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        검색결과 201

        2.
        2024.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Thyroid scanning using technetium-99m (99mTc) is the gold standard for diagnosing feline hyperthyroidism. In cats with an overactive thyroid, a thyroid scan is the most appropriate imaging technique to detect and localize any hyperfunctional adenomatous thyroid tissue. In this study, the pharmacological properties of the Technekitty injection (Tc-99m), developed as a diagnostic agent for feline hyperthyroidism using 99mTc as an active ingredient, were tested in FRTL-5 thyroid follicular cell line and ICR mice. The percentage of cell uptake of the Tc-99m in FRTL-5 thyroid cells was 0.182 ± 0.018%, which was about 6 times higher compared to Clone 9 hepatocytes. This uptake decreased by 38.2% due to competitive inhibition by iodine (sodium iodide). In tissue distribution tests by using ICR mice, the highest distribution was observed in the liver, kidneys, spleen, lungs, and femur at 0.083 hours after administration, and this distribution decreased as the compound was excreted through the kidneys, the primary excretory organ. Maximum distribution was confirmed at 1 hour in the small intestine, 6 hours in the large intestine, and 2 hours in the thyroid gland. Additionally, the total amount excreted through urine and feces over 48 hours (2 days) was 78.80% of the injected dose, with 37.70% (47.84% of the total excretion) excreted through urine and 41.10% (52.16% of the total excretion) through feces. In conclusion, the Tc-99m has the same mechanism of action, potency, absorption, distribution, metabolism, and excretion characteristics as 99mTc used for feline hyperthyroidism in the United States, Europe, and other countries, because the Technekitty injection (Tc-99m) contains 99mTc as its sole active ingredient. Based on these results, the Technekitty injection (Tc-99m) is expected to be safely used in the clinical diagnosis of feline hyperthyroidism.
        4,800원
        3.
        2024.09 KCI 등재 구독 인증기관 무료, 개인회원 유료
        This study develops a model to determine the input rate of the chemical for coagulation and flocculation process (i.e. coagulant) at industrial water treatment plant, based on real-world data. To detect outliers among the collected data, a two-phase algorithm with standardization transformation and Density-Based Spatial Clustering of Applications with Noise (DBSCAN) is applied. In addition, both of the missing data and outliers are revised with linear interpolation. To determine the coagulant rate, various kinds of machine learning models are tested as well as linear regression. Among them, the random forest model with min-max scaled data provides the best performance, whose MSE, MAPE, R2 and CVRMSE are 1.136, 0.111, 0.912, and 18.704, respectively. This study demonstrates the practical applicability of machine learning based chemical input decision model, which can lead to a smart management and response systems for clean and safe water treatment plant.
        4,000원
        6.
        2024.01 KCI 등재 SCOPUS 구독 인증기관 무료, 개인회원 유료
        The Spectro-Photometer for the History of the Universe, Epoch of Reionization and Ices Explorer (SPHEREx) will provide all-sky spectral survey data covering optical to mid-infrared wavelengths with a spatial resolution of 6.′′2, which can be widely used to study galaxy formation and evolution. We investigate the galaxy-galaxy blending in SPHEREx datasets using the mock galaxy catalogs generated from cosmological simulations and observational data. Only ∼0.7% of the galaxies will be blended with other galaxies in all-sky survey data with a limiting magnitude of 19 AB mag. However, the fraction of blended galaxies dramatically increases to ∼7–9% in the deep survey area around the ecliptic poles, where the depth reaches ∼22 AB mag. We examine the impact of the blending in the number count and luminosity function analyses using the SPHEREx data. We find that the number count can be overestimated by up to 10–20% in the deep regions due to the flux boosting, suggesting that the impact of galaxy-galaxy blending on the number count is moderate. However, galaxy-galaxy blending can marginally change the luminosity function by up to 50% over a wide range of redshifts. As we only employ the magnitude limit at Ks-band for the source detection, the blending fractions determined in this study should be regarded as lower limits.
        4,000원
        7.
