Baicalin, a flavonoid isolated from Scutellaria baicalensis, has anti-inflammatory, antioxidant, and neuroprotective effects. Glutamate is a major neurotransmitter that plays an important role in brain function, but excessive release of glutamate causes excitotoxicity and damages cells. We investigated the neuroprotective effects of baicalin in glutamate-exposed neurons. The mouse hippocampal neuronal cell line (HT22) was cultured in a general manner, glutamate and/or baicalin were treated on the cells. Baicalin was administered 1 hr before glutamate treatment. Cells were collected 24 hr after glutamate, and cell viability was measured using MTT assay. Reactive oxygen species (ROS) and lipid peroxidation (LPO) assays were performed to measure oxidative stress. Glutamate reduced cell viability in a dose- and time-dependent manner. MTT assay showed that baicalin treatment ameliorated the decrease in cell viability due to glutamate toxicity. The effect of baicalin is dose-dependent. Glutamate caused severe nerve damage, including condensation of the cell shape, loss of dendrites and axons. However, baicalin treatment attenuated these morphological changes, and the effect of baicalin was dose-dependent. ROS and LPO analyses showed that glutamate increases oxidative stress, and baicalin attenuates this change due to glutamate toxicity. The effect of baicalin on these results was dose-dependent. We confirmed that baicalin performs an antioxidant function against glutamate toxicity in neurons. In conclusion, these results suggest that baicalin exerts neuroprotective effects on damaged neurons through antioxidant activity.

Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic resource for the peripheral nervous system (PNS) and central nervous system (CNS) that is attributable to their capacity for neuronal differentiation. Human dental pulp stem cells (hDPSCs), which exhibit MSC-like traits, can differentiate into neuron-like cells and secrete critical neurotrophic factors; however, their therapeutic potential in peripheral nerve injury remains unexplored. This study investigated the regenerative effects of hDPSC transplantation following sciatic nerve injury (SNI) in rats. Transplantation of hDPSCs, STRO-1+ hDPSCs, or CD146+ hDPSCs after sciatic nerve transection in rats upregulated the levels of β3 tubulin, a marker of immature newborn neurons. Furthermore, the levels of glial cellderived neurotrophic factor, insulin-like growth factor 2, and the neuroregenerative factor NeuroD1 were upregulated. Motor dysfunction in rats with SNI was restored, as demonstrated by significantly higher sciatic functional index scores compared with the sciatic nerve transection group without transplantation. Transplantation of hDPSCs into injured peripheral nerves results in the upregulation of neurotrophic factors, differentiation into immature neurons, and promotion of motor function recovery. This approach holds promise as a valuable therapeutic strategy for repairing injured peripheral sciatic nerves, potentially providing a solution for nerve damage in both the PNS and CNS.

본 연구에서는 경피신경전기자극(TENS)을 이용하여 다양한 자극 강도에 따른 뇌혈관에 미치는 영향을 확인하고 자 한다. 특히 비지각적 감각의 전기자극을 통해 총경동맥(CCA)에서의 혈류 변화 및 혈관의 구조적인 변화를 확인 해 보고자 한다. 본 연구에는 20대의 건강한 성인 24명이 참여하였다. 자극 강도는 감각 역치 미만, 감각 역치, 그리 고 감각 역치 초과 세 가지를 각각 랜덤 순서로 적용하였다. 측정위치는 CCA 분기점의 1cm 하단에서 측정하였고, 혈류속도는 C-mode 도플러, 혈관의 구조는 B-mode 영상을 통해 측정하였다. 측정은 각각의 자극별로 중재 전, 중재 중, 그리고 중재 후에 수행하였고 각 세션마다 혈압의 변화를 측정하였다. 그 결과 최고 수축기 속도(PSV)는 역치 미만의 비지각적 감각자극에서 중재 후 유의하게 감소함이 확인되었다(p = .008). 역치 미만의 자극 후 PSV는 자극 전보다 평균 3.04% 유의하게 감소한 것으로 나타났다(p = .011). 반면 CCA의 혈관 직경의 변화는 모든 강도에서 자극 전후 유의한 변화가 나타나지 않았다. 본 연구에서 적용한 단시간의 비지각적 전기자극이 혈관의 직경이나 혈 압의 유의한 변화를 주지 않으면서 즉각적인 혈류속도 감소에 효과가 있음을 발견했다. 따라서 본 연구는 경동맥 부위에 환자의 불편함과 부작용이 없는 전기자극을 통해 뇌혈류의 조절이 가능하다는 것을 보여주는 중요한 시도로 평가될 수 있다.

