목적 : 청광 차단렌즈의 효과를 정량적으로 분석하는 방법을 새롭게 제시하고, 이를 시판하고 있는 기능성 렌즈에 적용하여 비교 분석함으로써 그 활용 가능성을 확인하고자 하였다. 방법 : 렌즈의 광투과율을 측정하고, 청광 차단 효율 함수를 적용하여 효율에 대한 정성적인 분석을 하였다. 또한 청광 차단 효율 결과를 적분하여 수치화하는 정량적인 분석 방법을 새롭게 도입하여, 시판중인 청색광차단 기능성 렌즈에 적용하여 비교분석하였다. 결과 : 정성적인 분석 방법을 일반렌즈, 코팅방법으로 제작된 2종의 렌즈와 착색방법으로 제작된 1종의 렌즈에 적용한 결과, 모든 렌즈는 단파장 영역의 빛을 차단하는 효과가 우수한 것으로 분석되었다. 하지만 정량적인 분석 방법에 의한 결과에서는 각 렌즈별 다소 차이가 있음을 확인하였다. 결론 : 다양해지는 디스플레이 장치 및 스마트폰의 광 특성이 날로 진화되고 변화되고 있으므로, 다양한 방법으로 광원과 광학제품에 대한 광특성 분석이 요구된다. 이에 따라, 본 연구에서 새롭게 도입한 정량적인 분석 방법이 효과적인 수단일 될 수 있는 가능성을 확인 하였다.

Purpose: The physical and optical characteristics for copolymers produced by adding 3-Iodoaniline and 3-chloroaniline to the various monomers commonly used for ophthalmic contact lenses were investigated. Methods: The basic hydrogel ophthalmic lens material with addition of 3-Iodoaniline and 3-chloroaniline respectively were polymerized by heating at 80℃ for 20 mins, and then 110 ℃ for 40 mins. To produce contact lenses, a cast mould method was used. The produced contact lenses samples underwent the pre-process by being hydrated in 0.9% NaCl saline for 24 hours. Afterward, their physical and optical properties were measured. Results: The results showed that the average value of refractive index increased and the water content decreased as the ratio of additive increased. The measurement of the optical transmittance of the copolymerized polymer with addition 3-Iodoaniline showed that the transmittance for visible ray, UV-B and UV A is 89.4~90.8%, 2.0~15.2% and 40.6~67.8%, respectively. Also, for samples with addition 3-Iodoaniline, the transmittance for visible ray, UV-B and UV-A was in the range of 89.8~90.6%, 5.0~22.2% and 57.6~73.8% respectively. Conclusions: It is expected that the results would contribute to a wider application of contact lenses containing aniline group which are to be used as ultraviolet ray blocking contact lenses.

Although a number of molecules have been implicated in the metastasis of oral squamous cell carcinoma (OSCC) , the precise molecular mechanisms that deterrnine the direction of rnigration and invasiveness of OSCC cells into the lymph nodes remain unclear, Chemokines are a superfarnily of small structurally related heparin- binding proteins‘ which have been identified as attractants that control the rnigration of leukocytes‘ especia lly during imrnune and inflammatory reactlOns Moreover, recent studies have demonstrated that several types 。f cancer express chemokine receptor‘s and use chemokines to metastasize to the target organ, However, there h ave been few reports on biological behaviors by downregulation 0 1' CXCR-4 in ora l cancel‘ cells We tried to screen several OSCC cell lines in order to obtain a suitable cell line model which had the cha ract eris tic of the constitutive ly expressed state of CXCR• 4 Of the several OSCC cell lines, only KOSCC-25B showed the high expression of CXCR-4 in both RT-PCR and Western blot analysis, siRNA-CXCR-4 infected subclones of KOSCC-25B(Si, 3‘ Si 1이 showed downregulation of CXCR-4 expression as expected‘ At serum-free co ndi tion‘ Si.3 s ubclone s ignif icantly decreased cell proliferations at 24 h and 48h and Si, lO subclone significant ly dec reased cell proliferations at 24 h Si ,3 clone dec reased to 67 ,4% and Si,lO clone to 65 ,5% in comparison to vector infected cells These data suggest that the downregulation of CXCR-4 expression could induce anti-rnigratory and ant i- rni g ratory effect

The silica nanoparticles were used as support of catalyst, filling material, electronic assembler, thin film material, and sensor material. And, the titania nanoparticles were used as pigment, dielectric substance, sensor and photocatalyst. In this paper, the spherical composite particles of TiO2/SiO2with narrow size distribution and phase pure were synthesized by ultrasonic spray pyrolysis method from TiOSO4 and colloidal silica solution. Using ultrasonic apparatus, this starting solution was vaporized to droplets, and these droplets were induced into tube furnace by carrier gas. The resulting composite powder was characterized by scanning electron microscopy, X-ray diffraction analysis, TG-DTA, in vitro sun protection factor(SPF) and BET surface area analysis.

