Animal experiments have demonstrated the effectiveness of fermented rice germ and soybean extracts in lowering blood alcohol concentration. A compound primarily derived from fermented soybean extract constitutes the principal component of DA-5521, an experimental dietary substance examined in this study. We investigated the possible hangover-alleviating effects of DA-5521 in individuals aged 19 to 50 who had previously experienced hangovers. Moreover, we enrolled 22 participants who met the eligibility criteria and conducted a double-blind, randomized, placebo-controlled crossover trial. Six hours after alcohol consumption, the test group exhibited a statistically significant reduction in blood acetaldehyde concentration compared with the placebo group. Further, our results displayed significantly lower levels in the DA- 5521 group at 0.50 and 0.75 h post-ingestion and substantially lower peak breath alcohol concentration compared to the placebo group. These findings confirm that consumption of DA-5521 can significantly ameliorate hangover symptoms by diminishing blood acetaldehyde concentration and reduce breath alcohol concentration.

목적 : 작업기반 가정방문 작업치료 중재를 통해 신경행동 문제와 일상생활활동 및 작업수행에 미치는 영향을 알아보고자 하였다. 연구방법 : 본 연구는 14명을 모집하여 무작위 배분으로 실험군 7명, 대조군 7명을 나누었고, 대조군은 사전·사후 평가만 실시하였고, 실험군은 주 2회, 총 8회기동안 작업기반 가정방문 작업치료 중재를 제공 하였다. 결과 : 작업치료 중재를 실시한 실험군에서 전반적 신경행동손상의 감정적/정서적 장애, 그 밖의 장애 항목과 구체적 신경행동손상의 조직화/순서화 항목에서 유의미한 장애 감소가 나타났으며, 일상생활활동 옷 입기 항목에서도 유의미한 기능 증진이 나타났다. 작업수행에서는 수행도와 만족도 항목에서도 유의미한 증진이 나타났으며, 중재를 실시하지 않은 대조군에서는 모든 항목에서 유의미한 변화가 나타나지않았다. 결론 : 작업기반의 가정방문 작업치료 중재를 실시하여 신경행동 문제와 일상생활활동 및 작업수행의 변화를 확인하였다. 본 연구를 지역사회에 거주하는 뇌졸중 환자를 위해 다양한 중재를 적용하기 위한 근거로 활용하길 권고한다.

Background: Short foot exercise, which is an intrinsic foot muscle exercise proposed by the foot core system, is used to improve the strength of intrinsic foot muscles and sensory input and function of the foot. However, there is a lack of studies that assessed the improvement in foot function after short foot exercise in patients undergoing rehabilitation after a modified Broström operation of the ankle joint. Objectives: To investigate the effects of short foot exercise on intrinsic foot muscle cross-sectional area and balance ability in patients who had undergone a modified Broström operation of the ankle joint. Design: A single blind, randomized controlled trial. Methods: Sixteen patients who were undergoing ankle rehabilitation exercises following the modified Broström operation were randomized into two groups. General physical therapy, short foot exercises, and ankle rehabilitation programs were performed in the experimental group (n=8), whereas general physical therapy and ankle rehabilitation programs were performed in the control group (n=8). For outcome measures, the intrinsic muscles of the foot were imaged using the Sonimage HS1 musculoskeletal ultrasound system. The Y-balance test and RS-foot scan system were used to confirm dynamic balance ability and static balance ability. Results: The cross-sectional area of the abductor hallucis and dynamic balance ability significantly improved in the experimental group that underwent short foot exercise compared to the control group (P<.05). In contrast, static balance ability was not significantly different between the two groups (P>.05). Conclusion: Short foot exercise successfully increased the cross-sectional area of the abductor muscle and improved dynamic balance after a modified Broström operation

Background: Although studies have been conducted on muscle thickness and balance in trunk stabilization exercise and exercise using vibration props, studies on trunk stabilization exercise using active vibration for spinal alignment are still insufficient to draw a conclusion. Objectives: To investigate the effect of trunk stabilization exercise using active vibration on the spinal alignment in adult females. Design: A randomized controlled trial. Methods: Twenty-six adult females were randomly assigned to the experimental group (active vibration) and 13 control groups (active non-vibrating) and exercised three times a week for 8 weeks. Each group was measured for spinal alignment before exercise and 8 weeks after exercise. Spinal alignment, trunk imbalance, pelvic tilt, and pelvic torsion were measured using a spinal alignment analyzer. Results: Trunk imbalance was a significantly different depending on the time in the experimental group and the control group (P<.05). Pelvic tilt was a significant difference between the groups (P<.05). Also, pelvic tilt was a significantly different depending on the time in the experimental group (P<.05), but the control group showed no significant difference (P>.05). Pelvic torsion was no significant difference in both groups (P>.05). Conclusion: This study demonstrates that trunk stabilization exercise using active vibration has a positive effect on the alignment of the spine.