Background: The transcutaneous electrical nerve stimulation (TNES) is the most used non-invasive treatment method in physical therapy. As the mobile TENS (MTENS) has become popular, patients with pain have started using MTENS to reduce pain. Objectives: To evaluate pain, range of motion, and muscle strength before and after using MTNES in patients with wrist pain. Design: Quasi-experimental research. Methods: We conducted an experiment with 80 patients; 15 patients were dropped out, and 35 and 30 patients were evaluated in the experimental group (EG) and control group (CG), respectively. Before and after using MTENS for 4 weeks, patients were evaluated using visual analogue scale (VAS), grip power, range of motion (ROM), and digital infrared thermography imaging (DITI). In the EG, electricity was applied for the MTENS device, while electricity was not applied in the CG. Results: A significant difference in pain reduction was observed between the EG and CG. In the EG, a significant difference in grip strength was also noticed before and after using the MTENS; patients showed significantly increased power grip and tip pinch. A significant difference was observed in pre-rest and post-test wrist ROM and DITI values. Conclusion: MTENS is an appropriate procedure for patients with wrist pain.

Background: The traditional treatment protocol in adhesive capsulitis cases is physical therapy agents and a home exercise program. The extensive majority of patients respond to conservative treatment, but the painful rehabilitation program makes it inconvenient for individuals to fully comply with the treatment. In order to reduce pain and spasm, intraarticular injections or suprascapular nerve block may be effective before the rehabilitation program. Objectives: To investigated the effect of suprascapular nerve block (SNB), which is added to standard physical therapy on pain, functionality and range of motion in patients with adhesive capsulitis (AC). Design: Retrospective study. Methods: This study included 46 patients who were treated for AC. Patients in both groups were given 15 season physical therapy and home exercise. The treatment group consisted of patients who underwent multiple SNB in addition to physical therapy and home exercise. Datas were analyzed retrospectively. Results: The Visual Analogue Scale (VAS), ROM, Shoulder Pain and Disability Index (SPADI) and Constant scores in both groups after treatment and at the third month follow-up (P<.001). In the comparison between the groups, it was determined that the improvement in VAS, ROM and SPADI scores in the treatment group at the 3-month control was statistically significant (P<.05). Conclusion: Multiple SNB added to physical therapy and home exercise program in cases of AC may be effective in terms of pain control, increasing joint range of motion and improving functionality.

Background: The spinal nerves, which start at the lumbar level, are connected to the nerve innervation in the knees. Currently, there is a lack of research on the treatment of knee pain through lumbar mobilization. Objectives: To investigate the effects of lumbar joint mobilization (LJM) and transcutaneous electronic nerve stimulation (TENS) on proprioception and muscular strength in volleyball players with chronic knee pain. Design: Two group pre-posttest. Methods: A total of 26 professional volleyball players with chronic knee pain were allocated to the LJM (n=13) and TENS (n=13) groups. In the LJM group, grade III - IV amplitude was applied 3 times for 1 minute (80 times per minute) at the affected lumbar (L2-3) facet joint in the prone position. In the TENS group, the TENS treatment device was used to directly apply or 15 minutes to the area of chronic knee pain (100 Hz, 150 ㎲). Proprioception was measured by knee flexion and extension angles, and muscle strength was evaluated using an isokinetic test. Measurements were taken before and after interventions. Results: In the eye opened conditiond, proprioception significantly increased during both knee extension and flexion after LJM, while only knee extension was significantly increased in the TENS group. There was also a significant difference in knee extension between the two groups. In the eye close conditiond, proprioception was significantly improved only during knee extension in the LJM group, and the difference in knee extension between the groups was also significant (P<.05). The maximum torque of the affected knee joint was significantly improved at 60°/sec in both groups (P<.05); however, there was no difference between the two groups. There was no significant difference in the maximum flexion torque within or between the groups. Conclusion: This study suggests that LJM improved proprioception and muscular strength in volleyball players with chronic knee pain.

