Stimuli-responsive biomaterials that alter their function through sensing local molecular cues may enable technological advances in the fields of drug delivery, gene delivery, actuators, biosensors, and tissue engineering. In this research, pH-responsive hydrogel which is comprised of dimethylaminoethyl methacylate (DMAEMA) and 2-hydroxyethyl methacrylate (HEMA) was synthesized for the effective delivery of doxorubicin (Dox) to breast cancer cells. Cancer and tumor tissues show a lower extracellular pH than normal tissues. DMAEMA/HEMA hydrogels showed significant sensitivity by small pH changes and each formulation of hydrogels was examined by scanning electron microscopy, mechanical test, equilibrium mass swelling, controlled Dox release, and cytotoxicity. High swelling ratios and Dox release were obtained at low pH buffer condition, low cross-linker concentration, and high content of DMAEMA. Dox release was accelerated to 67.3% at pH 5.5 for 6-h incubation at 37oC, while it was limited to 13.8% at pH7.4 at the same time and temperature. Cell toxicity results to breast cancer cells indicate that pH-responsive DMAEMA/HEMA hydrogels may be used as an efficient matrix for anti-cancer drug delivery with various transporting manners. Also, pH-responsive DMAEMA/HEMA hydrogels may be useful in therapeutic treatment which is required a triggered release at low pH range such as gene delivery, ischemia, and diabetic ketoacidosis.

This study provides a comparison and analysis of the predicted damages related to hazardous chemical substances used in “A” solar cell manufacturing process. In order to predict potential damages, different accident scenarios were established using the ALOHA model and the KOSHA guideline. This study evaluates chemical spills and leaks from cylinder and pipeline. Maximum distance of chemical movement, based on an initial concentration of 150 ppm, was estimated as up to 258 m in summer and 251 m in winter. The impacts of the leakage of chemicals such as ammonia, were dependent on the initial concentration of the chemical leaked, the atmospheric stability and temperature, and the wind speed. All of those however, were affected by air humidity.

To obtain geographical range and growth–kinetics parameters of mottled sake (Beringraja pulchra) populations in the Yellow Sea, three mark–recapture experiments were carried out. Overall, 991 tagged individuals were released, and 4.1% of them were recaptured with the mean release period of 339 d (range, 8–1,420 d) and the mean growth rate of 1.4 cm mon–1 (female, 1.5 cm mon–1; male 1.3 cm mon–1). In the first experiment, 667 individuals were released at Heuksan Island from April to June, 2007–2009, and 30 individuals were recaptured mainly at the north and the north–east coasts of the island, indicating absence of migration to the south of the island. In the second experiment, 323 individuals were released at several fishing grounds scattered in the Yellow Sea in 2010–2013, and 11 individuals were recaptured at points deviated to all directions from the releasing points. As the last, one individual was released with pop–up satellite archival tag at a costal point (34°37.2’N, 124°59.3’E) off Hong Island on May 21, 2010. The tagged individual migrated to a north–east location (35°50.4’N, 126°03.6’E) of Eocheong Island by Aug. 25, 2010. The data archived for the three months in the tag indicated that the migration path had depths of 48–80 m and temperature of 12.6–14.4°C. The results indicated that mottled sake populations had a localized habitat ranges at the north of Heuksan Island and the west of Hong Island while growing at the rate of 1.4 cm mon–1.

In this study, the control of microstructure for increasing surface roughness of Al with an electro-chemical reaction and a post treatment is systematically investigated. The Al specimen is electro-chemically treated in an electrolyte. In condition of the post treatment at 100oC for 10 min, a change of the surface microstructure occur at 50V (5 min), and a oxidized layer is at 400V, to which lead a decreasing surface roughness. The minimum temperature of the post treatment for a change of microstructure is 80oC. Moreover, in the condition of 300V (5 min), the electro-chemical reaction is followed by the post treatment at 100oC, the critical enduring time for the change of microstructure is 3 min. The longer post treatment time leads to the rougher surface. The treated Al specimen demonstrate better heat release ability owing to the higher surface roughness than the non-treated Al.

