Interferon-tau (IFNT) is known as a major conceptus protein that signals the process of maternal recognition of pregnancy in ruminants. Also, multiple interferon genes exist in cattle, However, molecular mechanisms of these bovine IFNT (bIFNT) genes whose expressions are limited have not been characterized. We and others have observed that expression levels of bovine subtype IFNT genes in the tissues of ruminants; thus, bIFNT1 and other new type I (bIFNTc1/c2/c3) gene co-exist during the early stages of conceptus development and non-trophoblast cells. Its genes transcription could be regulated through CDX2 and ETS2 and JUN and/or cAMP-response element binding protein (CREB)-binding protein (CREBBP) expression, a transcription factor implicated in the control of cell differentiation in the trophectoderm. Bovine ear-derived fibroblast cells, were co-transfected with luciferase reporter constructs carrying upstream (positions -1000 to +51) regions of bIFNT1 and other new type I gene and various transcription factor expression plasmids. Compared to each - 1kb-bIFNT1/ c1/c2/c3-Luc increased when this constructs were co-transfected with CDX2, ETS2, JUN and/or CREBBP. Also, Its genes was had very effect on activity by CDX2, either alone or with the other transcription factors, markedly increased luciferase activity. However, the degree of transcriptional activation of the bIFNTc1 gene was not similar to that bIFNT1/c2/c3 gene by expression plasmid. Furthermore, Sequence analyses also revealed that the expression levels of bIFNT1/c2/c3 gene mRNAs expression were highest on day 17, 20 and 22 trophoblast and, Madin-Darby bovine kidney (MDBK), Bovine ear-derived fibroblast (EF), and endometrium (Endo) non-trophoblast cells. But, bIFNTc1 mRNA had not same expression level, bIFNTc1 lowest levels than those of IFNT1/c2/c3 gene in both trophoblast and non-trophoblast cells. These results demonstrate that bovine subtype bIFNT genes display differential, in the trophoblast and non-trophoblast cells.

With the advent of the digital age, production and distribution of web pages has been exploding. Internet users frequently need to extract specific information they want from these vast web pages. However, it takes lots of time and effort for users to find a specific information in many web pages. While search engines that are commonly used provide users with web pages containing the information they are looking for on the Internet, additional time and efforts are required to find the specific information among extensive search results. Therefore, it is necessary to develop algorithms that can automatically extract specific information in web pages. Every year, thousands of international conference are held all over the world. Each international conference has a website and provides general information for the conference such as the date of the event, the venue, greeting, the abstract submission deadline for a paper, the date of the registration, etc. It is not easy for researchers to catch the abstract submission deadline quickly because it is displayed in various formats from conference to conference and frequently updated. This study focuses on the issue of extracting abstract submission deadlines from International conference websites. In this study, we use three machine learning models such as SVM, decision trees, and artificial neural network to develop algorithms to extract an abstract submission deadline in an international conference website. Performances of the suggested algorithms are evaluated using 2,200 conference websites.

최근 가상현실 기술이 대중들에게 인기와 관심을 가지기 시작하면서 다양한 콘텐츠가 등장하고 있다. 특히 가상현실 디바이스를 활용한 가상현실 게임이 사용자와 시장에서 많은 관심을 받고 있으며 가상 현실 게임이 많이 개발되고 있는 추세이다. 가상현실 게임의 특징은 가상현실 디바이스를 통해 현존감 을 느끼며 몰입감을 극대화 시킬 수 있다는 장점을 가지고 있다. 이러한 장점을 활용하여 가상현실의 공간형 디스플레이 환경에서 디바이스의 인터페이스를 통해 여러 상호작용 아이템과의 상호작용을 할 수 있어 현존감 있는 경험이 가능하다. 이러한 특징을 극대화하여 사용자에게 보다 높은 몰입감과 흥미를 발생 할 수 있는 방안을 연구 하고자 한다. 설계 방안을 제시하기에 앞서 대중화된 가상현실 게임내의 상호작용 아이템과 인터페이스 설계방식을 분석하여 몰입감을 증대 시킬 수 있는 방안을 찾는 것이 본 연구에 목적이다. 연구에서 게임의 인터페이스와 상호작용 아이템간의 관계를 정리하였고 이를 기반으로 가상현실 게임 사례를 들어 가상현실 게임 내의 아이템 인터페이스의 설계 방식을 비교 분석하는 연구를 진행하였다. 연구를 통해 보다 몰입감이 높은 가상현실 게임의 인터페이스 설계 방안의 기반이 되는 선행연구가 될 것으로 기대한다.