Heat shock proteins (HSPs) are highly conserved cellular proteins that contribute to adaptive responses of organisms to a variety of stressors. In response to stressors, cellular levels of HSPs are increased and play critical roles in protein stability, folding and molecular trafficking. The mRNA expression pattern of two well-known heat shock protein transcripts, HSP70 and HSP90 were studied in two tissues of nerve ganglia, cerebral ganglion and pleuropedal ganglion of Pacific abalone (Haliotis discus hannai). It was observed that both HSP70 and HSP90 transcripts were upregulated under heat stress in both ganglion tissues. Expression level of HSP70 was found higher than HSP90 in both ganglia whereas cerebral ganglion showed higher expression than pleuropedal ganglion. The HSP70 and HSP90 showed higher expression at Day-1 after exposed to heat stress, later decreased at Day-3 and Day-7 onwards. The present result suggested that HSP70 and HSP90 synthesize in nerve ganglion tissues and may provide efficient protection from stress.

Background: Surgery has been known as an inefficient approach to reduce back pain in patients with lumbar spinal stenosis; therefore, non-surgical treatments are necessary. However, there has been little research to analyze the effect of non-surgical treatments on lumbar spinal stenosis pain. Objective: To identify the effectiveness of 2 physiotherapeutic treatment approaches to relieve pain due to lumbar spinal stenosis. Design: Randomized controlled trial Methods: The participants were 36 lumbar spinal stenosis patients who were randomized in the joint mobilization group (JMG) and transcutaneous electrical nerve stimulation group (TENSG). Joint mobilization (JM) was conducted at the posteroanterior joint in the spinous process of the lumbar spine with stenosis. Transcutaneous electrical nerve stimulation (TENS) was applied on the lumbar spine with stenosis at a high frequency and intensity. Results: Visual analog scale (VAS) pain score significantly decreased in both groups, and the VAS value decreased more after JMG than that after TENSG. The pain thresholds of both groups also significantly increased, and that of JMG increased more compared to TENSG. In both the groups, significant improvements in VAS and pain thresholds were found, and JMG showed better results than TENSG. Conclusions: JM and TENS showed significant relief in both pain threshold and painpain, and JM showed more advanced relief compared to TENS.