Zn(BH4)2 was prepared by milling ZnCl2 and NaBH4 in a planetary ball mill in an Ar atmosphere, and XRD analysis, SEM observation, FT-IR analysis, DTA, and TGA were performed for synthesized Z (BH4)2 samples. 90 wt% MgH2+ 1.67 wt% Zn(BH4)2(+NaCl)+5 wt% Ni+1.67 wt% Ti+1.67 wt% Fe (named 90MgH2+1.67Zn(BH4) (+NaCl)+5Ni+1.67Ti+1.67Fe) samples were also prepared by milling in a planetary ball mill in an H2 atmosphere. The gas absorption and release properties of the Zn(BH4)2(+NaCl) and 90MgH2+1.67Zn(BH4)2(+NaCl)+5Ni+1.67Ti+1.67Fe samples were investigated. An FT-IR analysis showed that Zn(BH4)2 formed in the Zn(BH4)2(+NaCl) samples prepared by milling ZnCl2 and NaBH4. At the first cycle at 320 oC, 90MgH2+1.67Zn(BH4)2(+NaCl)+5Ni+1.67Ti+1.67Fe absorbed 2.95 wt% H for 2.5 min and 4.93 wt% H for 60 min under 12 bar H2, and released 1.46 wt% H for 10 min and 4.57 wt% H for 60 min under 1.0 bar H2.

Emission reduction of CH4 (methane gas) from rice paddy soil is a very important measure for climate change mitigation in agricultural sector. In this study, we investigated the changes in crop yield and CH4 emissions in response to application of biochar and fertilizers. The experimental site is located in Hwasung, Kyunggido and experimental design is the split-plot method with three replicates. Treatments included rice straw (RS) and biochar (BC) amendments nested with the conventional NPK fertilizer (NPK) and slow release fertilizer (SRF). Control was also prepared with the soil with the conventional NPK fertilization with no amendment. Measurement of CH4 emission was conducted during the growing season of 2014 using a dynamic chamber method. The results showed that application of rice straw increased daily CH4 emission rate by 15%, while application of biochar reduced daily CH4 emission rate by 38%. When we combined biochar application with slow release fertilizer, CH4 emission was reduced by 45%. Further, the crop yield was also increased in all treatments compared with the control except for the treatment of rice straw application with slow release fertilizer. Overall results imply that biochar amendment to agricultural soil can be an effective strategy to decrease annual CH4 emission with no reduction in crop yield.

The availability of digital distribution channels raises many new challenges for managers in the media industries. This is particularly true for movie studios where content can be stolen and released through illegitimate digital distribution channels before, or shortly after, the legitimate release date. In response to this potential threat, movie studios have spent millions of dollars attempting to protect their content from unauthorized release, to prosecute those who might distribute or consume pirated content, and to lobby governments to strengthen anti-piracy laws. However, there has been very little rigorous research to analyze whether, and how much, movie piracy cannibalizes legitimate box-office sales. In this paper, we analyze this question in the context of post-release movie piracy. We also consider whether going to the movies is substitutable by watching a pirated version at home. Even though there is a lag between the release in cinema-theaters and a DVD-release (that is when a pirated copy of a good quality is made available), we consider making decision at the certain moment, so time lag does not make any difference. Our study contributes to the growing literature on piracy and digital media consumption in the online community by presenting evidence of the impact of digital piracy, by differentiating the effect of post-release movie piracy from the other types of piracy that the extant literature has previously considered.

In this article, to predict the wear amount of nano particles in a worn nano composite, computational analysis pre/post-processor were developed using ABAQUS and visual basic programs. The abrasion, which is one of nano particles release scenarios, was applied in the computational analysis. Moreover, reciprocation, which is the abrasion type, was selected and incarnated in abrasion computational analysis. Also, to predict wear amount of nano composite in computational analysis, archard equation was applied and the predicted wear amount was evaluated compare with experimental value. The predicted wear amount of nano composite was increased in accordance with increasing force and was similar to result of experimental value.

The purpose of this study is to provide the case of influence of myofacial release(MFR) and cryotherapy in acute whiplash injury. The subjects were consisted of 3 adults(2 males, 1 female) who had been diagnosed with whiplash injury. The performance period was 1 weeks, 6 times and 1 time is 40min(MFR: 20min, cryotherapy: 20min). We measured neck pain(Visual analogue scale, VAS) and cervical alignment(cervical curvature & line of gravity). All measurements of each subject were measured at pre-treatment and post-treatment. The results are listed below. The neck pain(VAS) index decreased from 7.54cm to 4.11cm. The cervical curvature increased from 23.62°to 29.76°. The line of gravity decreased from 8.03mm to 3.66mm. Based on the results, it can be suggested that both MFR and cryotherapy can be used to neck pain and alignment in acute whiplash injury.

