This study aims to explore the theoretical concepts of inclusive development in relation to the spatial context, assessment the disparities in the social and economic development of the regions of Kazakhstan and substantiate the main mechanisms for overcoming them. In this research, authors propose the methodological tools for presenting a standard form of evaluation of social and economic development in the regions of Kazakhstan. In this study used methods, which based on measuring disproportions between the levels of economic and social development of the regions, as well as disproportions between the republican and regional levels. According to the author’s methodological approach, complex and integral indexes have calculated over the period 2012-2017 for a number of indicators adapted to the conditions of Kazakhstan. The calculated indexes proposed to use as instruments for measuring the level of the social and economic development. In addition, according the obtained indexes and the results of their ranking can be the basis for the development of regional programs and management decisions. This will improve the targeted support of the population in backward regions in order to ensure inclusive development and improve the quality of life of the population.

This study intended to examine the relationship between inflation and unemployment rate in Indonesia during 1987 to 2018 period. The study applied a quantitative method using Vector Error Correction Model (VECM) in order to comprehensively understand the causality between inflation and unemployment rates. The data were collected from various main sources including the World Bank, Central Bank of Indonesia, and Central Bureau of Statistics (BPS). The findings showed that inflation has a one-way relationship toward unemployment in Indonesia and it occurs at the third lag. Impulse Response Function (IRF), shows that the inflation rate are fluctuating in response to the shock of unemployment. The unemployment rate responses to shocks from inflation initially increased until it is eventually diminished. It shows that the shocks caused by the impact of inflation were only in the short term. Further, inflation in the three previous lags will have consequences for the unemployment rate in the year. Lastly, both in the long run and short run, unemployment did not affect inflation rates. These findings suggest that high inflation in Indonesia is determined the rising price of basic commodities and fuel. In addition, most companies in Indonesia applying capital intensive so that employment growth in Indonesia is small.

The purpose of the study is to analyze the main approaches to assessing human capital and develop proposals for its most objective assessment of it at the different levels of manifestation - individual, microeconomic and macroeconomic. The article considers the basic approaches to the evaluation of human capital, used in practice: retrospective (costly) and prospective (income based). Cost based methods involve measuring the value of human capital based on the total costs associated with its formation. The proposed additional evaluation criteria, in particular, the use of the expert approach and the developed indicators of a qualitative assessment of the human capital of the enterprise will allow development that is more efficient and use of available human resources. Human capital is becoming a major factor in the formation and development of an innovative economy and knowledge economy. Accordingly, the proposed additions to the assessment of human capital at the country level are aimed at assessing it from a new angle, taking into account the current global trends in the formation of an innovative economy and digitalization. They meet qualitatively new requirements for human capital as the main productive factor in the creation of new highly efficient technologies that promote the active development of the social sphere, science, education, health, etc.

Chinese cabbage grown during autumn season is confronted with drought conditions for a certain period, especially during the early growth stage. In this study, we investigated the effects of drought stress on plant growth characteristics, as well as free amino acid, carotenoid, and proline in Chinese cabbage. Chinese cabbage seeds (Bulam Plus) were germinated, and all the seedlings were transplanted into plastic containers (28 ㎝ diameter × 22 ㎝ high) containing a commercial growth medium. The soil water content was measured and maintained at 10% for the drought-stressed plants and at 30% for the control plants, for three weeks. The results revealed that plant growth parameters were lower in the drought-stressed plants than in the control plants. The total free amino acid content tended to decrease in both drought-stressed and control plants with time. The total free amino acid content was found to be lower in the drought-stressed plants than in the control plants and the proline content was unaffected. Moreover, at three weeks after treatment, carotenoid content in drought stressed plants was significantly higher than that in the untreated plants. We believe that our study makes a significant contribution to the literature because the effects of drought stress on plant growth parameters, free amino acid, carotenoids, and proline accumulation in autumn growing cultivar of Chinese cabbage have not been widely studied in Korea, and our study provides valuable information in this regard, as Chinese cabbage is consumed throughout the year in Korea.

