목 적: 수면중 Orthokeratology(OK) lens 착용이 각막 수평의 이측, 비측 경선의 형태 변화에 미치는 영향을 14일 동안 관찰하였다. 방법: 중등도 이하의 근시 이면서 각막난시가 적은 18명(19~32세)의 성인 그룹은 OK lens(BE; Capricornia Contact Lens Pty Ltd, Queensland, Australia)를 14일 동안 취침 중에만 착용하였으며, 또 다른 약도의 각막난시를 가지는 10명(19~32세)의 성인 그룹은 하루 밤 동안 J-Contour conventional RGP lens(Capricornia Contact Lens Pty Ltd)를 우안에만 착용하고 취침 하였다. 각막 전면의 지형 data는 Medmont E-300 topographer Version 3.9.8(Medmont Pty Ltd, Camberwell, Victoria, Australia)를 이용하여 측정 하였으며, OK lens 착용 그룹은 lens 착용 전날 기상 후 8~10시간이 경과한 후 lens 착용 후 1, 4, 7, 14일째 되는 날에는 기상 후 lens를 제거하고 8~10시간이 경과한 후 측정하였으며 RGP lens 착용그룹은 lens 착용 전날은 기상 후 8~10시간이 경과한 후 그리고 하루 밤 동안 lens를 착용한 후 아침에 lens를 제거하고 8~10시간이 지난 후 측정하였다. 각막 전면의 이측, 비측 경선의 형태는 Medmont E-300 topographer로 측정된 data를 이용하여 Interactive Data Language(IDL)computer program(student version 5.0; Research Systems, Inc, USA)을 사용하여 계산하였다. 결과: 근시는 OK lens 착용 전 S-2.64±0.99 D(mean±SD)이였으나 lens 착용 14일 경과 후 S-0.39± 0.49 D로 감소하였으며, OK lens 그룹에서는 통계적으로 유의한 각막 정점곡률의 증가와 asphericity가 증가하는 결과를 보였으며, 이러한 변화는 비측에서는 렌즈 착용 후 4일째 되는 날 처음으로 통계적으로 유의하였으나, 이측에서는 렌즈 착용 후 1일째 되는 날 통계적으로 유의하였다. 결 론: 근시교정용 OK lens는 각막의 이측을 비측보다 먼저 변형시킨다.

The purpose of this study was to determine the effect of contralateral hip adduction (CHA) on thickness of lumbar stabilizers during hip abduction in side-lying. Twenty healthy subjects without back pain were recruited for this study. The thickness of transverse abdominis (TrA), internal oblique (IO) and quadratus lumborum (QL) were measured by ultrasonography. Pelvic lateral tilting motion was measured using a three-dimensional motion analysis system. Measurements were performed at rest position (RP), preferred hip abduction (PHA) and abduction with contralateral hip adduction (CHA) in side-lying at the end of expiration. During the measurements, subjects were asked to maintain steady trunk alignment without hand support. Thickness of TrA and IO was significantly greater in CHA than in PHA and RP conditions. There was no significant difference in thickness of TrA and IO between PHA and RP conditions. Medio-lateral (M-L) thickness of QL was not significant between PHA and CHA conditions. Anterio-posterior (A-P) thickness of QL in PHA and CHA significantly decreased compared to RP condition. Angle of pelvic lateral tilting was significantly decreased in CHA compared to PHA condition. In conclusion, CHA can be recommended for increasing trunk stability without compensatory pelvic motion during hip abduction exercise in side-lying.

Abdominal muscle plays a crucial role in postural control and respiration control. However, thickness of abdominal muscle in the paretic side of a hemiplegic patient has not been reported in previous studies. The purpose of this research was to compare lateral abdominal muscle thickness between the nonparetic and paretic side in patients with chronic stroke using rehabilitative ultrasound imaging. Twenty two patients with chronic stroke participated in this study. Absolute thickness of transversus abdominis (TrA), internal oblique (IO) and external oblique (EO) was measured at the end of inspiration and expiration during quiet breathing, and relative thickness was calculated (thickness of each muscle as a percentage of total muscle thickness). Ultrasound imaging was recorded three times and the average value was determined for statistical analysis. Differences in absolute and relative lateral abdominal muscle thickness between the nonparetic and paretic side were assessed with paired t-tests. Absolute muscle thickness of the paretic side TrA was thinner than that of the nonparetic side at the end of inspiration and expiration during quiet breathing. Relative muscle thickness of the paretic side TrA was thinner than the paretic side only at the end of expiration during quiet breathing (p>.05). Therefore, it is necessary to strength TrA in patients with chronic stroke during physical therapy intervention. Further study is needed whether physical therapy intervension will induce TrA thickness in patients with chronic stroke in prospective study design.

