Purpose：Conventional pre-saturation pulse for suppressing venous signals cannot be applied to time-of-flight magnetic resonance angiography(TOF-MRA) at 7 Tesla MRI due to specific absorption rate(SAR) limitation. The SAR could be attenuated with using low saturation flip angle, but a few repetitions are needed to reach signals below the steady-state signal of the brain tissues. The purpose of this study was to suppress venous system with clinically acceptable acquisition time by using 90 degree flip angle. Methods：The standard slab-selective radio-frequency and gradient waveform were modified to new-shaped models by minimum-time variable-rate selective excitation(Min-VERSE) algorithm. Excitation slice profile was measured and evaluated by a phantom scan. In volunteer measurement, the vessel-tissue contrast ratio of the sinuses(VTCR_S) and middle cerebral artery(VTCR_MCA) were assessed in correlation to surrounding tissue and compared to the values measured by the conventional TOF(cTOF) pulse sequence. Results：The experimentally-measured profiles showed that there was good agreement between conventional and modified pulse. The total scan time was 5 min 55 sec(Min-VERSE 90 FA, TR 28 ms) and 8 min 50 sec(90 FA, TR 42 ms). The quantitative results of ROI analysis were nearly similar, except the venous signal and VTCR_S at Min-VERSE 90 FA. Conclusions：We have presented that the use of Min-VERSE with high flip angle was useful. The total acquisition time was faster about 3 minutes and the signal analysis was hardly different to the values acquired by the values of 90 FA at cTOF. Since 7T MRI has been suitable for ultra-high resolution imaging, our protocol would be used by default for diagnosing various intracranial vascular pathologies.

Milled carbon fiber (mCF) was prepared by a ball milling process, and X-ray diffraction (XRD) diffractograms were obtained by a 2θ continuous scanning analysis to study mCF crystallinity as a function of milling time. The raw material for the mCF was polyacrylonitrile- based carbon fiber (T700). As the milling time increased, the mean particle size of the mCF consistently decreased, reaching 1.826 μm at a milling time of 18 h. The XRD analysis showed that, as the milling time increased, the fraction of the crystalline carbon decreased, while the fraction of the amorphous carbon increased. The (002) peak became asymmetric before and after milling as the left side of the peak showed an increasingly gentle slope. For analysis, the asymmetric (002) peak was deconvoluted into two peaks, less-developed crystalline carbon (LDCC) and more-developed crystalline carbon. In both peaks, Lc decreased and d002 increased, but no significant change was observed after 6 h of milling time. In addition, the fraction of LDCC increased. As the milling continued, the mCF became more amorphous, possibly due to damage to the crystal lattices by the milling.

This study was performed to determine the optimal time of harvest for ramie leaves with the two varieties (Seocheon Seobang and Seoncheon Baekpi) by comparison of physiological activity and physicochemical characteristics. The crude protein, minerals, ascorbic acid, folate, chlorophyll, ACE inhibitory activity and AChE inhibitory activity were determined. The amount of crude protein in ramie leaf, which was collected in Seocheon-gun, Chungcheongnam-do, grew up steadily from early May to September. The content of calcium in was higher in Baekpi than in Seobang. Seobang displayed its highest value of 3,569.90 mg% in September, while Baekpi displayed its highest value of 3,163.84 mg% in October. Although, folate and vitamin C contents in the two varieties were slightly different, they were higher as the growth date grew in October. The highest value of chlorophyll content was observed in October, which was later in the vegetative state. ACE inhibitory activity and AChE inhibitory activity appeared to be higher in Baekpi than in Seobang. Between June and August, ACE inhibitory activity was highest in Baekpi variety.

Infrared(IR) heating has many advantages, such as energy efficiency, reduced heating time, cleanliness, equipment compactness, high drying rate and easy automation. These features of IR heating provide widely industrial applications, such as surface heat treatment in semiconductor fabrication, thermoforming of polymers, drying and disinfection of food products, heating to metal forging, and drying of wet materials. In this study, the characteristics of a protected gold mirror were examined by spectrophotometer and the lifetime of the coating layers were evaluated by a cross-cutting method and salt spray test. The effects of manufacturing conditions on the protected gold mirror were seen and remedies for these effects were noted in order to improve the properties of the protected gold mirror in the drying process. The reflectance and lifetime of the protected gold mirror was influenced by manufacturing conditions, such as surface roughness and forming conditions of the anti-oxide layer, the adhesion layer, the reflecting layer and the protection layer. The results of this study showed that the protected gold mirror manufactured using a buffing method for pre-treatment resulted in the most effective reflectance. In addition, Al2O3 coating on an Al substrate as an anti-oxide layer was more effective than the anodizing process in the test of reflectance. Furthermore, the protected gold mirror manufactured by layers forming of various materials resulted in the most effective reflectance and lifetime when coated with Al2O3 as the anti-oxide layer, coated Cr as the adhesion layer, and coated MgF2 as the protection layer.

