Background: The successful production of superior or transgenic offspring from in vitro produced embryos in cattle relies heavily on the quality of blastocyst stage embryos. In order to enhance the developmental competency of these embryos, a novel culture method was devised. Methods: This study utilized stem cell culture medium (SCM) from hESCs as a supplement within the culture medium for bovine in vitro produced embryos. To gauge the efficacy of this approach, in vitro fertilized embryos were subjected to culture in CR1aa medium enriched with one of three supplements: 0.3% BSA, 10% FBS, or 10% SCM. Results: The blastocyst development and hatching rates of one-cell zygotes cultured in CR1aa medium supplemented with SCM (23.9% and 10.2%) surpassed those cultured in CR1aa medium supplemented with BSA (9.3% and 0.0%) or FBS (3.1% and 0.0%) (p < 0.05). Furthermore, post-zygotic gene activation, cleaved embryos cultured in CR1aa medium supplemented with SCM (57.8% and 34.5%) exhibited notably higher rates (p < 0.05) compared to those cultured with BSA (12.9% and 0.0%) or FBS (45.7% and 22.5%) supplementation. Furthermore, the microinjection of SCM into the cytoplasm or pronucleus of fertilized zygotes resulted in elevated blastocyst development and hatching rates, particularly when the microinjected embryos were subsequently cultured in CR1aa medium supplemented with SCM from the 8-cell embryo stage onwards (p < 0.05), in contrast to those cultured with FBS supplementation. Conclusions: In conclusion, this study conclusively demonstrated that the incorporation of SCM into the culture medium significantly enhances the developmental progress of preimplantation embryos.

The pharmaceutical industry is an industry that provides medicines related to the health and life of the people. The pharmaceutical industry is a traditional regulation industry with the characteristics of R&D(Research and Development), purchasing, manufacturing, distribution and consumption under strict government management. Until now, pharmaceutical companies have continued to make efforts to maintain competitiveness through patent management, new product development, and marketing. However, industries are rapidly changing, including rising costs for developing new products and expanding generic markets. As these changes and uncertainties in the management environment increase, efforts are required to improve the competitiveness of the pharmaceutical industry from a new perspective. In this study, we intend to examine the impact of SCM(Supply Chain Management) dynamic capability of pharmaceutical companies on corporate performance through partnerships to respond to market changes and uncertainties. It was determined that the agility, visibility and flexibility that constitutes the SCM dynamic capabilities would affect the performance of pharmaceutical companies. In this study, the importance of SCM dynamic capabilities and cooperative relationships was identified through surveys by SCM managers of pharmaceutical companies. Consequently, in the pharmaceutical industry, which is a regulatory industry, we have identified that SCM dynamic capabilities and cooperative relationships with partner companies have a significant impact on corporate performance.

As the advent of the Fourth Industrial Revolution and Information Age, companies are in the state of infinite competition due to the rapidly changing technological environment and fierce competition. In this situation companies are making efforts to gain the competitive advantage by introducing information systems. Supply Chain Management (SCM) is considered a method to gain a competitive edge in rapid change. In fact, companies that already have introduced the SCM system are achieving company renovation with positive effects such as increase of sales stock reduction on-time delivery cost reduction and improved efficiency. This study was started to investigate the resistance that occurs in introducing the SCM system for small and medium-sized manufacturing industries that have not yet introduced the SCM system despite the importance of the SCM system, and to check the effect on the intention of the introduction. As the result of this study, the first is that the company has the higher technological innovation, the more positive the effect on Relative advantage Compatibility Perceived risk, Complexity. Second, The compatibility of the SCM system was rejected in innovation resistance, but it is adopted with the highest impact in the introduction intention. In addition, the mediating effect of innovation resistance was also rejected, confirming that if the SCM system is compatible for the company, it doesn’t affect the resistance and is the biggest factor to consider in the introduction of the SCM system. Third, the perceived risk of the SCM system doesn’t directly affect the intention to introduce, but has an indirect effect when mediation innovation resistance.