목적: 굴절이상별 세 그룹으로 분류한 우리나라 아동들의 안축장과 빛간섭단층촬영(OCT)로 측정한 황반두께, 망막신경섬유층두께 사이의 상관성을 알아보고자 하였다. 방법: 안질환이 없고 안과관련 수술 경험이 없는 아동 67명(134안)을 대상으로 원시, 정시, 근시 그룹으로 분류하였다. 황반부와 망막신경섬유층두께는 Cirrus HD-OCT를 이용하여 측정하였고, 안축장은 IOL Master를 이용하여 측정하였다. 결과: 안축장은 근시, 정시, 원시그룹 순서로 길게 측정되었다(p<0.05). 중심부황반의 두께는 근시, 정시, 원시그룹 순서로 두껍게 측정되었다(p<0.05). 주변부황반부는위쪽, 코쪽, 아래쪽부분에서 근시그룹이 가장 얇았다(p<0.05).황반의 중심부 두께는 안축장과 양의 상관관계가 있었다(r=0.283, p<0.05). 주변부 황반의 두께는 모두 안축장과 음의 상관관계를 보였다. 귀쪽망막신경섬유층두께(Temporal RNFL Thickness)는 근시그룹이 가장 두꺼운 결과를 보였고,안축장과통계적으로 유의한 양의상관성이 나타났다(r=0.39, p<0.05). 위쪽과 코쪽, 아래쪽의 망막신경섬유층 두께는 안축장과 모두 음의 상관성을 나타냈다. 코쪽 부분의 두께는 통계적으로 유의하게 나타났다(r=-0.23, p<0.05). 결론: 본 연구를 통해 우리나라 소아들의 OCT로 측정한 망막의 황반부의 두께, 망막신경섬유층의 두께와 안축장은 근시의 정도가 높을수록 안축장의 길이가 더 길게 측정되었으며, 굴절이상별 세 그룹에서 나타나는 차이점을 확인하였다.

The objective of this study was to investigate the dynamic neural mobilization program on the changes in muscle activity and nerve conduction velocity (NVC) in stroke patients. The participants were sampled and randomly divided into experimental group I (n=12) who underwent arm neural mobilization and experimental group II (n=13) who underwent arm dynamic neural mobilization. As the pretest, peripheral NVC of the radial, median, and ulnar nerves were measured using the Viking Quest; the biceps brachii, brachioradialis, flexor carpi radialis, and extensor carpi radialis activities were measured with sEMG. Each intervention program consisted of 10 trials per set and three sets per session. The intervention programs were performed once daily for four weeks (four days/week). Posttest measurements were taken equally as the pretest measurements. Significant differences in peripheral NVC in all sections of the radial and median nerves and wristbelow elbow and below elbow-above elbow areas of the ulnar nerve, as well as in muscle activity of all muscles except the biceps brachii. These findings indicate that dynamic neural mobilization was effective in increasing peripheral NVC and altering the muscle activity.

The Purpose of this study was to determine the effects of sciatic nerve mobilization on pain and lower back muscle strength in female patients in their 40s who have been diagnosed with lumbar radiculopathy. Using a simple blinded method, 20 female patients with neuropathy in the nerve segments between L4-S1 were randomly divided into one group (n=10) that would undergo sciatic nerve mobilization, and another group (n=10) that would perform lower back segment stabilization exercises. The two groups attended 3 sessions per week, with each session taking 30 minutes, for a duration of 4 weeks. In the preliminary examinations, the pain index as well as the isometric muscle strength of the lower back extensor and flexor muscles were measured. After the passing of 4 weeks. The same method of measurement was used for the concluding examinations. Comparison of the pain indices in the two groups revealed that they both experienced a statistically significant decrease, and further inspection revealed that the there was a more substantial difference in the sciatic nerve mobilization group. Results of comparing changes in the Isometric Muscle Strength lower back muscle and bending muscle by group, In comparison between groups, the isometric strength of the lower back extensor showed a more significant difference in the sciatic nerve mobilization group (p <.05). Conclulsion, it can be inferred that application of sciatic nerve mobilization has a positive effect on the pain index and isometric muscle strength of the lower back in female patients with lumbar radiculopathy in their 40s.