당해 연구의 제 1 부 논문에서 확률론적으로 접근한 데에 이어, 파이로처리 방사성 폐기물 처분장에 대하여 폐쇄 후 처분장 의 성능에 영향을 줄 수 있는 근계 영역 내 세가지 주요 설계 관련 요소에 대하여 각 핵종별로 최종 피폭 선량에 주는 민감 도를 결정론적인 방법을 통하여 조사해 보았다. 농축 피폭 집단에 방사선 피폭을 주는 주요한 핵종들이 처분장에서 유출된 후 처분 시스템 근계 영역 내 다양한 매질을 이동하는 것에 관련되어 이들 요소가 어느 정도의 영향을 주게 되는지 보기 위 하여 제 1 부에서 처분 용기의 수명, 선원항으로서의 처분 용기에서의 연간 핵종 유출률, 그리고 처분장 주요 인공 방벽으로 서의 완충재의 손실도 등의 변화를 확률론적 접근 방법으로 검토한 데 이어, 제 2 부의 이 연구를 통해서는 통계적인 확률 론적 민감도를 검토하는 대신 세가지 인자에 대하여 가장 나쁜 경우와 이상적인 조합을 구성한 후 이를 결정론적으로 평가 하여 인지된 3개의 요소들이 제 1 부에서의 결과와 동일하게 처분장 설계에 매우 중요할 수 있다는 결과를 얻을 수 있었다.

파이로처리 방사성폐기물 처분장에서 폐쇄 후 처분장의 성능에 영향을 줄 수 있는 근계 영역 내 세가지 주요 설계 관련 요 소에 대하여 주요 핵종별로 최종 피폭 선량에 주는 민감도를 확률론적인 접근을 통하여 조사하였다. 농축 피폭 집단에 방사 선 피폭을 주는 주요한 핵종들이 처분장에서 유출된 후 처분 시스템 근계 영역 내 다양한 매질을 이동하는 것에 관련되어, 이들 요소가 어느 정도의 영향을 주게 되는지 보기 위하여 처분 용기의 수명, 선원항으로서 처분 용기에서의 연간 핵종 유출 률, 그리고 처분장 주요 인공 방벽으로서 완충재의 손실도 등의 변화에 따른 결과를 검토하였다. 처분장에 대한 결정론적, 확률론적 안전성 평가를 병행 수행하여, 이 세가지 설계 요소의 물리적 변화가 통계적 분포를 가지고 일어난다고 가정하는 확률론적 접근 방법에 따른 연구 결과는 제 1 부의 이 연구에, 그리고 세가지 설계 요소가 가질 수 있는 조합을 서로 다른 시 나리오로서 비교하는 결정론적인 방법으로 접근한 결과는 별도로 제 2 부에 제시하였다. 두 가지 접근 결과와 함께 고려된 인자들에 대하여 모두 결과에 민감한 것으로 나타나 이러한 결과와 방법론은 향후 처분장 설계에 모범적인 피드백을 줄 수 있을 것으로 기대된다.

The dispersal distance and the flight behaviour of adult Platypus koryoensis were examined using mark-release-recapture experiment in central Korea in 2013. Sticky traps were attached to the trunks of oak trees toward release point and opposite direction up to 48.8m from the release point. For each direction, two traps were attached on upper (1.5m from ground) and lower (0.5m from ground) trunk. Platypus koryoensis which emerged within 24 hours were marked with fluorescent powder and released at 11:00 a.m. The number of recaptured beetles was counted after 30 and 90 minutes after release. The experiment was replicated three times on 20, 21, and 26 June. The numbers of beetles released were 299, 810, and 208, respectively. Recapture rates at 90 minutes after release on 20, 21, and 26 June were 0.09, 0.06, and 0.03, respectively. More than 85 percent of recaptured beetles were caught in 30m. The numbers of beetles caught by sticky traps in upper and lower trunk were not significantly different, indicating that P. koryoensis do not hover but just land and move to explore suitable for living site in trunk when they attack oak tree. The valley breeze which drive upward the valleys and mountain slopes in the daytime blew during experiment periods and maximum flight distance of P. koryoensis was 43m, even though the beetles flew against the wind.

