스트레스는 인체의 다양한 기관과 정신적 상태에 영향을 미치는 교감신경 항진을 야기시킨다. 본 연구의 목적은 만성 스트레스로 교감신경을 항진시킨 동물 모델에서 국내산 생강 에센셜오일이 스트레스 호르몬 및 뇌 조직 반응에 미치는 효과를 평가하였다. 평가 방법은 세포독성 평가 및 성분 분석을 수행하였으며, 혈청 바이오 마커와 뇌 조직의 병리학적 분석이 기초한 효과를 관찰하였다. 동물 실험에서 국산 생강 에센셜오일의 처리는 만성 스트레스로 교감신경을 항진시킨 동물 모델 제작 후 2주간 100 nl/㎖로 처리하였다. 그 결과, 국산 생강 에센셜오일은 100 nl/㎖ 농도 이하에서 독성이 없었으며, 6-진저롤 함량이 345 ppm으로 확인되었다. 국산 생강 에센셜오일의 처리는 대조군과 비교하여 혈청에서 부신피질호르몬, 코르티코스테론, 멜라토닌과 같은 스트레스 호르몬의 농도를 크게 줄였으며, 복측 피개부(VTA) 및 흑색질 치밀부(SNpc) 부분에서 TH-면역 반응이 때때로 중단되는 것을 효과적으로 보존하였다. 이와 같은 결과는 국산 생강 에센셜오일이 교감신경 항진을 개선했음을 나타내고 있다. 따라서 국산 생강은 교감신경 항진에 대한 아로마오일의 새로운 원료로 활용될 수 있다.

Background: Obstacle training affects lower limb muscle activity, balance, reducing the risk of falls, and making gait more stable. Objects: This study aimed to investigate the effects of aquatic and ground obstacle training on balance and muscle activity in patients with chronic stroke. Methods: The study subjects included 30 patients with stroke, who were divided into aquatic (n1= 15) and ground (n2=15) groups. Groups underwent obstacle training three times per week, 30 min per session, for six weeks that went as follows: walking over sites with the paralyzed leg, stepping onto and down from a box step, and walking over obstacles with the non-paralyzed leg. Results: The experimental results were obtained by comparing muscle activity. Activity of the rectus femoris, biceps femoris, tibialis anterior, and gastrocnemius were significantly increased in the aquatic group (p<.05). Activity of the biceps femoris and tibialis anterior were significantly increased in the ground group (p<.05); however, the rectus femoris and gastrocnemius were not significantly different. In the comparison of maximal distance regarding the limits of stability, it was significantly increased on the non-affected side, affected side, and anterior and posterior distance in the aquatic group (p<.05). It was significantly increased in the non-affected side and anterior and posterior distance the ground group (p<.05); however, maximal distance on the affected side distance was not significantly different. Conclusion: Gait training with aquatic and ground obstacles is effective for improving balance and gait ability of patients with stroke. However, it was more effective for the aquatic group than for the ground group.

만성 췌장염은 지속적인 췌장 염증과 섬유화로 비가역적 췌장 기능의 손상과 다양한 합병증이 발생하는 질환이다. 특히 만성 췌장염에서 발생한 췌담관 협착은 통증 또는 합병증이 발생하는 경우, 내시경 배액 치료가 필요하다. 그러나 내시경 치료 단독은 기술적 한계로 인하여 불충분한 치료 효과를 보이는 경우가 많아 항상 다학제 기반의 진단과 치료적 접근이 필요하다. 이에 추가하여 국내 실정에 맞는 만성 췌장염 진료지침의 개발을 기대한다.

Background: Most of the previous researches on the abnormality of breathing pattern have focused on the silence of functional movements owing to such abnormality, however, have not been clearly identified the relationship between the abnormal breathing pattern on one hand and kinesiophobia and flexion relaxation phenomenon (FRP) on the other hand. Objective: To compare patients with chronic low back pain (CLBP) and healthy person in the abnormality of breathing pattern, kinesiophobia, and FRP during flexion and extension of the trunk. Design: Case-control study. Methods: The research subjects consisted of a group of 15 healthy adults and another group of 15 patients with CLBP. Capnography was used to measure the endtidal CO2 (EtCO2) and respiratory quotient (RQ). The muscle activity of multifidus and erector spinae of the subjects was measured during flexion and extension of the trunk to identify their FRP. The Nijmegen Questionnaire (NQ) and Tampa Scale of Kinesiophobia (TSK) were utilized to measure their breathing patterns and kinesiophobia, respectively. The Kolmogorov-Smirnov (K-S) test was conducted in order to analyze the normal distribution of the measured data. Their general characteristics were identified by the descriptive statistics and the independent t-test was performed to identify the differences between the two groups in terms of abnormality of breathing pattern, kinesiophobia, and FRP. The level of significance was set at α=.05. Results: The patients with CLBP had significantly less EtCO2 and shorter breathing hold time (BHT) than normal healthy person (p<.05). The patient with CLBP also had significantly greater kinesiophobia than healthy person (p<.05), and had less FRP than the healthy person (p<.01). Conclusions: These results suggest that the CLBP had greater abnormality of breathing pattern and kinesiophobia with less FRP than healthy person.

