Hypertension is characterized by excessive renin-angiotensin system activity, leading to blood vessel constriction. Several synthetic compounds have been developed to inhibit renin and angiotensin-converting enzyme (ACE). These drugs often have adverse side effects, driving the exploration of plant protein-derived peptides as alternative or supplementary treatments. This study assessed the phenolic compound and amino acid content and the antioxidant and antihypertensive activity of 5 South Korean staple crops. Sorghum had the highest phenolic compound content and exhibited the highest antioxidant activity. Millet grains, particularly finger millet (38.86%), showed higher antihypertensive activity than red beans (14.42%) and sorghum (17.16%). Finger millet was found to contain a large proportion of branched-chain, aromatic, and sulfur-containing amino acids, which are associated with ACE inhibition. In particular, cysteine content was positively correlated with ACE inhibition in the crops tested (r=0.696, p<0.01). This study confirmed that the amino acid composition was more correlated with the antihypertensive activity of grains than the phenolic compound content. Finger millet mainly contained amino acids, which have higher ACE inhibitory activity, resulting in the strongest antihypertensive activity. These findings underscore the antihypertensive potential of select crops as plant-based food ingredients, offering insight into their biological functions.

For efficient design and manufacture of PWR spent fuel burnup detector, data simulated with various condition of spent fuel in the NPP storage pool is required. In this paper, to derive performance requirements of spent fuel burnup detector for neutron flux and dose rates were evaluated at various distances from CE16 and WH17 types of fuel, representatively. The evaluation was performed by the following steps. First, the specifications of the spent fuel, such as enrichment, burnup, cooling time, and fuel type, were analyzed to find the conditions that emit maximum radioactivity. Second, gamma and neutron source terms of spent fuel were analyzed. The gamma source terms by actinides and fission products and neutron source terms by spontaneous and (α, n) reactions were calculated by SCALE6 ORIGAMI module. Third, simulation input data and model were applied to the evaluation. The material composition and dose conversion factor were referred as PNNL-15870 and ICRP-74 data, respectively and dose rates were displayed with the MCNP output data. It was assumed that there was only one fuel modeled by MCNP 6.2 code in pool. The evaluation positions for each distance were selected as 5 cm, 10 cm, 25 cm, 50 cm, and 1 m apart from the side of fuel, respectively. Fourth, neutron flux and dose rates were evaluated at distance from each fuel type by MCNP 6.2 code. For WH 17 types with a 50 GWd/MTU burnup from 5 cm distance close to fuel, the maximum neutron flux, gamma dose rates and neutron dose rates are evaluated as 1.01×105 neutrons/sec, 1.41×105 mSv/hr and 1.61×101 mSv/hr, respectively. The flux and dose rate of WH type were evaluated to be larger than those of CE type by difference in number of fuel rods. The relative error for result was less than 3~7% on average secured the reliability. It is expected that the simulated data in this paper could contribute to accumulate the basic data required to derive performance requirements of spent fuel burnup detector.

본 연구는 주변 환경의 차이에 따른 화분매개곤충의 유입 특성을 파악하기 위하여 국립수목원 내 진화속을걷 는정원과 부추속전문전시원에 식재된 울릉산마늘의 화분매개곤충을 조사하였다. 2023년 5월 22일부터 6월 2일 까지 꽃이 70% 이상 개화하였을 때 포충망을 활용하여 8일간 곤충을 채집하였고, 각 전시원 별 식생(피도), 기후 (온도·습도·조도)를 조사하였다. 조사 결과 진화속을걷는정원에서 피도 60% 온도 26.4℃, 습도 31.5%, 조도 40953.6lx, 화분매개곤충 20과 450개체, 부추속전문전시원은 피도 90%, 온도 25.6℃, 습도 31.6%, 조도 6387lx, 화분매개곤충 15과 196개체로 나타났다. 온도와 조도가 상대적으로 높은 진화속을걷는정원이 채집된 곤충의 다양성과 방문 빈도가 높았다. 시간대별 곤충의 방문 빈도를 비교해본 결과 온도와 조도는 개체수가 증가할 때 같이 증가하는 경향을 보였으며, 습도는 반대의 경향을 보였다.