We conducted a investigation for dispersal ability of Aedes albopictus, a dengue vector mosquito, using mark-release-recapture method in Korea. A certain number of fluorescence marked Ae. albopictus was released in four different habitats – urban (Cheonan), suburban (Jochiwon), port (Pyeongtaek), and airport (Cheongju), and sticky traps and BG-traps were used to recapture the mosquito in designated time period. In case of urban and suburban areas, 100 sticky traps were used in 3-week period for both regions, and 19 BG-traps and 15 BG-traps were used in 36-hour period for urban and suburban areas respectively. Using sticky trap, 21 from 1,300 released mosquitoes (1.62%) were recaptured in urban area; while in suburban area, only 2 individuals (0.1%) were recaptured. Most of them were recaptured within 100m from releasing point and about 40% were within 20m distance. When BG-traps were used, 35 from 900 released mosquitoes (3.8%) were recaptured in urban area; while 26 mosquitoes (2.8%) were recaptured in suburban area. The maximum distance of dispersal was 200m in urban and 100m in suburban area, while most of them were recaptured in 50 ~ 80m range. In case of port and airport area, 15 and 10 BG-traps were used respectively to recapture 1,000 released mosquitoes in 5-day period. In port area, 23 mosquitoes (2.3%) were recaptured; while 166 mosquitoes (16.6%) were recaptured in airport area. The maximum distance of dispersal was 130m in both areas; while most of them were recaptured in 50m range. In conclusion, Ae. albopictus has a narrow dispersal range compared to other mosquitoes, a typical characteristic of genus Aedes, and their dispersal ability is greatly affected by various environmental factors. These results can provide basic information for effective prevention of Ae. albopictus and overseas inflow of dengue fever.

Release planning in a software product line (SPL) is to select and assign the features of the multiple software products in the SPL in sequence of releases along a specified planning horizon satisfying the numerous constraints regarding technical prece- dence, conflicting priorities for features, and available resources. A greedy genetic algorithm is designed to solve the problems of release planning in SPL which is formulated as a precedence-constrained multiple 0-1 knapsack problem. To be guaranteed to obtain feasible solutions after the crossover and mutation operation, a greedy-like heuristic is developed as a repair operator and reflected into the genetic algorithm. The performance of the proposed solution methodology in this research is tested using a fractional factorial experimental design as well as compared with the performance of a genetic algorithm developed for the software release planning. The comparison shows that the solution approach proposed in this research yields better result than the genetic algorithm.

여우는 한국에서 1980년대 이후로 절멸된 것으로 취급하고 있으며, 현재는 환경부에서 멸종위기 1급 동물로 지정되어 소백산국립공원에서 복원사업이 이루어지고 있다. 본 연구에서는 여우복원사업에 필요한 적정 모델링과 방사 전략을 수립하기 위하여, VORTEX 프로그램을 이용한 개체군 생존력 분석(Population viability analysis: PVA)을 수행하였다. 초기 개체군 0에서 매년 10개체(암5, 수5)를 향후 10년간 지속적으로 방사할 경우, 개체군의 이입으로 50년간 개체군 성장률은 0.018±0.204였으며, 절멸확률은 0.354로 나타났다. 최초 방사 후 16년차에 116.34로 최대 개체군 크기를 보였으나, 17년차부터 매년 1.22의 감소율을 나타내었다. 방사된 여우의 지속적인 성장과 절멸을 방지하기 위해서는 최초 방사 17년 이후 추가적인 방사가 필요하며, 장기적인 여우 존속을 위해서는 매년 12개체 이상을 방사하는 것이 필요한 것으로 분석되었다. 반면 연간 6개체 이하일 경우 50년 후의 절멸 확률은 80% 이상으로 나타났으며, 최소한의 개체군 성장을 위해서는 8개체 이상의 추가 방사가 필요한 것으로 나타났다. 설정된 조건값에서 매년 10개체씩 암수의 성비를 변화하여 6:4 로 10년간 방사할 경우 1:1 비율보다 안정적인 개체군 성장률을 보였으나, 암컷의 비율이 7:3이상으로 높아질 경우 부정적인 결과를 보였다. 재난요인으로 설정된 road-kill과 밀렵은 여우복원사업의 성패에 중요한 요인으로 확인되었다. 초기 적용값을 기준으로 각각의 요인이 3% 감소할 경우에는 절멸 확률은 30%로 낮아졌으며, 3% 이상 증가할 경우 50년 후의 절멸 확률은 약 90%에 이르는 것으로 분석되었다.

