Although fine-needle aspiration biopsy (FNAB) has been widely accepted as a valuable tool for differential diagnosis of head and neck tumors, the diagnostic value of FNAB in the management of salivary gland tumors has been questioned. This case report presents a patient with mucoepidermoid carcinoma of parotid gland diagnosed as pleomorphic adenoma by FNAB and discusses the pitfalls in the diagnosis of malignant salivary gland tumors.

총담관류는 담관낭종 중 가장 빈도가 낮은 질환으로 악성 종양 발생에 대한 보고가 드물어 총담관류로 인한 악성 발생 가능성에 대해서 이견이 존재한다. 저자들은 상부위장관 검진에서 우연히 발견된 십이지장 유두부 선종으로 내원한 환자에서 내시경 초음파를 이용하여 총담관류 내에서 발생한 선종으로 진단 후 올가미를 이용한 내시경 유두절제술을 통하여 완전절제에 성공한 증례를 경험하였다. 이에 총담관류 내 악성 종양 발생 가능성 및 총담관류의 진단과 내시경적 치료에 대한 문헌 고찰과 함께 보고하고자 한다.

Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Being pleomorphic, its histologic characteristics can be considerably varied, showing epithelial (ductal and non-ductal) cells and mesenchyme-like tissues (chondroid, myxoid, and osseous). Here, we present a rare case of a 76-year-old female presenting with a 2.0 cm PA with an epidermoid cyst of minor salivary glands on the soft palate.

Canalicular adenoma is an uncommon, benign salivary gland tumor. It has a significant predilection for occurrence in the minor salivary glands, with most cases occurring in the upper lip, followed by the buccal mucosa and palate. Rarely, canalicular adenoma can involve the major salivary glands, such as the parotid gland. Only a small number of cases of canalicular adenoma of the parotid gland have been reported in the literature. We report a rare case of canalicular adenoma on the left parotid gland of an 81-year-old man, and present a review of the literature.

The most common benign salivary gland tumor is pleomorphic adenoma. It affects major and minor salivary glands. Minor salivary gland tumors constitute <20% of all salivary gland neoplasms. Most minor salivary gland tumors occur on the palate. We present the case of a patient with pleomorphic adenoma that developed at a rare intraoral location. This patient presented to the Department of Oral and Maxillofacial Surgery of Seoul National University Dental Hospital.

Pleomorphic adenoma is the most common benign tumor of the salivary glands. About 80-90% of pleomorphic adenoma occurs in the parotid gland and about 5-10% of them occur in the submandibular gland and sublingual gland. The rest proportion comprises the minor salivary glands. The palate is the most common area, followed by the lips and the cheeks. Pleomorphic adenoma of the submandibular gland shows clinically a slow-growing, painless mass found on submandibular aspect. In this case report, we report a case of pleomorphic adenoma of the right submandibular gland in a 63-year old female patient who was referred from the department of neurosurgery, due to the heterogenous mass detected by computed tomography (CT) and magnetic resonance imaging (MRI)

Carcinoma ex pleomorphic adenoma (Ca ex PA) is an uncommon malignant tumor. It is an aggressive salivary carcinoma, arising from a primary or recurrent benign pleomorphic adenoma (PA). The most common clinical presentation of Ca ex PA is a firm mass in the parotid gland. Here we report a case of Ca ex PA, arising from a recurrent benign PA in the right parotid gland, in a 70-year old female patient. The lesion was first diagnosed as a PA and a superficial parotidectomy was performed. Re-operation was performed for recurrent PA. The second recurrence was diagnosed as Ca ex PA.

Pleomorphic adenoma is the most common benign tumor of the salivary glands. About 90% of these tumors occur in the parotid gland and 10% of them occur in the minor salivary glands. The most common sites for pleomorphic adenoma of the minor salivary glands are the palate, followed by the lips and the cheeks. Pleomorphic adenoma of the palate presents clinically as a painless, slow-growing mass found on posterior lateral aspect. In this case report, we report a case of pleomorphic adenoma of the palate in a 36-year old male patient whose initial diagnosis was vascular mass such as hemangioma or lymphangiohemangioma by preoperative CT and MRI.