The objective of this study was to examine the expression pattern of Kelch-like ECH-associated protein 1 (Keap1) in the maxillary 2nd molar germs of rats. We used the maxillary 2nd molar germs in rats’ pup at postnatal day 3 (bell stage), 6 (crown formation stage) and 9 (root formation stage). The investigation on mRNA and protein levels were done using reverse transcription - polymerase chain reaction and western blot. Localization of Keap 1 in the maxillary 2nd molar germs were revealed through immunofluorescence staining. Keap1 from the maxillary 2nd molar germs were mostly manifested on postnatal day 3 and dramatically decreased on postnatal day 6 and 9 at mRNA and protein levels, while amelogenin and ameloblastin increased during the development of maxillary 2nd molar germs. During immunofluorescence analysis, the strong immunoreactivity against Keap1 was detected in the apical side of ameloblasts at the presecretory and secretory stages. However, Keap1 expression was hardly observed in the ameloblasts at the maturation stage. These results shows that Keap1 is strongly expressed in the presecretory and secretory ameloblasts of amelogenesis, and suggest that Keap1 may be a crucial molecule for the regulatory mechanisms tasked with the formation of enamel layer.

This study evaluated the protective effects of a combination of eight B. abortus recombinant proteins that were cloned and expressed into a pMal vector system and DH5α: nucleoside diphosphate kinase (rNdk), 50S ribosomal protein (rL7/L12), malate dehydrogenase (rMDH), DNA starvation/stationary phase protection protein (rDps), elongation factor (rTsf), arginase (rRocF), superoxide dismutase (rSodC), and riboflavin synthase subunit beta (rRibH). The proteins were induced, purified, and administered intraperitoneally into BALB/c mice. The mice were immunized three times at weeks 0, 2, and 5 and then infected intraperitoneally (IP) with 5×104 CFU of virulent B. abortus 544 one week after the last immunization. The spleens were collected and the bacterial burden was evaluated at four weeks post-infection. The results showed that this combination produced a significant reduction of the bacterial burden in the spleen with a log reduction of 1.01 compared to the PBS group. Cytokine analysis revealed induction of the cell-mediated immune response in that TNF (tumor necrosis factor) and proinflammatory cytokines IL-6 (Interleukin 6) and MCP-1 (macrophage chemoattractant protein-1) were elevated significantly. In summary, vaccination with a combination of eight different proteins induced a significant protective effect indicative of a cell mediated immune response.

Triangulation is one of the fundamental problems in computational geometry and computer graphics community, and it has huge application areas such as 3D printing, computer-aided engineering, surface reconstruction, surface visualization, and so on. The Delaunay refinement algorithm is a well-known method to generate quality triangular meshes when point cloud and/or constrained edges are given in two- or three-dimensional space. In this paper, we propose a simple but efficient algorithm to triangulate Voronoi surfaces of Voronoi diagram of spheres in 3-dimensional Euclidean space. The proposed algorithm is based on the Ruppert’s Delaunay refinement algorithm, and we modified the algorithm to be applied to the triangulation of Voronoi surfaces in two ways. First, a new method to deciding the location of a newly added vertex on the surface in 3-dimensional space is proposed. Second, a new efficient but effective way of estimating approximation error between Voronoi surface and triangulation. Because the proposed algorithm generates a triangular mesh for Voronoi surfaces with guaranteed quality, users can control the level of quality of the resulting triangulation that their application problems require. We have implemented and tested the proposed algorithm for random non-intersecting spheres, and the experimental result shows the proposed algorithm produces quality triangulations on Voronoi surfaces satisfying the quality criterion.

