Collagen peptides have garnered significant attention as functional foods across multiple fields due to their capacity to regulate physiological and hormonal processes, offering numerous advantages. However, despite their broad range of applications, comprehensive research on the potential toxicity of these substances remains lacking. Therefore, this study sought to assess the acute oral toxicity of a collagen peptide derived from skate (Raja kenojei) skin (CPSS) in both rats and dogs. In the rat model, CPSS was orally administered at doses of 300 and 2,000 mg/kg to Sprague-Dawley rats. An escalating single-dose oral toxicity assessment at doses of 500, 1,000, and 2,000 mg/kg was carried out in beagle dogs with 3-day intervals between doses. Throughout the 14-day post-administration assessment period, clinical signs, mortality rates, changes in body weight, and necropsy observations were closely monitored. After oral administration, no signs of toxicity associated with CPSS were observed in either rats or dogs. Therefore, the oral LD50 (approximate lethal dose for 50% mortality) for CPSS in rats was determined to exceed 5,000 mg/kg, and the maximum tolerated dose for dogs was estimated to be above 2,000 mg/kg. Consequently, this study offers safety data on the use of CPSS in functional foods and medicinal applications.

Iron deficiency is known to be a common nutritional disorder in many countries, especially among children, women of childbearing age and pregnant women. SUNACTIVE Fe-P80 is a new type of iron supplement that applies nanotechnlateology for the purpose of overcoming the disadvantages of food supplements. This study was conducted to investigate the potential adverse effects of a 28-day repeated oral dose of SUNACTIVE Fe-P80 in rats. SUNACTIVE Fe-P80 was administered once daily by gavage to Sprague-Dawley rats for 28 days at doses of 0, 500, 1,000, and 2,000 mg/kg/day. Additional recovery groups from the control and highdose groups were observed for a 14-day recovery period. At the scheduled termination, the animals were sacrificed, their organs weighed, and blood samples collected. There were no treatment-related effects in the context of clinical signs, body weight, food intake, ophthalmoscopy, urinalysis, necropsy findings, organ weights, and hematologic, serum biochemical and histopathological parameters at any dose tested. Under the present experimental conditions, the no-observed-adverse-effect level of SUNACTIVE Fe-P80 was ≥ 2,000 mg/kg/day in both the sexes, and no target organs were identified. Thus, the results suggest that SUNACTIVE Fe-P80 is relatively safe, as no treatment-related adverse effects were observed following a 28-day repeated oral dose experiment.

본 연구의 목적은 음성 인터페이스(Voice User Interface, VUI)를 이루는 설계변수 중 사용자에게 긍정적인 감성을 유발하는 설계변수를 확인하는 것이다. 특히, 사용자의 성별과 설계변수의 조절 효과를 분석하여 VUI와 상호작용하는 동안 사용자가 만족할 수 있는 적절한 설계변수 수준을 찾아보고자 하였다. 선행연구를 통해 VUI에 사용되는 음성 설계변수 중에서 사용자의 감성 만족도에 영향을 미칠 수 있는 설계변수 6가지를 도출하였다. 설계변수는 수준을 조절할 수 있도록 Wizard of OZ를 활용하여 VUI 시스템을 구현하였고, 6가지 설계변수의 수준을 조합하여 사용자와 음성으로 대화를 할 수 있도록 구성하였다. 실험에 참여한 사용자는 총 80명으로, 남/여 성비를 고려하여 각 40명씩 모집하였다. 사용자는 VUI와 주어진 임무에 대한 정답을 알아내기 위해 자연스러운 대화를 진행하며, 그동안의 얼굴 표정 변화에 대한 이미지 데이터를 수집 및 표정 분석 소프트웨어를 통해 Valence 점수로 변환하였다. Valence 데이터 를 기반으로 빈도 및 카이제곱 분석을 통해 확인한 결과, 사용자의 성별과 AI gender간의 조절효과가 유의한 것으로 나타났다. 이 결과는 VUI를 설계할 때 사용자의 성별 차이를 고려하는 것이 좋다는 것을 의미한다. 결론적으로, 남성사용자의 경우 성인/남성/높은 톤의 음성, 여성 사용자의 경우 성인/여성/중간톤의 음성이 향후 만족스러운 인터랙션 구현을 위한 VUI 설계에 주요한 가이드라인인 것을 확인하였다. 본 연구의 결과를 통해 향후 다양한 인적 요소를 고려하여 UX 관점에서 인간-AI 상호작용을 보다 섬세하게 분석할 수 있을 것이며, 표정을 통한 실시간 감성 측정을 위한 기초연구로 활용될 수 있을 것이다.

