In this study, UiO-66-NH2 was synthesized and incorporated with graphene aerosol (UiO-66-NH2/GA) and ethylenediamine functionalized graphene oxide (UiO-66-NH2/GO-NH2). These composites were characterized using infrared spectroscopy, powder X-ray diffraction, ultraviolet–visible light spectroscopy, scanning electron microscope, and energy-dispersive X-ray spectroscopy. UiO-66-NH2/GO-NH2 exhibited 93% adsorption of quinoline in 5 h, UiO-66-NH2 and UiO-66-NH2/GA presented 80.4% and 86.5%, respectively. The high adsorption observed on UiO-66-NH2/GO-NH2 was attributed to the unique electronic properties, and hydrogen bonding between the nitrogen atom of quinoline and NH2- phenyl fragment of UiO-66-NH2, and N–H of ethylenediamine. GO also offered combined strong π–π interactions on its surface, and the oxygen coverage (~ 50%) on GO within the structure is responsible for the formation of strong hydrogen bonds with quinoline. Theoretical calculation suggested that UiO-66-NH2/GO-NH2 presented a more favourable adsorption energy (− 18.584 kcal/ mol) compared to UiO-66-NH2 (− 16.549 kcal/mol) and UiO-66-NH2/GA (− 13.991 kcal/mol). These results indicate that nanocomposites have a potential application in quinoline capture technologies in the process of adsorptive denitrogenation.

The International Atomic Energy Agency (IAEA) entails independent decision-making for the safety supervision of civil nuclear facilities. To evaluate and review the safety of nuclear facilities, the national regulatory body usually consults independent institutions or external committees. Technical Support Organizations (TSOs) include national laboratories, research institutions, and consulting organizations. Support from professional organizations in other countries may also be required occasionally. Most of the world’s major nuclear power countries adopt an independent nuclear safety supervision model. Accordingly, China has continuously improved upon the construction of such a system by establishing the National Nuclear Safety Administration (NNSA) as the decision-making department for nuclear and radiation safety supervision, six regional safety supervision stations, the Nuclear and Radiation Safety Center (NSC), a nuclear safety expert committee, and the National Nuclear and Radiation Safety Supervision Technology R&D Base, which serves as the test, verification, and R&D platform for providing consultation and technical support. An R&D system, however, remains to be formed. Future endeavors must focus on improving the technical support capacity of these systems. As an enhancement from institutional independence to capability independence is necessary for ensuring the independence of China’s nuclear safety regulatory institution, its regulatory capacity must be improved in the future.

The present study was designed to investigate the antiproliferative activity and molecular mechanisms of Bibimbap in HT-29 human colorectal adenocarcinoma cells. Bibimbap extract inhibited the proliferation of HT-29 cells by 50% at a concentration of 10.1±0.17 mg/mL for 48 h. The population of live cells decreased slightly, and the morphology changed with a reduction in cell volume (pyknosis) with Bibimbap. Treatment with 5 mg/mL of Bibimbap resulted in slight cell shrinkage. Furthermore, as the Bibimbap dose increased to 10 mg/mL, these characteristics were more evident, and HT-29 cells exhibited partial detachment by staining with the DNA-binding dye Hoechst 33342. Flow cytometric analysis by Annexin V and PI double staining showed that Bibimbap increased the levels of apoptosis. Analysis of the mechanism of these events showed that Bibimbap-treated cells exhibited a mitochondria-dependent apoptotic pathway through the modulation of caspase-3, caspase-8, caspase-9, and poly-ADP ribose polymerase, as well as Bax and Bcl-2 expression in dose- and time-dependent manners. Consequently, Bibimbap exerts a significant antiproliferative effect on HT-29 human colorectal adenocarcinoma cells.

Given the domestic situation, all nuclear power plants are located at the seaside, where interim storage sites are also likely to be located and maritime transportation is considered inevitable. Currently, Korea does not have an independently developed maritime transportation risk assessment code, and no research has been conducted to evaluate the release rate of radioactive waste from a submerged transportation cask in the sea. Therefore, secure technology is necessary to assess the impact of immersion accidents and establish a regulatory framework to assess, mitigate, and prevent maritime transportation accidents causing serious radiological consequences. The flow rate through a gap in a containment boundary should be calculated to determine the accurate release rate of radionuclides. The fluid flow through the micro-scale gap can be evaluated by combining the flow inside and outside the transportation cask. In this study, detailed computational fluid dynamic and simplified models are constructed to evaluate the internal flow in a transportation cask and to capture the flow and heat transfer around the transportation cask in the sea, respectively. In the future, fluid flow through the gap will be evaluated by coupling the models developed in this study.