The purpose of this study is to examine the relationship between internal corporate, supplier, and customer integrations for domestic SMEs on non-financial and financial performance through SCM performance such as flexibility and reduction of uncertainties. To this end, data was collected on 286 SMEs in Korea, and the structural relationships between SCM integration level, SCM performances, and management performance were analyzed. As a result of the analysis, first, it was found that the SCM integration level had a significant positive effect on the flexibility and reduction of uncertainties, which are SCM performances. Second, the flexibility and reduction of uncertainties showed significantly positive effects on the non-financial performance of the companies, but did not directly affect the financial performance positively. Third, the non-financial performance was found to have a positive effect on the financial performance. In addition, the SCM integration level did not have a direct effect on the financial and non-financial performance, but it was found that it affected management performance by mediating the flexibility and reduction of uncertainties, which are SCM performances. That is, although the SCM integration level did not directly affect financial and non-financial performance, it was confirmed that it affects management performance by mediating SCM performances, flexibility and uncertainty reduction. In other words, it was confirmed that the SCM integration level directly or indirectly affects SCM performances and overall management performance. These results imply the necessity to focus on competency in the supply chain management area according to the SCM performance expected by SMEs, and the step by step approaches to the expected effects. In a situation where prior SCM related studies have not been able to present SCM performances and management performance of SMEs that are relatively lacking in their capital and SCM construction capabilities, the findings of this study could suggest the importance of SCM integration from the perspective of SMEs. In addition, from the viewpoint of SMEs, this study suggested that a sequential approach for performance measurement is required (SCM performance → management performance) in relation to the performance factors to be established through SCM. 1

As globalization has been progressed, companies faced a situation in which it was difficult to secure global competitiveness only with their internal management systems. To overcome this, Supply Chain Management (SCM) emerged, which optimizes the whole supply chain process from suppliers to demand companies. In this study, it was analyzed that the effects of customer integration among the integration factors of SCM, and market orientation among the strategic orientations on management performances such as non-financial performance and financial performance through a mediating role of flexibility. At this time, it was analyzed whether CEO's support has a moderating effect on the influence of the market orientation. As a result of analysis, the customer integration was found to have an indirect effect on the non-financial performance and the financial performance through the flexibility. The market orientation was found to have a direct effect on the non-financial performance and at the same time, indirectly affected it through the flexibility. In addition, it was shown that more the level of CEO's support, higher the influence of the market orientation. This moderating effect had an indirect effect on the financial performance. Based on the above findings, various implications for improving management performance were proposed. This study suggests that investments in computerization such as ERP and smart factories can improve supply chain management performance and ultimately improve customer satisfaction and financial performance.

Supply chain management can be defined as an information system that connects the inside and outside of a company. Its purpose is to systematically and strategically manage the flow of information, resources and services to improve the long-term performance of the entire organization, including individual companies connected to the supply chain, and the quality of service provided to customers. The ultimate goal of SCM is to create synergy through organic integration of supply and demand based on cooperation and collaboration with stakeholders in the supply chain. This study is based on the hypothesis that the company's management performance will improve as the level of SCM improves. Most of the previous studies dealt with the relationship between corporate performance and SCM in the IT area. In this study, research was conducted through human capacity with IT system. The causal relationship was demonstrated, and there was a difference in the perception of the results of this study depending on whether or not smart factories were consulted in the era of the 4th Industrial Revolution. There is a need to examine the links between management's value chain and its causal relationship.

The present study identified several antecedents that create perceived resistance to supply chain management (SCM) change. This work particularly emphasizes SCM change, which is notable given its central role in reacting market orientation and varied environmental and managerial conditions. A careful case study on a small and medium sized food production company in South Korea leads to the formulation of our framework including one second-order construct of ‘resistance’ as well as eight first-order constructs of ‘implementing the payment terms’, ‘balancing of business process’, ‘fear of responsibility’, ‘business sustainability transparency’, ‘past experience of failure’, ‘competence of work personnel’, ‘cooperation with third parties’ and ‘sharing personnel information with partner’. The hypothesized relation of first- and second-order construct was validated using survey sample data collected from 350 respondents who completed their questionnaire instrument. Results from confirmatory factor analysis revealed that nomological validity was established at statistical significance level by identifying six first order constructs of ‘implementing the payment terms’, ‘fear of responsibility’, ‘business sustainability transparency’, ‘past experience of failure’, a conbined construct of 'competence of work personnel/ cooperation with third parties’ and ‘sharing personnel information with partner’. The findings from our work are expected to provide important insights to the strategy for SCM risk management for small and medium sized company.

Since the directly bonded interface between TiAl alloy and SCM440 includes lots of cracks and generated intermetallic compounds(IMCs) such as TiC, FeTi, and Fe2Ti, the interfacial strength can be significantly reduced. Therefore, in this study, Cu is selected as an insert metal to improve the lower tensile strength of the joint between TiAl alloy and SCM440 during friction welding. As a result, newly formed IMCs, such as Cu2TiAl, CuTiAl, and TiCu2, are found at the interface between TiAl alloy and Cu layer and the thickness of IMCs layers is found to vary with friction time. In addition, to determine the relationship between the thickness of the IMCs and the strength of the welded interfaces, a tensile test was performed using sub-size specimens obtained from the center to the peripheral region of the friction-welded interface. The results are discussed in terms of changes in the IMCs and the underlying deformation mechanism. Finally, it is found that the friction welding process needs to be idealized because IMCs generated between TiAl alloy and Cu act to not only increase the bonding strength but also form an easy path of fracture propagation.