The study investigates the factors that affect Kyrgyzstan’s bilateral trade flows with its main trading partners and attempts to predict trade potential for Kyrgyzstan. Using panel data, the gravity model is applied to estimate Kyrgyzstan’s trade from 2000 to 2016 for its 35 main trading partners. The coefficients derived from the gravity-model estimation are then used to predict trade potential for Kyrgyzstan. Results proved to be successful and explained 63% of the fluctuations in Kyrgyzstan’s trade. According to the results, Kyrgyzstan’s and its partners’ GDP have a positive effect on trade, while distance and partners’ population prove to have a negative effect. Predicted trade potential reveals that neighboring countries (China, Kazakhstan, Uzbekistan, and Tajikistan) and Russia still have a significant trade potential. Kyrgyzstan, being a less developed economy, even by Central Asia standards, can only achieve its goals of reducing poverty and becoming more developed by increasing its overall trade with the rest of the world. Therefore, it is essential to study the main determinants of Kyrgyzstan’s bilateral trade. In this way, we can help policy makers formulate policies to expand Kyrgyzstan’s trade. This study is the first attempt to apply to the gravity model to Kyrgyzstan in an attempt to predict trade potential.

Background : For the green approach of nanoparticles synthesizing, plant based technology has been considered as cost-effective and eco-friendly mass production. The oriental medicinal crop, Kalopanax septemlobus (Thunb.) Koidz. (Korean name: 음나무), the deciduous tree and a family of Araliaceae. Endemic tree of Asian countries, K. septemlobus being used for the treatment of various diseases. Phytochemicals of K. septemlobus such as polyphenols has highly probability of reducing agent for biosynthesizing nanoparticles. Methods and Results : In this study, we applied K. septemlobus ZnO nanoparticles (Ks-ZnO NPs) with procedures including green approach one-pot synthesis. For the characterization of nanoparticles, UV–Vis, FTIR, XRD, SEM and TEM were used. The formation of ZnO nanoparticles, the aurface plasmon resonance were observed at 372 ㎚ in UV-Vis spectroscopy. The presence of functional groups which as a capping agent and formation of ZnO nanoparticles were confirmed in FTIR result. The crystallization and morphology showed by XRD, TEM and SEM respectively. The photocatalytic activity of ZnO nanoparticles, was determined using Methylene blue (MB) dye degradation under UV irradiation (365 ㎚) which resulted rate constant is (−k) 0.1215 with 97.5% of degradation in 30 min. Conclusion : The result shows that phytochemicals in K. septemlobus extract have a potential as a reducing agent to form ZnO nanoparticles. The ZnO NPs are capable to degrade MB with in brief time.

Background : Panos extract is a mixture of four Panax plant extracts namely Dendropanax morbifera, Panax ginseng, Acanthopanax senticosus and Kalopanax septemlobus. We intended to use Panos extract for ZnO nanoparticles(NPs) synthesis and application for waste water treatment. Methods and Results : In the present study, we have synthesized Panos ZnO nanoparticles via co precipitation method. Characterization of the NPs has been done using X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR) and UV-Visible spectroscopy. An average of 75% efficacy in degrading the methylene blue dye has been observed. The nanoparticles showed antibacterial activity against E. coli and S. aureus. Conclusion : The results shows that Panos ZnO NPs can be a potential eco-friendly and economical tool for waste water management in the current scenario where there an intense urge to remediate the polluted environment through novel approaches such as Nanobiotechnology.