Ba0.5Sr0.5Co0.8Fe0.2O3-δ (BSCF) 조성을 갖는 치밀한 관형 분리막은 압출 성형 방법으로 제조하였다. Ba0.5Sr0.5Co0.8Fe0.2O3-δ 관형 분리막의 구조적 특성은 x-선 회절분석기 (XRD)와 전자 주사 현미경 (SEM)을 이용하여 분석하였으며, 상대밀도는 94.10%를 보였다. 산소투과량 분석은 700~950℃ 범위에서 공급 측과 투과 측의 운전조건에 따라 측정되었다. 공급 측과 투과 측에서 대기 중 공기와 진공펌프를 사용할 경우, Ba0.5Sr0.5Co0.8Fe0.2O3-δ 관형 분리막의 산소투과량은 900℃에서 1.37 mL/min·㎠로 높게 나타났다.

The purpose of this study was to investigate the variations in gait parameters in terms of the type of arm sling used in hemiplegic patients. Ten patients with hemiplegia and ten healthy adults participated in this study and walked at self-selected speeds on a GAITRite-instrumented carpet. The activities of the opposite shoulder girdle muscle including the latissimus dorsi, anterior deltoid, and posterior deltoid were simultaneously recorded using surface EMG during gait. They were randomly assigned a condition: without an arm sling, a single strap arm sling, a Harris hemi arm sling, a Rolyan humeral cuff arm sling, and a Bobath roll arm sling. The following gait variables were analyzed: the temporo-spatial parameters of velocity, step length, stride length, swing phase, stance phase, single support, step time and toe in/toe out. The statistical analysis was one-way ANOVA with repeated measures to compare the variation of each variable. In comparison of parameters in each trial in the hemiplegia group, the non-affected side stride length, single support, and toe in/toe out resulted in statistically significantly changes (p<.05). But without an arm sling group did not show any gait parameter differences with arm slings. This study found that several arm slings varied gait patterns in patients with hemiplegia and in healthy adults. In the EMG analysis, the Rolyan humeral cuff arm sling and the Bobath roll arm sling were higher muscle activity for the latissimus dorsi muscle than did the single strap ann sling. Further study should examine the problems that appeared in patients who worn arm slings by focusing on a larger number of subjects and by studying the variety of responses in more detail using an assessment tool that measures variation.

마이크로파를 열원으로 이용하는 화학반응은 어려운 반응을 활성화시킬 수 있고 반응시간과 속도를 가속화하여 고수득율 및 높은 분자량을 얻는 고분자를 합성하는데 유용하게 쓰일 수 있다. 본 연구에서는마이크로파를 이용하여 Diels-Alder 반응을 실시하고 열적으로 안정한 측사슬계 2차 비선형광학고분자를 합성하였다. 일반적인 수열반응을 통해 얻어진 고분자와 물리적, 열적, 광학적 특성을 비교 분석하였으며 마이크로파 가열을 활성화하기 위해 용매를 달리하고 이온성액제를 첨가하여 반응을 조절하였다. PAMID시리즈의 다양한 고분자를 합성하였으며 이중에서 PAMID-M2는 10분간 120W의 전력을 사용하여 얻어졌으며 이 때 사용한 용매는 이온성액제가 소량 첨가된 trichloroethane을 사용하였다. 얻어진PAMID-M2의 무게평균 분자량은 18,300이었으며 분포도는 1.3이었고 높은 유리전이온도 (123oC)를 나타냈다.

