Ensuring operational safety and reliability in Unmanned Aerial Vehicles (UAVs) necessitates advanced onboard fault detection. This paper presents a novel, mobility-aware multi-sensor health monitoring framework, uniquely fusing visual (camera) and vibration (IMU) data for enhanced near real-time inference of rotor and structural faults. Our approach is tailored for resource-constrained flight controllers (e.g., Pixhawk) without auxiliary hardware, utilizing standard flight logs. Validated on a 40 kg-class UAV with induced rotor damage (10% blade loss) over 100+ minutes of flight, the system demonstrated strong performance: a Multi-Layer Perceptron (MLP) achieved an RMSE of 0.1414 and R² of 0.92 for rotor imbalance, while a Convolutional Neural Network (CNN) detected visual anomalies. Significantly, incorporating UAV mobility context reduced false positives by over 30%. This work demonstrates a practical pathway to deploying sophisticated, lightweight diagnostic models on standard UAV hardware, supporting real-time onboard fault inference and paving the way for more autonomous and resilient health-aware aerial systems.

Amitriptyline hydrochloride (AMT), a tricyclic antidepressant, is known to exhibit antimicrobial effects against a wide range of bacterial species. This study aims to evaluate the effect of AMT on Brucella (B.) abortus infection in RAW 264.7 cells and ICR mice, which has not yet been clearly characterized. The results showed that all tested concentrations of AMT had no direct bactericidal effect on B. abortus survival at any incubation time point. Interestingly, RAW 264.7 cells pre-treated with a non-toxic high concentration of AMT before B. abortus infection showed a significant reduction in the phagocytosis of B. abortus at 20 min post-infection, compared to untreated cells. However, AMT treatment did not affect the intracellular replication of B. abortus compared to the control cells. Based on the reduced bacterial uptake observed in-vitro, an in-vivo experiment was conducted to assess whether daily oral administration of AMT at a dose of 20 mg/kg could inhibit B. abortus growth in ICR mice. The results showed that AMT treatment slightly increased both organ weights and bacterial loads, suggesting possible systemic effects of prolonged AMT exposure. In summary, these preliminary results provide initial insight into the potential effects of AMT on B. abortus infection both in-vitro and in-vivo. Therefore, further study should focus on dose optimization in-vivo and exploration of the underlying cellular mechanisms involved in AMT-mediated inhibition of phagocytosis during Brucella infection.