Background : Codonopsis lanceolata is a perennial herb called as ‘Deodeok’ (더덕) in Korea. The roots of C. lanceolate has been reported to have some antioxidant and antimicrobial properties. The chemically reactive saponins of C. lanceolata might be used as a capping agent for the surface of ZnO nanoparticle, ultimately making it a highly efficient photocatalyst. Methods and Results : In this paper, we report the one-pot green synthesis of ZnO nanoparticles via precipitation method using root extract of C. lanceolata. The structure of green synthesized Cl-ZnO NPs was characterized using XRD, EDX, DLS and morphology using TEM. The FT-IR exhibited the information about the functional groups that capped the metal nanoparticle and the formation of metal NPs was confirmed by UV–vis spectra at 356nm. The Cl-ZnO NPs were evaluated for their catalytic activity by measuring the degradation of methylene blue (MB) dye in aqueous solution under UV light (365 ㎚). The result showed efficient degradation of MB, which was degraded 70% within 30 min by Cl-ZnO NPs. Conclusion : This study proves that the green route synthesized ZnO NPs from the root extract of C. lanceolata are low cost, time efficient, bio-degradable and non- toxic. The UVvis spectra confirmed the synthesis of ZnO NPs from C. lanceolata root extract. The Cl- ZnO NPs mediated catalysis exhibited high photocatalysis rate in short time. Ultimately, the green rapid synthesized Cl-ZnO NPs from root extract can be used as an efficient

Background : Among medicinal plant sources, Abeliophyllum distichum is widely used in traditional Korean medicine. we report on the synthesis of nanostructured zinc oxide particles by both chemical and biological method. Highly stable and spherical zinc oxide nanoparticles are produced by using zinc nitrate and Abeliophyllum distichum leaf extract. Methods and Results : Zinc oxide (Ad-ZnONPs) nanoparticles synthesized from Abeliophyllum distichum at room temperature by aqueous extract of dried leaf and stem. The plant endemic in Korea alone and it is a monotypic flowering plant genus of olive family, Oleaceae. Catalytic and toxicity effect against human keratinocyte and adenocarcninomic human alveoloar. Ultra violet visible (UV-Vis) spectroscopy, field emission transmission electron microscopy (FE-TEM), energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, X-Ray powder diffraction (XRD), selected area electron diffraction (SAED) and Fourier transform infrared (FTIR) spectroscopy were engaged to illustrate the biosynthesized nanoparticles. The Zn-AdNPs has the ability in catalytic action and the cytotoxicity agent against different cell lines as investigated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide (MTT) assay Conclusion : The present studies reveals that facile approaching the biological synthesis of zinc oxide nanoparticles by using the A. distichum leaf and stem extract, which is revealed that recyclable method. The method is well suited for the green synthesis and dual function molecule as reducing agent and stabilizing agent for synthesis of nanoparticles. The nanoparticles also showing promising biological activities.

Angelica tenuissima, also known as Ligusticum tenuissimum, is classified as a food-related plant and has been used as traditional medicines treating headache and anemia in Asia. However, its anti-melanogenic effect has not been reported in detail. When the extract of Angelica tenuissima (ATE) was prepared by the extraction with 70% EtOH at 80°C (final yield = 22%), the contents of decursin and Z-ligustilide in ATE were determined 0.06% and 8.43%, respectively. Total flavonoid and phenolic content in mg ATE were 5.52±0.07 ㎍ quercetin equivalents and 237.27±13.24 ㎍ gallic acid equivalents, respectively. Antioxidant capacity of ATE determined by DPPH and ABTS assay was increased with a dose dependent manner up to 1000 ㎍/㎖. The amount of melanin synthesis followed by α-melanocyte stimulating hormone on B16F10 cells were significantly reduced in the presence of ATE (250 to 1000 ㎍/㎖, p<0.05). ATE (125 to 1000 ㎍/㎖, p<0.05) suppressed the tyrosinase activity but did not show any significant effect on α-glucosidase activity at the same condition. Taken together, ATE possesses tyrosinase inhibitory potential with significant antioxidant capacities. These effects of ATE might be involved in suppression of melanin synthesis, at least, in B16F10 cells. The anti-melanogenic potential of ATE will provide an insight into developing a new skin whitening product.