Malignant peripheral nerve sheath tumors (MPNSTs) are defined as malignant tumors arising from peripheral nerves or differentiating along the line of the elements of the nerve sheath. MPNSTs that originate from the brain parenchyma are exceptionally rare and are termed malignant intracerebral nerve sheath tumors. We experienced a case of the epithelioid variant of malignant intracerebral nerve sheath tumor (MINST) occurring in the right frontal lobe of a 50-year-old man. He underwent gross total resection of the tumor. Histologically, the tumor cells had round, polygonal, or ovoid nuclei and moderate amounts of eosinophilic cytoplasm, which was defined as epithelioid cells. The tumor cells were arranged in short cords or nests with vaguely nodular patterns embedded in the myxoid stroma. Regarding mitotic activity, 15 mitotic figures were noted per 10 high-power fields. Immunohistochemically, tumor cells were positive for S-100 protein and synaptophysin, but negative for glial fibrillary acidic protein, HMB-45, EMA, and AE1/ AE3. Furthermore, immunostaining for INI1 was negative. Loss of the tumor-suppressor gene product SMARCB1/ INI1 expression has been recognized in epithelioid MPNST, but not in conventional MPNST. Postoperatively, he underwent radiotherapy and was followed for almost 1 year without recurrence. The present case is the first report of the epithelioid MINST.

The purpose of this study was to evaluate the effects of mobilization of the sciatic nerve on hamstring flexibility, lower limb strength, and gait performance in patients with chronic stroke. This study was a randomized clinical trial with a crossover design. Sixteen subjects were recruited for this study. The subjects were randomly divided into two intervention groups and underwent either of the following two interventions: sciatic nerve mobilization or static stretching of the hamstring. We assessed hamstring flexibility, lower limb strength, and gait performance using a digital inclinometer, a hand-held dynamometer, and the 10-meter walk test, respectively. Subjects had a 24-hour rest period between each session in order to minimize carryover effects. Measurements for each test were assessed prior to and immediately after the intervention sessions. Using a two-way analysis of variance test with repeated measures, data from the two trials were analyzed by comparing the differences between both techniques. The level of statistical significance was set at .05. Sciatic nerve mobilization resulted in significantly better knee extensor strength (p=.023, from 15.32±5.98 to 18.16±6.95 ㎏) and knee flexor strength (p=.011, from 7.80±4.80 to 8.15±4.24 ㎏) in the experimental group than in the control group. However, no significant effects of static stretching of the hamstring were observed on hamstring flexibility from the ankle plantar flexion (p=.966) and ankle neutral positions (p=.210) and on gait performance (p=.396). This study indicated that the sciatic nerve mobilization technique may be more effective in muscle activation of the knee extensor muscle and knee flexor muscle than hamstring static stretching technique in patients with chronic stroke.