Background: It has been argued that changes in muscle activity in the upper trapezius and serratus anterior may or may not cause shoulder joint pain and dysfunction. Objective: To investigate the effects of active vibration exercise on muscle activity regarding scapular stabilization using a flexi-bar. Design: A randomized controlled trial. Methods: A total of 24 subjects were randomly assigned to a flexi-bar group with active vibration and general stick group with non-active vibration. Both groups performed the same four action programs for 6 weeks, three times a week for 30 minutes at a time. The upper trapezius muscle, middle trapezius muscle, lower trapezius muscle and serratus anterior muscle of the dominant side was measured by electromyography before and after the 6 weeks of exercise. The independent t-test and paired t-test were used to analyze data. Results: There was a significant difference between groups in upper trapezius muscle and serratus anterior muscle activity after exercise (P<.05). Also, there was a significant difference in upper trapezius muscle and serratus anterior muscle activity before and after exercise in the flexi-bar group (P<.05). Conclusion: This study demonstrates that active vibration exercise using a flexi-Bar contribute to reduce the activity of the upper trapezius muscle and promote the activity of the serratus anterior muscle.

This study aimed to identify the effects of kinesio taping (KT) applied in a proprioceptive neuromuscular facilitation (PNF) pattern on the pain, weight-bearing distribution (WBD), and walking ability of knee osteoarthritis (KOA) patients. Thirty women with KOA were randomly allocated to a control group (n=15) with KT at the quadriceps only, and a PNF pattern group (n=15) with KT at the quadriceps and gastrocnemius muscle. Pain intensity was measured using a visual analogue scale during walking. In addition, WBD, and walking ability were measured before and 30 minutes after KT application. The VAS significantly reduced in both groups after the intervention (p<.05). WBD (p<.05, ES=.32) and walking ability (p<.05, ES=.38) showed a significant change in the PNF pattern group, and in the inter-group comparison, the PNF pattern group showed a significant difference compared to the control groups. These results demonstrate that KT application with PNF pattern effectively attenuate the pain and improves WBD and walking ability in KOA patients.

The original focus of this study was to investigate the immediate effects of lumbar rotational mobilization on the one-legged standing ability. Fifteen subjects (6 men and 9 women, mean age = 22.77 (SD = 1.21), mean height = 165.46cm (SD = 11.65), mean weight = 61.46kg (SD = 8.29) volunteers from healthy individuals were recruited and randomized to a lumbar rotational mobilization (LRM) group and a trunk rotational exercise (TRE) group. Mobilization (grade 3 or 4) was applied to the LRM group on the lumbar spine (L1 to L5) in a side-lying, and trunk twist exercise (left and right side) was applied the to the TRE group with lunge position. Center of pressure (COP) and the velocity of the center of pressure (VCOP) of each participant were measured as a balance ability through one leg standing position. Results are as follows. In within-group difference, the COP of the LRM group reduced during standing with the right foot, but the VCOP change of the LRM was not statistically significant. In between-groups difference, COP of TRE group was decreased compared with LRM group only during left leg standing in the eyes (p <.05). The results of this study suggest that LRM is more effective than TRE in improving balance ability.

목적 : 본 연구는 작업치료 중심의 복합 인지재활이 경도 치매 환자의 인지기능에 미치는 영향을 분석하고 자 시행하였다. 연구방법 : 경도 치매 환자 40명을 실험군 20명과 대조군 20명으로 무작위 배정하였다. 실험군에는 작업치 료 중심의 복합 인지재활, 대조군에는 인지자극과 인지훈련의 전통적 방식의 중재를 시행하였다. 중재는 실험군과 대조군에 주 2회, 1회기에 2시간, 총 14회기를 진행하였다. 인지기능 검사 도구인 인지 수준 판별검사(Allen Cognitive Level Screen; ACLS), 한국형 간이정신 상태검사(Korean version of Mini-Mental State Examination; K-MMSE), 길만들기 검사-A(Trail Making Test-A; TMT-A) 를 이용하여 사전검사 및 사후검사를 시행하였다. 결과 : 작업치료 중심의 복합 인지재활과 인지자극과 인지훈련의 전통적 방식의 중재를 비교하면 고위 인지 기능을 판별하는 ACLS에서 실험군의 결과가 대조군보다 통계적으로 유의하게 향상된 것으로 나타났다 (p<0.05). MMSE-K, TMT-A는 실험군의 향상이 대조군보다 컸지만 통계적으로 유의하지는 않았다 (p>0.05). 결론 : 작업치료 중심의 복합 인지재활이 경도 치매 환자의 고위 인지기능을 증가시키는 데 효과가 있는 것 으로 확인되었다.

