We are proud that we are launching “Have 4,000 Students sign a Jeju 4.3 Petition to the U.S. Capitol” for enactment of “the Korea Jeju 4.3 Human Rights Act 2022” in 2022, which was result of various visits to offices of U.S. Congressman Mark Takano and Congresswoman Judy Chu on May 1, 2019. It was historic sentence for Jeju 4.3 Survivors, Mr. Dong-Soo Park of Sogil Village, Mr. Wonhue Boo of Hwabuk village, Ms. Hee-Chun Oh of Harye village dismissed all charges against the accused on January 17, 2019 by Presiding Judge Jaegal, Chang, Chung, Seung-jin and Seo, Youngwoo at the Korea Jeju Distict Court. “South Korean victims who were wrongfully charged with insurrection during an anti-communist crackdown from 1948 to 1949 and thrown in jail for defying violent paramilitary and military forces, are to receive more that $4 million in compensation for wrongful imprisonment following the Jeju 4.3 massacre, “South Korea Jeju Massacre victims awarded $ 4M in damages,” by Elizabeth Shim: UPI, August 21, 2019).

Cancer is the second leading cause of death worldwide and currently there are many approaches developing towards cancer treatment. Cancer treatments like chemotherapy and radiation therapy are often painful and have adverse effects. The mechanism of apoptosis is a complex process and it involves different pathways in its mechanism of action. Apoptosis can be caused by signals within the cell such as stress, or by extrinsic signals such as ligands binding to cell surface death receptors. The programmed cell death plays a important role in the several physiological and pathological processes. It plays important role in homeostasis. Flavonoids have gained importance as anticancer agents promoting cytotoxicity and apoptosis in cancer cells. Flavonoids are present in many medicinal plants which are a kind of ubiquitous natural products and essential active ingredients. They have strong biological activities with high efficiency and low toxicity, possessing good preventive and cure effects on different tumor forms. Flavonoids such as Scutellarein, Pectolinarigenin and Naringin have reported to possess significant anti-cancer effects on different cancer cell lines till date. In this review, we provide a summary about the anti-cancer effect of the three flavonoids and its mechanisms of action that can be used in future for understanding their potent anti-tumor properties.

Lysophosphatidic acid (LPA) is a lipid messenger mediated by G protein-coupled receptors (LPAR1-6). It is involved in the pathogenesis of certain chronic inflammatory and autoimmune diseases. In addition, it controls the self-renewal and differentiation of stem cells. Recent research has demonstrated the close relationship between periodontitis and various diseases in the human body. However, the precise role of LPA in the development of periodontitis has not been studied. We identified that LPAR1 was highly expressed in human periodontal ligament stem cells (PDLSCs). In periodontitis-mimicking conditions with Porphyromonas gingivalis -derived lipopolysaccharide (Pg-LPS) treatment, PDLSCs exhibited a considerable reduction in the cellular viability and osteogenic differentiation potential, in addition to an increase in the inflammatory responses including tumor necrosis factor-α and interleukin-1β expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. Of the various LPAR antagonists, pre-treatment with AM095, an LPAR1 inhibitor, showed a positive effect on the restoration of cellular viability and osteogenic differentiation, accompanied by a decrease in NF-κB signaling, and action against Pg-LPS. These findings suggest that the modulation of LPAR1 activity will assist in checking the progression of periodontitis and in its treatment.

HPT research studies and practices have been largely conducted in the corporate setting, leaving education as a neglected context despite its strong emphasis on performance in teaching, learning, and school management. In this study, we examine the application of the HPT standards and their effects on Korean teachers’ performance goal achievement for students. With HPT standards, we also investigate the interaction effect of teacher tenure on the relationship among HPT standards and goal achievement. The Hayes Process Model is adopted to examine the second-stage moderated mediation model. The findings support that the principle standards positively mediate the effect of the process standards on the teachers’ goal achievement, and teacher tenure moderates the HPT standards’ effects on goal achievement. The practical and theoretical implications of the results are discussed, as well as limitations and future research suggestions

The method of natural spawning is very passive and inconvenient for the study of developmental engineering in marine medaka, Oryzias dancena. The optimum concentration of human chorionic gonadotropin (HCG) and carp pituitary extract (CPE) for ovulation and spawning, and the injection time for the artificial spawning of marine medaka were analyzed in this study. The success rate, survival rate, and hatching rate were highest with 100 IU HCG kg-1 BW and 5 mg CPE L-1 in both male and female marine medaka (p<0.05). After obtaining unfertilized eggs and sperm by the injection of HCG and CPE into the broodstock of marine medaka, artificial fertilization could be successfully achieved any time fertilized eggs are needed in this species. This result should be useful for developing a study program for marine medaka as an experimental animal.