Chronic hypoxia is a major cause that increases neonatal mortality in the perinatal period. Vascular endothelial growth factor (VEGF) and its receptors induced by hypoxia are increased blood vessel permeability in the developing central nervous system and characterized as a critical factor in angiogenesis and vasculogenesis. This study investigated the development of the rat cerebellum with expression of VEGF and its receptors under chronic hypoxia in compare with normoxia. In addition, this study can contribute to the understanding of the effect development in the postnatal cerebellum. Rat pups were divided into two groups, normoxia and hypoxia group. The cerebellum of 35-day-old rat was removed and prepared for immunofluorescent staining. After staining, the sections were observed under the fluorescent microscope and were taken the picture using the microscopic-digital camera system. Expression of VEGF and Flk-1 restricted only to Purkinje cells, but feline sarcoma virus-like tyrosine kinase-1 (Flt-1) did not express in all of cerebellar layers. Under chronic hypoxia, expression of VEGF and fetal liver kinase-1 (Flk-1) increased in Purkinje cells but no changes in case of Flt-1. These results suggest that the source of VEGF and Flk-1 is Purkinje cells in the cerebellum. And increase of VEGF and Flk-1 expression in the murine cerebellum results from adaptive responses to chronic hypoxia.

Background: After stroke, in order to improve gait function, it is necessary to increase the muscle strength and to enhance the propriocetive function of the lower extremity. Objects: This study aimed to compare the effects of open kinetic chain (OKC) versus closed kinetic chain (CKC) isokinetic exercise of the hemiparetic knee using the isokinetic equipment on lower extremity sensorimotor function and gait ability in patients with chronic stroke. Methods: Thirty participants with chronic hemiplegia (> 6 months post-stroke) were randomly divided into 2 equal groups: CKC group and OKC group. Patients from both groups attended conventional physiotherapy sessions 3 times a week for 6 weeks. Additionally, subjects from the CKC group performed isokinetic exercise using the CKC attachment, while those from the OKC group performed isokinetic exercise using the OKC attachment. The isokinetic knee and ankle muscles strength, position sense of the knee joint, and spatiotemporal gait parameters were measured before and after interventions. Results: The knee muscles peak torque/body weight (PT/BW) and hamstring/quadriceps (H/Q) ratio significantly increased in both groups (p<.01). In particular, ankle plantarflexors PT/BW, position sense of the knee, gait velocity, and spatial gait symmetry significantly improved in the CKC group (p<.01, p<.05, p<.01, and p<.01, respectively). Conclusion: CKC isokinetic exercise can be an effective therapeutic intervention for the improvement of sensorimotor function of the lower extremity and gait functions, such as gait velocity and symmetry. CKC position in isokinetic strength training is effective to improve functional ability in patients with chronic stroke.

Chronic and unpredictable stress can disrupt the female reproductive system by suppression for secretion of gonadotrophin-releasing hormone (GnRH) and gonadotrophin, resulted in ovarian malfunction and infertility. In the recent days, kisspeptin has been highly highlighted as a hypothalamic peptide which directly stimulates synthesis and release for GnRH. However, in spite of the key role of kisspeptin in the female reproductive system, little information is still available on the changes of its expression during ovarian cycle under stressed condition. Therefore, we induced chronic and unpredictable stress series to the female mice to analyze kisspeptin expression in the brain and ovary. Stressed mice exhibited changes of behavior and body weight gain during the stress assessment, which suggested that the present stress model in mice was successfully established. In the brain level, kisspeptin expression was attenuated than control. In the ovary level, the stressed mice displayed irregularly shrunk oocytes with broken zona pellucida throughout the follicle stages, pyknotic granulosa cells, decreased number of developing follicles and increased number of atretic follicles than the control. In case of kisspeptin expression in the whole ovary tissue, the expression level was decreased in the stressed mice. In detail, the less intensity of kisspeptin expression in the antral follicles phase was observed in the stressed mice than control mice, indicating that local function of kisspeptin during ovary cycle is highly associated with development of ovarian follicles. We expect that the present study has important implications for the fields of reproductive biology.

