본 연구의 목적은 알츠하이머질환(Alzheimer’s disease: AD) 동물 모델을 대상으로 트레드밀 운 동(Treadmill exercise: TE)과 환경강화(environmental enrichment: EE) 처치가 인지기능, 근 기능, 및 밀 착연접 단백질 발현에 미치는 영향을 확인하는데 있다. AD 동물 모델을 제작하기 위해 aluminum chloride(AlCl3)를 90일간(40mg/kg/하루) 투여 하였으며 동시에 TE(10-12m/min, 40-60min/day) 혹은 EE에 노출시켰다. 그 결과 AlCl3 투여에 의한 인지기능 저하와 근 기능 감소가 TE와 EE에 의해 완화된 것 으로 나타났다. 또한, TE와 EE는 AD 질환에서 나타나는 β-amyloid(Aβ), alpha-synuclein 및 tumor necrosis factor-α(TNF-α) 단백질의 발현 증가를 감소시킨 것으로 나타났다. 게다가 TE와 EE는 AlCl3 투여에 의해 감소된 밀착연접 단백질(Occludin, Claudin-5 및 ZO-1)의 발현을 통계적으로 유의하게 증가시킨 것으로 나타났다. 마지막으로 Aβ 단백질과 밀착연접 단백질과의 상관분석을 실시한 결과 부적 상 관관계(Occludin: r=-0.853, p=0.001; Claudin-5 : r=-0.352, p=0.915; ZO-1 : r=-0.424, p=0.0390) 로 나타났다. 따라서 이를 종합해 보면 TE 혹은 EE 처치는 AD에 나타나는 병리학적 특징들을 일부 완화 시켜 인지기능과 근 기능을 일부 개선 시킬 수 있는 효과적인 운동 방법이라고 생각된다.

We present a practical vacuum pressure sensor based on the Schottky junction using graphene anchored on a vertically aligned zinc oxide nanorod (ZnO-NR). The constructed heterosystem of the Schottky junction showed characteristic rectifying behavior with a Schottky barrier height of 0.64 eV. The current–voltage (I–V) features of the Schottky junction were measured under various pressures between 1.0 × 103 and 1.0 × 10− 3 mbar. The maximum current of 38.17 mA for the Schottky junction was measured at – 4 V under 1.0 × 10− 3 mbar. The high current responses are larger than those of the previously reported vacuum pressure sensors based on ZnO nanobelt film, ZnO nanowires, and vertically aligned ZnO nanorod devices. The pressure-sensitive current increases with the vacuum pressure and reaches maximum sensitivity (78.76%) at 1.0 × 10− 3 mbar. The sensitivity and repeatability of the Schottky junction were studied by the current–time (I–T) behavior under variation of vacuum pressure. The sensing mechanism is debated from the surface charge transfer doping effect by oxygen chemisorption. The results suggest that this simple graphene/ZnO-NR Schottky junction device may have potential in the fabrication of vacuum pressure sensor with high sensitivity.

PURPOSES : This paper proposes an artificial neural network (ANN)-based real-time traffic signal time design model using real-time field data available at intersections equipped with smart intersections. The proposed model generates suitable traffic signal timings for the next cycle, which are assumed to be near the optimal values based on a set of counted directional real-time traffic volumes. METHODS : A training dataset of optimal traffic signal timing data was prepared through the CORSIM Optimal Signal Timing program developed for this study to find the best signal timings, minimizing intersection control delays estimated with CORSIM and a heuristic searching method. The proposed traffic signal timing design model was developed using a training dataset and an ANN learning process. To determine the difference between the traditional pre-time model primarily used in practice and the proposed model, a comparison test was conducted with historical data obtained for a month at a specific intersection in Uiwang, Korea. RESULTS : The test results revealed that the proposed method could reduce control delays for most of the day compared to the existing methods, excluding the peak hour periods when control delays were similar. This is because existing methods focus only on peak times in practice. CONCLUSIONS : The results indicate that the proposed method enhances the performance of traffic signal systems because it rapidly provides alternatives for all-day cycle periods. This would also reduce the management cost (repeated field data collection) required to increase the performance to that level. A robust traffic-signal timing design model (e.g., ANN) is required to handle various combinations of directional demands.

