안 실험을 실시하였는데 사무실 작업과 유사한 컴퓨터 워드작업을 행하였고, 피부온, 직장온, 의복하 습도, 발한량, 온열감, 습윤감, 쾌적감 등을 측정하였다. 대부분의 반응에서 25℃ 일반복장의 경우와 27℃ 쿨맵시복장의 경우가 유사한 결과를 나타내고 우수한 것으로 나타났다. 25℃ 쿨맵시복장의 경우에는 저강도 작업이 지속되면 직장온의 저하가 우려되었으며 27℃ 일반복장에서는 고 평균 피부온, 고 발한량, 높은 온열감 등을 보였다. 2차 실험은 일반복장을 착용한 채 환경온도를 점진적으로 하강시키면서 권장 여름철 냉방온인 27℃에서 쿨맵시 권장복장을 착용한 경우의 피부온도를 발현시키는 실내 환경온도를 찾는 것이었다. 그 결과 권장복장 경우의 피부온을 나타내려면 일반복장의 경우에는 환경온을 2℃를 더 낮추어야만 하였다. 여름철 실내 환경온을 27℃로 높이고 쿨맵시 권장복장을 착용하는 것이 사무실의 장시간 저강도 작업 하에서는 피부온, 주관적 온열감이 우수하였다.

대기 오염은 피부의 산화적 손상, 염증 및 노화를 일으킬 수 있다. 레스베라트롤은 폴리페놀 화합물의 일종으로 항산화, 항염증, 멜라닌 생성 억제 작용 등 다양한 생물학적 활성이 있는 한편 열과 빛에 약한 단점이 있다. 레스베라트릴 트라이아세테이트(RTA)는 레스베라트롤에 비해 안정하고, 피부 안전성과 미백 효능이 보고된 화장품 신소재이다. 본 연구의 목적은 직경 10 μ m 미만 대기 미립자 물질(PM10)에 노출된 인간 표피 각질형성세포(HEK)의 염증 반응에 대한 레스베라트롤과 RTA의 영향을 조사하기 위한 것이다. 배양된 HEK세 포를 레스베라트롤과 RTA의 유무 조건에서 PM10에 노출시키고, 세포 생존율, 반응성 산소종(ROS)의 생성 및 염증성 사이토카인의 발현을 분석하였다. PM10을 처리하였을 때 세포 생존율이 감소하였고 종양괴사인자- α(TNF-α), 인터루킨-1β(IL-1β), 인터루킨-6(IL-6) 및 인터루킨-8(IL-8)의 발현이 증가하였다. 레 스베라트롤과 RTA는 PM10으로 유도된 세포의 사멸과 ROS 생성을 경감시켰다. PM10에 의해 증가되는 여러 염증성 사이토카인의 발현은 레스베라트롤과 RTA에 의해 경감되거나(IL-6), 증진되거나(IL-1β), 변화하지 않았다(TNF-α 및 IL-8). PM10에 의해 유도된 IL-6단백질의 발현이 레스베라트롤과 RTA에 의해 감소되 었다. 본 연구의 결과는 레스베라트롤과 RTA가 대기 미립자 물질에 노출된 피부의 세포 손상과 염증 반응을 조절하는 작용이 있음을 시사한다.

This study surveyed the human thermal responses according to the green space types. Three green space type (forest trail, residential area and central building district) were set the research sites in Dongdaemun-gu, Seoul. The physical thermal environment factors were measured while the human thermal responses were investigated. The air temperature and radiant temperature showed higher in central building area where sky view factor was 0.799 than in forest trail where sky view factor was 0.651. The skin temperatures increased according to green space type and rectal temperatures showed the highest value in central building area. The thermal sensation vote and thermal comfort showed the differences only between forest trail and central building area. These results will use as base line data on the green space type management plan for thermal environment amenity.