The present study aimed at evaluating serum immunoglobulin G (IgG) avidity to Porphyromonas gingivalis in elderly patients with mild and severe chronic periodontitis. The avidity of antibodies against P. gingivalis present in the sera of 18 patients with mild chronic periodontitis and 18 patients with severe chronic periodontitis was evaluated using an ammonium thiocyanate-dissociated enzyme-linked immunosorbent assay (ELISA). The results showed that the mean absorbance value in serum IgG antibody titers was significantly higher in the severe chronic periodontitis group than in the mild chronic periodontitis group (198 ± 35 ELISA unit [EU] vs. 142 ± 32 EU, p < 0.01). However, there was no significant difference between the two groups in antibody avidity (65 ± 57 EU vs. 54 ± 27 EU). These findings suggest that humoral immune responses to P. gingivalis between mild and severe chronic periodontitis in elderly patients are characterized by the differences in the quantity rather than the quality of the antibodies.

목적 : 본 연구는 완곡추적 안구운동과 경부신전근 진동자극법의 결합중재가 만성 뇌졸중 환자의 편측무시와 일상생활활동 수행에 미치는 영향을 확인하는 것이다. 연구방법 : 본 연구는 발병 후 6개월 이상 지난 3명의 뇌졸중 편측무시 환자를 대상으로 하였으며, 단일대상연구 방법 중 ABAC디자인으로 연구를 진행하였다. 연구는 기초선(A1) 1주, 중재기(B) 2주, 기초선(A2) 1주, 그리고 중재기(C) 2주로 총 6주간 진행되었으며, 중재기(B)에서는 완곡추적 안구운동(Smooth Pursuit Eye Movement; SPEM)의 단일중재를, 중재기(C)에서는 경부신전근 진동자극법(Neck Muscle Vibration; NMV)과 SPEM의 결합중재를 실시하였다. 평가는 매회기 선 나누기 검사와 벨 테스트(Bells test)를 실시하였으며, 한국판 캐서린 버지고 척도(Korean-Catherine Bergego Scale; K-CBS)와 한국판 일상생활활동 중심 작업기반 신경행동 평가(Korean version of ADL-focused Occupation-based Neurobehavioral Evaluation; K-A-ONE)를 기초선(A1)의 첫 회기와 각 중재기의 마지막 회기에 시행하였다. 결과 : 연구결과 SPEM과 NMV를 단일 또는 결합하여 적용하였을 때 편측무시의 지필검사(선 나누기 검사와 벨 테스트)와 관찰적 검사(K-CBS와 K-A-ONE)에서 편측무시가 개선됨을 확인하였고, 특히 결합중재시에 더 효과가 좋았던 것으로 나타났다. 그리고 편측무시가 개선됨에 따라 일상생활활동의 수행(K-A-ONE)에서도 향상을 보였는데, 편측무시 환자의 일상생활을 저해하는 신경행동 손상은 편측무시 뿐만 아니라 공간관계나 마비와 같은 손상 등이 영향을 미치는 것으로 나타나 다양한 신경행동 손상의 중재를 포함하는 포괄적인 재활프로그램을 계획해야함을 확인하였다. 결론 : 본 연구를 통해 SPEM과 NMV의 결합중재가 만성 뇌졸중 환자의 편측무시를 감소시키고 일상생활 활동 수행을 향상시키는데 효과적인 중재라는 것을 확인하였다.