The rate of industrial accident reduction is slowing down as the attention of the Ministry of Employment and Labor and related agencies on risk assessment systems decreased. this paper focuses on weakness of legal system for the risk assessment in recent years. A survey was conducted to identify the status and condition of the risk assessment system applying on small and medium-sized manufacturing companies. A set of questionnaires is designed to reflect various perspectives of the companies regarding the problems and solutions of the system. The results refer that differentiated instructions and support systems in response to the actual conditions of the companies are mandatory to reinforce the efficiency of risk assessment system.

It was legislated in Korea that the small-sized enterprise with fewer than 50 employees should appoint at least one managing officer in order to improve safety and health of the employees since 2016. Study on the effectiveness of this legislation is hardly found, however. This study tried to evaluate effectiveness of the regulations for appointing the safety and health management officer in small-sized manufacturing companies and make suggestions to improve it. It was done by pairwise comparison between the level of safety and health achievement of 52 companies before and after the legislation. A scorecard system and questionnaires were devised for assessing the level of safety and health achievement and surveying awareness and practice of the regulation in the field. Results from quantitative and qualitative analyses performed in the study confirm that the safety and health achievement score has increased significantly after appointing the managing officer. It is also revealed that the lack of expertise and motivation of the appointed officer would yield pointless outcomes. Recommendations to make it better the effectiveness of the regulation are: to administrate requirements more strictly to be appointed as a safety and health management officer, to revise the curriculum to train the expertise of the appointed officers, and to expand financial support of the government to settle the safety and health management system.

Recently, in Seoul, Korea, GPR (Ground Penetration Rader)-based road cavities exploration technology was introduced for the exact cause analysis of road subsidence. The city of Seoul has identified a total of 2504 cavity in 2017 by using the introduced road cavities exploration technology, which shows that the incidence rate of road subsidence is reduced by 67%. However, GPR-based exploration technology is mainly concerned with cavities in the underground of the road pavement, and there is no effective method for areas with a danger zone depth of 1.5m or more and special areas such as narrow sidewalk. The EM (Electro Magnetic) method can be used to check the existence of cavities and poor ground in the underground using information on the location, shape, and electrical conductivity of the anomaly zone in the underground by measuring the electromagnetic field. Therefore, in this study, want to predict with a danger zone area by exploring the underground in the narrow sidewalk or park road by using the EM equipment which is capable of deep geological exploration, non - contact and equipment size change. In the previous research, the underground exploration was performed by simulating the ground and the cavities and the cavities including the metal. As a result, it was confirmed that an electrical resistivity anomaly zone occurred in the cavity regardless of the existence of the metal. Therefore, in order to analysis the applicability of the EM method in the underground cavities area according to the field simulation, this study will conduct the outside experiment by simulating actual sidewalk or asphalt pavement. In the future, the researchers will plan to examine the applicability of various factors such as type, condition and depth of road pavement.

국내 최초의 상업원전인 고리1호기가 2017년 6월에 영구 정지되었다. 고리1호기 해체를 시작으로 한국은 원전 해체시장에 본격적으로 발을 내딛는다. 원자력발전소 해체를 위해서는 고려해야 할 사항들이 많으며, 방사선환경영향평가 또한 그 중 하나이다. 방사선환경영향평가의 목적은 주변주민의 건강과 안전을 도모하기 위해, 해체 전 및 해체 중에 해당 시설에서 방 출되는 방사성물질로부터 주변주민이 받는 피폭방사선량이 규제 제한치를 초과하지 않음을 확인하는 것이다. 현재 국내에는 해체시 방사선환경영향평가서를 작성하는데 필요한 세부지침이 미비한 상황으로, 다수의 원전 해체 경험을 보유한 미국의 해체시 방사선환경영향평가서를 비교·분석하여 국내 상황에 맞는 해체시 방사선환경영향평가 방안을 개발하였다.