In this work, we developed silver nanowires and a silicon based Schottky junction and demonstrated ultrafast broadband photosensing behavior. The current device had a response speed that was ultrafast, with a rising time of 36 μs and a falling time of 382 μs, and it had a high level of repeatability across a broad spectrum of wavelengths (λ = 365 to 940 nm). Furthermore, it exhibited excellent responsivity of 60 mA/W and a significant detectivity of 3.5 × 1012 Jones at a λ = 940 nm with an intensity of 0.2 mW cm2 under zero bias operating voltage, which reflects a boost of 50%, by using the AC PV effect. This excellent broadband performance was caused by the photon-induced alternative photocurrent effect, which changed the way the optoelectronics work. This innovative approach will open a second door to the potential design of a broadband ultrafast device for use in cutting-edge optoelectronics.

Traf4 (Tumor necrosis factor Receptor Associated Factor 4) is a member of the tumor necrosis factor receptor (TNFR) - associated factors (TRAFs) family. TRAF4 is overexpressed in tumor cells such as breast cancer and associated with cytoskeleton and membrane fraction. Interestingly, TRAF4 was localized with tight junctions (TJs) proteins including OCLN and TJP1 in mammary epithelial cells. However, the expression patterns and biological function of Traf4 were not examined in preimplantation mouse embryos although Traf4-deficient mouse showed embryonic lethality or various dramatic malformation. In this study, we examined the temporal and spatial expression patterns of mouse Traf4 during preimplantation development by qRT-PCR and immunostaining, and its biological function by using siRNA injection. We found upregulation of Traf4 from the 8-cell stage onwards and apical region of cell – cell contact sites at morula and blastocyst embryos. Moreover, Traf4 knockdown led to defective TJs without alteration of genes associated with TJ assembly but elevated p21 expression at the KD morula. Taken together, Traf4 is required for TJs assembly and cell proliferation during morula to blastocyst transition.

Multi-walled carbon nanotubes (MWCNTs) grown by chemical vapor deposition retain the residual catalyst particles from which the growth occurred, which are considered a detriment to MWCNTs’ performance, especially electrical conductivity. The first direct measurements have been made of the electrical transport through the catalyst cap into the MWCNT using nanoscale 2-point-probe to determine the effects of the catalyst particle’s size and the diameter ratio with its associated MWCNT on the electrical transport through the catalyst cap as compared to the inherent conductivity of the MWCNT. The MWCNT diameter is independent of the catalyst size, but the ratio of the catalyst cap diameter to MWCNT diameter (DC/DNT) determines the conduction mechanism. Where DC/DNT is greater than 1 the resulting I–V curve is near ohmic, and the conduction through the catalyst ( RC+NT) approaches that of the MWCNT (RNT); however, when the DC/DNT < 1 the I–V curves shift to rectifying and RC+NT > > RNT. The experimental results are discussed in relation to current crowding at the interface between catalyst and nanotube due to an increased electric field.

Background: The serratus posterior inferior (SPI) muscle originates from the spinous process of T11-L2 and inserts at the lower border of the 9–12th ribs. This muscle is involved in thoracolumbar rotation and stability. Several positions can be used to improve trunk stability; the quadruped position is a good position for easily maintaining a neutral spine. In particular, during one arm lifting, various muscles act to maintain a neutral trunk position, and the SPI is one of these muscles. If trunk stability is weakened, uncontrolled trunk rotation may occur at this time. Tape can be used to increase trunk stability. There have been no studies on the effect of taping applied to the SPI muscle on thoracolumbar junction (TLJ) stability. Objects: This study compared the TLJ rotation angle between three different conditions (without taping, transverse taping, and SPI muscle direction taping). Methods: Thirty subjects were recruited to the study (18 males and 12 females). The TLJ rotation angle was measured during one arm lifting in a quadruped position (ALQP). Two taping methods (transverse and SPI muscle direction taping) were applied, and the TLJ rotation angle was measured in the same movement. Results: SPI muscle direction taping significantly reduced TLJ rotation compared to that without taping (p < 0.001) and with transverse taping (p < 0.001). There was a significant difference in the TLJ rotation angle between transverse taping and SPI muscle direction taping (p < 0.017). Conclusion: SPI muscle direction taping reduces the TLJ rotation angle during ALQP. Therefore, SPI muscle direction taping is one method to improve TLJ stability and reduce uncontrolled TLJ rotation during ALQP.

