HAE-06 extract is a mixture of four medicinal plants, namely Lonicerae Folium et Caulis (Lonicera japonica), Scutellariae Radix (Scutellaria baicalensis), Adenophorae Radix (Adenophora triphylla var. japonica), and Polygonati Oddorati Rhizoma (Polygonatum odoratum var. pluriflorum). The HAE-06 extract demonstrated a concentration-dependent relaxing effect and enhanced cAMP production in bronchial smooth muscle that had been stimulated to contract with acetylcholine. Using a blocker, it was confirmed that the effect was through the β2-adrenergic receptor/cAMP/PKA pathway. In addition, it is thought that the HAE-06 extract has a bronchial smooth muscle relaxation effect by reducing the inflow of Ca2+ through the K+ and Ca2+ channels present in the sarcoplasmic membrane. If research continues in the future, it is believed that it will be possible to use it as a material for pharmaceuticals and functional foods.

Nanosized and aggregated Y2O3:Eu Red phosphors were prepared by template method from metal salt impregnated into crystalline cellulose. The particle size and photoluminescent property of Y2O3:Eu red phosphors were controlled by variation of the calcination temperature and time. Dispersed nanosol was also obtained from the aggregated Y2O3:Eu Red phosphor under bead mill wet process. The dispersion property of the Y2O3:Eu nanosol was optimized by controlling the bead size, bead content ratio and milling time. The median particle size (D50) of Y2O3:Eu nanosol was found to be around 100 nm, and to be below 90 nm after centrifuging. In spite of the low photoluminescent properties of Y2O3:Eu nanosol, it was observed that the photoluminescent property recovered after re-calcination. The dispersion and photoluminescent properties of Y2O3:Eu nanosol were investigated using a particle size analyzer, FE-SEM, and a fluorescence spectrometer.

Transparent organic-inorganic hybrid hard coating films were prepared by the addition of SiO2 or ZrO2, as an inorganic filler to improve the hardness property, filler was highly dispersed in the acrylic resin. To improve the compatibility in the acrylic resin, SiO2 or ZrO2 is surface-modified using various silanes with variation of the modification time and silane content. Depending on the content and kind of the modified inorganic oxide, transparent modified inorganic sols were formulated in acryl resin. Then, the sols were bar coated and cured on PET films to investigate the optical and mechanical properties. The optimized film, which has a modified ZrO2 content of 4 wt% markedly improved in terms of the hardness, haze, and transparency as compared to neat acrylate resin and acrylate resin containing modified SiO2 content of 8 wt%. Meanwhile, the low transparency and high haze of these films slowly appeared at SiO2 content above 10 wt% and ZrO2 content of 5 wt%, but the hardness values were maintained at 2H and 3H, respectively, in comparison with the HB of neat acrylate resin.

Al2O3 nanosol dispersed under ethanol or N-Methyl-2-pyrrolidone(NMP) was studied and optimized with various dispersion factors and by utilizing the silane modification method. The two kinds of Al2O3 powders used were prepared by thermal decomposition method from aluminum ammonium sulfate(AlNH4(SO4)2) while controlling the calcination temperature. Al2O3 sol was prepared under ethanol solvent by using a batch-type bead mill. The dispersion properties of the Al2O3 sol have a close relationship to the dispersion factors such as the pH, the amount of acid additive(nitric acid, acetic acid), the milling time, and the size and combination of zirconia beads. Especially, Al2O3 sol added 4 wt% acetic acid was found to maintain the dispersion stability while its solid concentration increased to 15 wt%, this stability maintenance was the result of the electrostatic and steric repulsion of acetic acid molecules adsorbed on the surface of the Al2O3 particles. In order to observe the dispersion property of Al2O3 sol under NMP solvent, Al2O3 sol dispersed under ethanol solvent was modified and solventexchanged with N-Phenyl-(3-aminopropyl)trimethoxy silane(APTMS) through a binary solvent system. Characterization of the Al2O3 powder and the nanosol was observed by XRD, SEM, ICP, FT-IR, TGA, Particles size analysis, etc.

