본 연구에서는 중소기업에서 품질혁신활동을 추진할 때 정부와 모기업차원에서 지원이 가능한 요소들에 대해 Kano가 제시한 방법의 설문을 활용하여 조사하였다. 이 조사 결과를 Kano 분석과 함께 Timko가 제시한 고객만족계수를 활용하여 분석하여 품질혁신활동을 지원하는 정부와 모기업, 그리고 추진의 주체인 기업 등에 작용하는 매력적 요인과 일원적 요인, 당연적 요인 등을 밝히고자 하였다.

This study investigated whether orthodontic force influences the production of osteoprotegerin (OPG) and receptor activator of nuclear factor-kappa B ligand (RANKL) in vivo, both of which are affected by cortical activation. Mechanical force was applied to the maxillary premolars of orthodontic patients by fitting the transpalatal arch prior to cortical activation of the gingival tissue. Gingival crevicular fluid (GCF) samples were then collected from each patient using paper strips before and after 1, 3, 7 or 14 days of treatment. The OPG and RANKL levels in the GCF were determined by enzyme-linked immunosorbent assays. The levels of OPG were significantly increased after 1 day of fitting the appliance and decreased to basal levels at 3 days after fitting. In contrast, the RANKL levels were dramatically decreased at 1 day after fitting, but recovered to those of the untreated control at 3 days after the force application. The force-mediated changes in the OPG and RANKL levels of the GCF were unaffected by cortical activation during these experimental periods. Collectively, these results suggest that an acute and severe change between the OPG and RANKL levels plays an important role in stimulating the cellular responses required for alveolar bone remodeling by orthodontic treatment.

본 연구에서는 공간 과제 수행 시 21%의 산소 농도와 30%의 고농도 산소 공급이 변연계의 활성화에 어떠한 변화를 유발하는지 관찰하였다. 총 8명의 오른손잡이 남자 대학생을 본 연구의 실험 참여자로 선정하였다. 공간 과제를 수행하는 동안 3T MRI 를 이용하여 뇌기능 영상을 획득하였다. 실험은 21%의 일반 공기 중의 산소 농도와 30%의 고농도 산소를 각각 공급하면서 공간 인지 과제를 수행하는 두 개의 회기로 구성된다. 변연계를 대상이랑(cingulate gyrus), 시상(thalamus), 변연엽(limbic lobe), 시상하부(hypothalamus), 해마(hippocampus), 해마방회(parahippocampa gyrus), 편도(amygdala), 유두체(mammilary body)의 8 개의 영역으로 분리하여 뇌 활성화 영역을 비교하였다. 공간 과제 수행 시 두 가지 산소 농도에 따른 변연계의 활성화 영역은 거의 동일하였다. 그러나 21%의 산소 농도에 비해 30%의 고농도 산소 공급 시 대상이랑(cingulate gyrus)과 시상(thalamus) 영역에서 활성화가 증가하였다. 즉, 30%의 고농도 산소 공급 시 공간 인지 수행 능력의 증가는 공간 인지 처리와 관련이 있는 대뇌 피질 뿐만 아니라 시상(thalamus)과 대상이랑(cingulate gyrus) 같은 피질하 영역에서의 신경 활성화의 증가와도 관련이 있는 것으로 판단된다.

The effects of Ganoderma lucidum on glucose uptake was studied in L6 rat skeletal muscle cells. Glucose uptake in muscle cell was increased about 6-fold compared to control by mushroom extract treatment. This increasing effect to the glucose uptake was observed in muscle cells cultured with or without insulin. The levels of phosphor-acetyl CoA carboxylase were upregulated by G. lucidum extract treatment in insulinstimulated and basal culture conditions. However, G. lucidum extract did not affect protein kinaseB/Akt(Akt) level. Furthermore, the expression of phosphor-AMPactivated protein kinase(AMPK) was also up-regulated. AMPK is another regulatory protein in the glucose uptake pathway and energy metabolism. Thus, the treatment of G. lucidum extract in skeletal muscle cells increased the phosphorylation levels of AMPK and acetyl-CoA carboxylase, showing that the increase of glucose uptake by G. lucidum extract might be mediated via the activation of AMPK signaling pathway

