콩은 식물성 단백질과 지방을 얻기 위하여 가장 널리 재배되는 주요 콩과 작물이다. 그러나, 성숙 콩 실에는 가공적성과 품질 저하, 알러지 유발 및 소화 불량을 일으키는 성분이 포함되어져 있다. 콩 성숙 종실에서 주요 항영양성분으로 알려진 lectin, KTI, lipoxygenase 및 7S α' subunit의 4가지 단백질이 모두 부재하면서 stachyose의 함량이 낮은 대립 노란콩 ‘백세’ 품종이 국내 최초로 육성되었다. ‘백세’ 품종은 F-1-9와 F-1-6의 육성계통간 교배로 얻어진 집단에서 선발되었다. ‘백세’ 품종은 보라색 화색, 유한신육형, 회색 모용색 및 성숙시 연한 갈색의 협색을 가지며, 종피 및 제색은 노란색이다. ‘백세’의 종실 조단백질 및 조지방 함량은 각각 41.1%와 15.8%이었고, stachyose의 함량은 2.9 g/kg으로 대조 품종인 ‘대원’의 12.7 g/kg보다 훨씬 낮았다. ‘백세’는 콩 모자이크 바이러스, 콩 괴사병, 검은뿌리썩음병, 꼬투리 및 줄기 무름병, 불마름병에 대한 저항성을 나타내었다. ‘백세’는 6월 20일경 파종시 성숙기는 10월 16일경이며, 경장은 53 ㎝, 백립중은 31.0 g 정도이고 2020년 3곳에서의 평균 수량은 2.95 ton/ha-1 정도였다.‘백세’는 2023년 4월 6일 국립종자원에 콩 품종 등록(등록번호: 9515) 되었다.

The role of the gut microbiota in colorectal cancer (CRC) development has garnered attention, highlighting probiotics as potential adjuncts in CRC prevention and treatment. In recent years, probiotics and their derivatives have demonstrated mechanisms that may contribute to anticancer properties. This study investigates the cytotoxic effects of Bifidobacterium bifidum KCTC 3357, Lacticaseibacillus rhamnosus KCTC 5033, Limosilactobacillus reuteri VA 103, Bacillus galactosidilyticus VA 107, and Lactococcus taiwanensis VE101 on CT-26 mouse colon carcinoma cells using live cells, heat-killed cells (paraprobiotics), and cell-free supernatants (CFS, postbiotics) through an MTT assay. The results indicate that live bacterial strains, such as KCTC 3357, VA 103, and VA 107, promoted CT-26 cell viability, while heat-killed cells and CFS exhibited dose-dependent cytotoxicity. Inactivated forms of KCTC 3357 and VE 101, as well as CFS at 10 mg/mL concentration of KCTC 5033, VA 103, and VE 101, showed the strongest antiproliferative effects. These findings suggest that non-viable probiotic derivatives, such as paraprobiotics and postbiotics, offer promising therapeutic potential for CRC, providing a safer and more stable alternative to live probiotics. However, further research is required to explore their mechanisms of action, in vivo efficacy, and potential clinical applications.

Lithium-ion batteries (LIBs) are widely used as essential power sources for electric vehicles and energy storage systems. Among various cathode materials, Li[Ni0.9Mn0.1]O2 (NM90) has gained significant attention for enhancing the performance of LIBs due to its high energy density and nontoxicity. However, increasing the nickel content introduces challenges, including structural instability and cation mixing. To address these issues, we propose a surface coating strategy using nitrogendoped carbon quantum dots (NCQDs). NCQDs provide high electrical conductivity and electrochemically active sites, so the NCQDs coating effectively enhanced both structural stability and electrical/ionic conductivity. The NCQDs were synthesized via a hydrothermal method, and NM90 were synthesized by co-precipitation. The fabricated NCQD/NM_5 electrode exhibited superior electrochemical properties, including a high initial capacity of 189.6 mAh/g, excellent rate performance, and an outstanding capacity retention of 81.5 % after 200 cycles in 1C. These superior results demonstrate that surface modification using the NCQDs strategy for Li[Ni0.9Mn0.1]O2 cathode materials will contribute to the further development of cycle stability and ultrafast performance in energy storage systems.