Tritium is a radioactive isotope of hydrogen with a half-life of about 12.3 years, and it is commonly found in the environment as a result of the production of Nuclear Power Plants. The World Health Organization (WHO) has established guidelines for the permissible levels of tritium in drinking water. The guideline value for tritium in drinking water is 10,000 Bq/L. It is important to note that the guideline value for tritium is not a legal limit, but rather a recommendation. National and local authorities may establish legal limits that are more restrictive than the WHO guideline value based on local conditions and risk assessments. The Australia and Finland have set a limit for tritium in drinking water at 76,103 Bq/L and 30,000 Bq/L respectively, which is more than three to seven times higher compare to guideline value of WHO. The United States Environmental Protection Agency (EPA) has set a maximum contaminant level (MCL) for tritium in drinking water at 20,000 picocuries per liter (pCi/L), which is equivalent to 740 Bq/L. The Health Canada has set a guideline value for tritium in drinking water at 7,000 Bq/L. Assuming drinking water corresponding to each tritium limit (or guideline value) for one year, the expected exposure dose is 0.01 mSv to 1 mSv. It means that the tritium in drinking water below the limits or guideline value does not pose a significant risk to human health.

It is likely to occur internal exposure for workers in Nuclear Power Plants (NPPs) due to the intake of radionuclide. To assess the internal exposure dose the measurement of activity for remain radionuclide is necessary. The Whole Body Counters (WBCs) are commonly used for measurement of remain radionuclide activity in human body. Korea Hydro & Nuclear Power Co., Ltd. (KHNP) conduct performance test of WBCs in all NPPs for every year to confirm the performance of equipment. The performance test is conducted using unknown sources and the participants of the comparison test submit the radionuclide and activity of the unknown sources measured by WBC as a result. The performance indicator and criteria for WBC recommended in the American National Standards Institute (ANSI) N13.30 report published in 2011 are applied. The performance indicator is Root Mean Squared Error (RMSE) and criteria is 0.25 or less. The results of performance test performed in 2022 for all WBC is meet the ANSI N13.30 criteria. And the RMSE values are confirmed from 0.01 to 0.23. This means that the residual radioactivity measurement results using WBC are reliable.

Nuclear power plant decommissioning generates significant concrete waste, which is slightly contaminated, and expected to be classified as clearance concrete waste. Clearance concrete waste is generally crushed into rubble at the site or a satellite treatment facility for practical disposal purposes. During the process, workers are exposed to radiation from the nuclides in concrete waste. The treatment processes consist of concrete cutting/crushing, transportation, and loading/unloading. Workers’ radiation exposure during the process was systematically studied. A shielding package comprising a cylindrical and hexahedron structure was considered to reduce workers’ radiation exposure, and improved the treatment process’s efficiency. The shielding package’s effect on workers’ radiation exposure during the cutting and crushing process was also studied. The calculated annual radiation exposure of concrete treatment workers was below 1 mSv, which is the annual radiation exposure limit for members of the public. It was also found that workers involved in cutting and crushing were exposed the most.