This papers focuses on remanufacturing processes in a closed loop supply chain. The remanufacturing processes is considered as one of the effective strategies for enterprises’ sustainability. For this reason, a lot of companies have attempted to apply remanufacturing related methods to their manufacturing processes. While many research studies focused on the return rate for remanufacturing parts as a control parameter, the relationship with demand certainties has been studied less comparatively. This paper considers a closed loop supply chain environment with remanufacturing processes, where highly fluctuating demands are embedded. While other research studies capture uncertainties using probability theories, highly fluctuating demands are modeled using a fuzzy logic based ambiguity based modeling framework. The previous studies on the remanufacturing have been limited in solving the actual supply chain management situation and issues by analyzing the various situations and variables constituting the supply chain model in a linear relationship. In order to overcome these limitations, this papers considers that the relationship between price and demand is nonlinear. In order to interpret the relationship between demand and price, a new price elasticity of demand is modeled using a fuzzy based nonlinear function and analyzed. This papers contributes to setup and to provide an effective price strategy reflecting highly demand uncertainties in the closed loop supply chain management with remanufacturing processes. Also, this papers present various procedures and analytical methods for constructing accurate parameter and membership functions that deal with extended uncertainty through fuzzy logic system based modeling rather than existing probability distribution based uncertainty modeling.

Recently, weight lightening is a key issue for various mechanical components to improve the fuel efficiency. For this reason, many researchers have been studying focused on the development of surface hardening treatment and metallic materials with high strength and wear resistance. In this study, we examine the formation of carbide at the surface of the gear machined by SCM420H steel after super-carburizing in order to improve the wear resistance of gear. The experimental results show that super-carburizing heat treatment gives rise to carbide dispersion across wider range of depth and higher carbon concentration than general carburizing heat treatment. Carbide having spheroidal or spherical shape had a size under 2 micro-meter produced in austenite grain boundaries or within austenite grains during super-carburizing. The super-carburized specimen maintained the hardness, HV700 above, at the 0.6mm depth and had a 10.4% lower coefficient of friction which was 0.766. This results from the dispersed carbide which lowered the coefficient of friction and ended up affecting wear resistance. Consequently, we conclude that super-carburizing heat treatment has more influence on the improvement of hardness, wear resistance compared to general carburizing heat treatment.

The size of the market for SCM information systems have globally and steadily increased. And there are businesses that obtained innovative business performance by introducing SCM information systems. However, many businesses have still undergone trial and error in the process to introduce and operate SCM. As external factors including suppliers, customers, etc. and internal factors of businesses have been analyzed to be failure factors of executing SCM information systems, the businesses that try to introduce SCM information systems need to understand possible failure factors and establish the solutions. Therefore, this study tries to verify the diffusion of SCM information systems and effects on bullwhip effects. The study is expected to suggest empirical data that people will refer to the establishment of next counterstrategies according to the lapse of the period that systems are introduced based on theoretical bases related to the diffusion of SCM information systems.

In this study, SCM440 alloys are investigated to research the effect of wear resistance. For this purpose, three wear factors which are friction force, wear loss and coefficient of friction applied to test wear-resistance. For the wear test, ball-on-disk was used to assess the variation of wear characteristics. Lastly, the coefficient of wear was calculated by using the Archard's wear equation in SCM440 alloys. The applied normal load was fixed at 30N in all test. The test results showed that SCM440 alloy's Vickers hardness average value is near 671.4Hv, the friction force is 4.11N through the Ball-on-disk test, the coefficient of friction and the wear loss are 0.431 and 0.080 respectively. Finally, Archard’s wear value of SCM440 alloys could be shown approximately 0.1514.

It is expected that the temperature in Pyeongyang will be similar to that (16.6℃) in Seogwipo in the late 21st century, and most of South Korea will enter the subtropical climate due to climate change. Change in the precipitation pattern like the range of fluctuation caused by climate change will lead to expanded uncertainty in securing reliable water supply, along with a serious impact on demands for living and industrial water due to change in the volume and period of river outflow. As industrial water for production activities is estimated based on the contract quantity, it is difficult to apply rationalization of water usage and incentives in water recycling. Therefore many companies are making efforts in complying with the effluent standard while spending few resources on such rationalization and recycling. This study researched water risk management over 115 Korean companies by 28 questions in 4 categories. Through the research, this study aims to understand water risk management levels and seek response plans.