This study aims to objectively measure the efficiency of nanotechnology R&D programs by systematically evaluating the inputs and outputs of nanotechnology R&D activities and to find implications for improving the efficiency of nanotechnology R&D programs. Data on input factors such as R&D investment, R&D manpower, R&D period, and output factors such as paper, patent, and commercialization for R&D projects which started from 2008 or afterwards and ended by 2011 are gathered through National Science and Technology Knowledge Information Service, which are used for efficiency evaluation. In this study, we analyzed R&D efficiency in detailed technology units in depth. The process taken in this study is as follows. First, the basic statistics of input and output factors to compare and analyze R&D investment, R&D manpower, R&D period, paper, patent, and commercialization status by technology unit are analyzed. Next, DEA models are utilized to derive the overall efficiency, pure technology efficiency, and scale efficiency by conducting the efficiency evaluation for each technology unit, from which implications for strategic budget allocation are derived. In addition, partial efficiency evaluation is conducted to identify advantages and disadvantages of each technology unit. In turn, cluster analysis is performed to identify similar technology units, from which implications for efficiency improvement are derived.

The objectives of this study were to find out the plant to enhance immune activity among 42 kinds of foods frequently consumed by the Korean elderly consisting of 5 food groups and 5 wild plants. Each sample was assessed the immunoactive effect by measuring NFkB/ AP1 gene expression, nitric oxide and cytokine production in RAW-Blue™ cell. Soybean sprouts of 47 plants showed the highest NF-κB/AP1 gene expression at the level of 1.13 ± 0.03 (O.D. 650 nm) and Soritae, sweet potato, banana, apple, garlic, crown daisy, cabbage and Ailanthus altissima also had high activity of NF-kB/AP1 gene in RAW-Blue™ cell stimulated by LPS. NO production of Ailanthus altissima was significantly higher than that of other plants and 16 plants of glutinous sorghum, black rice, Seoritae, Heuktae, sweet potato, banana, apple, garlic, mungbean sprouts, spinach, crown daisy, young pumpkin, cabbage, soybean sprouts, Actinidia arguta and Aster scaber were the next best activity. The above results selected 17 out of 47 plant samples. Moreover, soybean sprouts was significantly shown to increase TNF-α (1,509.55 ± 1.38 pg/mL) and IL-1β (54.56 ± 1.08 pg/mL) cytokines in comparison with RAW-Blue cell stimulated by LPS. According to the results of in vitro evaluation, the ethanol extract of soybean sprout increased the production of immune-enhancing cytokines by proliferation of macrophages. In addition, NF-kB transcription factor activity and NO production ability were excellent, and it was selected as a material having excellent immunological activity.

본 연구는 Deci와 Ryan의 자기결정성이론을 바탕으로 게임사용 동기가 게임행동에 미치는 영향에 대해서 분석하였다. 게임사용 동기는 내재적 동기와 외재적 동기로 구분하였으며, 게임행동은 게임 선용과 게임과몰입으로 구분하였다. 분석을 위해 한국콘텐츠진흥원의 2016년 게임 과몰입 실태 조사의 자료 중 3,000명의 성인을 대상으로 실시한 온라인 조사의 자료를 활용하였다. 자료는 잠재변 수간의 관계를 알아볼 수 있는 구조방정식모형 분석방법을 통해 분석하였다. 분석은 Mplus 7.4 프 로그램을 활용하여 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 내재적 동기는 게임선용과 정적인 관계가 있었다. 둘째, 외재적 동기는 게임선용과 게임과몰입과 정적인 관계가 있었다. 게임과 몰입과의 관계의 효과크기가 게임선용과의 관계의 효과의 크기보다 세 배 이상 크게 나타났다. 본 연구는 한국사회에 만연한 게임에 대한 부정적인 인식에서 벗어나, 게임으로 인한 긍정적인 결과와 부정적인 결과에 대하여 균형 있는 접근을 시도하였다는 점에서 의의가 있다. 또한 자기결정성이론을 바탕으로 게임사용자와 게임제공자의 긍정적인 게임사용을 촉진하기 위한 시사점을 제시하였다.