A new embryonic cell line (OFEC-17FEN) derived from olive flounder Paralichthys olivaceus was developed. OFEC-17FEN cells were subcultured for <30 passages over ~200 days. OFEC-17FEN cells had a doubling time of 114.34 h and modal diploid chromosome number was 48. The pluripotency genes POU5f1 and NANOG were expressed in OFEC-17FEN cells. However, the lack of several pluripotency-related genes expression indicates that OFEC-17FEN cells are not stem cells. OFEC-17FEN cells transfected with plasmid pEGFP-c1 exhibited a strong green fluorescent signal at 48 h after transfection. Accordingly, OFEC-17FEN cells may be useful for both basic research and biotechnological application.

The Northern States of Malaysia comprises of four states (Penang, Kedah, Perlis and Perak) still record high poverty incidence eventhough Malaysia has experienced a remarkable reduction of poverty over the past century. Economic activities in Perlis and Kedah that are predominantly agriculture in the rural area contribute to this disparity. To add, rural households are also subject to risks and uncertainties that make them more vulnerable to poverty. This study examines the impact of risks and assets on households’ vulnerability to poverty. A survey of 400 respondents was conducted in December 2015 in the northern region of Malaysia. From these 400 questionnaires, only 298 were considered valid and used in the analysis. Using a logistic probability function, the results indicated that risks are not a significant threat to households. Gender and strata are crucial elements that significantly determine households’ vulnerability. While human capital and financial capital significantly reduce households’ vulnerability to poverty, physical and natural capitals were not statistically significant. The study suggests that the government and practitioners design strategies and policies with an assets-based approach. The asset-based approach is more appropriate for linking the causes of poverty to vulnerability.

Banks play a crucial role in bringing stability and economic development through their expected contribution in proper financial resource mobilisation across the economy. Despite the importance, there is little focus in recent literature which provided the empirical evidence how the global financial crisis affect the bank efficiency in Bangladesh. Thus, this paper aims to examine the effect of the global financial crisis and other factors on the efficiency of Bangladesh commercial banks. By employing the Data Envelopment Analysis (DEA) method, we computed the technical efficiency of individual banks operating in the Bangladesh banking sector during 2000 to 2013. The empirical findings indicate that the Bangladesh banking sector has exhibited the highest efficiency level during 2001, while efficiency seems to be at the lowest level during 2010. The study finds that crisis along with bank size, capital adequacy ratio, return on average equity and real interest rate have a significant effect on bank efficiency in Bangladesh. In order to keep the sound financial development of Bangladesh, banks operating in the Bangladesh banking sector have to consider all the potential technologies which could improve their profit efficiency levels, since the main motive of banks is to maximise shareholders’ value or wealth through profit maximisation.

This study extends research into whether disclosure of corporate and financial information is associated with firms’ costs of equity capital. This study sets out to examine empirically the determinants of corporate disclosure in the annual reports of 37 largest and most liquid firms listed on Kazakhstan Stock Exchange (KASE) in Kazakhstan. It also reports the results of the association between company-specific characteristics and disclosure of the sample companies. Based on the analysis of existing empirical research, the disclosure index has been constructed and regression analysis of the influence of the disclosure index on the cost of equity capital has been conducted. The obtained results show that the received findings correlate with foreign empirical studies, and the disclosure index in this sample has a negative impact on the cost of equity capital. Using cost of equity capital estimates derived from capital asset pricing model, we find that firms with higher levels of financial transparency are associated with significantly lower costs of equity capital. Economic theory assumes that by increasing the level of corporate reporting, firms not only increase their stock market liquidity, but also decrease the investors’ estimation risk, arising from uncertainty about future returns and payout distributions. The results show that firms on the Kazakhstan market can reduce their cost of equity capital by increasing the level of their voluntary corporate disclosures.