This research was conducted to estimate the characteristics of carbon dioxide decomposition using an inorganic sludge. The inorganic sludge was composed of high amount (66.8%) of Fe2O3. Hydrogen could be reduced with 0.247, 0.433, 0.644, and 0.749 at 350, 400, 450, and 500℃, respectively. The carbon dioxide decomposition rates at 250, 300, 350, 400, 450, and 500℃ were 32, 52, 35, 62, 75, and 84%, respectively. High temperature led to high reduction of hydrogen and better decomposition of carbon dioxide. The specific surface area of the sludge after hydrogen reduction was higher than that after carbon dioxide decomposition. The specific surface area of the sludge was more decreased with increasing of temperature.

목적 : 본 연구는 머리 각도에 따른 목뿔위근육의 활성 정도를 확인하여 임상에서 삼킴 기능 증진을 위한 치료적 적용시 목뿔위근육들이 보다 활성화 되는 자세를 확인하고 이를 치료에 적용하기 위하여 시행되었다. 연구 방법 : 대전광역시 OO대학교에 재학중인 학생들을 대상으로 실험참가 대상자들을 모집하여, 지원자 중 무작위로 39명의 학생(남 24명, 여 15명)들을 선정하여 실험을 진행하였다. 프랑크포트 수평면이 지면과 수평이 되는 각도를 기준으로 머리각도 중립 자세(head flexion 0°)를 설정하였으며, 방사선 촬영을 통하여 머리각도 15°하방, 머리각도 15°상방 상태를 확인한 후, 각각의 상태(머리 중립 0°, 머리 굴곡 15°, 머리 신전 15°)에서 3회씩(1회 삼킴 후 10초 휴식) 마른 삼킴과 젖은 삼킴을 시도하였다. 결과 : 마른 삼킴과 젖은 삼킴 모두에서 중립시보다 머리 각도를 15°굴곡하였을 경우 목뿔위근육들이 보다 활성화되는 것을 알 수 있었다. 이에 반하여 머리 각도를 15°신전하여 삼킴을 시도하였을 경우에는 통계적으로 유의할만한 결과를 보이지 않았다. 결론 : 머리를 굴곡시킨 자세에서 삼킴을 유도하는 것이 좀더 목뿔위근육을 활성화시키고 목뿔의 가동성을 높여, 보다 안전한 식이를 위한 방법으로 제안될 수 있을 것이다.

이 논문에서는 충청도지역의 주요 문화공간인 공연장을 중심으로 지방 공연장의 운영 실태와 공연장의 규모 및 시설의 형태, 년 간 행사되는 공연물의 공연 실적 등을 통해 지방문화 예술의 문제점을 제시하고 지방문화의 발전 활성화를 위한 구체적 방안을 모색하고자 한다. 충청도지역의 공연장의 형태와 시설 및 공연 실적의 비교는 최근에 신설된 공연장을 포함한 비교적 공연활동이 활발한 공연장을 중심으로 하였으나 공연예술 보다는 일반교양 행사에 주로 대관 되는 지방 공연장의 특성으로 인해 극히 적은 수의 공연 실적을 토대로 충청도지역의 공연활동을 평가하는 자체가 무리가 있다. 그러나 공연장의 공연 시설 및 공연 실적을 통하여 무용을 포함한 각종 공연물이 공연장으로 인해 발생되어질 수 있는 문제점을 발견하고 보완함으로서 무대예술의 발전과 나아가 지방문화의 발전을 꾀할 수 있는 방법을 제시하는데 도움이 될 수 있을 것으로 사료되는바 상호 비교를 감행하였다. 그러므로 본 논문은 충청도지역의 문화공간인 주요공연장을 중심으로 공연장의 운영현황 분석을 통해 충청도지역과 문화예술의 활성화를 위한 개선방안을 제시하는데 그 목적을 둔다.

