Extracellular vesicles (EVs) are nanovesicles that carry bioactive cargoes of proteins, lipids, mRNAs, and miRNAs between living cells. Their role in cellular communication has gained the attention of several research reports globally in the last decade. EVs are critically involved in sperm functions, oocyte functions, fertilization, embryonic development, and pregnancy. The review summarizes the state-of-theart of EVs research in the diagnostic and therapeutic (theranostic) potentials of the EVs during the pregnancy that might provide a solution for gestational disturbances such as implantation failure, maternal health problems, gestational diabetes, and preeclampsia. EVs can be found in all biological fluids of the fetus and the mother and would provide a non-invasive and excellent tool for diagnostic purposes. Moreover, we provide the current efforts in manufacturing and designing targeted therapeutics using synthetic and semi-synthetic nanovesicles mimicking the natural EVs for efficient drug delivery during pregnancy.
Renewable energy is frequently seen as one of the world’s most promising industries, as it promises a sustainable future in the surge of climate change. Nevertheless, several trade disputes emerge as nations implement policies to boost the domestic green energy industry, putting current trade laws to the test and leaving the detrimental effects on the development of renewable energy technologies. As a result, trade tensions have risen, particularly in bilateral relations between the United States and China. It is impossible to deny that current trade disputes over renewable energy products have practical consequences for governments, institutions, and enterprises. Rising trade protectionism in the energy industry may endanger the fulfillment of specific sustainable development targets. Keeping that in mind, this study aims to examine the recent trade disputes over China’s renewable energy products at the multilateral forum of the WTO, while analyzing protectionism in the context of international trade and practices.
Camel (camelus dromedarius) is a unique large mammalian species that can survive harsh environmental conditions and produce milk, meat, and wool. Camel reproduction is inferior when compared to other farm animal species such as cattle and sheep. Several trials have been reported to increase camel reproduction and production through assisted reproductive techniques (ARTs) such as in vitro fertilization and cloning. For these reasons, obtaining enough mature oocytes is a cornerstone for ARTs. This demand would be improved by the oocyte in vitro maturation (IVM) systems. In this review, the current approaches and views from different laboratories using ARTs and the IVM to produce embryos in vitro in camel species. For the last two decades, conventional IVM system was the common approach, however, recently the bi-phasic IVM system has been introduced and showed promising improvement in IVM of camel oocytes. Detailed studies are needed to understand camel meiosis and IVM to efficiently increase the production of this species.
The effects of the number of frozen-thawed ram sperm per single and double intra-cervical artificial insemination (AI) on fertility in ewes were studied. A total of 89 non-pregnant ewes were synchronized for oestrus with two doses of 100 μg PGF2α (Cloprostenol) 9 days apart. The ewes were randomly assigned to one of four groups; D200 (n = 23; double AI with 200 × 106 sperm), S200 (n = 24; single AI with 200 × 106 sperm), D100 (n = 24; double AI with 100 × 106 sperm) and S100 (n = 18; single AI with 100 × 106 sperm). Ewes were inseminated within 12 to 18 h for single AI and, within 10 to 12 h and 16 to 18 h for double AI after the onset of oestrus. The onset of oestrus ranged from 28 to 76 h (54.33 ± 1.28 h). The high percentage (29.2%) of ewes showed oestrus between 51 to 60 h. The non-return rates were highest in group D200 (56.5%) and differed significantly (p < 0.05) from group S100 (11.1%). No ewes were pregnant in group S100, and the pregnancy rates among the remaining groups did not differ. The mean gestation period was 152.8 ± 0.5 days and no difference was observed among the groups. The lambing and multiple birth rates were 100% in group D200. The single and twin lambing was highest in group D100 (33.3%) and group D200 (83.3%), respectively. Only one triplet lambing and the highest lambing size (2.2 ± 0.2) was recorded in group D200. In conclusion, double AI with 200 × 106 sperm showed comparatively most practical for achieving high pregnancy rates and lambing performances in Bangladeshi ewes under field conditions.