Pseudo-pheochromocytoma is defined as an adrenal tumor that has the typical characteristics of pheochromocytoma likely hypertension but is histopathologically diagnosed to other types of adrenal tumors. 11-year-old, castrated male Maltese presented for a left adrenal mass with hypertension. According to clinical signs and radiological features, a temporary diagnosis was made of pheochromocytoma. The adrenalectomy was performed and the histopathological examination of the resected adrenal gland was diagnosed as cortical adenocarcinoma. This report describes the case of pseudo-pheochromocytoma in a dog and implies the salience that even if pheochromocytoma is diagnosed based on all test results, pseudo-pheochromocytoma should not be excluded.

Subunit vaccines are being developed as a potential therapy for preventing microbial pathogen infection. In this study, the immunogenicity of recombinant Brucella (B.) abortus Fe/Mn superoxide dismutase (rFe/Mn SOD) protein as a subunit vaccine against B. abortus was investigated in BALB/c mice model. Brucella Fe/Mn SOD gene was cloned into a pcold-TF DNA vector. The bacterial recombinant protein was expressed using the Escherichia coli DH5α strain with a size of 82.50 kDa. The western blotting assay showed that rFe/Mn SOD reacted with Brucella-positive serum, indicating the potential immunoreactivity of this recombinant protein. After the second and third vaccinations, the peripheral CD4+ T cell population was increased significantly in the rFe/Mn SOD-immunized mice group compared to the PBS control group. Moreover, immunization of this recombinant protein increased the CD4+ T cell population from the first vaccination to the third vaccination. Meanwhile, the CD8+ T cells were slightly enhanced after the second vaccination compared to the first vaccination and compared to control groups. Fourteen days after the bacterial infection, the splenomegaly and the number of bacteria in the spleen were evaluated. The result showed that both rFe/Mn SOD and positive control RB51 decreased the bacterial replication in the spleen and the splenomegaly compared to control groups. Altogether, these results suggested that rFe/Mn SOD could induce host immunity against B. abortus infection.

The Seoul Radio Astronomy Observatory (SRAO) operates a 6.1-meter radio telescope on the Gwanak campus of Seoul National University. We present the efforts to reform SRAO to a Very Long Baseline Interferometry (VLBI) station, motivated by recent achievements by millimeter interferometer networks such as Event Horizon Telescope, East Asia VLBI Network, and Korean VLBI Network (KVN). For this goal, we installed a receiver that had been used in the Combined Array for Research in Millimeterwave Astronomy and a digital backend, including an H-maser clock. The existing hardware and software were also revised, which had been dedicated only to single-dish operations. After several years of preparations and test observations in 1 and 3-millimeter bands, a fringe was successfully detected toward 3C 84 in 86 GHz in June 2022 for a baseline between SRAO and KVN Ulsan station separated by 300 km. Thanks to the dual frequency operation of the receiver, the VLBI observations will soon be extended to the 1 mm band and verify the frequency phase referencing technique between 1 and 3-millimeter bands.

Organisms constituting a large proportion of marine ecosystems, ranging from bacteria to fish, exhibit fluorescence and bioluminescence. A variety of marine organisms utilize these biochemically generated light sources for feeding, reproduction, communication, and defense. Since the discovery of green fluorescent protein and the luciferin-luciferase system more than a century ago, numerous studies have been conducted to characterize their function and regulatory mechanism. The unique properties of fluorescent and bioluminescent proteins offer great potential for their use in a broad range of applications. This short review briefly describes the functions and characteristics of fluorescent and bioluminescent proteins, in addition to summarizing the recent status of their applications.

존재의 정체성은 지속적으로 성장하여 지고의 의식을 분출하고 감싸고 그것의 일부가 된다. 그럼에도 불구하고 그러한 노력은 현상 세계의 실증된 경험이 초래하는 모순과 분열을 정복하고 극복할 수 있는 강하고 단호한 의지를 예상하고 전제한다. 우파니샤드는 비이원성과 이원성을 번성하는 절대자의 형태로 이 문제에 대한 견해를 제시한다. 우리가 살고 있는 세상은 동일한 절대자의 창조적 본능과 창조적 의지의 결과이다. 따라서 정확히 세계 그 자체인 시초가 있지만 지고의 종말이 있으며, 시초부터 종말까지의 움직임이나 진행은 때때로 현전의 방식에서 그러하듯이 명백히 어려움을 겪으며, 다른 경우에는 확인된 부재로 성취된다. 그 정도에 이르기까지 끈기, 인내, 추측, 명상 등의 상태가 존재한다. 사무엘 베켓의 예술적 기교에서 그러한 상황을 다루는 방식은 그의 소설과 드라마에서 등장인물, 상황, 행동, 사건 및 관계가 이 세상의 모순과 다양성을 표현하는 것에서 잘 드러난다. 한편 등장인물들은 압도되는 모습을 보이며, 부재하는 초월적인 것에서 안도감을 찾는다. 실제와 외견은 모순되고 실제는 이해의 필요성에 따라 확장된다. 우파니샤드는 그러한 상황을 이해하는 하나의 틀이 될 수 있는데, 베켓은 그러한 신념체계를 지속적으로 드러낸다.