Lettuce is an important annual leafy vegetable and bitterness is its potent flavor character. Lettuce germplasm differ their phenotypic characters and sesquiterpene lactones (SLs) contents which are important for consumer’s acceptance. This study was carried out to evaluate the phenotypic characters and SLs contents in one hundred lettuce germplasm in Jeonju, Korea. Twenty-three agro-morphological (16 qualitative and 7 quantitative) traits and two SLs (lactucin and lactucopicrin) contents were studied in these germplasm. Germplasm exhibited the variation in qualitative and quantitative characters. Average plant weight was 423.9 g with a range from 116.0 to 905.0 g. Lactucin content was varied from 19.7 (IT 294226) to 194.4 ㎍/g (IT 294298) with an average concentration of 84.7 ㎍/g. Lactucopicrin ranged from 82.5 (IT 300134) to 2228.6 ㎍/g (IT 294210) with an average concentration of 586.3 ㎍/g. Total SLs content was ranged from 120.1 (IT 300134) to 2286.6 (IT 294210) ㎍/g with the average concentration of 671.0 ㎍/g. Significant (p≤0.05) differences were found between crisp head and butter head germplasm for lactucin, lactucopicrin and total SLs content. Crisp head germplasm revealed the highest average lactucin (112.9 ㎍/g), lactucopicrin (734.8 ㎍/g) and total SLs content (847.7 ㎍/g). Crisp head and leafy type germplasm exhibited more total SLs content (847.7 and 744.7 ㎍/g, respectively) than cos (524.9 ㎍/g) and butter head type (519.4 ㎍/g). Principal component analyses of the quantitative traits indicated that the first principal component axis accounted more than 91% of the total variation. This study revealed the ample genetic variation in the agro-morphological traits and SLs contents to support the selection for improved lettuce varieties.

Background : Oxidative stress condition refers as disturbed homeostasis between the generation of reactive oxygen species (ROS) and the antioxidant system that results in severe pathological conditions. To balance such an oxidative stress condition external antioxidant sources are required. Methods and Results : In view of the above, present study was carried out to investigate the cytoprotective role of the strawberry (Fragaria × ananassa var. Seolhyang) root extract (SRE) against oxidative stress condition stimulated by H2O2 in murine macrophages Raw 264.7 cells and further evaluation of intracellular ROS level, lipid peroxidation and myeloperoxidase (MPO) activity as oxidative stress markers. Cytoprotective effect of SRE was evaluated by quantifying survival of macrophages challenged by H2O2 in presence and absence of SRE. Finding suggest a 60.1 ± 7.5% cell survival in H2O2 treated cells as compare to 100% survival in control cells. However, a significant increase in cell survival with 62.7 ± 2.9, 74.2 ± 5.2 and 81.3 ± 3.3% were observed in the cells treated with 2.5, 5, 10 μg/ml of SRE respectively. A reduced ROS level together with inhibition of the lipid peroxidation and MPO activity was observed in the cells treated with SRE as compare to only H2O2 treated cells. Conclusion : Our results signify the potency of SRE to protect the cells from oxidative stress implied by H2O2 and can be used as a source of antioxidant for health benefits.

Background : barley (Hordeum vulgare L.), is a member of the grass family Poaceae (Gramineae) consider the fourth most important cereal crop and primarily used to feed the animals. The second most common use of barely is for malt, which is used mostly in beer, but also in hard liquor, malted milk and flavoring in a variety of foods. As immense economic importance a fast and high germination is required in order to achieve its desired production. In regard to this the present study was performed to evaluate the effect of beneficial microbes (BM), on barely seed germination when mixed with in the synthetic germination medium. Methods and Results : Barely seeds were surface sterilized using 0.01% HgCl2 solution and transfer for germination in the medium supplemented with 200 and 500 X diluted BM separately. Effectiveness of the BM were determined by calculating the germination percentage (GP), germination index (GI), mean germination time (MGT), germination time 50% (T50) and compared with control seeds germinating in absence of BM. Results obtained from the study suggest that BM at 200 X dilution is much efficient to speed up the germination process (66.7 ± 2.3 %) in contrast to 500X diluted BM (61.4 ± 3.6 %). Results of the other germination parameters (GI, MGT and T50) supported the 200X BM effective for seed germination as compare to 500X and control. Conclusion : Our results signify that BM has potential to enhance the germination efficacy of barley seeds and thus could be used to improve the germination.