목적 : 본 연구는 가상현실 프로그램이 뇌졸중 환자의 실행 기능, 균형능력에 미치는 영향을 알아보고자 하 였다. 연구방법 : 발병 6개월 이후의 뇌졸중 환자 64명을 대상으로 하였고, 무작위 난수 생성 기능을 사용하여 가상현실 치료군과 비디오 관찰군으로 두 집단을 나눈 뒤 하루 20분, 주 3회, 5주간 실시하였다. 가상현실 치료군에는 NintendoⓇ 사의 Wii FitTM을 사용한 가상현실 치료(Virtual Reality Therapy; VRT)를, 비디오 관찰군에는 Wii FitTM의 데모 비디오 관찰(Video Observation; VO)을 시행하였으며 동일 기간 동안 20분의 일반 작업치 료 및 운동치료를 함께 중재 받았다. 중재 전·후의 차이를 비교하기 위하여 한국판 행동 통제 척도(Korean version of Behavioral Dyscontrol Scale; BDS-K)와 기능적 뻗기 검사(Functional Reaching Test; FRT), 일어나 걸어가기 검사(Timed Up and Go test; TUG)를 사용하였다. 결과 : 실험 결과 두 집단의 중재 후 점수 간 비교에서 BDS-K에 유의한 차이를 보였다(p<.05). 또한, 가 상현실 치료군의 중재 전-후 변화를 분석한 결과 BDS-K, FRT, TUG에서 대조군보다 유의한 증가를 보였다(p<.05). 결론 : 본 연구에서는 가상현실 프로그램을 받은 집단에서 실행 기능과 균형능력의 향상을 보였으며, 중재 후 두 집단의 비교 결과 실행 기능에 향상이 있음을 확인하였다. 본 연구의 결과를 통해 가상현실 프로 그램을 수행하고자 하는 치료사들에게 임상적 결정을 내리는 기초 자료를 제공하고자 한다.

Background: Many studies regarding task-oriented training have recently demonstrated functional improvement in patients with post-stroke hemiparesis. The task-oriented approach is very diverse, and chronic stroke patients must have access to a sustained systematic treatment program to enhance their walking ability. Objectives: This study aimed to compare the effects of the task-oriented circuit training and treadmill training on walking function and quality of life in patients with chronic stroke. Methods: Fourteen patients with chronic stroke volunteered for this study. The subjects were randomly divided into a task-oriented circuit training group and a treadmill training group with 7 patients in each. Each training regimen was performed for 30 min a day and 3 days a week for 4 weeks. Assessment tools included the Timed Up-and-Go Test (TUGT), 10-m Walk Test, 6-min Walk Test (6MWT), and the Stroke Impact Scale (SIS). Results: The change in results of the TUGT, 6MWT, and SIS measured prior to and following the training regimens appeared to be significantly different between the two groups (p<.05). In addition, after the intervention, significant differences were found for all parameters in the task-oriented circuit training group and for the TUGT, 6MWT, and SIS in the treadmill training group (p<.05). Conclusion: The findings suggest that task-related circuit training and treadmill training may be helpful to improve walking function and quality of life of patients with post-stroke hemiparesis. Additionally, a task-related circuit training program may achieve more favorable outcomes than a treadmill program.

The purpose of this study is to explore the effects of mobilization of C0-C1 and C7-T1 applied to asymptomatic individuals with reduced upper cervical rotation during the FRT. Design: parallel randomized controlled trial. 48 subjects(38.52 years±15.13) with C1-C2 rotation hypomobility in TFR joined the study and were randomized into three groups(C0, C7, control group). FRT in both directions was measured before and after the intervention. C0 intervention consisted of a dorsal translatoric mobilization of C0-C1 in the cervical neutral position. C7 intervention consisted of a ventral cranial translatoric mobilization of C7- T1 in neutral position and the control group maintained a supine position. C0 group experienced a FRT ROM to the restricted side increase of 17.64。(SD=4.55), that was significantly greater (P<0.001) than 5.95。 (SD=4.81) of the C7 group and 2.45。(SD=5.05) of the control group. The results showed that a dorsal translatoric mobilization of C0-C1 in neutral position restored the physiological FRT mobility in subjects with C1-C2 hypomobility and experienced statistical significant improvement in FRT as compared to a C7-T1 translatoric mobilization and a control group. (Level of evidence: 1b).