본 연구의 목적은 유아교사의 인권의식, 전문성인식, 삶의 만족도가 다문화교 수효능감에 미치는 영향을 알아보는 것이다. 본 연구를 위해서 예비조사및 본조사를 구분하여 진행하였고, 본 조사는 2019년 7월 10일부터 8월 20일까지 전라남도 지역에 위치한 유아교사 141명을 대상으로 설문조사를 실시하였다. 수집 된 자료는 설문 문항에 대한 신뢰도를 검증하기 위하여 Cronbach α 계수와 유아교사의 인권의식, 전문성인식, 삶의 만족도, 다문화교수효능감 간의 관계를 살 펴보기 위하여 Pearson 적률상관분석 및 유아교사의 인권의식, 전문성인식, 삶의 만족도가 다문화교수효능감에 미치는 영향을 알아보기 위하여 중다회귀분석을 실시하였다. 연구결과로는 첫째, 다문화교수효능감과 삶의 만족도, 전문성인식 간에 유의미한 정적 상관관계가 있는 것으로 나타났다. 둘째, 다문화교수효 능감에 영향을 미치는 변수로는 교사의 전문성인식이 유의미한 정적 예측변인으로 나타났다. 이에, 본 연구결과는 다문화정책 지원을 위한 교사교육 프로그 램개발에 의미있는 기초자료를 제공해 줄 것으로 판단한다.

본 연구에서는 자연재해에 대한 집계구 단위의 인명 취약성 지수 평가 방법론을 제안하였다. 인명 취약성 지수는 자연재해에 대한 인명의 리스크 지수(Risk Index) 평가 시 필수적으로 요구되는 것으로써 인명의 노출도(Exposure)와 민감도(Sensitivity)가 고려된 취약성 대리변수의 결합으로 평가될 수 있다. 본 연구에서는 경주시를 평가 시범지역으로 선정하여 자연재해에 대한 인명 취약성 지 수 방법론을 적용하였다. 자연재해 인명 리스크와 관련된 문헌조사를 통하여 6개의 취약성 대리변수(인구밀도, 직업, 취약계층, 성별, 교육수준, 외국인)가 선정되었으며, 선정된 취약성 대리변수는 기 설정된 점수화 기준에 따라 평가치가 산정된 후 정규화 방법에 따라 무차원화 되었다. 각각의 취약성 대리변수를 결합하기 위한 가중치는 인명 취약성 지수 관련 문헌에서 적용된 가중치를 메타분석(Meta- Analysis)하여 파악되었다. 인명 취약성 지수를 평가하기 위해 필요한 인구 통계자료 데이터베이스는 통계청에서 제공하는 집계구별 인구 통계자료를 기초로 구축되었다. 경주시에 대한 인명 취약성 지수 평가의 경우, 인명에 대한 노출도 및 민감도가 높은 공동주택 단 지에서 가장 취약할 수 있음을 확인하였다. 본 연구에서 제안된 취약성 지수 평가 방법론은 집계구 단위 지역에서의 자연재해 리스크 를 신속하게 평가할 시 활용가능하다.

The US has huge interests in Hong Kong. In 1992, a few years before China resumed its sovereignty over Hong Kong in 1997, the US adopted the U.S.-Hong Kong Policy Act of 1992. The keynote of the Act is to enhance the cooperation with and maintain the treatment to Hong Kong. This tune has changed in the Hong Kong Human Rights and Democracy Act of 2019, which is obviously the response of the US to widespread protests in Hong Kong arising from the Extradition Bill proposed by the Government of Hong Kong SAR. The new law includes several negative elements. It marks a change in the US policy towards Hong Kong and furthermore represents a change in the US policy towards China. The new law should not merely be understood as the US’s support for democracy and human rights in Hong Kong. Instead, it should be considered as a major leverage which the US may maneuver to engage a rising China.