A 10-year-old castrated male Korean shorthair cat weighing 4 kg was referred with signs of insulin-resistant diabetes mellitus based on clinical signs of polyuria, polydipsia, and polyphagia. Diagnosis of pituitary-dependent hyperadrenocorticism (PDH) was made based on results of an adrenocorticotropic hormone stimulation test and a dexamethasone screening test. In addition, plasma concentrations of insulin-like growth factor 1 (IGF-1) increased. Radiography, ultrasonography, and computed tomography (CT) revealed hepatomegaly, renomegaly, and adrenomegaly affecting both adrenal glands as well as multiple cysts in a generally enlarged pancreas. Magnetic resonance imaging (MRI) showed that the cat’s pituitary gland was enlarged. The pituitary gland had a predominantly unilateral extension to the left. The signal intensity of the pituitary gland on precontrast T1 weighted images was hypointense compared to that of soft tissue and hyperintense compared to that of cerebrospinal fluid. On T2 weighted images, the pituitary gland was predominantly hypointense with a hyperintense rim. Contrast enhancement of the pituitary gland was not evident, and a mild degree of ring-like enhancement was seen. In addition, mild peritumoral edema was present. This is the first report of a cat with suspected double adenoma of the pituitary gland on the basis of compatible clinical signs, increased serum IGF-1 concentration, PDH, CT images, and MRI findings in diabetic cats with insulin resistance.

Lysyl oxidase (LOX) family, the copper dependent amine oxidase, oxidizes lysine residues in extracellular collagen and elastin. LOX increases the strength of the extracellular matrix and plays an important role in tumor development and metastasis. It has been reported that increased LOX protein and RNA are found in head and neck squamous cell carcinoma. Moreover some studies regarded LOX as a prognostic marker of oral and oropharyngeal squamous cell carcinoma. However there has not been any report on LOX expression of salivary gland tumors. Here, we investigated LOX expression in mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) of salivary gland and compare it to those of pleomorphic adenoma (PA). We evaluated LOX expression in eighteen MEC, eighteen ACC and twenty PA cases by immunohistochemical examination. Whereas PA showed relatively low density of LOX expression, ACC revealed more cases that showing high staining intensities for LOX. Significantly increased LOX expression was found in the cases of ACC when compared to those of PA (P = 0.010).

Endoscopic snare papillectomy (ESP) for ampulla of Vater tumor (AVT) has been performed successfully instead of surgical ampullectomy (SA) because ESP is a less invasive procedure than SA. Hemorrhage, perforation and pancreatitis are relatively common complications of ESP and other rare complications such as cholangitis, liver abscess has been reported. Recently we encountered a case of acute acalculous cholecystitis after ESP for AVT, which was treated successfully with percutaneous cholecystostomy with intravenous antibiotics. We therefore report this case with a brief review of the literature.

Carcinoma ex pleomorphic adenoma is a rare malignant salivary gland tumor. The carcinomatous component of the carcinoma ex pleomorphic adenoma is mostly one type such as adenocarcinoma NOS, salivary duct carcinoma and undifferentiated carcinoma. We present a case of carcinoma ex pleomorphic adenoma including two carcinomatous components. The tumor occurred in the palate of a 70-year-old man. Histopathologically, the tumor was composed of both benign pleomorphic adenoma and the carcinoma area that showed adenocarcinoma NOS and squamous cell carcinoma. Finally this case was diagnosed as carcinoma ex pleomorphic adenoma including two carcinomatous components

Malignant mixed tumor is an aggressive malignant neoplasm composed of heterologous malignant epithelial and stromal components. It is a rare neoplasm, accounting for 0.05 % of all salivary gland tumors and 0.16 % of all malignant salivary gland tumors. The tumor may occur in the background of a preexisting pleomorphic adenoma or may arise de novo. We report on an 84-year-old female who was diagnosed with carcinosarcoma on her left parotid gland. Microscopically, the tumor consisted of two components - mainly myxoid chondrosarcoma (75%), poorly differentiated carcinoma and a few remnants of benign pleomorphic adenoma in the periphery of the tumor.