The objective€of this study is to analyze the needs and€determine the requirements of€elder drivers for effectively€using In-vehicle Information Systems (IVIS), by reducing cognitive and physical impact on this vulnerable group. The persona method was used to determine the relevant characteristics of older drivers. Task analysis was performed in order to obtain general interaction problems of the personas when using a common function of recent days IVIS. The results were classified in the different usability goals as general requirements, specific needs. This study suggest improvement directions in order to develop an elderly friendly IVIS; in addition, different usability metrics were suggested. In this way, elder drivers would easily interact with new powerful functions supplied by IVIS of modern cars; while improving safety and comfort of an rapidly aging society.

우리나라 서남해역에서 추진될 해상풍력 발전 단지에서 생산된 전기와 기존의 전력망과의 계통연계를 위해서는 해저케이블 설치가 필수적인 요소이다. 특히 해저케이블 설치에 대한 경제성, 시공성 및 안정성 확보를 위해서는 해저케이블 경과지와 해저케이블 보호공법 설계가 이루어져야한다. 본 논문에서는 1979년부터 2002년까지 한국해양과학기술원에서 구축한 장기 파랑산출자료와 제3세대 파랑모델인 SWAN(Simulating WAves Nearshore)을 이용하여 해상풍력단지가 조성될 해역에 대해 만조와 간조시 파랑시뮬레이션을 수행하여 해저케이블 경과지와 보호공법 설계를 위한 기초자료를 제공하고자 하였다. 연구결과, 서남해 해상풍력단지가 조성될 해역의 연평균 Hs는 1.03 m, Tz는 4.47s이고, 주파향은 북서(NW)와 남남서(SSW) 방향이다. NW에서 입사되는 조건(Hs: 7.0 m, Tp: 11.76s)에서 만조시 천해설계파랑 Hs의 분포는 약 4.0~5.0 m, 간조시에 약 2.0~3.0 m로 계산되었다. SSW에서 입사되는 조건(Hs: 5.84 m, Tp: 11.15s)에서 만조시 천해설계파랑 Hs의 분포는 약 3.5~4.5 m이고, 간조시에는 약 1.5~2.5 m로 계산되었다. 해저케이블 경과지 중 경도 UTM 249749~251349 구간 약 1.6 km에서는 NW로 입사되는 파랑의 영향이 크며, UTM 251549~267749 구간 약 16.2 km에서는 SSW로 입사되는 파랑의 영향이 지배적이다. 파랑집중 현상이 두드러지게 나타나는 해역은 위도와 하왕등도 사이 해역으로, 이 해역에서는 주변해역 보다 상대적으로 높은 파고를 나타내고 있다.

As S. Korea is becoming an “aged society”, workers in the country would be exposed to higher risk of workplace injuries due to their reducing work abilities as they are getting old. To identify the relationship between the work ability and the incident rate of workplace injuries, the work ability index (WAI) scores were surveyed from 409 workers occupied in different manufacturing industries reside on north GyoengBuk area. The workplace injury statistics in the year of 2010 for the corresponding industries were analyzed and summarized with the WAI scores by age groups, years of service, and sizes of business. The results showed the WAI scores of the workers occupied in the higher risk of workplace injury was lower than that of the workers of the lower risk. It means the lower the WAI score, the higher the chance of being injured during the task. It is concluded that appropriate correlation exists between the WAI scores of workers and the incident rate of workplace injury. It is recommended to administrate individual work abilities of aged workers in order to keep low rate of workplace injuries in upcoming aged and highly aged society.