In 2005, groundwater contamination due to unplanned releases of radioactive materials from the US. Nuclear Power Plants (NPPs) such as Braidwood and Indian Point was confirmed. The following year, in 2006, The Nuclear Regulatory Commission (NRC) established a task force team to investigate the history of unplanned release of all NPP in the US. As a results 217 events of unplanned release including leaks and spills were identified in the US NPPs. The NRC regulates the radioactivity concentration of off-site groundwater by setting a reporting levels (RLs), and if exceeds the RLs, the licensee must report within 30 days. When the off-site groundwater is used as drinking water or non-drinking water, the RLs for tritium in groundwater are 740 Bq·L−1 or 1,110 Bq·L−1, respectively. Whereas the NRC does not set the RLs for on-site groundwater. The Nuclear Energy Institute (NEI) issued the guidance document “Industry groundwater protection initiative” NEI 07-07 in 2007. And the members of the NEI promised with regulatory body and local governments to implement groundwater monitoring/protection program according to the NEI 07-07. The document states that when the on-site groundwater is used as drinking water, the RL (740 Bq·L−1) for off-site groundwater will be applied and the licensee voluntarily reported to the NRC. And also, NPPs are setting the Investigation Level (IL) below the RP and the IL is various among the NPPs. The IL is the standard by which detailed investigations are implemented when the level (radioactivity concentration) is exceeded.

There are many Systems, Structures, and Components (SSCs) in Nuclear Power Plants (NPPs). The systems include radiological waste treatment system, spent fuel pool cooling, emergency core cooling systems, etc. The structures include reactor building, piping vaults, radioactive waste storage facilities, etc. The components include valves, pumps, piping segments, etc. Radionuclides exist in some of these SSCs and unplanned release may occur when leaks or spills from them. And also Work Practice (WP) is another reason of unplanned release in NPPs. The WP is defined as an action taken by individuals during maintenance, operational or support activities, which could result in or prevent a spill or leak of a radioactive solid, liquid or gas that has a credible mechanism for contamination of groundwater. According to the results of the Electric Power Research Institute (EPRI) survey, a total of 323 unplanned release event occurred at US NPPs from 1970 to 2014. Among them, 219 events were counted to have occurred at pressurized water reactors (PWRs). In addition, it was confirmed that 41 of the 44 PWR sites (about 93%) in the US, operated at the time of the survey period, had experienced at least one unplanned release events of licensed material which impacted groundwater. This means that the US PWR sites have experienced an average of approximately 5 unplanned release event per site. The source with the most unplanned releases, including SSCs and WP, was miscellaneous systems with a percentage of about 33% (72 events). Miscellaneous systems include pipes, and it was confirmed that unplanned releases mainly occurred in pipes such as the main steam system, condensate and feedwater system, and emergency core cooling system. And the percentage was high in the order of WPs (21%, 45 events), radioactive effluents (20%, 43 events), refueling water storage (8%, 17 events), radioactive waste/material operations (7%, 16 events), spent fuel storage (5%, 12 events), unknown (4%, 9 events), and structures (2%, 5 events). The history of the unplanned release of the US NPPs will be considered when revising major SSCs in the domestic NPP groundwater monitoring program.

In order to monitor the contamination of groundwater due to unplanned release of radioactive materials and the spread to off-site environments, the nuclear power plants (NPPs) conduct groundwater monitoring program (GWMP) in Korea. The GWMP should be established based on the groundwater flow model reflecting the conceptual site model (CSM) of the NPP’s site. In this study, in order to optimize the GWMP, the existing CSM and the groundwater flow model of the domestic NPPs site was updated by reflecting the latest groundwater level. As part of the CSM improvement, the hydrogeological units were subdivided more detailed from three to six through the review of hydrogeological characteristics of the NPPs site. In addition, major variables that affect groundwater flow, such as water conductivity, have been updated. The groundwater flow model was revised overall as the CSM was improved. In particular, the excavation depth of the structure and backfill area generated during the construction stage of the NPP structures was accurately reflected, and the drainage boundary conditions were realistically reflected. To verify the revised groundwater flow model, steady-state correction was performed using the groundwater level measured in April, 2021. As a results of the steady-state correction, the standard error of estimate, root mean square (RMS), normalized RMS, and the correlation coefficient were 0.32 m, 1.692 m, 5.608%, and 0.964, respectively. This means that the groundwater flow model is reasonably constructed. The CSM and groundwater flow model improved in this study will be used to optimize the monitoring location of groundwater in NPPs.