This study examined the influence of operating parameters on the electrosorptive recovery system of lithium ions from aqueous solutions using a spinel-type lithium manganese oxide adsorbent electrode and investigated the electrosorption kinetics and isotherms. The results revealed that the electrosorption data of lithium ions from the lithium containing aqueous solution were well-fitted to the Langmuir isotherm at electrical potentials lower than –0.4 V and to the Freundlich isotherm at electrical potentials higher than –0.4 V. This result may due to the formation of a thicker electrical double layer on the surface of the electrode at higher electrical potentials. The results showed that the electrosorption reached equilibrium within 200 min under an electrical potential of –1.0 V, and the pseudo-second-order kinetic model was correlated with the experimental data. Moreover, the adsorption of lithium ions was dependent on pH and temperature, and the results indicate that higher pH values and lower temperatures are more suitable for the electrosorptive adsorption of lithium ions from aqueous solutions. Thermodynamic results showed that the calculated activation energy of 22.61 kJ mol–1 during the electrosorption of lithium ions onto the adsorbent electrode was primarily controlled by a physical adsorption process. The recovery of adsorbed lithium ions from the adsorbent electrode reached the desorption equilibrium within 200 min under reverse electrical potential of 3.5 V.

숭고는 미학과 밀접한 관계를 지닌 개념으로서, 대상에 대해 명상할 때 에 우리의 정신과 육체의 정서적 감각에 광범위한 영향을 미친다. 롱자이너스는 숭고 를 고양된 스타일을 재현하는 문학작품에서의 “숭고한 열정의 존재”로 정의하고, 에드 먼드 버크는 거리감을 두고 자연의 파괴적 위력에 연관된 숭고의 경험에서의 고통과 즐거움에 초점을 맞추어 공포와 환희의 균형을 맞춘다. 칸트는 버크의 공포와 환희의 기이한 형태를 결합하고, 라깡은 프로이트와 칸트의 문맥에서 극단과 무한을 추구하여, 칸트의 숭고를 넘어서는 승화의 개념을 구성했다. 본 논문은 라깡의 숭고와 승화의 문맥에서 예이츠의 “비극적 환희”에 재현된 숭고를 예이츠의 시에서 찾아, 예이츠의 숭고의 시학을 살펴본다.

Osteoporosis is a major worldwide public health problem that poses a great economic burden to society. Puerariae Radix, the dried root of Pueraria lobata (Wild.) Ohwi, has been widely used in Asia. This study investigated the effects of Puerariae Radix (PR) on bone loss in ovariectomized (OVX) mice. C3H/HeN mice (10 weeks old) were divided into sham and OVX groups. The OVX mice were treated with vehicle, 17β-estradiol (E2), PR (oral administration, 250 mg/ kg/day) or PR (intraperitoneal administration, 50 mg/ kg/every other day) for 6 weeks. Grip strength, uterus weight, serum alkaline phosphatase (ALP), estradiol concentration and osteoclast surface levels were measured. Tibiae were analyzed using microcomputed tomography. There were no significant differences in the degree of grip strength, body weight and uterine weight between OVX group and PR-treated group. As compared with the OVX group, the serum estradiol levels were significantly increased in the PR-treated group. PR (i.p.) significantly preserved trabecular bone volume, trabecular bone number, structure model index and bone mineral density of proximal tibiae metaphysic. The administration of PR lowered serum ALP and osteoclast surface levels in OVX mice, suggesting that PR can reduce the bone turnover rate in mice. The results indicate that the supply of PR can prevent OVX-induced bone loss in mice.