Background: Chronic low back pain (CLBP) causes morphological changes in muscles, reduces muscle strength, endurance and flexibility, negatively affects lumbar stability, and limits functional activity. Plank exercise strengthens core muscles, activates abdominal muscles, and improves intra-abdominal pressure to stabilize the trunk in patients with CLBP. Objects: We investigated the effect of plank exercise on abdominal muscle thickness and disability in patients with CLBP. Methods: We classified 33 subjects into 2 groups: An experimental (n1=17) and a control group (n2=16). Patients in the experimental group participated in plank exercise and those in the control group participated in stretching exercise. Patients in both groups attended 20-minute exercise sessions thrice a week for 4 weeks. Abdominal muscle thickness in each subject was evaluated ultrasonographically, and disabilities were assessed using the Oswestry disability index (ODI). Results: Four weeks later, abdominal muscle thickness showed a significant increase over baseline values in both groups (p<.05). Patients in the experimental group reported a more significant increase in the thickness of the external oblique muscle than that in the control group (p<.05). ODI scores in the experimental group were significantly lower after intervention than before intervention (p<.05). Conclusion: Plank exercise increases the thickness of the external oblique muscle and reduces disability secondary to mild CLBP. Therefore, plank exercise is needed to improve lumbar stability and functional activity in patients with mild CLBP.

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin's lymphoma, and usually showed painless neck swelling, fever, sweat, and weight loss. Although about 5% of all lymphomas appeared in the oral area, the primary maxillofacial lymphomas were rare and sometimes clinically tended to be misdiagnosed such as chronic periodontitis, osteomyelitits, etc. This study demonstrated three cases of primary DLBCL mimicking localized osteomyelitis at mandible or maxilla. A series of histological and immunohistochemical examination using different biomarkers of lymphoreticular cells were performed to characterize the neoplastic cells of DLBCL. The first case occurred in a 45 years old male exhibiting mandibular osteomyelitis and neck swelling. The second case simply showed a gingival swelling at left upper premolar area in a 55 years old male. And the third case is from an 84 years old female who felt numbness at left lower lip and had severe periodontitis involving regional alveolar bone resorption. All of three cases had experienced no systemic manifestation of lymphoreticular malignancy before the diagnosis of oral lymphoma. Immunostainings of CD3, CD20, TNFα, BCL-2, Ki-67, PCNA, and c-Myc were strongly positive in these tumor cells, while those of p53 and CD31 were slightly positive, and CD56 immunoreaction was negative. These three cases were diagnosed as DLBCL and referred to the hemato-oncology unit for treatment. Therefore, every chronic granulomatous periodontal lesion hardly cured by simple medical treatment should be carefully explored through pathological examination, and it was presumed that DLBCL is closely related to the chronic inflammatory periodontal lesions recruiting mucosa-associated lymphoid cells in older patients. It was also suggested that DLBCL be differentially diagnosed from T-cell lymphoma, Burkitt’s lymphoma, and Hodgkin’s disease, etc. with immunohistochemical determination of tumor cell subtypes as soon as possible in order to be treated with appropriate therapy.

Background: Compared to healthy people, patients with chronic lower back pain have reduced balance abilities which may cause proprioception problems, patients with chronic lower back pain avoid physical activities due to pain, and reduced activity levels lead to muscle weakening, which can further exacerbate pain. Recently, there have been many studies on the use of sensory stimulation; and among these studies, interventions that use vibrational stimulation have shown functional improvements in the patients. Objects: This study examined the effects of a stabilization exercise with vibration stimulation on the balance ability and disability in patients with chronic back pain. Methods: The subjects of the study were 30 persons who were randomly assigned to the experimental group and the control group, with 15 subjects in each. The subjects were evaluated before and after intervention via a balance ability test, the Korean Oswestry disability index (KODI) test, a pain test, and a proprioceptive sensory test. Both groups received general physical therapy. The experimental group performed the stabilization exercise with vibration stimulation, and the control group performed a general stabilization exercise, three times a week for six weeks. Results: After the intervention, both groups showed significant improvements in the balance ability test, the KODI test, the pain test, and the proprioceptive sensory test. The experimental group showed statistically significant, higher improvements than the control group in the balance ability test, the KODI test, and the proprioceptive sensory test. Conclusions: The stabilization exercise with vibration stimulation for patients with chronic back pain has been reported to provide greater functional improvements than the conventional intervention method. Therefore, the stabilization exercise in a vibration stimulation environment could be a useful intervention for patients with chronic back pain.

The purpose of this study was to investigate the effects of sling exercise on muscle activity and balance on football players with chronic ankle instability. Eight subjects performed Biodex and sling exercises for four weeks and compared the muscle activity and balance ability of the uninjured and injured feet. Stable and unstable foot % MVIC did not change significantly after treatment in all muscles. The total balance ability was not significantly different between the two groups, however, increased only in the unstable side. The anterior/posterior balance ability also represented no significant difference between the groups and was significantly improved only in the unstable side. The medial/lateral balance ability was not significantly different between the groups and was significantly improved only in the unstable side. This study suggests that sling exercise contributes to improving % MVIC, total balance ability, anterior/ posterior balance ability, and medial/lateral balance ability of the unstable side.