본 연구의 목적은 경상남도 하동에서 생산된 녹차의 사료적인 가치를 평가하는 것이다. 먼저, 하동에서 생산되는 녹차의 특성을 이해하기 위하여 일반성분, 항산화 활성 및 항균성활성 분석을 행하였으며, 녹차는 조단백질을 20%이상, 조섬유를 약 19% 함유하고 있으며, 높은 항산화 및 항균활성을 보였다. 68주령 하이라인브라운 레그혼 96수를 개체별 케이지에 수용하여 8주간의 사양실험을 수행하였을 때, 사료에 첨가된 녹차(1% 까지)는 산란계의 사료섭취량, 사료요구율 및 헨데이 난생산성(%)에 대한 영향이 없었다. 녹차는 급여 3-4주에 일시적으로 정상란의 산란율을 감소시켰고, 5-6주에 난중을 증가시켰다. 급여후기에 계란의 신선도(Haugh unit)의 감소를 지연시켰다(P<0.05). 녹차 급여는 난각강도와 무게에 영향을 미치지 않았다. 사료 중 녹차의 함량이 증가함에 따라 혈중 creatinine 과 amylase의 농도와 칼슘의 함량이 유의적으로 감소하였다(P<0.05). 따라서 이상의 결과는 하동녹차는 산란계의 사료에 충분히 이용 가능한 것으로 사료된다.

For the purpose of reuse the wasted by-products from the skate process to the health functional food or medicinal material, chondroitin sulfate was extracted from the skate cartilage with the method of hydrolysis with protease enzyme, and the contents of chondroitin sulfate and hydrolyzed protein were measured qualitatively and quantitatively. The effects of chondroitin sulfate on body weight or liver weight changes, hepatotoxicity elimination and anti-inflammatory actions were measured from in vivo test with feed-treated mice. From the hydrolytic extraction of skate cartilage with the mixture of 1% alcalase and 1% protease for 4 hours, the extraction yield of chondroitin sulfate was about 32.55%. The content and molecular weight of chondroitin sulfate was 26.63% and 2.85×105 Da., respectively and the content ratio of chondroitin sulfate to protein was measured to 1 to 2.76 with gel permeation chromatography. For the odor component, trimethylamine decreased about 30% but almost not ammonia from chondroitin sulfate with the treatment of activated carbon. From the feeding chondroitin sulfate to mice, the control effect of body and liver weights decrease was measured, anti-inflammatory action and hepatotoxicity elimination action were also measured. From these results, process operation conditions for manufacturing of chondroitin sulfate were suggested.

The aim of this study was to investigate and development collagen peptide materials from skate skin. Protein and fat content of collagen peptide showed about 95% and 0.1%, respectively. Average molecular weight of collagen peptide was measured as 1,015. In the analysis of amino acid, glycine and hydroxy proline content in collagen peptide was 19.32% and 16.25%, respectively, showing a typical characteristics of the collagen peptide. In obese db/db mice ingested 500 mg/day of collagen peptide for 18 days, the amounts of food and water intake were decreased considerably, contents of triglyceride, total cholesterol were decreased significantly in white adipose tissue of db/db mice. The final yield of collagen peptide was 17.23% in the optimized process for mass production. These results indicate that collagen peptide from skate skin may serve as candidates of fat reduction in adipose tissue and could be used as functional food and cosmetic ingredients.

The purposes of this study were to investigate ecotourism goals of conservation and increasing residents' benefits based on perceptions from the stakeholders of the Upo wetland. The stakeholders are residents, five villages' reprensentatives, people who were residents but now live out of the area, civil officals, and environmental NGO staffs of he Upo wetland. The results of this study were as follows: While the perceptions of environmental conservation among interviewees were positive, the residents' perceptions about residents' benefits were very negative in the Upo wetland. People who used to reside and then moves out had pride about the Upo and they wanted to return to live in the Upo wetland area. Even though the wetland is named as one of the most well known ecotourism sites by the Ministry of Environment and Korean National Ecotourism Organization(KNTO), the Upo wetland area is not an ecotourism site yet based on the definition of ecotourism goals which seek generating conservation and residents' benefits in this study. There are suggestions for this wetland area. The conservation policy with the residents' benefits are strongly recommended.