The International Organization for Standardization (ISO) published ISO 9001 Quality Management System (QMS)-Requirements in 1987 and has revised four times since then. ISO 9001:2015 is the latest edition. This latest edition has two most noticeable changes. The first major change of new edition focuses on performance with an emphasis on Risk-Based Thinking (RBT) to enhance the process approach. The new edition consists of ten clauses whose first three clauses are largely same as older edition but risks are clearly stated and stressed in last seven clauses, emphasizing on Plan-Do-Check-Act cycle at all levels in the organization. The second major change is that the new edition has the same overall structure as other ISO management system standards known as High Level Structure (HLS) with Annex SL. The companies obtained the certificate of new ISO 9001:2015 QMS by September 15, 2018 in order to maintain as an ISO QMS registered firm. In this article we collected transition audit data from more than 100 companies that registered ISO 9001:2015 QMS for recent three years. We performed a statistical analysis to disclose the relationships between the characteristics of companies and the minor nonconformities found in ISO 9001:2015 requirements during transition audit processes. We also aim to interpret the findings and deduce the implications of the statistical results.

This study is aimed at analyzing the research trends on the internationalization policy of Chinese higher education. Descriptively, it would respectively research the policy change and political reasons thereof, the change of internationalization policies of Chinese university, and the change of the researches on the topic, and uncover the relation between the policies and researches by retrieving the relevant research journals from the academic sources including CNKI, China’s largest academic article database. In order to collect as many articles as possible concerning the research topic, the keyword search in the database was adopted with words expressing the meaning of the topic. In conclusion, internationalization policy of higher education has become an important issue in higher education in China. With the change of the policies, researches focusing on internationalization policy of higher education have increased a lot and have made a new research area in China. After analyzing the research trends, it could be believed that the researches in this area would continue to increase in the future and scholars from the higher education field should pay attention to it.

Linear carbon chains (LCCs) encapsulated inside the hollow cores of carbon nanotubes (CNTs) have been experimentally synthesized and structurally characterized by Raman spectroscopy and transmission electron microscopy. However, in terms of electronic conductivity, their transportation mechanism has not been investigated theoretically or experimentally. In this study, the density of states and quantum conductance spectra were simulated through density functional theory combined with the non-equilibrium Green function method. The encapsulated LCCs inside (5,5), (6,4), and (9,0) single-walled carbon nanotubes (SWCNTs) exhibited a drastic change from metallic to semiconducting or from semiconducting to metallic due to the strong charge transfer between them. On the other hand, the electronic change in the conductance value of LCCs encapsulated inside the (7,4) SWCNT were in good agreement with the superposition of the individual SWCNTs and the isolated LCCs owing to the weak charge transfer.

Place memory is a new way of seeing as a new concept of cultural landscape research. Various research works and discussions have recently spread in landscape studies. In particular, the, which is visible and material, is a medium in which collective memory is embedded in place memory. The purpose of this study is to extract places of memory from the collective memory of residents of Janghang, Korea, and to visualize it through semantic relations. For this purpose, semi-standardized interviews (34 persons) were conducted with residents, and frequency analysis and semantic network analysis were used. As a result, the interviewees recalled only 127 places in Janghang that existed between 1920 and 2010. Locals remember the city based on places of memory. This means that the city could be illustrated according to specific places that are frequently mentioned. For instance, the top 25 places (top 20%) explain 65.6% of all the places in the city, and the top 39 places (top 30.8%) could describe 78.7% of the places. Some places are referred to more frequently when they are in the city’s symbolic landscape, and the city’s identity is projected on them. Some places were mentioned only infrequently but were nevertheless very important places by which to understand Janghang. These places of memory have not appeared in the documentary records before, which shows the value of the collective memory of the locals and the effectiveness of the interviewing method. In the clustering of the semantic network, six groups of places appeared. The local residents remembered the modern industrial city and recalled it in connection with the sites of daily life. This shows the possibility of looking not only at public memory and famous heritage as a macro history but also at daily life and meaningful places as a micro history about locals. This study has significance as an initial research that identified and visualized places of memory from the perspective of local residents. Such an approach could be useful in the study of everyday life and the conservation of modern heritage.