목적 : 본 연구는 편마비형 뇌성마비 아동에게 수정된 건측 상지 운동 제한 치료(Modified Constraint-Induced Movement Therapy)를 적용하여 환측 손 기능에 미치는 효과를 알아보기 위한 것이다. 연구방법 : 연구 대상자는 만 7세 2개월인 편마비형 뇌성마비 남자 아동으로 수정된 건측 상지 운동 제한 치료를 적용하여 손 기능에 미치는 효과를 알아보기 위해 개별실험 연구 방법인 ABA 디자인을 사용하였다. 기초선 자료는 수정된 건측 상지 운동 제한 치료를 시행하지 않고 4회기에 걸쳐 연구자가 Grooved Pegboard 검사와 장악력 검사를 사용하여 아동의 손 기능을 측정하였다. 치료 시기에는 총 10주 동안 하루 5시간씩 건측 손을 제한하고 주 3회 1시간씩 집중적인 상지 치료를 실시하고, 훈련 후 주 1회 손 기능을 측정하였다. 치료 이후 다시 기초선을 4회기 동안 측정하였다. 손 기능과 함께 일상생활에서 손을 얼마나 자주 사용하는지 보는 손사용의 빈도와 얼마나 잘 사용하는지 보는 손사용 숙련도는 치료를 실시하기 전과 치료가 종료된 이후 보호자와의 상담을 통해 각각 1회 측정하였다. 결과 : Grooved Pegboard 검사 결과 기초선 기간보다 치료 기간에 수행 시간이 감소되었으며 치료가 종결된 이후에도 그 효과가 유지되었다. 하지만 악력 검사에서는 기초선 기간과 치료 기간, 치료가 종결된 이후에 큰 변화를 보이지 않았다. 손사용의 빈도를 보는 Pediatric Motor Activity Log (PMAL) 검사에서는 치료 전보다 치료 후에 손사용의 횟수가 증가되었으나 손사용의 숙련도에서는 큰 변화가 없었다. 결론 : 본 연구에서 수정된 건측 상지 운동 제한 치료는 편마비형 뇌성마비 아동의 저하된 손 기능을 향상시키는 유용한 치료 방법임을 보여주었다. 추후 연구에서는 개별연구의 단점을 보완하기 위해 더 많은 뇌성마비 아동을 대상으로 수정된 건측 상지 운동 제한 치료의 효과를 알아보는 연구가 시행되어져야 하며, 치료 효과의 지속성에 대한 연구가 필요하다.

In chronic ambulatory hemiplegic patients, structural changes might be developed at both ankles possibly due to unequal and repetitive weight bearing on tendons and ligaments. We examined ankles by sonography to find out structural changes of tendons and ligaments of both ankles in ambulatory hemiplegic patients. Nineteen ambulatory hemiplegic patients over 1 year were included as study subjects. All subjects had no previous trauma or disease history in their ankle joints and they were able to walk independently or with supervision but had spastic ankles with equinovarus tendency. We examined both ankle joints by sonography to see joint effusion and measure width, thickness, and area of tendons of the tibialis anterior, tibialis posterior, and Achilles, and also ligaments of the anterior talofibular and calcaneofibular. We compared sonographic features of the hemi-side ankle with the sound-side ankle. There were no significant differences between hemi-side and sound-side ankles in almost all measured parameters of tendons and ligaments. However, the width of the hemi-side tibialis posterior tendon (8.61±1.37 mm) was narrower than the sound-side tendon (7.24±1.52 mm). With the amount of active joint motion and weight bearing possibly preventing ligament and tendon atrophy even though marked weakness, spasticity occurred during the chronic hemiplegic phase.

To develop effective training methods for strengthening a weakened quadriceps femoris muscle in hemiplegic patients, we examined the effects of maximal isometric contraction of the nonparalyzed knee joint on the electromyographic activities of the paralytic muscle. An electromyogram (EMG) was used to record the electromyographic activities of the paralytic quadriceps femoris muscle in 27 hemiplegic patients. The maximal isometric contraction was measured for each subject to normalize the electromyographic activities. The maximal isometric extension and flexion exercises were randomly conducted when the knee joint angles of the nonparalyzed knees were 0˚, 45˚, and 90˚. The patients were encouraged to maintain maximal isometric contractions in both knee joints during each measurement, and three measurements were taken. A one-minute rest interval was given between each measurement to minimize the effects of muscle fatigue. An average from the three values was taken as being the root mean square of the EMG and was recorded as being the maximal isometric contraction. The electromyographic activity obtained for each measurement was expressed as a percentage of the reference voluntary contraction, which was determined using the values obtained during the maximal isometric contraction. The results of this study are summarized as follows: First, when the knee joint angle of the nonparalyzed knee was 0˚, the electromyographic activities of the paralytic medial aspect of rectus femoris were related to measurement by a maximal isometric flexion exercise than by an extension exercise (p<.05). Second, when the knee joint angle of the nonparalyzed knee was 90˚, the electromyographic activities of the paralytic lateral aspect of rectus femoris were related to measurement by a maximal isometric flexion exercise than by an extension exercise (p<.05). The results show that myoelectrical activities of paralytic quardriceps were not related to measurement angles and exercise directions of the nonparalized knee joint. Studies on various indirect intervention to improve muscular strength of patients with nervous system disorders of the weakened muscle should be constantly conducted.