The progress of science and technology has driven the development of the society, and the application of threedimensional simulation technology in all walks of life has greatly improved people's life. Maritime affairs is an important part of comprehensive transportation. The improvement of maritime supervision and service level is conducive to the construction of domestic first-class economic law enforcement system and international leading maritime management institutions. Now the application of 3D simulation technology to maritime supervision is studied, aiming to improve the quality and efficiency of supervision, make maritime supervision more convenient and have further guarantee. Maritime supervision of ship environment is often more troublesome than personnel management. In the process of monitoring and control, many uncontrollable environmental factors greatly increase the difficulty of supervision, among which the port environment is more complex, which is a difficulty of monitoring and control in maritime supervision. This paper uses MapInfo Professional, Win Topo, Multigen Creator and other operating software to construct the Qingdao port visual simulation environment. The port topographic cloud map of Qingdao Port was captured, and the collected image information was converted into data through MapInfo Professional and Win Topo software, and then modeled by Multigen Creator software. After completing the general terrain outline, the established simulation scene was made more realistic and realistic through some detail processing and optimization means. By describing the establishment of 3D simulation terrain in Qingdao Port, the application status of the simulation technology in ship environment and port management is reflected, which provides a reference for the deeper application of 3D simulation technology in maritime supervision.

Image recognition is not very effective in the water environment due to multiple factors, such as high scattering and high scattering in the water column. This is why the relevant parameters in the Faster R-CNN network model need to adjust continuously to improve the effectiveness of water detection. The control variable method adjusts the program's learning rate by tuning the network model's parameters. Then, the number of training rounds is adjusted according to the loss function of each round, and finally, we can get the number of matches with the minimum loss function. Based on the experimental results on the dataset, it is shown that the proposed method not only selects the learning rate with the best detection results but also has the strongest robustness and achieves a 96%-99% recognition rate for passenger ships, cargo ships, warships, and bridges compared with other learning rates. Experiments show that the Faster R-CNN network model detects water targets with significant results, and the best network model learning rate parameter is 6×10-3.

This study investigated changes in psychological stress levels of 60 firefighters after participation in an eight-week Equine-Assisted Learning (EAL) program consisting of 16 sessions. The Korean versions of the Posttraumatic Diagnosis Scale (PDS-K), the Center for Epidemiological Studies Depression Scale (K-CESD), and the Difficulties in Emotional Regulation Scale (K-DERS) were used for measurements. Participants were divided into two groups according to level of posttraumatic stress symptoms (PTSS): the PTSS risk group and the PTSS non-risk group. Results showed that PDS-K, K-CESD, and K-DERS scores were significantly reduced after the program in the PTSS risk group. Significant reduction was also found in all sub-scales of PDS-K: re-experiencing, avoidance/emotional numbing, and hyperarousal. Moreover, in the PTSS risk group, there were greater improvements with significant group x time interactions. These findings suggest that EAL is effective in relieving PTSD and PTSD-related symptoms of firefighters with subsyndromal or more severe levels of PTSD.

A field experiment was conducted at Chishaka, Wedza district in the province of Mashonaland East, Zimbabwe during the 2020/2021 cropping season to determine effect of integrated nutrient management (INM) on cabbage (Brassica oleracea var. capitata) yields, net returns, and residual soil fertility. A total of six treatments were evaluated in a randomised complete block design (RCBD) with five replications. Treatments comprised T1 (control, 100% recommended chemical fertilizer), T2 (25% Cattle manure + 25% Chicken manure + 50% Ammonium nitrate), T3 (50% Compound S + 50% Chicken manure), T4 (50% Compound S + 25% Goat manure + 25% Chicken manure), T5 (farmer practice, 75% Compost + 25% Chicken manure), and T6 (50% Compost + 50% Chicken manure). All rates of organic manures were applied based on N equivalence. The soil was sandy loam with low soil organic carbon (1.28%), nitrogen (0.175%), and phosphorus (6.59 mg/kg) for all experimental plots. Results indicated that INM significantly improved soil and crop productivity. INM treatments T4, T3, and T2 recorded significantly maximum yield and yield components which were statistically at par. These treatments also gave the best strategy to improve major soil nutrients and maintain soil fertility. Similarly, the maximum net profit was obtained from combined application of treatments T4, T3, and T2. Treatment with 100% chemical fertiliser gave relatively lower yields and net benefit value than T4, T3, and T2. These results indicate that INM has the great potential to reduce the use of chemical fertilisers without decreasing soil fertility or crop yields. Therefore smallholder resource constrained farmers can adopt INM as a strategy, to enhance resource use efficiency and sustain soil health and crop productivity for improved livelihoods.