Bone morphogenetic protein (BMP) 2 is a potent osteogenic factor. Although both Smad1/5 and mitogenactivated protein kinases (MAPKs) are activated by BMP2, the hierarchical relationship between them is unclear. In this study, we examined if BMP2-stimulated MAPK activation is regulated by Smad1/5 or vice versa. When C2C12 cells were treated with BMP2, the activation of extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun-N-terminal kinase was evident within 5 min. The knockdown of both Smad1 and Smad5 by small interfering RNA did not affect the activation of these MAPKs. In addition, neither the overexpression of Smad1 nor Smad5 induced ERK activation. When ERK activation was induced by constitutively active MEK1 expression, the protein level and activation of Smad1 increased. Furthermore, the inhibition of constitutively active BMP receptor type IB-induced ERK activation significantly suppressed Smad1 activation. These results indicate that Smad1/5 activation is not necessary for BMP2-induced MAPK activation and also that ERK positively regulates Smad1 activation.

This study was designed to investigate the effect of kinetin on in vitro development of parthenogenetic porcine oocytes exposed to demecolcine prior to activation. In vitro matured metaphase II stage oocytes were incubated in 0 or 2 g/ml demecolcine supplemented defined culture medium for 3 h and the oocytes were activated electrically. The parthenogenetic porcine embryos were then cultured in 0 or 200 M kinetin supplemented defined culture medium for 7 days. Regardless of demecolcine treatment, kinetin supplementation increased blastocyst rates significantly (7.0% versus 12.1% and 4.9% versus 8.5%; Control versus Kinetin and Demecolcine versus Kinetin + Demecolcine, respectively, p<0.05). Demecolcine treatment before activation tended to decrease blastocyst rates regardless of kinetin supplementation although it is not statistically significant. Total cell numbers in the blastocysts also tended to be elevated in embryos when supplemented with kinetin, however only the result between Kinetin and Demecolcine groups is statistically significant (37.6 7.2 versus 28.1 9.5, respectively, p<0.05). In conclusion, the present report shows that kinetin enhances developmental competence of parthenogenetic porcine embryo regardless of demecolcine pre-treatment before parthenogenetic activation when they were developed in defined culture condition.

Recently, it is becoming the big issue internationally where the safety problem of the industrial product including the foodstuffs. The way is able to construct the trust of the consumer that the external specialized agency independently operating confirm

This study is performed to investigate the difference of the spinal stability system with and without low back pain. There were 9 participants with low back pain and 9 asymptomatic subjects to be recruited, they were measured thoracic and lumbar curvature, trunk muscle activation in upright sitting postures and slump sitting, back muscle endurance, and lumbar proprioception. Spinal curvature and surface electromyography of 4 trunk muscles were measured in an upright sitting postures and slump sitting in 18 subjects. The result of the study was that there were significant differences between the groups in spinal curvature (p<.05), significantly higher external oblique activity and less internal oblique in the low back pain group than the healthy subjects (p<.05), and significantly less proprioception in the low back pain group (p<.05). But there was not a significant difference between the trunk muscle endurance groups. According to the result, the low back pain group had greater thoracic extension and higher global muscle activity in the upright sitting posture and less proprioception. This study was useful to suggest postural training for normal muscle activation, selective muscle strengthening to prevent chronic deterioration, and helpful in making a treatment plan to indicate a synthetic care method that includes increasing proprioception.

In order recently to plan the economic position improvement and an independence of the disability the concept which is the "Disability Firm Activity Promotion Law" establishes and "the Disability firm" uses. But the policy the Disability Firm Activity Promotion Law which is an obstacle for the true feelings Disability firm was about there is a lingering. Promotes the activity of the Disability firm from the research which sees the Disability Firm Activity Promotion Law revision direction for the competitive improvement of the Disability firm.