        2023.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Roridin E, a constituent of Podostroma cornu-damae, has excellent medicinal properties and exhibits powerful anticancer effects. However, being a poisonous mushroom, P. cornu-damae is difficult to find in its natural environment. Therefore, only a limited amount of roridin E is isolated from P. cornu-damae. We isolated roridin E from mycelial culture medium of P. cornu-damae and examined its effects on five breast cancer cell lines. The purity of the isolated roridin E was 96%. It exhibited anticancer effects on all five breast cancer cell lines, with an IC50 of at least 0.0006 mg/L. To the best of our knowledge, this is the first report on the investigation of effects of roridin E isolated from the mycelium of P. cornu-damae mushrooms on five breast cancer cell lines. However, safety issues should be investigated and addressed in future studies before roridin E is used in clinical settings.
        4,000원
        10.
        2022.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Many manufacturers applying third party logistics (3PLs) have some challenges to increase their logistics efficiency. This study introduces an effort to estimate the weight of the delivery trucks provided by 3PL providers, which allows the manufacturer to package and load products in trailers in advance to reduce delivery time. The accuracy of the weigh estimation is more important due to the total weight regulation. This study uses not only the data from the company but also many general prediction variables such as weather, oil prices and population of destinations. In addition, operational statistics variables are developed to indicate the availabilities of the trucks in a specific weight category for each 3PL provider. The prediction model using XGBoost regressor and permutation feature importance method provides highly acceptable performance with MAPE of 2.785% and shows the effectiveness of the developed operational statistics variables.
        4,000원
        12.
        2022.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Veronica L., the largest genus in the family Plantaginaceae, is widespread in various habitats. Due to their long-blooming flowers, Veronica species have high horticultural value as indoor potted, garden, and landscape plants. Furthermore, Veronica plants are extremely important owing to their notable diversity in habitat usage, ploidy level, and evolution. Several native taxa, which are of key interest in breeding programs and phylogenetic studies, have been identified in Korea. The genome sizes and chromosomal characteristics are basic cytogenetic features of all taxa, and their knowledge is a prerequisite when commencing genome sequencing projects. It can provide essential information for cytogenetic, taxonomic, phylogenetic, and evolutionary studies. Thus, cytogenetic analysis and genome size estimation of seven Veronica taxa native to Korea were conducted in this study. Fluorescence in situ hybridization (FISH) karyotype analysis and chromosome counting was conducted using metaphase chromosomes probed with 5S and 45S rDNA. Nuclear DNA content and genome size were determined using flow cytometry. FISH karyotype analysis revealed a common number of 5S loci and varying 45S signals that create distinctive rDNA distribution patterns in each taxon. The results indicated that the seven investigated Veronica taxa have calculated genome sizes (1C values) ranging from 517.1 to 862.0 Mbp. This study is the first to report the chromosome number and karyomorphology of seven Veronica taxa native to Korea, as well as the use of rDNA markers for identifying individual chromosomes. These findings contribute to the crucial understanding the genomic characteristics of species within the genus Veronica, serve as a basis for studying Veronica phylogeny and evolution, and provide valuable information for future breeding programs.
        4,300원
        13.
        2021.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        포인세티아(Euphorbia pulcherrima. Willd. Ex Klotzch) ‘Red Ball’은 국립원예특작과학원에서 2019년에 육성한 품종이다. ‘Red Ball’은 긴 관상 기간을 가지는 ‘Christmas Eve’를 모본으로 빨간색 주름진 덮개잎이 볼 타입 꽃을 만드는 ‘Winter Rose Early Red’를 부본으로 교배하여 획득한 실생 계통을 선발하여 육성하였다. 2016년부터 2018년 생육, 개화, 균일성 등에 대하여 1,2차 특성 검정을 실시하였다. 이후 2019년 3차 특성검정을 실시하여 최종선발한 후 직무육성품종심의회에 상정하여 ‘Red Ball’로 명명하였다. ‘Red Ball’품종은 전체적으로 짧은 적색 덮개잎을 가지며 꽃 모양이 납작하지 않아 입체감이 높다. 또한 단일 처리후 약 5.5~6주가 경과하면 완전히 착색되어 출하가 가능할 만큼 착색소요기간이 짧다. ‘Red Ball’은 2021년 4월 12일에 국립종자원에 품종등록(제8497호) 되었다.