법의 역사에서 ‘법의 지배’ 즉 ‘법치주의’가 가지는 의미는 매우 크다. 1215년 왕과 귀족 사이에 합의된 마그나 카르타(Magna Carta)는 법의 힘에 대한 신뢰에 바탕을 둔 귀족들의 이익에서 시작되었지만, 절대적이고 자의적인 왕의 권력을 능가할 수 있는 보편적인 ‘법의 지배’의 힘을 보여주는 것이다. 인권의 보호를 위해서도 ‘정의의 이념’과 함께 법의 지배는 중요한 의미를 지닌다. 아리스토텔레스, 롤즈, 오킨, 그리고 코넬 역시 ‘평균적 정의’와 더불어 ‘배분적 정의’를 실현하고자 하였다. 자연법론자인 풀러와 법실증주의자인 라즈도 ‘형식적 합법성’ 내지 ‘법 준수’ 라는 점에서 ‘법의 지배’에 대하여 직간접적으로 지지하고 있다. 타마나하 역시 인권과 인간 존엄을 보장할 것을 주장하며 광범위한 영역에서 법의 지배의 힘을 주장하고 있다. 법이 인간의 자유와 평등이라는 이상을 기초로 공정한 내용으로 제정되고 집행한다면, 모든 인간에게 유익하다. 이러한 점에 법의 지배의 중요성이 있다. 그리고 모든 인간에게 유익할 뿐만 아니라, 인간의 인권을 지키는 데도 중요하다. 법의 지배가 제대로 이루어진다면 시민들의 권리도 지켜질 뿐만 아니라 소수자의 인권 역시 지켜진다. 이 연구에서는 가장 소수자 중 어쩌면 가장 많은 수를 차지하는 여성의 인권을 ‘법의 지배’와 연관하여 분석하였다. 이는 형식적 법치주의 발전 단계에서 많은 권리에 여성에서 주어졌지만, 간과되어 왔던 권리를 현대법의 이상인 실질적 법치주의와 연계하여 보장하고자 하는 세계적인 흐름과도 부합한다.

Bilobalide isolated from the leaves of Ginkgo biloba has several pharmacological activities such as neuroprotective, anti-inflammatory, and anticonvulsant. However, the effect of bilobalide on cancer has not been clearly established. The main purpose of this study was to investigate the effect of bilobalide on cell growth and apoptosis induction in FaDu human pharyngeal squamous cell carcinoma. This was examined by 3-[4,5-dimethylthiazol-2-yl]-2,5- diphenyltetrazolium bromide assay, nuclear 4′,6-diamidino-2-phenylindole dihydrochloride staining, DNA fragmentation analysis, and immunoblotting. Bilobalide inhibited the growth of FaDu cells in dose- and time-dependent manners. Treatment with bilobalide resulted in nuclear condensation and DNA fragmentation in FaDu cells. Furthermore, it promoted the proteolytic cleavage of procaspase-3/-7/-8/-9 with increase in the amount of cleaved caspase-3/-7/-8/-9. Bilobalide-induced apoptosis in FaDu cells was mediated by the expression of Fas and the activation of caspase-8, caspase-3, and poly (ADP-ribose) polymerase. Immunoblotting revealed that the antiapoptotic mitochondrial protein Bcl-2 was downregulated, but the proapoptotic protein Bax was upregulated by bilobalide in FaDu cells. Bilobalide significantly increased Bax/Bcl-2 ratio. These results suggest that bilobalide inhibits cell proliferation and induces apoptosis in FaDu human pharyngeal squamous cell carcinoma via both the death receptor-mediated extrinsic apoptotic pathway and the mitochondrial-mediated intrinsic apoptotic pathway.

There has been a significant decline in the number of rail accidents in Korea since system safety management activities were introduced. Nonetheless, analyzing and preventing human error-related accidents is still an important issue in railway industry. As a railway system is increasingly automated and intelligent, the mechanism and process of an accident occurrence are more and more complicated. It is now essential to consider a variety of factors and their intricate interactions in the analysis of rail accidents. However, it has proved that traditional accident models and methods based on a linear cause-effect relationship are inadequate to analyze and to assess accidents in complex systems such as railway systems. In order to supplement the limitations of traditional safety methods, recently some systemic safety models and methods have been developed. Of those, FRAM(Functional Resonance Analysis Method) has been recognized as one of the most useful methods for analyzing accidents in complex systems. It reflects the concepts of performance adjustment and performance variability in a system, which are fundamental to understanding the processes of an accident in complex systems. This study aims to apply FRAM to the analysis of a rail accident involving human errors, which occurred recently in South Korea. Through the application of FRAM, we found that it can be a useful alternative to traditional methods in the analysis and assessment of accidents in complex systems. In addition, it was also found that FRAM can help analysts understand the interactions between functional elements of a system in a systematic manner.

The aim of this paper to provide grounds for Jeju 4.3 Human Rights educational activities to students. We have 2015 Revised Social Studies Curriculum Basic Direction - Goals and Contents of Korean History - Goals of Korean History (Revised July 27, 2018). It helps students to grasp the process of pre-modern Korean history, and use it as the basis for understanding self-identity and tradition comprehensively and systematically. Through the in-depth understanding of modern and contemporary history in Korea, students develop the ability to gain insight into the historical problems of modern Korean society. Through the process of exploring and interpreting various historical materials, students develop their ability to think critically with a critical mind and identify the historical roots of the problems faced by modern Korean society and their relevance to the world, and jointly seek ways to solve problems that can be realized at the learner level.