PURPOSES : This study prioritizes the potential technology for establishing an efficient traffic control in the ramp junction of urban deep underground tunnels in the future. We considered most of the applicable technologies that ensure traffic safety at the on-off ramp junction. METHODS : This study proposes a methodology to prioritize the applicable technology for establishing efficient traffic control in the ramp junction of an urban deep underground tunnel using an analytical hierarchy process (AHP). First, an AHP structure was developed. Second, an individual survey was conducted to collect the opinions of road and transportation experts. Based on the survey results, weights were estimated depending on the relevant criteria of the developed structure. The estimated weights were verified using the consistency index (CI) and consistency ratio (CR). In addition, a sensitivity analysis was performed to confirm the reliability of the estimated weights. Finally, the potential technology for an efficient traffic control in the ramp junction of an urban deep underground tunnel was prioritized. RESULTS : In the first level of hierarchy, traffic demand control had the highest priority, and ramp metering, section speed control, and shoulder lane control were selected in the second level of hierarchy. CONCLUSIONS : These results implied that prioritizing would be useful in establishing traffic operation strategies for traffic safety when constructing and opening deep underground tunnels in urban areas in the future.

우리나라의 고속국도 건설 역사는 이미 50년이 넘었다. 그러나 고속국도의 주요 시설물들 자체에 대한 연구는 찾아볼 수 없었다. 주요 시설물 중 운전자들이 중요하게 여기는 분기점의 분포 및 명칭 특성을 분석하였다. 2020년 6월 현재 108개 분기점에 대한 분석 결과는 다음과 같다. 노선별 단순 총수는 주요 간선 노선들에 많지만, 단위 거리 당 분기점 수는 단거리 노선에 훨씬 더 많았다. 지역별로는 경기, 경남 등 대도시 주변에 집중되어 있었는데, 면적과는 달리 인구 대비 분기점 수는 오히려 더 적었다. 분기점 명칭의 어종은 99.1%가 한자어였으며, 평균 음절수는 2.17음절로 매우 짧고, 지수분포를 보였다. 명명 유연성 측면에서는 행정구역명 관련 분기점 명칭이 87.0%로 압도적이었으며, 그 중에서도 읍･면･동 관련 명칭과 시･군･구 관련 명칭이 대부분을 차지하였다. 어종, 음절 및 명명 유연성 특성은 행정구역명을 우선적으로 따르는 ｢시설물 명칭 부여 기준｣의 영향이 크다.

Recent studies showed that tight junctions (TJs) integrity and assembly are required for blastocyst development in mouse and pig models. However, the biological functions of TJs associated with embryo implantation and maintenance of pregnancy were not investigated yet. To examine whether disrupted TJs affect further embryo development, we employed RNAi approach and inhibitor treatment. The embryos were injected with Cxadr (Coxsackievirus and adenovirus receptor) siRNA for knock down (KD) and treated with Adam10 (A Disintegrin and Metalloproteinase specific inhibitor 10; GI254023X; SI). We compared blastocyst development and paracellular sealing assay using FITC dextran uptake between control and KD or SI embryos. Finally, we transferred control and Cxadr KD or Adam 10 SI treated blastocyst to uteri of recipients. Cxadr KD and Adam 10 SI showed lower blastocyst development and more permeable to FITC-dextran. Moreover, we observed that half of KD and inhibited embryos failed to maintain pregnancies after the second trimester. Our findings suggested that TJs integrity is required for the maintenance of pregnancy and can be used as a selective marker for the successful application of assisted reproduction technologies.