Probiotics have been evaluated as therapeutic agents for cancer treatment in an increasing number of studies. This study investigated the inhibitory and cytotoxic effects of specific Lactobacillus strains on a human colorectal adenocarcinoma cell line (HT-29). The strains assessed were Limosilactobacillus (L.) reuteri VA 102, Ligilactobacillus (L.) animalis VA 105, and Limosilactobacillus (L.) reuteri KCTC 3594 (ATCC 23272). The viability of HT-29 cells was evaluated using the MTT assay. The findings revealed that cell-free supernatants (CFS) exhibited significant anticancer effects. Heat-inactivated L. reuteri VA 105 and L. reuteri KCTC 3594 induced a pronounced reduction in cell viability. Furthermore, live cultures of L. reuteri VA 105 and L. reuteri VA 102 also showed reduced cell viability compared to the control group. These results suggest that CFS and heat-inactivated cells may be more suitable for therapeutic applications than live bacteria owing to their improved safety profiles and reduced potential for adverse effects. Our findings also emphasize the potential anticancer benefits of these LAB strains.

Graphene-based solar cells and supercapacitors integrated into photosupercapacitors represent a pioneering advancement. These devices leverage the exceptional properties of graphene, such as high conductivity and large surface area, to enhance both solar energy conversion and energy storage. The integration of these technologies into photosupercapacitors creates a multifunctional device capable of harnessing solar energy and storing it efficiently. This innovative approach holds promise for sustainable and versatile energy solutions, marking a significant step towards developing efficient and compact energy storage systems. This integration addresses the intermittent nature of solar power generation by providing a continuous and reliable power supply through energy storage. Supercapacitors are one such energy device with a high-power density and excellent specific capacitance which is integrated will a dye-sensitized solar cell (DSSC) comprising a single system of photosupercapacitor. A novel electrode material of NiO/CuO/Co3O4/rGO was synthesized which serves as the Pt-free counter electrode of DSSC and working or storage electrode of supercapacitor later was used as the intermediate electrode and storage electrode of a photosupercapacitor. The integrated photosupercapacitor device had a photovoltage of 0.81 V with arealspecific capacitance, energy and power density of 190.12 mF cm− 2, 17.325 μW h cm− 2 and 0.162 mW cm− 2, respectively. The device self-discharged in 385 s with an overall conversion efficiency of 2.17%, resulting in a self-charged energy device.

In recent years, the search on fabrication of highly efficient, stable, and cost-effective alternative to Pt for the hydrogen evolution reaction (HER) has led to the development of new catalysts. In this study, we investigated the electrocatalytic HER activity of the Toray carbon substrate by creating defect sites in its graphitic layer through ultrasonication and anodization process. A series of Toray carbon substrates with active sites are prepared by modifying its surface through ultrasonication, anodization, and ultrasonication followed by anodization procedures at different time periods. The anodization process significantly enhances the surface wettability, consequently resulting in a substantial increase in proton flux at the reaction sites. As an implication, the overpotential for HER is notably reduced for the Toray carbon (TC-3U-10A), subjected to 3 min of ultrasonification followed by 10 min of anodization, which exhibits a significantly lower Tafel slope value of 60 mV/dec. Furthermore, the reactivity of the anodized surface for HER is significantly elevated, especially at higher concentrations of sulfuric acid, owing to the enhanced wettability of the substrate. The lowest Tafel slope value recorded in this study stands at 60 mV/dec underscoring the substantial improvements achieved in catalytic efficiency of the defect-rich carbon materials. These findings hold promise for the advancement of electrocatalytic applications of carbon materials and may have significant implications for various technological and industrial processes.