        4,000원
        14.
        2021.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Roridin E, produced by Podostroma cornu-damae, is a mycotoxin with anticancer activity. To increase the content of roridin E, submerged culture conditions were optimized using response surface methodology. Three factors, namely, medium initial pH, incubation time and agitation speed were optimized using a Box–Behnken design. The optimum submerged culture conditions to increase the content of roridin E included a medium with an initial pH of 4.0, an incubation time of 12.90 days, and an agitation speed of 63.03 rpm. The roridin E content in the submerged culture, under the aforementioned conditions, was 40.26 mg/L. The findings of this study can help lower the current price of roridin E and promote its related research.
        4,000원
        17.
        2021.03 KCI 등재 구독 인증기관 무료, 개인회원 유료
        A pregnancy diagnosis is an important standard for control of livestock’s reproduction in paricular dairy cattle. High reproductive performance in dairy animals is a essential condition to realize of high life-time production. Pregnancy diagnosis is crucial to shortening the calving interval by enabling the farmer to identify open animals so as to treat or re-breed them at the earliest opportunity. MicroRNAs are short RNA molecules which are critically involved in regulating gene expression during both health and disease. This study is sought to establish the feasible of circulating miRNAs as biomarkers of early pregnancy in cattle. We applied Illumina small-RNA sequencing to profile miRNAs in plasma samples collected from 12 non-pregnant cows (“open” cows: samples were collected before insemination (non-pregnant state) and after pregnancy check at the indicated time points) on weeks 0, 4, 8, 12 and 16. Using small RNA sequencing we identified a total of 115 miRNAs that were differentially expressed weeks 16 relative to non-pregnancy (“open” cows). Weeks 8, 12 and 16 of pregnancy commonly showed a distinct increase in circulating levels of miR-221 and miR-320a. Through genome-wide analyses we have successfully profiled plasma miRNA populations associated with pregnancy in cattle. Their application in the field of reproductive biology has opened up opportunities for research communities to look for pregnancy biomarker molecules in dairy cattle.
        4,000원
        18.
        2021.03 KCI 등재 구독 인증기관 무료, 개인회원 유료
        The choice of the culture medium is an important factor for the mass production of mycelia in submerged cultures. The influence of liquid medium on the mycelial dry weight of Paecilomyces tenuipes was investigated in this study. The regression equation is expressed as Y=-1292.94187+17.78612X1+18.92425X2+2.11464X3-0.019375X1X2-0.006276X1X3+0.008177X2X3- 0.070169X1 2-0.292175X2 2-0.008818X3 2, where Y represents the value of the mycelial dry weight (g/L), X1 is the particle size of wood sawdust in liquid medium (mesh), X2 is the concentration of the wood sawdust in liquid medium, and X3 is incubation time (h). The medium was optimized using a response surface methodology, and the optimal medium contained 30 g of wood sawdust (140 mesh), 20 g of glucose, and 10 g/L of peptone. Under these conditions, the mycelial dry weight reached 38.1 g/L (actual value). The culture medium containing wood sawdust is simple and easy to use, highly efficient, and eco-friendly, and its effectiveness in large preparations of P. tenuipes mycelia with low material costs has been demonstrated.
        4,000원
        19.