To study the dispersion factors of silica sol prepared from fumed silica powder, we prepared silica sol under an aqueous system using a batch type bead mill. The dispersion properties of silica sol have a close relationship to dispersion factors such as pH, milling time and speed, the size and amount of zirconia beads, the solid content of fumed silica, and the shape and diameter of the milling impellers. Especially, the silica particles in silica sol were found to show dispersion stability on a pH value above 7, due to the electrostatic repulsion between the particles having a high zeta potential value. The shape and diameter of the impellers installed in the bead mill for the dispersion of fumed silica was very important in reducing the particle size of the aggregated silica. The median particle size (D50) of silica sol obtained after milling was also optimized according to the variation of the size and amount of the zirconia beads that were used as the grinding medium, and according to the solid content of fumed silica. The dispersion properties of silica sol were investigated using zeta potential, turbiscan, particle size analyzer, and transmission electron microscopy.

CMP(Chemical Mechanical Polishing) Processes have been used to improve the planarization of the wafers in the semiconductor manufacturing industry. Polishing performance of CMP Process is determined by the chemical reaction of the liquid sol containing abrasive, pressure of the head portion and rotational speed of the polishing pad. However, frictional heat generated during the CMP process causes agglomeration of the particles and the liquidity degradation, resulting in a non-uniform of surface roughness and surface scratch. To overcome this chronic problem, herein, we introduced NaCl salt as an additive into silica sol for elimination the generation of frictional heat. The added NaCl reduced the zata potential of silica sol and increased the contact surface of silica particles onto the sapphire wafer, resulting in increase of the removal rate up to 17 %. Additionally, it seems that the silica particles adsorbed on the polishing pad decreased the contact area between the sapphire water and polishing pad, which suppressed the generation of frictional heat.

This study aims to address the effect of interferential current therapy and thereby to provide basic resources to physical therapies for internal medicine by identifying symptoms for functional dyspepsia and serum gastrin level that shows gastric motility. Following results were obtained by performing interferential current therapy to 16 subjects composed of 8 for functional dyspepsia group and 8 for control group for 20 minutes a day, 3 days a week, for 6 weeks. In control group, serum gastrin level was significantly( p<.01), lowered after the therapy whereas there was no significant difference observed in all questions from questionnaire for symptoms of functional dyspepsia between before and after the therapy. In functional dyspepsia group, serum gastrin level was significantly(p<.01), lowered after the therapy and there was also significant(p<.01) reduction in every question from questionnaire for symptoms of functional dyspepsia between before and after the therapy. There was more significant decrease in serum gastrin level and reduction in questionnaire for symptoms of functional dyspepsia in the functional dyspepsia group compared to the control group(p<.01). This study confirms the interferential current therapy as an effective therapeutic method for internal diseases including functional dyspepsia since it not only improves the symptoms of functional dyspepsia but also allows the gastric motility close to normal.

본 연구는 BSC의 성공적 구축과 활용에 있어 최근 변화하는 경영환경에 적절하게 대응하고, 기업의 경영활동에서 비재무적 요소가 차지하는 중요성을 감안하여 무형적자원의 대표적 요소인 R&D 지출과 관련하여 BSC의 KPI를 개발하고, 개발된 지표의 효용성을 실증분석을 통해 검정하고자 하였다. 본 연구를 통해 BSC의 KPI로써 개발된 PEI(Patent Efficiency Index)는 R&D 지출과 R&D의 output 개념인 특허와의 상관성을 고려하여 특허의 효율성 측면에서 만들어 졌으며, 기존의 R&D관련 KPI가 가진 문제점을 해결하고, R&D 성과측정에 관한 새로운 KPI개발을 시도 하였다는 점에서 연구적 의의가 있다고 하겠다. 또한 지표의 효용성에 대한 실증분석 결과, 논문의 관심변수인 PEI는 종속변수인 기업경영성과의 대용치로 나타내어진 ROA(총자산이 익률)과 토빈Q에 각각 유의한 양의 영향을 미치는 것으로 나타났으며 그동안 기존 연구들에서 많은 관심을 가져왔던 R&D 지출보다 R&D의 성과측정지표로서의 설명력이 더 높은 것으로 나타났다. 이상 결과를 통해 개발된 PEI는 기존의 R&D 지출이 기업성과에 미치는 영향을 설명하는데 있어 설명하지 못하는 추가적인 설명력을 가진다고 할 수 있다. 나아가 이 지표를 통해 기업이 얼마나 효율적인 R&D 활동을 하고 있는지 알 수 있으며, 이는 기업의 R&D 활동의 효율성이 높을 때 기업의 가치나 성과가 높아진다는 것을 시사한다. 본 연구는 기업의 R&D 지출과 기업경영성과 간의 관련성을 특허와 R&D 지출의 효율적인 측면을 측정한 PEI를 통하여 직접적으로 입증함으로써 기존의 R&D 비용 외에 기업의 기업경영성과를 가늠하고 판단할 수 있는 중요한 지표로 쓰일 수 있다는 것을 규명할 수 있을것으로 기대된다.