In this study, an attempt was made to approximate the main characteristic values of Bi0.5(Na0.78K0.22)0.5TiO3 (= BNKT) depending on the content of Fe2O3 additives, aiming to approach the values of lead(Pb) piezoelectric ceramic materials (PZT). Specifically, when the piezoelectric coefficient (d33) value of lead(Pb) piezoelectric ceramic material (PZT polycrystalline ceramic powder) is 300[pC/N] or higher, it is applied for hard purposes such as ultrasonic welding machines and cleaning machines, and when it exceeds 330[pC/N], it is applied for soft purposes like piezoelectric sensors. In this study, research and development were conducted for devices with a piezoelectric coefficient (d33) of 300[pC/N] or more for actuators. For this purpose, K+ exceeding 0.02 to 0.12 mol% was added to (Na0.78K0.22)0.5Bi0.5TiO3 to analyze structural changes due to K+ excess, and (Na0.78K0.22)0.5Bi0.5TiO3 + 8mol% K2CO3 Ti4+ was substituted with Fe3+ to manufacture lead-free piezoelectric materials. As a result, ceramics with Fe3+ substitution at x = 0.0075 yielded an average value of d33 = 315[pC/N]. Furthermore, for ceramics with Fe3+ substitution at x = 0.0075, the average values of maximum polarization (Pmax), residual polarization (Prem), and coercive field (Ec) were found to be 39.63 μC/cm2, 30.45 μC/cm2, and 2.50 kV/mm, respectively. The reliable characteristic values obtained from the research results can be applied to linear actuator components (such as the zoom function of mobile cameras, LDM for skin care, etc.) and ultrasonic vibration components.

본 연구에서는 호흡동조화기법의 대안으로 딥러닝 자유호흡기법에서 b-value 별 겉보기확산계수 값을 평가하고 확 산강조영상과 겉보기확산계수 지도의 해부학적 일치성을 분석하여 적절한 여기횟수 값을 알아보고자 하였다. 연구 방법은 2023년 7월부터 2024년 1월까지 간 자기공명영상 검사가 의뢰된 성인 남녀 35명을 대상으로 하였고 사용 장비는 Magnetom Skyra 3.0T(Siemens, Germany)를 이용하였다. 자유호흡기법의 비교를 위해 b-value 50, 400, 800(s/mm2)의 여기횟수를 각각 딥러닝 호흡동조화기법에서 2,3,4으로 딥러닝을 이용하지 않은 일반 자유호 흡기법에서 4,6,8으로 검사하였다. 딥러닝을 추가한 일반 자유호흡기법에서는 1,2,3 여기횟수, 2,3,4 여기횟수, 3,5,6 여기횟수, 4,6,8 여기횟수로 변화하였다. 연구 결과 딥러닝 자유호흡기법에서 간의 좌엽과 우엽, 담낭의 평균 겉보기확산계수 값은 딥러닝 호흡동조화기법과 비교하여 모두 통계적 유의성을 확인하였다. 한편 정성적 평가의 해 부학적 일치성을 분석한 결과 딥러닝 자유호흡기법의 3,5,6 여기횟수와 4,6,8 여기횟수에서 가장 높은 점수를 얻었 으며 검사 시간에서는 딥러닝 호흡동조화기법과 비교하여 약 51%, 40% 감소하였다. 따라서 간 진단에 있어 딥러닝 자유호흡기법에서 b-value 별 적절한 여기횟수 값을 이용한다면 겉보기확산계수 지도의 정확도 유지와 함께 검사 시간을 감소시킬 수 있어 임상적으로 유용한 검사가 될 것으로 사료된다.