The purpose of the present study was to investigate the effect of IFN- on prostaglandin synthesis, cyclooxygenase-2 (COX-2) gene expression in vitro and concentration of progesterone (P4) in endometrial cells. Epithelial and stromal cells cultured in vitro were isolated from bovine endometrium and stimulated with increasing doses of IFN- (0, 0.02, 0.2 and 2 ug/ml). Human chorionic gonadotropin (hCG, 1.5 IU/ml) was used as a positive control. Prostaglandin and levels in the culture media were analyzed by enzyme immunoassays and total RNA was extracted from the cells for RT-PCR. P4 concentrations of blood samples were assayed by chemiluminescent immuno assays system. In epithelial cells, COX-2 gene expression was increased in the presence of IFN- (p<0.05), but it was not significantly different in all groups of stromal cells except for 2 ug/ml IFN- group (p<0.05). Although IFN- did not affect and production in epithelial cells, it decreased and production significantly in stromal cells (p<0.05). In vivo experiment, blood concentration of P4 was significantly increased after addition of IFN- (1 ug/ml). The results indicate that PG production was mediated by COX-2 expression in stromal cells but it was not affected in epithelial cells and this suggest that treatment of IFN- could improve the implantation environment of uterine by maintenance of high P4 concentration.

Release planning for incremental software development is to select and assign features in sequence of releases along a specified planning horizon. It includes the technical precedence inherent in the features, the conflicting priorities as determined by the representative stakeholders, and the balance between required and available resources. The complexity of this consideration is getting more complicated when planning releases in software product lines. The problem is formulated as a precedence-constrained multiple 0-1 knapsack problem. In this research a genetic algorithm is developed for solving the release planning problems in software product lines as well as tests for the proposed solution methodology are conducted using data generated randomly.

본 연구는 사회복귀를 예정하고 있는 수형자들의 원예치료 및 원예활동에 대한 요구와 선호도를 조사하여 사회복귀예정 수형자를 대상으로 한 교정ㆍ교화 원예치료프로그램 개발을 위한 식물 및 원예활동에 대한 기초 자료를 마련하기 위하여 수행되었다. 설문지 분석 결과, 남성, 40대, 고졸이하가 가장 많았고 사기에 기독교가 가장 많았다. 교정·교화프로그램으로써 원예치료가 제공되는 것에 대해서 바람직하다는 의견이 약 70%, 교정·교화프로그램으로써 원예치료가 제공되었을 때 60% 이상이 참여할 의사가 있다고 밝혔다. 원예활동 경험은 없는 사람이 많았고, ‘산책, 견학, 여행 등의 식물감상활동’을 가장 선호하고 다음으로‘실내외에서 식물 가꾸기’,‘식물을 이용한 장식 및 공예활동’순이었다. 선호하는 식물은 화훼를 가장 선호했고, 화훼식물 중에서는‘난초류’를, 채소식물 중에서는‘열매채소’를, 열매채소 중에서는‘토마토’를 가장 선호하는 것으로 나타났다.

모래운반선은 호퍼도어를 갖는 경우 제한된 범위내에서 창구덮개의 설치를 면제 받을 수 있으나, 현재 국내에는 호퍼도어를 갖고 있는 선박이 단 한척도 없어 창구덮개를 면제받는 선박이 없는 실정이다. 따라서 모래운반선의 창구덮개 관련 현행 규정의 검토와 사고사례 조사 그리고 현재 운항하고 있는 모래운반선에 대한 설비현황, 복원성능 및 내항성능 평가를 통하여 모래운반선에 대한 창구덮개 면제 조건을 검토하였다. 그 결과, 모래운반선의 경우 창구덮개를 면제 받기 위해서는 화물창의 크기를 조정하여 모래를 화물창 상단부까지 가득 싣더라도 흘수가 만재흘수선을 넘지 않도록 하고, 적절한 풍우밀 조치를 취함으로써 충분한 예비 부력과 복원력 확보가 요구된다. 또한, 배수펌프의 용량은 화물창의 액상상태인 모래를 1시간 이내에 소성상태가 될 수 있도록 배수하기에 충분한 용량이어야 하며, 모든 운항상태에서 작동 가능하여야 한다. 본 연구는 모래운반선의 작업 특성상 창구덮개의 설치작업이 현실적으로 상당히 어렵고, 특히 기상악화시 인명사고로 이어질 수 있는 현실적인 문제점을 항해안전과 관련된 시설기준을 보다 강화함으로써 개선한 것이다.