The aim of this is to examine the effects of SSP therapy on the internal carotid arteries blood flow of 24 tension type headache patients(study group) and non tension type headache patients(control group), and on the reduction of their headaches, when applied to the acupuncture points. It stimulated the acupuncture point of headache 6 place with the SSP. It measured VAS and the blood flow of the internal carotid arteries with TCD. When the internal carotid arteries blood flow of study group and control group were compared by period, a significant difference was found in the 4th period(p<.05). When the Visual Analog Scale of study group and control group were compared by period, a significant difference was found in the 4th period(p<.05). The comparison of each measurement result of the internal carotid arteries blood flow of the study group found significantly increased. The comparison of each measurement result of the VAS of study group found significantly decreased. With regard to the control group, the VAS significantly decreased. The silver spike point low frequency electrical stimulation treatment, when applied to the acupuncture point, can significantly influence the internal carotid arteries blood flow of headache patients and can significantly reduce their headaches.

This study was performed to investigate the effects of Needle Electrode Electrical Stimulation(NEES) on ischemia-induced cere˗ brovascular accidents. After obstruction and reperfusion of arteries in white mice, the amounts of necrosis and inflammation related sub˗ stances Bax, IL-6, Caspase-3, and COX-2 were measured in neurons of the fore-brain. The following results were obtained. This study used 21 male specific pathogen free(SPF) SD rats, 8 weeks of age and approximately 300g in weight. Each exposed artery was completely occluded with non-absorbent suture thread and kept in that state for 5 minutes. The sutures were then removed to allow reperfusion of blood. Test group is control group(common carotid artery occlusion models), a GI(underwent common carotid artery occlusion), and NEES(underwent NEES after artery occlusion). The GI and NEES groups were given 12, 24, or 48 hours of reperfusion before NEES. NEES device(PG6, ITO, Japan, 9V, current, 2Hz) was used to stimulate the bilateral acupoint ST36 of the SD rats for 30 minutes while they were sedated with 3% isoflurane. An immuno-his˗ tochemistry test was done on the forebrains of the GI induced rats. Both Bax and Caspase-3 immuno-reactive cells, related to apoptosis, were greater in the GI than the NEES group. Cox-2 and IL-6 immuno-reactive cells, related to inflammation, were greater in the GI and NEES groups than the control group. We can expect that applying NEES after ischemic CVA is effective for preventing brain cells from being destroyed. And we can conclude NEES should be applyed on early stage of ischemic CVA.

In higher plants, formate dehydrogenase (FDH; EC 1.2.1.2) is a NAD-dependent enzyme that catalyzes the oxidation of formate into carbon dioxide. Although FDHs have been reported to be induced by various abiotic stresses, the function of FDHs in biotic stress is rarely known. In this work, we describe the identification of pepper mitochondrial FORMATE DEHYDROGENASE1 (CaFDH1) as a positive regulator of cell death and disease resistance. Transient expression of CaFDH1 in Nicotiana benthamiana leaves caused hypersensitive response (HR)-like cell death, where D-isomer specific 2-hydroxyacid dehydrogenase signature was crucial for the induction of the cell death. Localization analysis using green fluorescence protein showed that CaFDH1 targeted to the mitochondria with the mitochondria targeting sequence at N-terminal region. However, the mitochondrial localization of CaFDH1 is not essential for the induction of HR-like cell death, because the cytosolic CaFDH1 could elicit cell death response. Silencing of CaFDH1 in pepper significantly compromised the cell death response and salicylic acid (SA) levels, but enhanced growth of Xanthomonas campestris pv. vesicatoria. In contrast, transgenic Arabidopsis overexpressing FDH1 exhibited enhanced resistance to Pseudomonas syringae pv. tomato. Taken together, these data suggest that CaFDH1 has a role in HR cell death and defense response to microbial pathogens.