일반적인 3-전극 시스템의 순환전압전류법을 사용하여 유기부식억제제인 트리에탄올아민 (TEA)을 첨가하여 SCM440 강에 대한 전류-전압 곡선을 측정하였다. 그 결과 SCM440 강의 C-V특성 은 순환전압전류법으로부터 산화전류에 기인한 비가역 공정으로 나타났다. 확산계수는 부식억제제 TEA 의 농도를 2.5 x 10-4 M에서 5,0 x 10-4 M로 2배로 증가시킴에 따라 확산계수는 각각 2.561 x 10-6 cm2s-1에서 1.707 x 10-6 cm2s-1로 1.5배로 감소하므로 부식억제효과가 좋음을 알 수 있었다. 그리고 전 해질 농도변화에 따르는 효과는 전해질 농도를 0.5 N에서 1.0 N로 증가시키면, 확산계수는 각각 5.12 x 10-6 cm2s-1에서 2.56 x 10-6 cm2s-1로 2배로 감소하므로 1.0 N의 전해질의 사용이 적합하였다.

This paper addresses order-lot pegging issues in the supply chain of a semiconductor business. In such a semiconductor business (memory or system LSI) order-lot pegging issues are critical to achieving the goal of ATP (Available to Promise) and on-time production and delivery. However existing pegging system and researches do not consider capacity limit on bottleneck steps. This paper presents an order-lot pegging algorithm for assigning a lot to an order considering quality constraints of each lot and capacity of bottleneck steps along the entire FAB. As a result, a quick and accurate response can be provided to customer order enquiries and pegged lot lists for each promised orders can be shown transparently and short or late orders can be detected before fixing the order.

우리나라는 국가연구개발사업의 결과로 얻어진 성과가 기술이전 되거나 사업화되어 사회로의 확 산이 되도록 하기 위한 여러 법령과 제도가 시행되 고 있다. ｢특허법｣, ｢과학기술기본법｣, ｢기술의 이 전 및 사업화의 촉진에 관한 법률｣, ｢국가연구개발 사업의 관리 등에 관한 규정｣(이하 ‘국연사규정’이 라 한다) 등의 법령들이 무형적 결과물의 확산 정 책에 관련하여 기본적인 원칙을 규정하고 있는데, 해당 법령들은 무형적 결과물에 대한 주요 용어인 “실시”, “기술이전”, “사업화”, “기술료”, “양도” 및 “양여” 등에 대한 개념정의가 치밀하지 못하고, 동 일한 용어에 대해서 법령 내에서 또는 법령 간에 상충하는 부분이 있어 해당 법령들의 해석과 적용 에 있어 논란의 여지가 있다. 한편, 연방정부의 지원을 통해 발생한 기술 및 특허에 대한 소유권의 귀속을 정부에서 연구기관 참여기업 등으로 할 수 있도록 하는 것을 골자 로 한 미국의 Bayh-Dole Act가 1980년에 시행 된 이래, 우리나라도 ｢과학기술기본법｣ 및 ‘국연사 규정’ 등 통해 국가연구개발사업의 무형적 결과물 의 소유권 귀속을 연구개발기관 등으로 할 수 있도 록 하는 등 연구개발결과물이 민간으로 널리 확산 될 수 있도록 노력하고 있다. 그럼에도 불구하고 ‘국연사규정’은 무형적 결과물을 소유한 기관이 해 당 결과물을 타 기관으로 양도(또는 양여)하는 것 을 제한하고 있어 연구결과물의 사회적 확산에 대 해 일정 부분 규제로서 작용하고 있다. 또한 동규 정은 무형적 결과물의 소유기관이 해당 결과물에 대한 권리를 포기하는 경우 발명자(연구책임자)에 게 양도(또는 양여)할 수 있도록 하고 있으나 그 요건 등의 현실성이 부족하여 해당 조항은 사문화 될 수 있다고 생각한다. ‘국연사규정’이 정하고 있는 기술실시계약에 있 어서 국내 중소기업 우선 제도는 지식재산권 시장 의 글로벌화 시대에 해외 시장으로의 기술실시에 제한을 가하는 것이므로 무형적 결과물의 사회적 확산에 대한 규제로 작용하는 부분이 있다. 한편, 동 규정 및 일부 중앙행정부처의 훈령은 기술료 감 면 제도를 두어 사실상의 국내 기관의 지원 정책을 시행하고 있는데, 해당 기술료 감면 제도 및 이에 근거한 정부의 조치는 WTO체제에서의 GATT가 채택한 ‘보조금 및 상계조치 협정’에 위반될 여지가 있으므로 기술료 감면 제도 및 정책을 수립⋅시행 함에 있어 해당 협정에 위배되지 않도록 유의할 필 요가 있다 국가연구개발사업에 대한 기술이전⋅사업화 촉 진 정책 및 제도를 시행함에 있어 통일적인 법령 정비를 시행하는 한편 불필요거나 의도치 않게 발 생한 규제를 풀어 국가연구개발사업의 결과물이 사회적으로 널리 확산될 수 있도록 하는 법체계를 구축해 나갈 필요가 있다고 생각한다.