The practice of relationship marketing strategies is the core of the success of marketing for any kind of organizations. The study develops relevant research issues and propositions for empirical investigation based on the strategies of relationship marketing offered by Berry (1983) such as core service strategy, customization strategy, augmentation strategy, relationship pricing strategy, and internal marketing strategy. Relating to relationship marketing theory, agencies and clients are aware of in providing and taking core services, Agencies customize the relationship and augment the services to satisfy and retain their clients. Considering the account size and length of relationship agencies offer relationship pricing. All agencies maintain strong interaction among the employees and different departments as a part of their internal marketing practice.
The article empirically examines the practice of internal marketing based on a case study of an advertising agency. To this end, explaining the significance of internal marketing for the success of external marketing and the concept of internal marketing, the article reports research findings which link theory and practice.
The basic premise of this paper is to determine the exclusivity of the concept “social business” comparing other concepts seemingly parallel to it. To this end, through scope and evaluation of the concept, the article focuses on how social business adds superior value, addresses social problems, and may motivate the business community to dedicate their talents and energy and invest money in this business.
The main object of this research was to examine the effect of sintering conditions on the microstructure of tungsten heavy alloys and how the resulting modification of the microstructure can be used to optimize their mechanical properties. Alloys composed of 88%, 93% and 95% wt. of tungsten and the balance is Ni: Fe in the ratio of 7:3 were sintered at different temperatures for different sintering holding times in hydrogen atmosphere. It was shown that the mechanical properties of the alloys, and especially their ductility, are harmed when tungsten grains are contiguous.
Work motivation is critical for ensuring sustainability of any business firm. Motivated personnel essentially helps an organization achieve its organizational goal and objective. Hence, it has become an essential duty for business managers and management committees to identify the motivating factors that would strongly affect their employees. The purpose of the current research is to identify which are the factors that motivate service employees most at their workplace in Bangladesh. The study has used survey questionnaires to collect data from service employees. Convenience sampling is used for data collection. A total of 240 questionnaires were distributed and 183 completed questionnaires were returned (response rate: 77%). The study used purposeful motivating factors, which are ranked (from 1 to 10) by the service employees according to the significance of the factors. Mean value is applied to determine the most crucial motivating factor, where the factor with lowest mean value is considered as the highest significant motivating factor. Results reveal that job certainty, career growth and advancement opportunity, and quality working environment have been the most crucial and influential motivating factors for the service employees. The study adequately underlines the necessity of motivational factors and provides some guidelines to keep employees motivated.
The main purpose of this study is to examine the impact of intellectual capital disclosure (ICD) on firm performance in the pharmaceutical and chemical industry of Bangladesh. In this study, 21 listed pharmaceutical and chemical companies have been selected as sample for 2016 and 2017. This study used the intellectual capital disclosure index developed by Rahman, Sobhan, and Islam. Return on assets and return on equity have been used as the proxy variable of firm performance. In this study, content analysis is performed to assess the level of disclosure regarding intellectual capital and pooled cross-sectional analysis is used to assess the relationship between ICD and firm performance. The study has found a positive and significant relationship between ICD and firm performance. Besides, an in-depth analysis of this study shows that all the components of ICD namely internal capital disclosure, external capital disclosure, and human capital disclosure are also positively and significantly associated with firm performance. The study suggests the development of an intellectual capital disclosure framework by the regulatory authority for mandatory compliance. This will improve the quality and quantity of ICD in the annual reports. Besides, firms should more emphasize on ICD which will help to improve their performance.
Purpose - The purpose of this study is to find out the intellectual capital disclosure (ICD) and its determinants in the pharmaceutical and chemical industry of Bangladesh.
Research design, data, and methodology - This research study is conducted on the listed firms of pharmaceutical and chemical industry in Bangladesh during the period of 2016 to 2017. This study develops a self-structured intellectual capital disclosure index; and the proxies of determinants of ICD are used as board characteristics (board size, independent directors and female directors), ownership structures (institutional ownership and director ownership), and firm characteristics (firm size, leverage and performance). The study uses a content analysis to analyze the extent of ICD and a pooled cross-sectional method to find the determinants of ICD.
Research Findings - This study finds that intellectual capital disclosure is positively associated with firm size, leverage, and firm performance and negatively associated with director ownership and institutional ownership. This study also finds that there is no significant association of ICD with independent director or female director.
Conclusions - The study recommends that the regulatory authority should develop mandatory guidelines on ICD for ensuring proper and consistent disclosure about the intellectual capitals. Besides, the companies should include a separate section in the annual reports to disclose the measurement and management of intellectual capital.