Alterations in cell surface receptors and adhesion molecules which regulate cell-cell and cell-matrix interactions have been 뻐plicated in tumor processes. In order to investigate the effect of integrin expression on the invasiveness of oral sqllamous cell carcinoma, integ띠1 expression in the celllines such as SCC-4, SCC-9, SCC-15, and SCC-25 was analyzed, and the comparison between cell adhesion assay towards extracellular matrix proteins and in vitro invasion assay following inhibition of the functional domain of the integrins using blocking antibodies against the specific integrins 낀 nd Arg-Gly-Asp (RGD) peptide were carried out. The expression of integrin a 2, a 3, a 6 was detected in all oral squamous cell carcinoma celllines. In contrast, the expression of a vß6 integrin is detected in SCC-4 and SCC-9, not in SCC-1 5 and SCC-25. 까1e adhesion of SCC-4 cell line to collagen 1, laminin, and fibronectin was significantly reducecl by σeatment with a 3-, a 6-, and a vß6-blocking antibody, respectively (p (0.05). 꺼.1e invasion of SCC-4 cell line throllgh Matrigel was significantly reduced by treatment with v 6-blocking antibody and RGD pepticle (p(0.05). These results sllggested that specifìc integrins play an in1portant role in the process of adhesion and invasion of oral squamous cell carcinoma cells and the expression of a vß6 integrin is believed to the enhance its invasivene잃.

Background : Ginseng (Panax ginseng C. A. meyer) is a medicinal herb which has been used for prevention and treatment of diseases in Korea, China and Japan for a long time. Ginseng is well known to have effects such as immunity enhancement, anticancer, antioxidative effect and blood circulation improvement. These pharmacological effects of ginseng have been reported to be due to various ginsenoside components. Recently, many studies have been actively conducted to identify the major components and functionalities of ginseng berry. Ginsenoside, a representative active ingredient of ginseng, is distributed in various parts of ginseng. However, contents of certain ingredient such as ginsenoside Re which have antidiabetic effect is higher in ginseng berry. This study was conducted to compare ginsenoside content and UV blocking effect according to the color of ginseng berry. Methods and Results : The ginseng berry extracts for the component analysis and UV-blocking effect test were obtained by harvesting the ginseng berry by color in 4-years-old ginseng cultivated, and then removing the seeds and extracting only the flesh of the ginseng berry and the peel with methanol. Ginsenosides analysis was carried out by dissolving 100 ㎎ of the extract in 2 ㎖ of methanol, filtering it with a 0.50 ㎛ filter and using it as a sample for HPLC analysis. Analysis of ginsenoside content showed that the total ginsenoside and ginsenoside Rb2 content of yellow ginseng berry were 23.9 and 2.9 ㎎/g, while those of red berry was 19.6 and 2.3 ㎎/g, respectively. The UV blocking effect of yellow ginseng berry was 17.4%, which was higher than that of red berry. Conclusion : The ginsenoside content and UV blocking effect of yellow ginseng berry were superior to those of red berry. These results suggested that yellow berry is more useful as cosmetic material for UV protection.

블루라이트는 가시광선영역의 파장 중 가장 에너지가 높은 파장으로 피부노화 유발 및 활성산소를 유발하는 것으로 알려져 있으며, 피부의 유해 기작에 관한 연구가 진행 중이다. 화장품 분야에서의 블루라이트 차단 소재 연구 및 관련 제형연구는 아직 초기 단계에 있으며, 블루라이트 차단 측정과 관련된 시험법 또한 명확하게 정립되어 있지 않다. 블루라이트 차단 효능 평가 시험법은 해외 자외선 차단제의 차단효과 평가 방법을 참고하여 확립하였다. 국내에 고시되어 있는 자외선 차단제 원료 27종 중 17종에 대하여 블루라이트 차단효과를 평가하였으며, 블루라이트 차단 효과는 징크옥사이드가 14.97%, 비스에칠헥실옥시페놀메톡시페닐트리아진이 16.32%, 메칠렌비스-벤조트리아졸릴테트라메칠부틸페놀이 35.47%, 티타늄디옥사이드가 65.96% 순으로 나타났다. 또 한 동일 함량의 티타늄디옥사이드의 입자크기에 따른 블루라이트 차단효과를 확인한 결과 Nano-티타늄디옥사이드 보다 Micro-티타늄디옥사이드가 두 배 이상의 차단효과가 높게 나타냈다. 제시된 블루라이트 차단효과 평가 시험법은 블루라이트 차단 소재 탐색 및 화장품 제형 연구에 활용될 수 있을 것이다.