It is well-known that the primary role of a vehicle exhaust system is to reduce the exhaust emissions and noise caused by a running vehicle. However, as vehicle exhaust systems are being evaluated and improved in various ways to satisfy consumer needs, technologies for reducing noise and vibration are significantly being developed. The biggest challenge in designing an exhaust system is generating the optimal back pressure and flow velocity for a running vehicle, thereby maximizing the performance, while simultaneously reducing the noise caused by the exhaust emissions. In this study, we designed the junction chamber shapes of various exhaust systems, which are applicable to V6 and above engines, and conducted a CFD analysis of the exhaust gas flowing through an exhaust pipe. In addition, we precisely measured the noise and vibration caused by a vehicle and analyzed the correlation.

PURPOSES : The purpose of this study is to analyze the magnitude of shoving of asphalt pavement by junction type between airport concrete and asphalt pavements, and to suggest a junction type to reduce shoving. METHODS : The actual pavement junction of a domestic airport, which is called airport “A”was modified by placing the bottom of the buried slab on the top surface of the subbase. A finite element model was developed that simulated three junction types: a standard section of junction proposed by the FAA (Federal Aviation Administration), an actual section of junction from airport “A”and a modified section of junction from airport“ A”. The vertical displacement of the asphalt surface caused by the horizontal displacement of the concrete pavement was investigated in the three types of junction. RESULTS: A vertical displacement of approximately 13 mm occurred for the FAA standard section under horizontal pushing of 100 mm, and a vertical displacement of approximately 55 mm occurred for the actual section of airport “A”under the same level of pushing. On the other hand, for the modified section from airport“ A”a vertical displacement of approximately 17 mm occurred under the same level of pushing, which is slightly larger than the vertical displacement of the FAA standard section. CONCLUSIONS: It was confirmed that shoving of the asphalt pavement at the junction could be reduced by placing the bottom of the buried slab on the top surface of the subbase. It was also determined that the junction type suggested in this study was more advantageous than the FAA standard section because it resists faulting by the buried slab that is connected to the concrete pavement. Faulting of the junctions caused by aircraft loading will be compared by performing finite element analysis in the following study.

Establishment of the Adherens junction (AJ) and Tight junction (TJ) are important steps in terms of morphological formation during preimplantation develoment. Particularly, TJ complex is crucial for cavitation in blastocyst. So far, many TJ protein/genes are revealed. However, the biological function and regulation of TJ were not elucidated during post implantation. We depleted several TJ and TJ associated genes using RNA interference, and examined preimplantation development with TJ. We tested functionality of paracellular sealing to determine integrity of TJ formation and examined TE differentiation indirectly using outgrowth assay in vitro. We observed defect of paracellular permeability in the TJ related genes knockdown(KD) blastocyst and abnormal outgrowth. Particularly, trophoblast cells were not stretched out in the KD groups. Finally, we did embryo transfer using the TJ genes KD and control blastocysts into surrogate mothers. We found lower of the implantation rates/ maintenance of pregnancy in the TJ KD groups (less than 40%) than in the controls (about 80%). In conclusion, TJ integrity is can be used as a selective marker for developmentally competent embryos and successful pregnancy.