Purpose The purpose of this – study is to empirically investigate the impact of capital structure on firm performance. Research design, data, and methodology – This study examined the impact of capital structure on the performance of cement companies listed on the Karachi Stock Exchange during the period 2009-2013. The authors hypothesize that there is a negative relationship between capital structure and firm performance. To examine the association, the authors run a Pearson correlation and multiple regression analysis. Results – Results reveal a strong negative relationship between debt to asset and firm performance variables (GPM, NPM, ROA, and ROE). Further, there is a positive relationship between debt to equity and firm performance variables (GPM and NPM), anda negative relationship between debt to equity and firm performance variables (ROA and ROE). Moreover, capital structure variables significantly impact firm performance. Conclusions – This study concluded that financial analysts and managers should emphasize on the optimal level of capital structure and efficient utilization and allocation of resources to achieve the targeted level of productive efficiency in business
The effect of biofertilizer in enhancing nutrient quality and antioxidant property of rice grain was investigated. The experiment was carried out in a randomized complete block design with 3 replications and 7 treatments namely : RF = N-P2O5-K2O(11-5.5-4.8kg~;10a-1); half of the recommended fertilizer rate, HRF=N-P2O5-K2O(5.5-2.75-2.4kg~;10a-1): HRF+Bio 250=HRF combined with 250 kg Biofertilizer 10 a-1 ; HRF+Bio 500=HRF combined with 500 kg Biofertilizer 10 a-1; Bio 250=250 kg Biofertilizer 10 a-1; Bio 500=500 kg Biofertilizer 10 a-1; and NF=No Fertilizer. Results showed that HRF+Bio 500 obtained a significantly higher protein content but a significantly lower amylose content compared with RF and NF treatments. Highest phytic acid content was recorded in NF treatment while the lowest was observed in HRF+500 treatment. The highest values in both electron donating ability and reducing power were obtained in HRF+Bio 500 treatment. All treatments obtained higher reducing power than that of the RF treatment and that NF treatment showed comparable values in both electron donating ability and reducing power with those of the treated plots. Highest antimutagenicity property was also observed in HRF+Bio 500 treatment followed by Bio 500 treatment. This study showed the possibility of using biofertilizer to enhance nutritional quality and antioxidant property of rice.
An experiment was carried out at the Field Laboratory of the Department of Crop Botany, Bangladesh Agricultural University, Mymensingh from March to July, 2001 to investigate the effect of biofertilizers on morpho-physiological characters of okra. The experiment was laid out in a randomized complete block design with four replications. There were nine treatments such as ~textrmT0 (control), ~textrmT1 (Azotobacter biofertilizer), ~textrmT2 (Azospirillum biofertilizer), ~textrmT3 (Azotobacter+Azospirillum biofertilizers), ~textrmT4 (Azotobacter+Cowdung 5 ton ~textrmha-1 ), ~textrmT5 (Azospirillum+Cowdung 5 ton ~textrmha-1 ), ~textrmT6 (Azotobacter+Azospirillum+Cowdung 5 ton ~textrmha-1 ), ~textrmT7 (Cowdung 5 ton ~textrmha-1 ) and ~textrmT8 (60% Nitrogen). The experimental results revealed that significant variations exist among the treatments regarding morphological characters e.g. plant height, number of leaves/plant, stem base diameter, tap root length, and physiological characters like, root dry weight, leaf area index and crop growth rate. Number of leaves/plant, stem base diameter, root length, root dry weight, leaf area index and crop growth rate were found higher in ~textrmT4 , ~textrmT5 , ~textrmT6 and ~textrmT8 than the others. In all the parameters, ~textrmT8 gave the similar result with biofertilizers in combination with cowdung treatments and ~textrmT7 showed identical with ~textrmT0 (control). Biofertilizer treatments had insignificant effect on 1000-seed weight(g). Experimental results mentioned above revealed that morpho-physioligical characters of okra could be modified by the application of biofertilizer+cowdung. However, biofertilizers+Cowdung treatments were comparable to ~textrmT8 (60% Nitrogen) in this study. This suggests that ~textrmT4 or ~textrmT6 or ~textrmT5 were more benificial in environmentally friendly okra cultivation and may be used as an alternative of inorganic nitrogen by saving cost of production and sustaining productivity.