본 연구에서는 완도 해역에서 단기적인 수온의 변화에 영향을 주는 요인을 파악하기 위하여 시계열 분석을 실시하였다. Power spectrum 결과에서 기온은 약 24 hr에서 peak를 보였으나 수온과 조위는 약 12 hr 및 24 hr에서 peak가 나타났다. 수온과 조위의 상관 성을 파악하기 위해 coherence 분석을 실시한 결과, 두 변수는 반일주기에서 0.92로 높은 상관성을 보였다. 또한 수온의 시·공간적인 분포를 파악하기 위하여 수치실험을 실시하였다. 대조기에는 최강 낙조와 최강 창조 시의 평균 수온차가 0.3 인 반면, 소조기에는 평균 수온차가 0.13 로 작았다. 대조기의 수온차가 큰 이유는 비교적 수온이 낮은 외해수가 강한 조류에 의해 창조 시 유입되고 낙조 시 빠져나가기 때문인 것으로 판단된다. 전반적으로 수온은 외해보다 연안에서 높게 나타났다. 외해보다 연안은 수심이 얕기 때문에 일사량에 의해 수온이 빠르게 증가하기 때문인 것으로 사료된다.

In the present study, we investigate the effects of milling time and the addition of a process control agent (PCA) on the austenite stability of a nanocrystalline Fe-7%Mn alloy by XRD analysis and micrograph observation. Nanocrystalline Fe-7%Mn alloys samples are successfully fabricated by spark plasma sintering. The crystallite size of ball-milled powder and the volume fraction of austenite in the sintered sample are calculated using XRD analysis. Changes in the shape and structure of alloyed powder according to milling conditions are observed through FE-SEM. It is found that the crystallite size is reduced with increasing milling time and amount of PCA addition due to the variation in the balance between the cold-welding and fracturing processes. As a result, the austenite stability increased, resulting in an exceptionally high volume fraction of austenite retained at room temperature.

A pultruded fiber reinforced polymer plastic (PFRP) structural is one of the most widely used composite member in construction. In generally, PFRP members is composed of plate elements so that it needs to evaluate stability problems when they are used by construction members. On the other hand, creep effect may be occurred in PFRP members under sustained load. Primary to experiment for PFRP creep, previous works are studied. In the previous work related to buckling of PFRP member, it can be calculated buckling strength of PFRP members when it is known that material property of longitudinal and transverse direction of PFRP members. The researches for creep behavior of PFRP has been conducted and time-dependent degradation elastic moduls can be predicted by the empirical equation. In this study, it will be conducted creep test for PFRP and time-dependent stress-strain relationship will be plotted. It is expected that long-term buckling behavior of PFRP is evaluated by theoretical and numerical method such as finite element method.