The aim of this study was to investigate effects of reaching distance on movement time and trunk kinematics in hemiplegic patients. Eight hemiplegic patients participated in this study. The independent variables were side (sound side vs. affected side) and target distance (70%, 90%, 110%, and 130% of upper limb). The dependent variables were movement time measured by pressure switch and trunk kinematics measured by motion analysis device. Two-way analysis of variance with repeated measures was used with Bonferroni post-hoc test. (1) There were significant main effects in side and reaching distance for movement time (p=.01, p=.02). Post-hoc test revealed that there was a significant difference between 110% and 130% of reaching distance (p=.01). (2) There was a significant main effect in side and reaching distance for trunk flexion (p=.01, p=.00). Post-hoc test revealed that there were significant differences in all pair-wise reaching distance comparison. (3) There was a significant side by target distance interaction for trunk rotation (p=.04). There was a significant main effect in target distance (p=.00). Post-hoc test revealed that there were significant differences between 70% and 110%, 70% and 130%, 90% and 110%, 90% and 130% of target distance. It was known that trunk flexion is used more than trunk rotation during reaching task in hemiplegic patients from the findings of this study. It is also recommended that reaching training is performed with limiting trunk movement within 90% of target distance whereas reaching training is performed incorporating with trunk movement beyond 90% of target distance in patients with hemiplegia.

This study investigated the irradiation pattern of muscles on the affected side in stroke patients after application of diagonal 2 extension (D2 ex) proprioceptive neuromuscular facilitation in the unaffected upper extremity. Seven stroke patients participated. Electromyographic activities were recorded in the iliopsoas, biceps brachii, and triceps brachii were recorded by surface electrodes at rest, D2 ex with knee extension, and D2 ex with knee 90 flexion, normalized by maximal voluntary isometric contraction (MVIC) values. The medial frequencies of biceps brachii in both sides were also measured to compare muscle type recruited. %MVIC of biceps brachii and triceps brachii were significantly higher in D2 ex than at rest (p<.05). There was no difference in median frequency of biceps brachii between the affected and unaffected side (p>.05). This suggests that proprioceptive neuromuscular facilitation using D2 ex may improve muscle activities of the paretic side and that the irritation pattern of the affected side may respond to maintain body equilibrium according to movement of the sound side.

The purpose of this study was to determine the differences in joint moment in the intact limb of uni-transfemoral amputees and to identify the implications of knee osteoarthritis. As an experimental method, three-dimensional gait analysis was performed on 10 uni-transfemoral amputees and 10 healthy males. Kinematics and kinetics at the hip, knee, and ankle joint were calculated. As a statistical method, independent t-tests were conducted to perform a comparison between the transfemoral amputee group and the control group. The results showed that the external knee adduction moment increased in the transfemoral amputee group (.22 Nm/kg) compared with that of the control group (.13 Nm/kg) at terminal stance (p=.008). External knee flexion moment also increased in the transfemoral amputee group (.24 Nm/kg) but this difference was not statistically significant. External hip flexion moment increased in the transfemoral amputee group (1.35 Nm/kg) compared with that of the control group (.45 Nm/kg) at initial stance, and external hip extension moment decreased in the transfemoral amputee group (-.26 Nm/kg) compared with that of the control group (-.76 Nm/kg) at terminal stance. Although external ankle plantarflexion moment of the transfemoral amputee group increased, it was not found to be statistically significant. The results suggest that the intact limb joint moment of the uni-transfemoral amputees during walking can be different from that of healthy subjects. In conclusion, it was found that there is a link between the increase of external knee adduction moment and the prevalence of knee osteoarthritis in uni-transfemoral amputees. This result is expected to provide some objective data for rehabilitation programs related to knee osteoarthritis in transfemoral amputees.