Porphyromonas gingivalis is among the major etiological pathogens of chronic periodontitis. The virulence mechanisms of P. gingivalis is yet to be identified as its activity is largely unknown in actual disease process. The purpose of this study is to identify antigens of P. gingivalis expressed only in patients with chronic periodontitis using a unique immunoscreening technique. Change Mediated Antigen Technology (CMAT), an antibody-based screening technique, was used to identify virulence-associated proteins of P. gingivalis that are expressed only during infection stage in patients having chronic periodontitis. Out of 13,000 recombinant clones screened, 22 tested positive for reproducible reactivity with rabbit hyperimmune anti-sera prepared against dental plaque samples acquired from periodontitis patients. The DNA sequences of these 18 genes were determined. CMAT-identified protein antigens of P. gingivalis included proteins involved in energy metabolism and biosynthesis, heme and iron binding, drug resistance, specific enzyme activities, and unknown functions. Further analysis of these genes could result in a novel insight into the virulence mechanisms of P. gingivalis.

Disulfiram is a drug used to treat alcohol dependence. Recent studies have shown that disulfiram also has anti-cancer effects. Considering that many anti-cancer agents have side effects, including immunosuppression, it is important to check if disulfiram has some cytotoxicity to immune cells. In this study, mouse spleen cells were treated with disulfiram and the metabolic activity was measured. Disulfiram increased the cell death of spleen cells according to annexin V-FITC/PI staining analysis. In addition, disulfiram decreased the mitochondrial membrane potential of spleen cells. The toxicity of disulfiram was concentration dependent. Interestingly, disulfiram affected the population of lymphocytes and the subset of spleen cells was altered. This study provides clinicians and researchers with valuable information regarding the toxicity of disulfiram to mouse spleen cells, particularly lymphocytes.

Angiotensin receptor blockers, such as telmisartan, are considered effective in the treatment of hypertension and proteinuria due to chronic kidney disease (CKD) in cats. It selectively blocks the AT1 receptor and does not affect the AT2 receptor, thus effectively blocking the activity of the renin angiotensin aldosterone system. This study aims to compare over time the changes in various indicators, including systemic hypertension and proteinuria, before and after the administration of telmisartan in cats with CKD. Decrease in blood pressure (BP) (p<0.001) and urine protein to creatinine (UP/C) ratio (p<0.001) were found to be statistically significant over time after the administration of telmisartan. BP and the UP/C ratio were 160 ± 22.2 and 0.50 ± 0.647 before telmisartan administration (Day 0), 150 ± 21.0 and 0.27 ± 0.487 on the 30th day (Day 30), 150 ± 17.0 and 0.25 ± 0.376 on the 60th day (Day 60), and 140 ± 17.8 and 0.15 ± 0.233 on the 90th day (Day 90) after administration, respectively. BP and UP/C were statistically significantly lower in cats with CKD over time at each time point from Day 0 to Day 90 at 30 day intervals. Especially after 90 days of telmisartan administration, the improvement of BP and UP/C were estimated to be about 20 mmHg and 0.35, respectively. In conclusion, the oral administration of telmisartan to cats with CKD is effective in improving BP and proteinuria, which has a positive effect on long-term survival in cats with CKD.

Background: Posterior-anterior (PA) vertebral mobilization, a manual therapy technique has been used for relieving pain or stiffness treating in spinal segment for in clinical practice, however evidence to gauge efficacy is yet to be synthesised. Objects: This study aimed to investigate the effect of PA mobilization of the thoracic spine on the respiratory function in patients with low back pain (LBP). Methods: The study participants included 30 patients with chronic LBP. They were randomly allocated to the experimental and control groups. The experimental and control groups received PA mobilization of the T1-T8 level of the thoracic spine and placebo mobilization, respectively. All patients received interventions for 35 minutes a day, five times a week, over 2-week period, respectively. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), forced expiratory flow 25∼75% (FEF25∼75%), and chest wall expansion were measured before and after the intervention. Statistical analysis was performed using independent t-test and two-way analysis of variance, and Pearson’s correlation analysis was used to compare the correlation between respiratory function and chest measurement. Results: The experimental group showed significant improvements in FVC, FEV1, PEF, FEF25∼75% (p<.05), and chest wall expansion (p<.05) compared with the control group. Conclusion: PA mobilization of the upper thoracic spine may be beneficial for improving respiratory function parameters including FVC, FEV1, PEF, FEF25∼75%, and chest wall expansion in patients with chronic LBP.