목 적：MRCP검사시 CS SPACE breath-hold기법을 사용하여 조영전과 Gd-EOB- DTPA 사용후 영상을 시 간대별로 획득하여 영상의 변화를 통해 담즙의 변화를 알아보고, 이를 바탕으로 3D T2강조 자기공명 담췌관 조영영상의 적절한 획득시기를 알아보고자 하였다. 대상 및 방법：2017년 11월부터 2018년 1월까지 본원에 내원하여 Gd-EOB-DTPA를 사용하여 MRCP검사를 시행한 42명을 대상으로 하였고 장비는 SIEMENS사의 Magnetom Skyra 3.0T를 사용하였다. Compressed Sensing SPACE breath-hold 기법으로 조영전과 Gd-EOB-DTPA를 사용한 역동적 조 영검사 후 delay 4m, 6m, 8m 때의 3D T2강조 자기공명 담췌관 조영영상을 MIP기법을 사용하여 영상 을 재구성한 뒤, RHD, LHD, CBD의 SNR과 CNR을 측정하였고, 정성적 평가는 조영전과 Gd-EOB-DTPA사용후 delay 4m, 6m, 8m때의 RHD, LHD, CBD를 복부전문 영상의학과 전문의 1명과 10년 이상 경력의 MRI전문 방사선사 1명이 5점 척도로 평가하였다. 결 과：조영전 RHD, LHD, CBD의 평균 SNR은 33.07, 32.18, 38.43 였고, Gd-EOB-DTPA사용후 delay 4m때의 평균 SNR은 38.1, 36.33, 43.16, delay 6m때는 37.79, 37.67, 44.46, delay 8m때는 30.24, 35.29, 41.45였다. CNR은 조영전이 평균 22.27, 21.36, 27.59, Gd-EOB-DTPA 사용후 delay 4m때는 27.1, 25.32, 32.12, delay 6m때는 26.81, 26.71, 33.41, delay 8m때는 19.14, 24.21, 30.28 였다. delay 8m때의 RHD의 SNR과 CNR만 조영전과 비교해서 통계적으로 유의하지 않았으며(p>0.05) 나머지는 통계적으로 유의했다(p<0.05). SNR과 CNR이 조영전부터 delay 8m때까지 순차적으로 계속 증가하는 경우는 전체의 47.6%였고, 조영전보다 delay 6m때의 SNR과 CNR이 더 높 지만 delay 8m때 감소하는경우가 전체의 40.5%, 조영전보다 delay 4m때의 SNR과 CNR이 더 높지만 delay 6m, 8m때 감소하는경우는 전체의 11.9%였다. 정성적 평가는 조영전 RHD, LHD, CBD의 평균 점수가 4.48, 4.55, 4.93였고, Gd-EOB-DTPA사용후 delay 4m때는 4.48, 4.55, 4.86, delay 6m때 는 4.12, 4.5, 4.88, delay 8m때는 3.55, 4.1, 4.64 였다. 조영전과 delay 4m은 통계적으로 유의한 차이가 없었고(p<0.05), 조영전과 delay 6m은 RHD만, 조영전과 delay 8m은 RHD, LHD가 통계적으 로 유의한 차이가 있었다(p>0.05). 결 론：조영전과 Gd-EOB-DTPA사용후 delay 4m때의 영상의 진단적 차이가 없었으며, delay 4m때가 SNR 과 CNR이 더 높았기 때문에 delay 4m때 breath-hold 3D T2강조 자기공명 담췌관 조영영상을 얻는것 이 검사시간도 단축하고 더 좋은 영상을 얻을 수 있을겄으로 생각되며, 담췌관에 질병이 의심되는 환자에 서 respiratory-triggered 3D T2강조 자기공명 담췌관 조영영상은 역동적 조영검사 후에 바로 시행하 여 delay 6m전에 검사를 획득한다면 담도배설이 시작되기 전에 영상을 획득하거나 담도배설이 어느정도 시작되었어도 높은 신호때부터 영상이 얻어졌기 때문에 조영전과 영상의 차이가 없고 시간을 많이 단축 하는 방법이 될거라 생각된다.

Honey bee has been widely used as a model insect for biological sciences because of its sociality and specialized labor division. For the investigation of the seasonal and labor-dependent expression patterns of genes putatively involved in its sociality, quantitative real-time PCR (qRT-PCR) can be applied to quantify gene expression level and selection of reliable reference gene(s) for normalization is an accurate step. In this study, using three softwares (geNorm, NormFinder and BestKeeper), we evaluated seasonal expression stabilities of four reference genes that have been widely used for qRT-PCR in forager and nurse heads. Among four candidates, two genes, rpS18 and gapdh, were suggested to be the optimal reference genes for qRT-PCR.

Machines and facilities are physically or chemically degenerated by continuous usage. One of the results of this degeneration is the process mean shift. By the result of degeneration, non-conforming products and malfunction of machine occur. Therefore a periodic preventive resetting the process is necessary. This type of preventive action is called ‘preventive maintenance policy.’ Preventive maintenance presupposes that the preventive (resetting the process) cost is smaller than the cost of failure caused by the malfunction of machine. The process mean shift problem is a field of preventive maintenance. This field deals the interrelationship between the quality cost and the process resetting cost before machine breaks down. Quality cost is the sum of the non-conforming item cost and quality loss cost. Quality loss cost is due to the deviation between the quality characteristics from the target value. Under the process mean shift, the quality cost is increasing continuously whereas the process resetting cost is constant value. The objective function is total costs per unit wear, the decision variables are the wear limit (resetting period) and the initial process mean. Comparing the previous studies, we set the process variance as an increasing concave function and set the quality loss function as Cpm+ simultaneously. In the Cpm+, loss function has different cost coefficients according to the direction of the quality characteristics from target value. A numerical example is presented.