목적 : 본 연구에서는 뇌졸중 환자에게 손상측 손의 주먹 쥐기 동작을 실시하여 동측 경상 운동 발현 유무를 확인하고, 동측 경상 운동과 손상측 상지 기능의 관계를 비교해 보고자 하였다. 연구방법 : 2개의 전자 악력계를 이용하여 손상측 손으로 대상자가 할 수 있는 최대의 힘으로 주먹 쥐기를 10초 동안 유지하는 것을 시행한 후 동측 경상 운동을 측정하고, 동측 경상 운동의 유무에 따라서 경상 운동이 나타나는 환자군 15명과 경상 운동이 나타나지 않는 환자군 15명으로 구분하였다. 경상 운동의 유무에 따른 손상측상지의 기능을 비교하기 위해서 퍼글-마이어 평가, 퍼듀 페그보드 검사, 악력 측정을 실시하였다. 결과 : 동측 경상 운동이 나타나는 환자군과 경상 운동이 나타나지 않는 환자군의 집단 간의 손상측 상지 기능의 비교에서 퍼글-마이어 평가, 퍼듀 페그보드 검사, 악력 모두에서 통계학적으로 유의한 차이를 보였다(p<.05). 동측 경상 운동이 나타나는 환자군이 경상 운동이 나타나지 않는 환자군보다 상지의 전반적인 기능에서 좋지 않은 것으로 나타났다. 결론 : 뇌졸중 이후에 나타나는 동측 경상 운동은 상지 기능에 좋지 않은 영향을 미치는 것을 알 수 있고, 운동 결함이 있는 동측 경상 운동이 나타나는 환자에서 뇌졸중 이후 회복 과정의 임상적 양상을 알 수 있다. 따라서 뇌졸중 환자의 평가와 치료에 있어서 동측 경상 운동을 고려해야 하며, 앞으로 뇌졸중 환자에서 경상 운동의 지속적인 평가와 치료적 중재에 관한 연구가 필요할 것이다.

본 연구에서는 한우 체외수정란의 이식에 있어서 수정란 측 요인들이 수란우의 임신과 유산에 미치는 영향을 검토하였다. 이식에 제공하는 배반포의 수량에 따른 임신율은 1개, 2개 및 3개 이식 군에서 각각 32, 44 및 였고, 유산율은 로서 2개 이식군의 임신율과 유산율이 가장 높았으나 유의차는 인정되지 않았다. 배반포 등급에 따른 임신율은 , 유산율은 로서 유사한 경향이었다. 배반포의 발생 단계에 따른 임신율은 로서 비슷하였으나, 유산율은 HB군이 LB

목적 : 본 연구를 통하여 뇌손상으로 인한 편마비 아동들에게 10주 동안 적용된 수정된 강제유도 운동치료가 환측 상지의 운동․감각능력 및 일상생활에서의 환측 상지 사용 빈도에 미치는 효과를 알아보고자 하였다. 연구방법 : 본 연구는 개별사례 실험 연구 방법 중 반전연구(reversal design or ABA design)로 설계되었으며, 서울장애인종합복지관에서 뇌병변으로 인한 편마비 진단을 받고 재활치료 중인 4명의 아동을 대상으로 17주간 실시되었다. 총 17주의 연구기간은 3주간의 기초선 1기간, 10주간의 치료 적용기간, 4주간의 기초선 2기간(치료후 관찰기간)으로 이루어져 있다. 치료 기간 동안 대상 아동들에게 주 5회, 하루 5시간동안 강제유도 운동치료를 적용하였다. 치료 전․후의 환측 상지의 기능을 평가하기 위해 두점 인식능력과 모노필라멘트를 사용한 촉각 검사, 멜버른 검사를 실시하였고, Motor Activity Log(MAL) 중 아동에게 적용 가능한 20항목을 발췌한 부모작성일지를 사용하여 환측 상지 사용빈도를 측정하였다. 결과 분석을 위하여 대상자별로 측정된 상지의 운동 및 감각기능과 일상생활에서 환측 상지 사용 빈도의 평균값을 기술 통계적으로 제시하고 시각적 그래프를 통하여 기초선, 치료기간과 치료 후의 차이를 비교하였다. 결과 : 수정된 강제유도 운동치료 후 편마비 아동의 상지 운동 및 감각기능과 일상생활에서의 환측 상지 사용 빈도가 치료 전에 비해 향상되었고, 이러한 치료 효과는 치료종료 후 1개월까지 유지되었다. 결론 : 본 연구 결과는 장시간의 건측 상지 운동 제한에 따른 거부감으로 인해 아동에게 적용하기 어려웠던 기존 강제유도 운동치료의 문제점을 개선한 수정된 강제유도 운동치료는 적용시간을 각 아동의 특성에 맞게 조절하여 활용한다면 임상 재활치료에서 편마비 아동의 기능회복에 효과적으로 적용될 수 있을 것으로 기대된다.