Pilot Aptitude Research Equipment (PARE) is a simulator developed to measure or research pilot aptitude and train for student pilots. Design of an ergonomic PARE operation console is required to operate the equipment effectively. This study carried out five steps : (S1) operator questionnaire survey, (S2) anthropometric design formula development, (S3) usability evaluation, (S4) improvement design, and (S5) validation considering both Physical User Interface (PUI) and Graphic User Interface (GUI) of PARE operation console. The operator questionnaire surveyed needs for each PUI and GUI part of the console from two PARE actual operators. In terms of PUI, the anthropometric design formula was developed by using design variables, body dimensions, target population characteristics, and reference posture related to the PARE console. In terms of GUI, the usability evaluation was conducted by three usability testing experts with a 7-point scale (1 : very low, 4 : neutral, 7 : very high) on GUI of the PARE operation console by seven usability criteria. The improved PARE operation console was designed to reflect the optimal values of design variables calculated from design formula, the results from usability testing, and the operator’s needs. The improvement effect was observed by 20 people who had experience with the PARE operation console. As a result of the validation, monitor visibility and cockpit visibility for the improved PUI design and visibility and efficiency for the improved GUI design were significantly increased by more than 90% respectively. The improved design of the PARE operation console in this study can contribute to enhance operation performance of the PARE.

The purpose of this research is to evaluate Seoullo 7017 based on Universal Design (UD) principles and guidelines. To derive UD principles applicable to the site context, we used the 2017 Seoul Universal Design Guideline and assessment index provided by the Universal Design Research Center and established 11 evaluation criteria. With respect to research methods, a literature review and on-site field survey were applied, through which we derived UD principles and evaluation criteria to identify UD problems. The 11 evaluation criteria consist of pedestrian space, facilities, access, main entrance, parking lots, trails, restrooms, convenience facilities, information facilities, rest areas, and playgrounds, and these were associated with UD principles for evaluation. As a result, the main entrance had the highest UD score, while parking lots had the lowest in terms of equity, safety, simplicity, and accessibility. Restrooms received a lower UD score because of poor conditions of security and alert systems. Rest areas were found to be uncomfortable for disabled people. With respect to the internal trails, we found the lack of braille block and irregular placement of planting pots made blind people uncomfortable when walking. In terms of UD principles, flexibility received the highest score, followed by amenity, equity, simplicity, tolerance, accessibility, and safety. Flexibility received the highest score, owing to the provision of proper information about convenience facilities and trails, while safety received the lowest, based on poor access to parking lots, inadequate paving materials and colors, and a lack of 24-hour security systems. We hope this research contributes to improving the universal design, so that people are not discriminated against in the use of the park in terms of age, sex, or physical disability. We expect the study to help facilitate empirical studies to verify UD principles and provide improved quality of UD for Seoullo 7017.

This paper studied balanced regional development focused on employment in Korea, by analyzing regional disparity between regional and industrial employment. A Gini-coefficient decomposition method and Panel Granger causality test were conducted, using raw data of the Census on Establishments reported by the Statistics Korea. The regional and industrial disparity of employment, based on the Gini-coefficient decomposition method, have increased by year. However, the growth rates of disparity are on the decrease. Most of employment disparity occurred from regional disparity between SMA (Seoul Metropolitan Area) and Non-SMA. Industrial disparity are occurred mainly by the service industry. The amount of contribution to the whole disparity of inter/intra regional employment was differed by each industrial sector. Also the causal relationship between employment growth of manufacture and that of service industry was analyzed by Panel Granger causality test. In national level, the employment growth in manufacture industry has conduced that in service industry. On the other hand, in the Non-SMA, only the employment growth in manufacture industry has augmented that in service industry. In conclusion, to reduce employment disparity, the strategy for balanced regional development should be emphasized. Different strategies are needed across regions and industries. Basically creating new job in the Non-SMA is inevitable. In view of stable employment, manufacture industry is more desirable rather than service industry.