목 적 : 삼차신경통은 심한 전기적 통증, 전 격통이 삼차신경 분지 중 하나 혹은 그 이상의 영역에 걸쳐 나타나는 안면통증 증후군이다. 삼차신경통의 발생기전은 정확히 알려져 있지 않으나 대부분의 경우 특별한 원인을 찾을 수 없는 특발형이다. 이에 본 연구에서는 삼차신경통 환자의 진단에 있어 중요한 Protocol인 3D VISTA와 3D SPACE를 비교하여 진단적 가치에 도움이 되는 Sequence를 알아보고자 하였다. 대상 및 방법 : 2013년10월 1일부터 12월 30일까지 본원에서 검사한 환자 20명을 대상으로 조사하였다. 남성9명, 여성 11명 이었으며 평균 연령은 52세였다. 검사에 사용된 장비는 3.0T 자기공명 영상 장비(Siemens skyra, Phillips Ingenia)를 이용하여 cranial nerve를 검사하였다. 사용된 Siemens skyra 3D SPACE 매개변수로는 TR/TE:1190/203ms, matrix: 320×320, Slice thickness: 0.5mm, Flip angle: 135, slice/slab: 112, voxel size: 0.28×0.28×0.5를 이용하였다. Phillips Ingenia 3D VISTA 매개변수로는 TR/TE: 2000/200ms, matrix: 320×320, Slice thickness: 0.6mm, Flip angle:90°, slice/slab: 100, voxel size:0.6×0.6×0.6 를 이용하여 영상을 획득하였다. 평가방법은 정량적 분석과 정성적 분석을 통해 영상을 분석하였으며, 정량적 분석은 trigeminal nerve와 Cerebellum에 ROI를 신호 대 잡음비(SNR)와 대조도 대 잡음비(CNR)를 측정하였다, 정성적 분석은 3D VISTA와 3D SPACE의 영상으로 해부학적 구조의 명확도와 전반적인 영상의 평가를 방사선사 3명 전문의2명에게 의뢰하여 정성적 분석을 하였다. 결 과 : 정략적 분석한 결과 3D VISTA 와 3D SPACE 평균 신호대 잡음비는 trigeminal nerve right/left 173.01/213.47평균 신호대 잡음비는193.24로 측정되었고, 3D SPACE의 trigeminal nerve right/left 99.61/130.83 평균 신호대 잡음비는115.22로 측정되었고, Cerebellum 137.32/58.06으로 측정되었다. 3D VISTA 와 3D SPACE sequence의 trigeminal nerve와 Cerebellum의 평균 대조도 대 잡음비는 114.74/120.18로 측정 되었다(p<0.05). 정성적 분석으로는 trigeminal nerve와 Cerebellum의 영상을 영상의학과 판독의 1명, 신경과 전문의 1명 방사선사 3명에게 의뢰하여 인공물 발생 정도, 해부학적 구조의 명확도, 영상선명도 및 전체적인 영상의 질을 평가한 결과 3D VISTA와 3D SPACE 영상이 4.3/4.1로 측정되었다(p<0.05). 결 론 : 고자장의 MRI 장비의 개발과 보급, 새로운 검사기법의 개발로 인해 현재 측두골과 같은 미세한 구조물이 주를 이루는 부위의 검사에서 MRI검사의 진단적 가치와 효용성은 다른 검사에 비해 탁월하여 질병의 확진과 치료 과정에서의 예후 등을 평가할 수 있기에 임상적 가치가 매우 높다고 평가받고 있다. 3TMR 장비에서 사용하는 sequence 중 T2 강조영상을 대표하는 3D VISTA와 3D SPACE를 비교해본 결과 3D VISTA sequence가 SNR이 높게 측정이 되었으나 CNR을 비교해 보면 SPACE sequence가 높게 측정 되었다. 두 가지 매개변수에서 정량, 정성 평가는 큰 차이를 보이지는 않고 있다. 따라서 정확한 판독을 위하여 DWI, Post 3D FLAIR 을 추가하여 사용한다면 진단에 유용하리라 사료된다.

The present study purposed to examine the effects of transcutaneous electrical nerve stimulation, self-stretching and functional massage on the recovery of muscle contraction force for muscle fatigue caused by sustained isotonic contraction. The subjects of this study were 45 healthy students. They were divided into transcutaneous electrical nerve stimulation group(n=15), self-stretching group(n=15) and functional massage group(n=15), and using Primus RS. We observed the pattern of changes in maximal voluntary isometric contraction force(MVIC) after causing muscle fatigue in quadriceps femoris muscle through sustained isotonic contraction. Maximal voluntary isometric contraction force(MVIC) were greatly increased after transcutaneous electrical nerve stimulation, self-stretching and functional massage. In the comparison of recovery rate of muscle contraction force for muscle fatigue caused by sustained isotonic contraction among the treatment groups, it did not show any significant differences. However, it showed that each treatment may be effective in recovery of muscle fatigue caused by sustained isotonic contraction.