목적 : 본 연구는 인지 중재 비율을 조절한 점진적 관찰감소 동작관찰훈련과 기존의 동작관찰훈련에 대한 상지기능 변화를 비교하여 효율적인 중재 방법을 알아보고자 실시하였다. 연구방법 : 14명의 만성 뇌졸중 환자를 대상으로 7명의 실험군은 점진적 관찰감소 동작관찰훈련을, 7명의 대조군은 기존의 동작관찰훈련을 주 3회, 30분씩, 4주간 실시하였고 각 군은 기존에 실시하던 전통적 작업치료 및 물리치료 역시 시행하였다. 상지 운동기능의 사전, 사후 평가는 울프운동기능검사(Wolf Motor Function Test; WMFT), 상지기능장애 설문지(Disabilities of the Arm, Shoulder and Hand; DASH), 상자와 나무토막 검사(Box and Block Test; BBT)를 사용하였고, 각 군의 중재 전과 후의 차이는 윌콕슨 부호 순위검정(Wilcoxon signed-ranks test), 두 군 간의 중재 후 효과 비교는 맨 휘트니검정(Mann-Whitney U test)을 사용하여 분석하였다. 결과 : 점진적 관찰감소 동작관찰훈련군과 기존의 동작관찰훈련군은 모두 WMFT, DASH, BBT에서 통계적으로 유의한 변화가 있었다(p<.05). 점진적 관찰감소 동작관찰훈련군과 기존의 동작관찰훈련군의 상지기능 변화량 비교에서는 WMFT의 소요시간과 DASH의 점수에서 점진적 관찰감소 동작관찰훈련군이 더 많은 변화 가 있었으며 통계적으로 유의한 차이가 있었다(p<.05). 결론 : 본 연구 결과 중재기간에 따라 인지 중재 비율을 고려한 점진적 관찰감소 동작관찰훈련이 기존의 동작관찰훈련보다 상지기능 향상에 효과적이었다는 것을 알 수 있었다. 따라서 만성 뇌졸중 환자의 상지기능 향상을 위한 동작관찰훈련의 중재 시 인지비율을 고려한 중재 전략이 필요하다.

목적 : 본 연구는 양손 협응력 훈련도구의 활용과 평가를 적용하여 만성 뇌졸중 환자의 시지각 능력과 양손 기민성의 효과에 대해 검증하고 훈련도구로서의 역할을 제시하는데 목적을 두었다. 연구방법 : 본 연구의 선정기준에 적합한 41명을 무작위로 선정하여 실험군 21명과 대조군 20명으로 성별·연령별 동질성을 확보하여 분류한 후 실험군은 매일 양손훈련도구와 일반작업치료를 각각 15분간 실시하고, 대조군은 일반작업치료를 30분간 실시하였다. 훈련 제공기간은 주 5회 6주 동안 실시하였다. 평가는 Motor-free Visual Perception Test-3(MVPT-3)와 Complete Minnesota Dexterity Test(CMDT)를 활용하여 모든 집단에 실시하고 실험군은 양손 협응력 훈련도구의 수행능력 측정을 추가로 실시하였으며 평가는 총 3회(훈련 전, 3주후, 6주후)를 시행하였다. 결과 : 실험군에 대한 양손 협응력 훈련도구의 평가결과 수행시간에 대한 통계적 차이는 없었으나(p>.05) 수행시간은 평가 주차별로 감소하였으며, 오류수는 통계학적으로 유의한 차이를 보였다(p<.05). MVPT –3에서 실험군은 훈련기간에 따라 유의한 차이(p<.05)로 증가하였고 대조군은 유의한 차이를 보이지 않았다(p>.05). 또한, 집단간 분석에서 통계학적으로 유의한 차이(p<.05)를 보인 훈련기간은 3주후와 6주 후 훈련이었다. CMDT에서는 집단과 훈련기간에 따른 유의한 차이를 보이지 않았다(p>.05). 결론 : 양손 협응력 훈련도구의 활용 및 평가를 통해 만성 뇌졸중 환자의 시지각 기능과 상지 기능향상에 효과적인 훈련도구로서의 적용이 가능함을 보였으며 향후 병실이나 가정에서도 누구나 쉽게 활용할 수 있을 것을 기대한다.