Inflammation is a protective mechanism against pathogens, but if maintained continuously, it destroys tissue structures. Aggregatibacter actinomycetemcomitans is a gram-negative, facultative anaerobic bacterium often found in severe periodontitis. A. actinomycetemcomitans invades epithelial cells and triggers inflammatory response in the immune cells. In this study, we investigated the effect of water-soluble rosehip extract on A. actinomycetemcomitansinduced inflammatory responses. A human monocytic cell line (THP-1) was differentiated to macrophages by phorbol 12-mystristate 13-acetate treatment. The cytotoxic effect of extract was determined using the 3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetrazolium bromide assay. The effects of extract on bacterial growth were examined by measuring the optical densities using a spectrophotometer. THP-1-derived macrophages were infected A. actinomycetemcomitans after extract treatment, and culture supernatants were analyzed for cytokine production using enzyme-linked immunosorbent assay. Protein expression was measured by western blotting. Extract was not toxic to THP-1- derived macrophages. A. actinomycetemcomitans growth was inhibited by 1% extract. The extract suppressed A. actinomycetemcomitans-induced tumor necrosis factor-α, interleukin (IL)-1β, and IL-8 production. It also decreased mitogen-activated protein kinase (MAP kinase) and nuclear factor-κB (NF-κB) phosphorylation. Moreover, the extract inhibited the expression of inflammasome components, including nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3, Absent in Melanoma 2, and apoptosis associated speck-like protein containing a CARD. And cysteine-aspartic proteases-1 and IL-1β expression were decreased by the extract. In summary, extract suppressed A. actinomycetemcomitans growth and decreased inflammatory cytokine production by inhibiting activation of MAP kinase, NF-κB, and inflammasome signaling. Rosehip extract could be effective in the treatment of periodontal inflammation induced by A. actinomycetemcomitans infection.

본 연구는 원통형 종이포트 토마토 육묘시 Diniconazole의 처리방법이 도장억제 및 근권발달에 미치는 영향을 검토하기 위하여 수행되었다. 그 결과, 엽면적, LAR, 초장, 충실도, 생체중, RGR 및 R/S 에서 시험구간 유의한 차이를 보였다. 동일한 농도를 처리했을 경우, 근권부와 지상부의 흡수도 차이로 인해 저면관수가 엽면살포에 비해 도장억제에 효과적이었다. 저면관수는 엽면시비의 10분의 1의 농도만으로도, 20~30%정도의 동일한 도장억제 효과를 얻을 수 있었다. 디니코나졸 처리에의한 근권부 반응이 흥미로웠는데, 저면관수시 총근장, 근권부피, 평균 근경 및 근단수가 증가하였다. 특히, 0.3mm 이하의 초미세근이 감소하고 0.3~0.6mm의 세근이 증가하였다. 따라서 원통형 종이포트 육묘시 저면관수를 하는 것이 기존 엽면시비에 비해 사용량이 적으면서도 도장억제 및 근권부 활착률을 높힐 수 있을 것으로 판단된다.

In this study, the effects of heat-moisture treatment (boiling or steaming for 45 min) prior to hot air drying (70 o C for 8 h) on water activity (Aw), moisture (MC), Brix, color, and texture of dried sweet potato slices were investigated to identify the best pretreatment condition for producing dried sweet potato with the best eating quality. Dried sweet potato slices pretreated by boiling (BL) showed significantly lower Aw, MC, and hardness while Brix was significantly higher than with steaming (ST) treatment. There were no significant differences for the color, springiness, cohesiveness, gumminess, and brittleness indexes. At 8 h drying, the Aw, MC, Brix, and hardness of the BL and ST samples were 0.81 and 0.82, 19.71% and 25.53%, 53.80% and 49.40%, and 20.49 kg/cm 2 and 31.98 kg/ cm 2 , respectively. This information will be useful for manufacturers in the production of dried sweet potato slices. These findings provide evidence of the feasibility of heat-moisture treatments in the production of dried sweet potato.