This study purposed to examine the effect of low power laser on pain response and axonal regeneration. In order to prepare peripheral nerve injury models, we crushed the sciatic nerve of Sprague-Dawley rats and treated them with low power laser for 21 days. The rats were divided into 4 groups: normal group(n=10); control group(n=10) without any treatment after the induction of sciatic nerve crush injury; experimental group I(n=10) treated with low power laser(0.21mJ/㎟) after the induction of sciatic nerve crush injury; and experimental group II(n=10) treated with low power laser(5.25mJ/㎟) after the induction of sciatic nerve crush injury. We measured spontaneous pain behavior(paw withdrawal latency test) and mechanical allodynia(von Frey filament test) for evaluating pain behavioral response, and measured the sciatic function index for evaluating the functional recovery of peripheral nerve before the induction of sciatic nerve crush injury and on day 1, 7, 14 and 21 after the induction. After the experiment was completed, changes in the H & E stain and toluidine blue stain were examined histopathologically, and changes in MAG(myelin associated glycoprotein) and c-fos were examined immunohistologically. According to the results of this study, when low power laser was applied to rat models with sciatic nerve crush injury for 21 days and the results were examined through pain behavior evaluation and neurobehavioral, histopathological and immunohistological analyses, low power laser was found to affect pain response and axonal regeneration in both experimental group I and experimental group II. Moreover, the effect on pain response and axonal regeneration was more positive in experimental group I to which output 0.21mJ/㎟ was applied than in experimental group II to which 5.25mJ/㎟ was applied.

This study demonstrated that hyaluronic acid (HA) accelerated peripheral nerve regeneration after crush injury to the common peroneal nerve in an experimental rabbit model. Ten male New Zealand White rabbits, weighing 1.8 to 2.0 kg, were used in this study. After creating the nerve crush model in every right leg, rabbits were divided into two groups. Animals in group A received application of HA into the area surrounding the crushed nerve, and group B was the sham control. Electrophysiological assessment was performed every week. After 10 weeks, nerve histological examination, muscle weight and muscle histology were used to evaluate regeneration of the injured common peroneal nerve. No differences in electrophysiological assessment were observed between the two groups. In peripheral nerve histology, myelinated nerve fibers were observed more frequently and less connective tissue was observed in the crushed nerve of group A. Fewer muscle degenerative changes, such as fibrosis, atrophy, and centrally located myonuclei, were detected in group A than in group B. In conclusion, HA could become a potential neuroprotective agent for improvement of peripheral nerve regeneration after crush injury.

Peripheral nerve injuries are very common in clinics and often result in severe functional deficits. The aim of this study was to evaluate the effect of treadmill running and electro-acupuncture on nerve regeneration and functional recovery of muscle activity following sciatic nerve crush injury in a rat model. A comparative study was conducted over 30 days on 60 adult male Sprague-Dawley rats grouped into sham control (C), electro-acupuncture (EA), treadmill (T), and treadmill plus electro-acupuncture (TEA). The left sciatic nerve was crushed for 30 sec using a hemostatic forceps and functional activity was evaluated with sciatic functional tests, nerve conduct velocity, muscle weight, and histology at 10, 20, and 30 days after injury. Muscle weight was significantly (P<0.05) increased between days 10 and 30 in the TEA group. In histology, the degree of damage was scored as C > TEA > T > EA, although necrosis and fibrosis of muscle was observed only in the TEA group. The EA and TEA groups showed rapid recovery with better myelinated axons on day 10. These results suggest that application of the TEA method with balanced exercise is a useful treatment option for peripheral nerve injury regeneration and muscle activity.

Facial numbness restricted to the distribution of the mental nerve(mental neuropathy) is called "numb chin syndrome". The clinical importance of this syndrome is associated with first recognition of involvement of malignant diseases. The malignant neoplasm with numb chin syndrome show rapid progression and high mortality. We present a 43-year-old female who had been treated by radiotherapy for precursor T-cell leukemia/lymphoma involving the central nervous system( CNS) previously and later developed mental nerve invasion without central nervous system recurrence. MRI images revealed the CNS tumor mass remitted, and there was no identified peripheral nervous system(PNS) involvement including the mental nerve invasion, nevertheless the patient complained of consistent numbness and pain on right mandibular area. This is the first case of precursor T-cell leukemia/lymphoma accompanying mental nerve invasion without recurrence for central nervous system. Proper interpretation for mental neuropathy may lead to the prompt diagnosis and therapeutic intervention.