The BCBJ (Back Contact and Back Junction) or back-lit solar cell design eliminates shading loss by placing the pn junction and metal electrode contacts all on one side that faces away from the sun. However, as the electron-hole generation sites now are located very far from the pn junction, loss by minority-carrier recombination can be a significant issue. Utilizing Medici, a 2-dimensional semiconductor device simulation tool, the interdependency between the substrate thickness and the minority-carrier recombination lifetime was studied in terms of how these factors affect the solar cell power output. Qualitatively speaking, the results indicate that a very high quality substrate with a long recombination lifetime is needed to maintain the maximum power generation. The quantitative value of the recombination lifetime of minority-carriers, i.e., electrons in p-type substrates, required in the BCBJ cell is about one order of magnitude longer than that in the front-lit cell, i.e., 5 × 10−4 sec vs. 5 × 10−5 sec. Regardless of substrate thickness up to 150 μm, the power output in the BCBJ cell stays at nearly the maximum value of about 1.8 × 10−2 W·cm−2, or 18 mW·cm−2, as long as the recombination lifetime is 5 × 10−4 s or longer. The output power, however, declines steeply to as low as 10 mW·cm−2 when the recombination lifetime becomes significantly shorter than 5 × 10−4 sec. Substrate thinning is found to be not as effective as in the front-lit case in stemming the decline in the output power. In view of these results, for BCBJ applications, the substrate needs to be only mono-crystalline Si of very high quality. This bars the use of poly-crystalline Si, which is gaining wider acceptance in standard front-lit solar cells.

The electrical properties of Au/n-type Ge Schottky contacts with different contact areas were investigated using current-voltage (I-V) measurements. Analyses of the reverse bias current characteristics showed that the Poole-Frenkel effect became strong with decreasing contact area. The contribution of the perimeter current density to the total current density was found to increase with increasing reverse bias voltage. Fitting of the forward bias I-V characteristics by considering various transport models revealed that the tunneling current is dominant in the low forward bias region. The contributions of both the thermionic emission (TE) and the generation-recombination (GR) currents to the total current were similar regardless of the contact area, indicating that these currents mainly flow through the bulk region. In contrast, the contribution of the tunneling current to the total current increased with decreasing contact area. The largest E00 value (related to tunneling probability) for the smallest contact area was associated with higher tunneling effect.

The a-Si:H/c-Si hetero-junction (HJ) solar cells have a variety of advantages in efficiency and fabrication processes. It has already demonstrated about 23% in R&D scale and more than 20% in commercial production. In order to further reduce the fabrication cost of HJ solar cells, fabrication processes should be simplified more than conventional methods which accompany separate processes of front and rear sides of the cells. In this study, we propose a simultaneous deposition of intrinsic thin a-Si:H layers on both sides of a wafer by dual hot wire CVD (HWVCD). In this system, wafers are located between tantalum wires, and a-Si:H layers are simultaneously deposited on both sides of the wafer. By using this scheme, we can reduce the process steps and time and improve the efficiency of HJ solar cells by removing surface contamination of the wafers. We achieved about 16% efficiency in HJ solar cells incorporating intrinsic a-Si:H buffers by dual HWCVD and p/n layers by PECVD.

This paper investigates the dependence of a-Si:H/c-Si passivation and heterojunction solar cell performances on various cleaning processes of silicon wafers. It is observed that the passivation quality of a-Si:H thin-films on c-Si wafers depends highly on the initial H-termination properties of the wafer surface. The effective minority carrier lifetime (MCLT) of highly H-terminated wafer is beneficial for obtaining high quality passivation of a-Si:H/c-Si. The wafers passivated by p(n)-doped a-Si:H layers have low MCLT regardless of the initial H-termination quality. On the other hand, the MCLT of wafers incorporating intrinsic (i) a-Si:H as a passivation layer shows sensitive variation with initial cleaning and H-termination schemes. By applying the improved cleaning processes, we can obtain an MCLT of 100μsec after H-termination and above 600μsec after i a-Si:H thin film deposition. By adapting improved cleaning processes and by improving passivation and doped layers, we can fabricate a-Si:H/c-Si heterojunction solar cells with an active area conversion efficiency of 18.42%, which cells have an open circuit voltage of 0.670V, short circuit current of 37.31 mA/cm2 and fill factor of 0.7374. These cells show more than 20% pseudo efficiency measured by Suns-Voc with an elimination of series resistance.