        2020.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        본 연구는 2006년부터 2019년까지 개최된 경관 조성용 화 훼를 주제로 하는 지역축제의 시기 및 지역에 따른 변화와 화 훼류의 이용 및 생산현황 분석을 통해 향후 경관화훼 연구에 대한 기초자료를 제공하고자 수행하였다. 2006년부터 2019년 까지 개최된 지역축제 10,800건 중 경관화훼 관련 축제를 시 기별 및 지역별 개최수와 활용된 식물의 종류와 생산현황을 분석하였다. 지역축제 10,800건 중 꽃축제는 1,312건으로 연 평균 94건이 개최되었으며 지역축제의 12.1%를 차지하였다. 지역축제는 2008년 최고점에서 감소하다 2014년 이후 지속적 으로 상승하고 있는 반면 꽃 축제의 비율은 2008년에서 2010 년까지 소폭 감소하였다가 지속적으로 높아져 2019년에는 15.5%를 차지하였다. 계절별 평균적인 개최비율은 봄 66.7%, 가을 25.7%, 여름 6.8%, 겨울 0.8%로 봄에 가장 많이 집중되 었으며, 여름과 겨울에는 매우 적게 나타났다. 지역별로 살펴 봤을 때 전남은 매년 평균 18건으로 개최수가 많을 뿐만 아니 라 2010년 이후 지속적으로 늘어나는 경향을 보인 반면 경남 의 경우는 매년 평균 10건으로 2010년 이후 지속적으로 감소 하다 2016년부터 증가하였다. 이외에 강원도, 경기도, 서울, 전북, 충남 등에서 매년 평균 9건 정도가 개최되었으며 그 다 음으로 충북, 경북, 제주도, 대구 등에서 3~4건이 개최되었고, 인천, 울산, 부산, 광주, 대전 등은 2건 이하로 전반적으로 대구를 제외한 광역시에서 꽃 관련 축제가 적은 것으로 나타났 다. 인터넷으로 검색된 소규모 축제를 포함하였을 때 2019년 개최건수는 경기도(49건), 전남(40건), 서울(28건), 제주도(25 건), 충남(25건), 경남(24건), 강원도(17건), 경북(12건) 등으로 나타났다. 경관용 화훼류는 목본류가 연평균 51건의 꽃축제에 서 주제식물로 활용되었으며, 일년초(11건), 그래스(9건), 숙 근초(8건), 수생식물(3건), 구근류(3건) 순으로 나타났다. 주제 식물은 목본류(12종), 일년초(4종), 관상용 그래스(4종), 다년 초(3종), 구근류(3종)으로 26종이 사용되었으며, 구근류를 제 외한 대부분의 식물이 2~4개의 축제에서 중복으로 활용되었 다. 경관조성용 화훼생산량은 경남, 전남, 울산, 경북, 전북, 강원도, 경기도, 충북, 충남 순으로 나타났다. 품목별로는 국 화와 메리골드가 100만분 이상, 팬지류와 페튜니아는 50만분 이상, 색양배추, 베고니아, 백일홍, 패랭이류, 샐비아, 맨드라 미 등이 10만분 이상 생산되었다.
        4,000원
        20.
        2020.09 KCI 등재 구독 인증기관 무료, 개인회원 유료
        포인세티아(Euphorbia pulcherrima Willd. Ex Klotzch) ‘Flame’ 은 국립원예특작과학원에서 2015년에 육성한 품종이다. ‘Flame’ 은 단일감응기간이 짧은 적색 포엽의 깊은 열편을 가진 ‘Eckalba’ 와 밝은 적색의 포엽을 가진 국내 육성 품종 ‘Candle Light’를 2013년에 교배하여 획득한 실생 계통을 선발 육성하였다. 2014 년부터 2015년까지 생육 및 개화 특성, 균일성에 대하여 1, 2차 특성검정을 실시하였으며, 2015년에 3차 특성검정을 실시하여 최종선발한 후 직무육성품종심의회에 상정하여 ‘Flame’으로 명명하였다. ‘Flame’ 품종의 포엽은 밝은 적색을 띠며 열편이 깊다. 초장과 초폭은 중간이나 적심하지 않아도 많은 분지가 발생하여 풍성한 수형을 이룬다. 단일처리후 약 7.5주가 경과하면 완전히 착색되어 출하가 가능하다. 이 품종은 2018년 1월 24일에 국립 종자원에 품종등록(등록번호 6921호)되었다.
        3,000원
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