In this paper, we propose an Elman recurrent neural network to predict and analyze a time series of power energy consumption. To this end, we consider the volatility of the time series and apply the sample variance and the detrended fluctuation analyses to the volatilities. We demonstrate that there exists a correlation in the time series of the volatilities, which suggests that the power consumption time series contain a non-negligible amount of the non-linear correlation. Based on this finding, we adopt the Elman recurrent neural network as the model for the prediction of the power consumption. As the simplest form of the recurrent network, the Elman network is designed to learn sequential or time-varying pattern and could predict learned series of values. The Elman network has a layer of “context units” in addition to a standard feedforward network. By adjusting two parameters in the model and performing the cross validation, we demonstrated that the proposed model predicts the power consumption with the relative errors and the average errors in the range of 2%~5% and 3kWh~8kWh, respectively. To further confirm the experimental results, we performed two types of the cross validations designed for the time series data. We also support the validity of the model by analyzing the multi-step forecasting. We found that the prediction errors tend to be saturated although they increase as the prediction time step increases. The results of this study can be used to the energy management system in terms of the effective control of the cross usage of the electric and the gas energies.

Salmonella는 전세계적으로 식중독을 유발하는 주요 원 인 균으로서, 식중독을 유발하는 Salmonella를 신속하게 검출하는 방법은 식품 안전을 위한 중요한 도구이다. Realtime PCR은 식중독균을 검출하기 위한 신속검사법으로 널 리 사용되어 왔다. 최근에는 NBS LabChip real-time PCR 이라는 새로운 시스템이 칩타입으로 조작이 간편하며 초 고속의 real-time PCR 시스템이라는 보고가 있었다. 본 연 구에서는 살모넬라의 신속한 검출을 위하여 NBS LabChip real-time PCR에 기반하여 real-time PCR 반응 시간이 20 분 이내인 검출법을 확인하고자 하였다. 프라이머와 프로 브 설계를 위해 두 개의 타겟 유전자(invA, stn)가 선택되 었으며, 특이도와 민감도(검출한계)를 평가함으로 개발된 검출법을 검증하고자 하였다. 본 연구에서는 특이도 검증을 위해 Salmonella 균주 42주와 Non-Salmonella 균주 21 주를 포함하였으며, 본 방법으로 Salmonella 42주에 대해 서만 정확하게 검출이 가능하였다. 검출한계는 살모넬라 genome DNA 기준으로 101 copies/μL 였으며, 소시지에서 는 4시간 증균 이후 접종균수로서 101CFU/g 에서 102 CFU/ g까지 검출이 가능하였다. 본 연구에서 개발된 검출법은 신속한 식중독 원인조사에 활용될 수 있을 것으로 기대된다.

지구온난화와 기후변화는 많은 환경문제를 야기하였고 특히 아고산식물의 생존을 위협하고 있다. 아 고산식물종의 생활사 파악과 온·습도의 자료 구축은 아고산식물종의 보전전략 수립에 매우 유용할 것 이다. 본 연구의 목적은 가야산국립공원의 아고산지대에 자생하는 솔나리, 설앵초, 기생꽃, 개회향 및 금강애기나리 등 5종을 대상으로 2012년부터 2016년까지 5년간 개화, 낙화시기 모니터링 조사와 및 온·습도변화는 개화, 낙화시작시기를 기준으로 각각 20일간 조사하여 개화와 온·습도 간 상관관계를 분석하였다. 이를 통해 아고산지역의 생물기후학적 연구를 위한 기초자료를 제공하고자 한다. 변수들에 대한 신뢰도 검정결과, Cronbach Alpha 값은 0.741로 신뢰성이 높았다. 각 식물종의 개화시기 분석결 과 솔나리 평균 7월 23일(SD=6.5), 설앵초 평균 5월 8일(SD=8.7), 기생꽃 평균 6월 1일(SD=2.8), 개 회향 평균 8월 16일(SD=4.3) 및 금강애기나리 평균 5월 22일(SD=5.1)로 나타났다. 개화기간은 기상요 소 간의 상관관계에서 모두 정(+)의 관계를 보였으며, 일최고온도와 일평균온도의 상관계수가 각각 0.711, 0.613로 상대적으로 높게 나타났다. 한편, 식물종의 생활사를 파악하기에 기상자료만으로 분석 하였으나 해발고도에 따른 상관성을 비롯하여, 사면, 향 및 미기후 등 다양한 환경요인을 종합적으로 분석하지 못한 한계점을 지니고 있어 향후 아고산지역 식물종을 모니터링 할 때 기초자료를 더욱 축적 해 나갈 필요성이 있다.