This study aimed to determine the effect of lower trapezius muscle strengthening exercises on pain, neck disability index (NDI), cervical range of motion (ROM), and lower trapezius muscle strength in patients with unilateral neck pain. Following baseline measurements, the subjects (N=40) with unilateral neck pain were randomized into one of two 5 weeks exercise intervention groups: a experimental group (EG, n1=20) that received strength training of the lower trapezius muscles or a control group (CG, n2=20) that received routine physical therapy program. Each group participated in the intervention for 30 minutes, 3 times a week, for 5 weeks. All participants performed 2 repetitions of each intervention per day. The numeric pain rating scale for pain, NDI, ROM, and lower trapezius strength were recorded both pre- and post-intervention for both groups. Paired t-tests were used to determine significant changes post-intervention compared with pre-intervention and independent t-tests were used to analyze differences in the dependent variables between the 2 groups. After the 5-weeks intervention, both groups experienced significantly decreased pain and disability level (p<.05) and significantly increased cervical flexion, extension, lateral flexion, and rotation ROM (p<.05). The EG that received strength training of the lower trapezius muscles showed greater improvements in pain and functional disability level, cervical rotation, and lower trapezius strength than the CG (p<.05). These results suggest that a lower trapezius strengthening exercises reduce neck pain and neck disability level and enhance cervical ROM and lower trapezius strength level in patients with unilateral neck pain.

목적 : 본 연구는 두 가지 유형의 근전도 유발 신경근 전기자극치료를 이용하여 뇌졸중 환자의 마비측 상지 기능과 일상생활활동에 미치는 영향을 알아보고자 하였다. 연구방법 : 뇌졸중 발병 6개월 이내의 아급성기 뇌졸중 환자 20명을 대상으로 무작위 대조 실험을 진행하였다. 두 집단을 대상으로 근전도 유발 전기자극치료와 상상 훈련 결합된 근전도 유발 전기자극치료를 하루 20분간, 주 5회, 4주간 실시하였다. 상지기능평가로 울프운동기능평가(Wolf Motor Function Test; WMFT), Fugl-Meyer Assessment (FMA)를 사용 하였으며 일상생활활동 평가로 수정바델지수(Modified Barthel Index; MBI)를 사용하였다. 결과 : 1) 4주간의 중재 후, 상상 훈련 결합된 근전도 유발 전기자극치료를 받은 집단에서 FMA와 WMFT의 통계학적 유의한 향상을 보였다(p<.01). MBI 평가 역시 통계학적 유의한 향상을 보였으며 특히 개인활동 항목에서 유의한 향상을 보였다(p<.05). 2) 근전도 유발 신경근 전기자극치료를 받은 집단의 경우 FMA의 손목 움직임 항목과 WMFT에서 유의한 향상을 보였다(p<.05). 또한 MBI 전체 점수에서 통계학적 유의한 향상은 없었지만 개인활동 항목에서만 통계학적 유의한 향상을 보였다(p<.05). 결론 : 본 연구를 통해 두 유형의 근전도 유발 신경근 전기자극치료는 급성기 뇌졸중 환자의 상지 운동 회복과 일상생활활동에 효과적인 치료라는 것을 알 수 있었다.

목적 : 본 연구는 만성 뇌졸중 환자를 대상으로 상상훈련과 근전도 유발 신경근전기자극의 결합된 치료가 마비측 상지 기 능과 일상생활활동에 미치는 영향을 알아보고자 하였다. 연구방법 : 2012년 8월부터 2013년 2월까지 K의료원에 외래 치료 중인 44명의 만성 뇌졸중 환자를 대상으로 무작위 대 조 실험을 하였다. 두 집단은 전통적 재활치료와 함께 실험군은 상상 훈련과 근전도 유발 전기자극의 결합된 치료를, 대조군은 일반적인 전기자극치료를 회당 30분간, 주 5회, 6주간 실시하였다. 상지기능평가로 Fugl-Meyer Assessment (FMA)와 Manual Function Test (MFT)를 사용 하였으며 일상생활활동 평가로 수정바델지수(Modified Barthel Index; MBI)를 사용하여 중재 전·후 평가를 실시하였다. 결과 : 1) 6주간의 중재 후 실험군의 FMA, MFT 점수의 비교 결과 통계학적 유의한 변화를 보였다(p<.01). 2) 실험군의 MBI 점수의 비교 결과 통계학적 유의한 변화는 없었다. 하지만 개인위생과 옷 입기 항목에서 통계학적 유의한 변화를 보였다(p<.05). 반면 대조군의 경우 약간의 점수 향상은 있었지만 모든 평가에서 통계학적 유의한 변화는 없었다. 결론 : 만성 뇌졸중 환자를 대상으로 상상훈련과 근전도 유발 전기자극의 결합된 치료가 기능적 전기자극치료에 비해 뇌 졸중 환자의 마비측 상지기능을 향상 시킨다는 것을 확인하였으며, 손의 움직임과 관련된 일상생활활동 수행능력에도 영향을 미친다는 것을 알 수 있었다.