The purpose of this study was to investigate the effect of Modified Constraint-Induced Therapy (MCIT) on the effected upper extremity of children with hemiparesis. Four children with hemiparetic upper extremity caused by brain injuries were trained by MCIT for ten weeks. During the same period, all of the subjects were also involved in thirty-minute regular physical therapy and occupational therapy. During the treatment period, the unaffected upper extremities of the subjects were restrained by a specially designed hand splint or a mitten for five hours a day, five days per week. For two hours out of the five-hour restraint period, the affected upper extremities were intensively trained by performing various functional tasks, which were individually structured to emphasize use of the affected arm. A single-subject design with A-B-A reversal was employed in this study. The affected limb motor ability was evaluated by Melbourne Assessment, measuring the time to grasp and release nine pegs, and measuring grasping power. As a consequence of this study, the affected limb motor test scores of all four subjects in the baseline period were improved during the treatment period. Furthermore, the treatment effect was maintained during a one-month follow-up period. The results of this study support the assumption that MCIT is an effective therapeutic method to improve the sensory and motor abilities of hemiparetic children. It also increases the frequency of functional use of the hemiparetic hands of brain-injured children. Based on the results of this study, it can also be assumed that the modified CIT method is especially beneficial to these children by reducing the negative emotional effects of forceful restraint of the unaffected upper extremity. To optimize the functional recovery of the paretic upper extremity by CIT, the restriction period per day should be decided individually, according to the characteristics of the individual.

본 연구는 임상 조건하에서 수정란이식의 효율성 증대를 위하여 수란우 측면의 산차, 체점수(BCS), 발정 발현과 유도, 황체 형태, 자궁 크기 및 자궁각 위치가 체외수정란이 이식된 수란우의 임신과 유산에 미치는 효과를 검토하였다. 미경산우의 임신율이 경산우에 비하여 유의하게 높았으나, 유산율은 유사한 경향이었다. BCS에 따른 임신율은 차이가 없었으나 유산율은 BCS 3.0 미만군이 군 에 비하여 유의하게 높았다. 수란우의 발정 발현과 유도 방법, 황체

본 연구는 임상 조건하에서 수정란이식의 효율성 증대를 위하여 이식 시술자 측면의 숙련도, 난이도, 소요시간, 주입 위치, 자궁의 출혈 및 위치 조절이 체외수정란이 이식된 수란우의 임신과 유산에 미치는 효과를 검토하였다. 임신율은 숙련된 시술자, 자궁각 2/3 지점에 이식 및 위치 조절군이 유의하게 높은 경향이었으나, 이식 난이도, 소요시간 및 출혈에 따른 차이는 인정되지 않았다. 한편 시술자 측의 요인에 따른 유산율은 유사한 경향이었다.

The purpose of this study was to analyze the presence of ipsilesional movement deficit, with segmental performance in each proximal or distal upper extremity. The visuoperceptual complex task of the ipsilesional upper extremity was investigated in patients with unilateral brain damage and a control group of healthy sex-age-matched controls. Tracking movements were tested in the proximal and distal upper extremities. Movements were measured by the accuracy index, which was normalized to each subject's own range of motion and took into account any differences between subjects in the excursion of the tracking target. The findings revealed that stroke patients experienced difficulties with tracking movement of both proximal and distal segments in the upper extremities on the so-called "non-affected side", irrespectively of the extent of patient's age, time since onset, or severity of contralateral upper extremity. Therefore, the unilateral brain damage affected ipsilateral motor function of the proximal and distal upper limbs in the performance of complex motor tasks, requiring central processing and the higher order cognitive function in the integrity of both hemispheres.