Background: The continuous co-contraction of the trunk muscles through trunk stabilization exercises is important to patients with lumbar spinal stenosis (LSS). However, intentional abdominal muscle contraction (IAMC) for trunk stabilization has been used only for specific training in the treatment room. Objects: The purpose of this study was to provide feedback to adults with LSS to enable IAMC during activities of daily living (ADLs). Methods: The participants with spinal stenosis were divided into an experimental group of 15 adults and a control group of 16 adults. Electromyographic signals were measured while the subjects kept their both hands held up at 90°. The measured muscles were the rectus abdominis (RA), external oblique (EO), internal oblique (IO), and erector spinae (ES). Pelvic tilt was measured using a digital pelvic inclinometer. The degree of pain was measured using the visual analogue scale (VAS) and functional capacity was measured using the Korean version of the Oswestry disability index (KODI). Results: While the experimental group showed statistically significantly higher activities in the RA, EO, and IO after the intervention compared with the control group. Pelvic tilt was significantly decreased only in the experimental group. Both the experimental and control groups exhibited statistically significant declines in the VAS and KODI (p<.01). In terms of the levels of changes, the experimental group exhibited a statistically significant larger decline only in the VAS and the pelvic tilt when compared with the control group (p<.05). Conclusions: The subjects could stabilize their trunks, and relieve their pain and dysfunctions and reduce pelvic tilt by learning abdominal muscle contraction during ADLs.

작물생육의 품질 및 생산량에 중요한 영향을 미치는 온실 내 환경관리에 대한 연구는 활발히 진행되고 있다. 주로 온실 내 환경분포를 측정하는 방법으로는 한 두 지점에 대해서만 측정하여 온실 전체를 관리하는 시스템 으로 이루어졌으며 기존 환경데이터 측정방식은 각각의 데이터 로거 및 센서간의 배선들로 인하여 복잡한 시스템으로 구성되었다. 본 연구에서는 온실 내 설치 된 각 환경센서들로부터 지점별 데이터를 획득하고 획득된 데이터는 모니터링 프로그 램을 통하여 공기유동흐름을 측정하는 장치를 개발하였다. CAN 네트워크 통신을 통하여 환경센서들의 배선 토폴로 지를 간소화 했으며 프로토콜의 견고함으로 온실 내 모니 터링을 안정적으로 데이터를 수집할 수 있도록 구현되었다. 온실 내 공간의 환경요인 분포(온·습도 및 풍속 등) 들을 12개 지점에 배치하고 온·습도 및 풍속의 환경 데이 터는 상세히 파악할 수 있도록 X, Y, Z 축으로 다수의 측 정점(총 36점)을 선정하였다. 데이터 손실 및 다양한 온실 조건을 고려하여 비트레이트를 저속 125kbit/s로 구현하여 온실 내 100m 구역내에서 센서를 추가적으로 연장(총 90 개)할 수 있도록 구축되었다. 온도, 습도, 일사량, 풍향, 풍 속, 대기압 및 강우량 등 측정된 데이터는 LabVIEW에 연 동되어 실시간으로 센서 정보 출력이 가능하도록 구현되었다. 온실 내 환경 분포는 사용자의 편의에 따라 환경분포를 수평(XZ), 수직(YZ)축으로 가시화 할 수 있으며, 보간의 범위를 원하는 값으로 설정하여 보간 할 수 있도록 구현되었다. 추후에 온실 내의 공간에 따라 온도, 습도, 풍속, CO2 등의 환경 측정 실험을 통하여 CFD 모델링과의 검증 및 비교에 활용할 수 있을 것으로 판단된다.