본 연구는 자유학기제에서 농업 연계 프로그램의 필요성과 활용 가능성을 탐색하고 텃밭을 활용한 자 유학기제 농업 연계 프로그램의 개발방향을 제시하는 것을 목적으로 한다. 이를 위해 학생과 교사를 대상으로 자유학기제 운영 만족도, 개선 요구사항, 농업 연계 프로그램의 필요성과 활용 가능성에 대한 인식을 조사하였다. 연구결과, 학생과 교사 모두 농업 연계 프로그램이 자유학기제의 교육적 목표에 부합한다고 인식하였으며, 특히 환경학과의 융합 가능성이 높게 평가되었다. 텃밭을 활용한 프로그램 의 구체적인 활동으로는 식물기르기, 수확, 요리 및 공예 활동 등이 적합하다고 분석되었다. 본 연구는 텃밭을 활용한 자유학기제 프로그램의 개발에 필요한 기초자료를 제공하며, 맞춤형 프로그램 개발, 전 문 강사 배치, 인프라 확충 등을 제언하였다.

외국인투자유치를 통해서 지역발전과 경제성장을 이루려는 목적으로 도입된 경제자유구역이 2003년 본격적으 로 도입된 지 20년이 넘었다. 그동안 경제자유구역 연구는 주로 정책적인 측면에서 이루어졌다. 경제자유구역에 실제로 투자한 외국인투자가 시각에서 한국의 경제자유구역이 어떻게 받아들여지고 있는가를 정확하게 평가하는 것이 필요하다. 이에 본 연구에서는 인천경제자유구역 송도지구에서 장기간에 걸쳐서 투자와 경영활동을 성공적으 로 수행하고 있는 4개의 외국인투자기업(삼성바이오로직스, 셀트리온, 얀센백신, 아이센스)에 대한 사례분석을 통 해서 경제자유구역에 대한 심도 있는 평가와 경제자유구역 발전을 위한 정책적 시사점을 도출하고 있다. 본 연구 에서는 더닝의 해외직접투자 절충이론 ‘OLI 프레임워크’를 적용하여 사례를 자세히 분석하고, 경제자유구역 관련 정 책적 시사점을 도출하였다. 본 연구 결과 외국인투자가의 다양한 기업특유우위(Ownership specific advantage) 를 확인할 수 있었고, 각 사례 기업이 중요하게 평가한 인천경제자유구역의 다양한 입지특유우위(Location specific advantage)도 파악할 수 있었다. 100% 지분율의 얀센백신 사례에서는 내부화우위(Internalization advantage) 를 확인할 수 있었으며, 소수지분으로 투자한 나머지 사례에서는 한국기업과 파트너가 되어 협력적 투자를 실행한 동기도 확인할 수 있었다. 본 사례연구 결과로 도출된 정책적 시사점은 첫째, 외국인투자유치에서 결정적인 역할을 한 양질의 토지를 확충할 경제자유구역 추가 지정, 둘째, 경제자유구역 내 외국기업 단독 또는 협력 등 다양한 방식의 연구개발 사업에 대한 지원을 확충 등이다.

Probiotic lactic acid bacteria are live microorganisms that provide health benefits when administered in adequate amounts and may exhibit antiproliferative effects on various cancer cell lines, including colon cancer. This study investigates the cytotoxic effects of three Lactobacillus strains - Limosilactobacillus (L.) reuteri VA 102, Ligilactobacillus (L.) animalis VA 105, and Limosilactobacillus (L.) reuteri KCTC 3594 (ATCC 23272) - on mouse colon carcinoma cells (CT-26). Live cells, heat-killed cells, and cell-free supernatant (CFS) of Lactobacillus sp. were prepared and used to treat CT-26 cells at different concentrations. The cytotoxic effect was assessed using the MTT assay. The results indicated that the CFS of all strains significantly reduced the viability of CT-26 cells in a dose-dependent manner, with the VA 102 strain showing the most pronounced effect. Heat-killed cells of L. reuteri VA 102 and L. reuteri KCTC 3594 (ATCC 23272) also reduced cell viability. These findings suggest the potential anticancer properties of these Lactobacillus strains and indicate that CFS and heat-killed cells may offer a safer and more effective alternative to live bacteria for therapeutic applications. Our study contributes to the understanding of the potential of Lactobacillus strains, particularly L. reuteri VA 102, L. reuteri KCTC 3594 (ATCC 23272), and L. animalis VA 105, as possible candidates for cancer treatment and control.