Heat shock protein (HSP) 70, the highly conserved stress protein families, plays important roles in protecting cells against heat and other stresses in most animal species. In the present study, we identified and characterized four Hsp70 (RuHSP4, RuHSC70, RuHSP12A, RuGRP78) family proteins based on the expressed sequence tag (EST) analysis of the Korean rose bitterling R. uyekii cDNA library. The deduced RuHSP70 family has high amino acid identities of 72-99% with those of other species. Phylogenetic analysis revealed that RuHsp70 family clustered with fish groups (HSP4, HSC70, HSP12A, GRP78) proteins. Quantitative RT-PCR analysis showed the specific expression patterns of RuHsp70 family members in the early developmental stages and several tissues in Korean rose bitterling. The expression of 4 groups of Hsp70 family was detected in all tested tissue. Particularly, Hsp70 family of Korean rose bitterling is highly expressed in hepatopancreas and sexual gonad (testis and ovary). The expression of Hsp70 family was differentially regulated in accordance with early development stage of Rhodeus uyekii.

Much effort has been expended to find agronomically important QTLs for improving soybean yield. However, the complexity of genome, such as genome duplication, limits the utility of genome-wide association studies and linkage analyses to identify genes controlling yield traits. We propose the variation block method, a three-step process for recombination block detection and comparison. The first step is to detect variations by comparing short-read DNA sequences of the cultivar to a reference genome of the target crop. Next, sequence blocks with variation patterns are examined and defined. The boundaries between the variation-containing sequence blocks are regarded as recombination sites. All the assumed recombination sites in the cultivar set are used to split the genomes, and the resulting sequence regions are named as variation blocks. The practicality of this approach was demonstrated by the identification of a putative locus determining soybean hilum color and known genes such as flower color gene. We suggest that the variation block method is an efficient genomics method for recombination block-level comparison of crop genomes. We expect that this method holds the prospect of developing crop genomics by bringing genomics technology to the field of crop breeding.

Rice flour is used in many food products. However, dough made from rice lacks extensibility and elasticity, whereas that of wheat is suitable for many food products including breads. We have produced marker-free transgenic rice plants containing a wheat TaGlu-Ax1 gene encoding the HMG-GS from the Korean wheat cultivar ‘Jokyeong’ using the Agrobacteriummediated co-transformation method. The TaGlu-Bx7-own promoter was inserted into a binary vector for seed-specific expression of the TaGlu-Ax1 gene. Two expression cassettes comprised of separate DNA fragments containing only TaGlu-Ax1 and hygromycin phosphotransferase II (HPTII) resistance genes were introduced separately to the Agrobacterium tumefaciens EHA105 strain for co-infection. Each EHA105 strain harboring TaGlu-Ax1 or HPTII was infected to rice calli at a 3:1 ratio of TaGlu-Ax1 and HPTII, respectively. Then, among 210 hygromycin-resistant T0 plants, we obtained 20 transgenic lines with both TaGlu-Ax1 and HPTII genes inserted into the rice genome. We reconfirmed integration of the TaGlu-Ax1 gene into the rice genome by Southern blot analysis. Transcripts and proteins of the wheat TaGlu-Ax1 were stably expressed in the rice T1 seeds. Finally, the marker-free plants harboring only the TaGlu-Ax1 gene were successfully screened at the T1 generation.