We analyze the time data recorded in Korean astronomical almanacs for the years from 1913 to 1945, which belong to the period in which Japan occupied Korea (1910--1945). These almanacs, published by Japanese scholars, differ from previous almanacs in terms of organization, content, and calendrical methods. In this study, we first extract twelve kinds of time data from the almanacs at the following times: solar terms, rising and setting of the Sun and Moon, transit of the Sun, phases of the Moon (i.e., new Moon, first quarter Moon, full Moon, and last quarter Moon), and eclipses of the Sun and Moon. Then, we compare the time data with that obtained from modern calculations. Even though all time data in the almanacs are tabulated in units of minutes, we calculate the data in units of seconds and determine the root mean square (RMS) deviation values for each kind of time data to estimate the accuracy of the data. Our findings are as follows: First, the kind and tabulation method of time data changes several times. For instance, solar transit time is listed only for six years from 1937 to 1942. Second, the times of two equinoxes and those of a new Moon are considerably close to midnight. Third, there are some typographical errors in the almanacs, particularly in the times of moonrise and moonset. Fourth, the contact times for lunar eclipses represent the times of the umbra and not of the penumbra, which is different from the times for solar eclipses. Finally, the RMS deviation values are approximately 0.5 min on average in all kinds of time data, even though they show slightly large differences in the times related to the Moon. In conclusion, we believe that this study is useful for investigating the time data in the almanacs of other East Asian countries that were published during the same period, such as China, Japan, and Manchuria.

Biological efficiency (BE), the ratio of fresh mushrooms harvested per dry substrate weight, expressed as the percentage of Lentinula edodes, also known as shiitake, was determined using the ‘Sanjo 701’ strain stored in the Department of Mushroom at the Korea National College of Agriculture and Fisheries. The mycelia were grown in glass columns with varying levels of moisture content and varying mixing periods of 0.5, 1, 2, and 3 hours. The substrate was sterilized using a steam pressure autoclave sterilizer at normal and high pressure to avoid contamination. The results showed that mycelial growth (126 mm/15 days) was optimized at 55% moisture content. The best mycelial growth of 117 mm/15 days was obtained with 2 hours of mixing time. Normal pressure sterilization yielded better results with mycelial growth of 96 mm/15 days at 100°C compared to 88 mm /15 days with sterilization at 121°C. Mycelial density was higher, i.e. 3(+++), with normal pressure sterilization compared to 2(++) with high pressure sterilization. Furthermore, sawdust mixed with 5% woodchips increased the substrate porosity and yielded higher mycelial growth. Thus, we demonstrated that the optimum harvest or potential increased yield of shiitake can be obtained by modulating moisture content, mixing time, and substrate porosity.

H2O maser emission at 22 GHz in the circumstellar envelope is one of the good tracers of detailed physics and kinematics in the mass loss process of asymptotic giant branch stars. Long-term monitoring of an H2O maser spectrum with high time resolution enables us to clarify acceleration processes of the expanding shell in the stellar atmosphere. We monitored the H2O maser emission of the semi-regular variable R Crt with the Kagoshima 6-m telescope, and obtained a large data set of over 180 maser spectra over a period of 1.3 years with an observational span of a few days. Using an automatic peak detection method based on least-squares fitting, we exhaustively detected peaks as significant velocity components with the radial velocity on a 0.1 km s−1 scale. This analysis result shows that the radial velocity of redshifted and blue-shifted components exhibits a change between acceleration and deceleration on the time scale of a few hundred days. These velocity variations are likely to correlate with intensity variations, in particular during flaring state of H2O masers. It seems reasonable to consider that the velocity variation of the maser source is caused by shock propagation in the envelope due to stellar pulsation. However, it is difficult to explain the relationship between the velocity variation and the intensity variation only from shock propagation effects. We found that a time delay of the integrated maser intensity with respect to the optical light curve is about 150 days.

In this study, we assessed antioxidant, anti-diabetic, and anti-Alzheimer activities of Opuntia ficus-indica var. saboten (OFI) at harvest time. OFIs were cultivated December 2015~November 2016 in Jeju island. The 70% ethanol extracts of OFI were used to investigate total polyphenol and flavonoid contents, antioxidant(DPPH and ABTS radical scavenging assay), anti-diabetic(yeast α-glucosidase and rat α-glucosidase inhibition assay), and anti-Alzheimer(Acetylcholinesterase and butyrylcholinesterase inhibition assay) activities. Total polyphenol and flavonoid contents of OFIs were 17.40~23.11 μg garlic acid/mg Ex and 2.17~6.22 ug (+)-catechine/mg Ex, respectively. DPPH and ABTS radical scavenging activity of OFIs were 131.98~184.90 mg ascorbic acid(AA) eq/100 g and 63.60~101.83 mg AA eq/100 g, respectively. In the anti-diabetic and anti-Alzheimer activities, 70% ethanol extracts of OFI exhibited moderate inhibition activity, compared to control (acarbose and beberine). Total polyphenol and flavonoid contents, antioxidant, anti-diabetic, and anti-Alzheimer activities were no significant differences by season, respectively. Therefore, information on comparative biological evaluations of OFI may be a beneficial in exploring functional food and drug development.