The purpose of this study was to investigate the initial bone tissue change and ,to repair on the Miniscrew and surrounding tissue under the various types orthodontic forces by use of niti closed spring through the polarizing φ>larizing microscopic fmdings. For this study, three young adult mongrel dogs(experimental group 1, 2, 3) were used, and 12 titanum miniscrew(a1, a2, a3, b1, b2, b3, c1, c2, c3, d1, d2, d3) were inserted into the palatal bone. The experimental design was consisted of equal opposite group(B), extrusion group(C), double same sided group(D). and group(A) was controlled. Group B, C, D miniscrews were loaded with 150gm of force immediately after placing to palatal side, and group B miniscrews were loaded with changed force of equal amount to buccal side after 10 없ys. and Group C was loaded extrusive force, group D was loaded double amount to palatal side at same time. The experimental animals in each group and control group were sacrified at one, three, and six weeks following implatation the miniscrew to make the samples for polarizing microscofic findings on palatal bone and miniscrew. All samples were examed and compared the 비stologic changes through the polarizing microscpe. The obtained results were as follows. 1. Under equal 01ψ。site force group, the histologic features of tissues around Miniscrew in experimental B group was no difference between the control group under equal opposite force group 2. Under extrusive force after lateral force group, it's bone density was decreased less than control groupunder extrusive force after lateral force group. πùs group was most p∞r bone densi마 ofall. 3. Under double same side group, inital feature was sirnlar to control group , but after 6weeks bone density was decreased along the Miniscrew surfaceunder double same side group. Based on these experimental results, in the prac디ce ， Miniscrew was usefull as skeletal anchorage in immediately load after implantation on alveolar bone under lateral force and opposite lateral force, but at applied extrusive force and double opposite side force were non- useful as skeletal anchorage with long-term treatrnent.

World Health Organization(WHO) revised the classification of neoplasms and other tumours related to odontogenic apparatus in 1992. The aim of this study was to classify the odontogenic tumors of Korean according to the WHO Histologic classification. A total of 271 cases were reviewed for the study which were diagnosed as odontogenic tumors at the department of Oral Pathology, Yonsei University College of Dentistry for the period from Jan. 1997 to March 2003. Clinical and pathology reports were reviewed & radiographic feature were examined. The following results were obtained : 1. Among 271 cases, 269 cases(99.3%) were diagnosed as benign odontogenic tumors, and the remaining 2 cases(0.7%) were malignant tumors, which were diagnosed as odontogenic ghost cell carcinoma and squamous cell carcinoma ex odontogenic cyst. 2. Four cases were not able to classify into the WHO classification. All of them were belonged to mixed odontogenic tumors; two cases of adenomatoid odontogenic tumor with calcifying epithelial odontogenic tumor, one case of adenomatoid odontogenic tumor with odontoma, odotogenic cyst and one case of ameloblastoma with immature odontoma. 3. The most frequent odontogenic tumour was odontoma(45.2%), followed by ameloblastoma (29.2%), odontogenic fibroma(9.2%) 4. One case of atypical amelobalstoma and one case of calcifying odontogenic cyst with ameloblastic fibroma were not able to subclassify histologically. 5. Male to female ratio of odontogenic tumors was 1.2:!. Odontogenic tumors mainly occured in the first and second decade, occurred twice as much as in the mandible than in the maxilla 6. The odontogenic tumors was discovered by routine oral x-ray examination, whereas the chief complaint of ameloblastoma were swelling, pain. 7. Ameloblastoma, adenomatoid odontogenic tumor, calcifying odontogenic cyst and odontoma were related to the impacted teeth and tooth displacement. The root resorption was frequently observed in ameloblastoma and calcifying odontogenic cyst.

쌀엿강정은 쌀을 호화 건조하여 유탕처리하거나 가압 등으로 팽화시켜서 제조한다. 이때 호화과정에서 가열기구나 호화의 정도가 쌀의 팽화에 영향을 미칠 것으로 판단되어 이들 처리에 따라 팽화량(크기, 비중), 사진촬영, 주사형 전자현미경(SEM)으로 관찰 비교하였다. 1. 전기밥솥이나 압력솥, 혹은 증기로 찌는 등 밥의 형태로 쌀을 호화시킨 것은 팽화쌀이 서로 부착된 것이 많아 좋지 않았다. 전기밥솥이나 압력솥의 경우는 팽화쌀의 표면에 파괴된 부분이 나타났다. 압력솥이나 증기고 찌는 경우는 쌀의 팽화량이 작았다. 2. 쌀을 세정하여 바로 많은 양의 물로 끓이는 방법이 좋았으며, 쌀을 불려서 끓이는 방법과 팽화량에 차이를 보이지 않았다. 쌀을 불리더라도 익을 정도로만 단시간에 끓일 경우에는 오히려 팽화량이 작았다. 3. 쌀을 끓이는 시간이 길수록 팽화는 컸으나 너무 지나칠 정도로 끓일 경우에는 쌀의 표면이 파괴되거나 균열이 생겨서 외관이 좋지 않고 팽화량도 작았다.

바지락포자층 Perkinsus는 Apicomplexa 문에 속하는 기생성 원생동물로서 유럽에서는 바지락의 대량폐사 원인 생물로 잘 알려져 있으며 우리나라에서도 90년대 초반부터 나타나고 있는 바지락 폐사의 원인생물로 추정되고 있다. 이 연구는 우리나라 바지락포자충 감염분포 조사의 일환으로 제주 연안에 서식하는 바지락의 바지락포자충 감염 현황과 감염도, 조직병리학적 현상, 유주자 형성 그리고 서식지의 퇴적물 조성에 따른 감염 특성을 조사하기 위하여 실시되

The acetaminophen (APAP), an antipyretic and analgesic agent, induces the hepatotoxicity by increasing influx of calcium and destabilizing the cellular membrane which can be caused by N-acetyl p-benzoquinoneimine generated by cytochrome P-450 (CYP-450) when it is overdosed. Diltiazem (DIL), a calcium channel blocking agent, has been known to suppress the CYP-450 activities. To study the effect of DIL in APAP treated rats, the serum biotransformational enzyme analyses and the liver histopathologic examination were conducted on the rats which had been administered DIL at 3, 6, 9 and 12 hours after the 3,000 mg/kg of APAP administration. Following a single dose of DIL administered 12 hours after APAP administration, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, malondialdehyde and calcium contents of liver and microsome were significantly reduced. Glutathione S-transferase (GST) activity was significantly increased. Histopathologic studies showed that DIL had prevented the development of centrilobular necrosis induced by APAP in liver tissue. Our results suggested that diltiazem could inhibit the formation of free radical and the influx of calcium and could increase GST activity. Therefore, diltiazem can be administered at the time of 12 hours after overdosed APAP to diminish the liver damage.