As Jeju people hopes to make an effort to find its place for 4.3 Grand Tragedy in the Sun, they will contribute to world peace beyond the Jeju 4.3 Tragedy. It will be a starting point that Jeju people propose to U.S. Congress “the Korea Jeju Human Rights and Peace Island Act 2021". It was meaningful that Jeju National University students suggested their idea about enactment of Jeju 4.3 Reconciliation Act to U.S. Congress at the meeting of both office of Congressman Mark Takano and Congresswoman Judy Chu on May 1, 2019. It may be going forward for us to do Jeju Massacre Consultation based on Jeju 4.3 Reparative Justice with cooperation of both U.N. lawyer and international law professors. It would be a historic achievement in the Human Rights and Democracy in 21st century similar to the Civil Liberty Act 1988 to Japanese Internment cases and the Hong Kong Human Rights and Democracy Act 2019 to Hong Kong democratization.

Brucellosis is the most common zoonosis worldwide, which is caused by Brucella spp. In humans, it can be mainly occurred by direct contact with infected animals or consumption of contaminated dairy products. This study focused on human brucellosis caused by B. melitensis discovered from Chinese worker in Korea in 2015. We investigated molecular epidemiological evidence to find the infection source. We first performed several PCR methods including 16S rRNA PCR, multiplex PCR and real-time PCR to identify Brucella species. We also conducted MLVA typing for epidemiological trace-back analysis. The isolate from the patient was confirmed to B. melitensis through Brucella-specific PCR. In clustering analysis with B. melitensis from foreign countries, this human isolate was correlated with B. melitensis isolates from humans and sheep in China by 99.9% similarity. Thus, we assumed the brucellosis patient has been already infected in China followed by migration to Korea according to molecular epidemiological analysis with history evidence. Moreover, we suggest it needs to take measures to reduce the risk for intercountry transmission of brucellosis due to the influx of infected people from abroad.

Despite the maritime industry’s significant role in the global economy, maritime accidents are a threat to life at sea and maritime economic performance. Furthermore, the human factor still accounted for as the main factor causing maritime accidents. Every year, many maritime accidents occur in Japan and Hong Kong, with collisions being the most common. In this study, Human Error Assessment and Reduction Technique (HEART) method is applied to the collisions data to identify the common mistakes committed by seafarers by determining the generic task, error-producing conditions and the value of Human Error Probability (HEP). This study aims to find the causes of collision in Japan and Hong Kong, compare them between the two countries, and apply HEART methodology to various maritime accidents. The data was sourced from the maritime accident data report of the Japan Transportation and Safety Board and the Government of the Hong Kong Special Administrative Region of the Marine Department from 2008 to 2016. There are 27 collision cases for Japan and 21 for Hong Kong. In general, human error is the most common factor leading to collisions. In conclusion, in Japan’s collision assessment, fairly simple tasks performed rapidly or with scant attention are identified as the most common generic task. However, in Hong Kong, most of the accidents occur during complex tasks. Japan has 101 EPCs for 27 cases while there are 115 EPCs for 21 cases that occurred in Hong Kong. Both Japan and Hong Kong have the time shortage, inadequate checking of progress, and poor information exchange among seafarers on the bridge as the common error-producing conditions occurred.

At present, ECDIS has been widely used in ship positioning, collision avoidance and navigation, and has developed into an important part of integrated navigation and automation system. However, most ECDIS software focuses too much on system function and technical level when realizing powerful navigation AIDS, neglecting the problems that the crew are most concerned about, such as realizing the human-computer interface operation quickly and simply as well as obtaining the information of human-computer interaction effectively and accurately. In order to improve the design of Electronic Chart Display and Information system（ECDIS）human-computer interface and its usability effectively, a new method for evaluating ECDIS human-computer interface is proposed. Starting from the concept and connotation of usability, five-factor personality model is used to measure the users’ personality type in reference to the essence of usability (user’s emotional experience) and calculate the basic emotional variant of users. Then, according to the users’ emotional stimulation after finishing the given ECDIS task and combining with the system Usability scale (SUS), a tool dedicated to usability testing and five dimensions of usability evaluation proposed by Jakob Nielsen, father of usability, the emotion relationship model of usability and users is established by using partial least square method ( PLS ), and the validity of the model is verified with an aim to locate the key indicators that affect the usability of the ECDIS human-computer interface, It will be more helpful to improve the usability of ECDIS human-computer interface.