Wolfiporia cocos is an edible fungus commercially cultivated in Asia. To investigate metabolic changes of W. cocos mycelia under both light and dark culture conditions, gas chromatography mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) analyses were performed. In terms of the total amount of sugars, alcohols, amino acids, organic acids, fatty acids, and purines, there no significant differences between the W. cocos mycelia cultivated under light (L) or dark (D) conditions (p < 0.05). However, there were some differences with respect to the production of particular sugars and proteins. The levels of trehalose (L: 17.2 ± 0.3% vs. D: 13.9 ± 1.6%), maltose (L: 0.9 ± 0.1% vs. D: 0.3 ± 0.1%), turanose (L: 0.7 ± 0.2% vs. D: 0.1 ± 0.1%), glutamine (L: 1.6 ± 0.3% vs. D: 0.7 ± 0.2%), and proline (L: 0.3 ± 0% vs. D: 0.1 ± 0%) were all significantly higher under light condition (p < 0.05). In contrast, the levels of galactose (L: 13.7 ± 1.2% vs. D: 17.6 ± 2.0%), aspartic acid (L: 0.6 ± 0.1 % vs. D: 0.9 ± 0.1%), cystathionine (L: 0.6 ± 0.1% vs. D: 0.8 ± 0 %), and malic acid (L: 0.7 ± 0.1% vs. D: 1.2 ± 0.1%) were higher under the dark condition. It is worth noting that the amount of pachymic acid, a pharmaceutically active compound of W. cocos, was 1.68 times greater under the light condition (p < 0.05).

Over the past decade, platelet-rich plasma (PRP) and platelet derivatives have been widely investigated in the field of regenerative medicine due to their high concentrations of platelet- related growth factors, cytokines, and other proteins. Recently, many clinical studies have suggested their regenerative therapeutic efficacy in treating several disorders in medical field. However, their therapeutic applications are not well characterized in veterinary medicine as in human and experimental animals. This article reviews functional roles of platelets, scientific concepts, and clinical use of PRP and platelet derivatives in veterinary medicine. It also presents guidelines for veterinary applications of PRP in the future.

PURPOSES : The aim of this study is to evaluate the stripping resistance of a bead coating via the Hamburg wheel tracking test and image analysis. METHODS : First, the stripping resistance of the bead coating was evaluated via the Hamburg wheel tracking test. A pneumatic wheel with a load of 175±2 N was used to simulate repeated skid cycles. Several bead coating mixtures with different numbers of coating layers, i.e., zero, one, two, three, and four layers, i.e., zero, one, two, three, and four layers,were conducted. Finally, an image analysis program was developed to analyze surface images captured from the Hamburg wheel tracking test. RESULTS : The results show that the samples with more coating layers exhibit higher stripping resistance. After 500 stripping cycles, the percentage of bead loss is 4% to 28%. At 80% bead loss, the mixture with one coating layer presents more skid cycles than the control sample without a coating layer. CONCLUSIONS : Incorporating a coating layer can improve the stripping resistance of glass beads under repeated skid cycles. Additionally, an image analysis program is established in this study to determine the percentage of bead loss caused by the stripping test.

This research will examine how the Indonesian constitution can effectively protect the indigenous people’s rights to customary land when the land is under construction for infrastructure building. The authors will mainly discuss the relevance of justice for ensuring the rights to live and property of indigenous people under the Indonesian constitution. In this essay, the authors examine how constitutional and human rights protections interact with one another to ensure the security of customary land in Indonesia. The analysis will be carried out by two methodological approaches. One is the statute approach which is based on laws and regulations being specifically targeted. To implement the statutory approach, all Indonesian laws and regulations concerning the constitutional relationship and human rights to protect customary land will be reviewed. The other is the conceptual approach to identify the ideas that give rise to legal notions, the legal principles or legal arguments for solving the problem.

This paper summarizes and assesses the international trend, both in doctrine and in legal provisions dealing with conflict of laws in intellectual property field and reviews the relevant provisions in the Part 5th on applicable law to civil relations evolving foreign elements of the Vietnam’s 2015 Civil Code. The author shows that the two new provisions of the Vietnam’s 2015 Civil Code, namely Article 679 and Article 683, has partly caught up with the international trend in recognizing conflicts of laws and providing choice-of-law rules for resolving these conflicts in the intellectual property relations. The shortcoming of the Vietnam’s 2015 Civil Code is the absence of a particular provision dealing with the conflict of laws in case of infringement of intellectual property rights. On that basis, the paper offers comments and suggestions on the need to make the provisions of the Vietnam’s Civil Code more specific in the future.