Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer and is associated with high recurrence, poor treatment, and low survival rates. Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that regulates the response to hypoxia, a major factor in the tumor microenvironment that affects tumor development and progression in various cancer types. However, microRNA (miRNA) sequence analysis revealed that only a few miRNAs targeting HIF-1α had been discovered. In the present study, we investigated HIF-1α expression in OSCC and the effect of HIF-1α-targeting miRNAs on the progression and metastatic potential of OSCC. We analyzed public databases to explore which miRNAs target HIF-1α expression. In addition, the expression of proteins involved in the cell cycle, proliferation, and apoptosis in HSC-2 cells was analyzed after miRNA-126 mimic treatment. Furthermore, to investigate the effect of miRNA-126 on the proliferation and invasion ability of OSCC cells, 5-ethynyl-2′-deoxyuridine and Transwell assays were performed. The activities of MMP-2 and MMP-9 were evaluated via gelatin zymography. Our results showed that miRNA-126, which targets HIF-1α, enhances OSCC cell proliferation by regulating the cell cycle and reinforces the cell mobility of OSCC via HIF-1α expression. These findings suggest that miRNA-126 may be a novel marker for OSCC treatment and the development of new tools for patients with OSCC.

Recently, the Defense Advanced Research Projects Agency(DARPA) in the United States is studying a new concept of war called Mosaic Warfare, and MUM-T(Manned-Unmanned Teaming) through the division of missions between expensive manned and inexpensive unmanned aircraft is at the center. This study began with the aim of deriving the priority of autonomous functions according to the role of unmanned aerial vehicles in the present and present collaboration that is emerging along with the concept of mosaic warfare. The autonomous function of unmanned aerial vehicles between the presence and absence collaboration may vary in priority depending on the tactical operation of unmanned aerial vehicles, such as air-to-air, air-to-ground, and surveillance and reconnaissance. In this paper, ACE (Air Combat Evaluation), Skyborg, and Longshot, which are recently studied by DARPA, derive the priority of autonomous functions according to air-to-air collaboration, and use AHP analysis. The results of this study are meaningful in that it is possible to recognize the priorities of autonomous functions necessary for unmanned aircraft in order to develop unmanned aerial vehicles according to the priority of autonomous functions and to construct a roadmap for technology implementation. Furthermore, it is believed that the mass production and utilization of unmanned air vehicles will increase if one unmanned air vehicle platform with only essential functions necessary for air-to-air, air-to-air, and surveillance is developed and autonomous functions are expanded in the form of modules according to the tactical operation concept.

Several water tanks installed in the building were damaged during the Gyeongju earthquake (2016) and the Pohang earthquake (2017). Since a water tank for fire protection is very important component, seismic safety should be ensured. In this study, an interaction between a water tank and a building was studied by the dynamic analysis of the RC building with the water tank. In case the water tank was installed on the roof of the RC building, it was confirmed that it did not significantly affect the response of the building. Based on the result, dynamic response characteristics of the water tank in the building were studied using two SDOF models represented dynamic behavior of the water tanks under earthquake. An earthquake time-history analysis was carried out with variables of aspect ratio of the tank, story of the building, and installed location in the building using three kinds of earthquakes.

In the 21st century, information and communication technology (ICT) worldwide presents a new vision for agriculture. Time and place, as well as the high-tech industry, to overcome barriers to the fusion of the so-called "smart agriculture," are changing the agricultural landscape. Core container production in precision agriculture for mushroom cultivation, optimal temperature, humidity, irradiation, self-regulation of factors such as carbon dioxide, and environment for mushroom cultivation were adopted. Lentinula edodes (shiitake) is an edible mushroom native to East Asia, cultivated and consumed in many Asian countries. It is considered to be medicinal in certain practices of traditional medicine. We used different controlled light sources (Blue-Red-White-combined LED, blue LED, red LED, and fluorescent light) with different LED radiation intensities (1.5, 10.5, and 20.5 μmol/㎡s for LEDs) to compare growth and development. Mushrooms were treated with light in a 12-hour-on/ 12-hour-off cycle, and maintained in a controlled room at 19~21°C, with 80~90% humidity, and an atmospheric CO2 concentration of 1,000 ppm for 30 days. Growth and development differed with the LED source color and LED radiation intensity. Growth and development were the highest at 10.5 μmol/㎡s of blue LED light. After harvesting the fruit bodies, we measured their weight and length, thickness of pileus and stipe, chromaticity, and hardness. The 10.5 μmol/㎡s blue-LED-irradiated group showed the best harvest results with an average individual weight of 39.82 g and length of 64.03 mm, pileus thickness of 30.85 mm and pileus length of 43.22 mm, and stipe thickness of 16.96 mm with fine chromaticity and hardness. These results showed that blue LED light at 10.5 μmol/㎡s exerted the best effect on the growth and development of L. edodes (shiitake) mushroom in the ICT-system container-type environment.

PURPOSES : As a research to develop a cement treated base course for an airport pavement which can enhance its drainage, this paper investigated the strength, infiltration performance and durability of the pervious concrete with respect to maximum coarse aggregate sizes and compaction methods. METHODS : This study measured compressive strength, infiltration rate, continuous porosity and freeze-thaw resistance of pervious concrete specimens, which were fabricated with five different compaction methods and different maximum aggregate sizes. In addition, in order to reduce the usage of Portland cement content and to enhance environment-friendliness, a portion of the cement was replaced with Ground Granulated Blast Furnace Slag (GGBS). RESULTS: Compressive strength requirement, 5 MPa at 7 days, was met for all applied compaction methods and aggregate sizes, except for the case of self-compaction. Infiltration rate became increased as the size of aggregate increased. The measured continuous porosities varied with the different compaction methods but the variation was not significant. When GGBS was incorporated, the strength requirement was successfully satisfied and the resistance to freezing-thawing was also superior to the required limit. CONCLUSIONS: The infiltration rate increased as the maximum size of aggregate increased but considering construct ability and supply of course aggregate, its size is recommended to be 25mm. With the suggested mix proportions, the developed pervious concrete is expected to successfully meet requirements for strength, drainage and durability for cement treated base or subbase course of an airport pavement.

흑사병과 종교전쟁들로 인한 죽음과 파괴의 참상을 처참하게 경험한 시대에 과연 음악이 당대의 현실을, 당대 예술창작의 거대 주제였던 ‘바니타스’를 외면할 수 있었겠는가에 대해 의심을 품고 시작한 이 고찰의 끝에서 얻어지는 결론은, 바니타스의 주제가 당대 바로크 음악의 한 켠에 명료히 자리하고 있었다는 것이다. 그렇게 팜필리와 헨델의 오라토리오 《시간과 깨달음의 승리》(Il trionfo del Tempo e del Disinganno)에 문학과 회화의 바니타스 알레고리들이 수용되어 있고, 푀르스터의 《부자와 가난한 나사로의 대화》(Dialogo de Divite et Paupere Lazaro)에는 바니타스 개념의 근원인 구약성경의 전도서 구절이 강력하게 천명되고 있다. 바니타스의 메시지가 《시간과 깨달음의 승리》에서처럼 대본의 구도에 스며있기도, 《부자와 가난한 나사로의 대화》에서처럼 또 다른 중심적 메시지를 압도하며 존재하기도 한다. 바니타스의 상징들 및 메시지에 대한 작곡가의 취급도 섬세해서 음정과 선율, 화성, 악기 및 성부 편성 등에 의해 그것들이 정교한 음악적 색채를 덧입는다.

콘크리트는 내화재료로서 우수한 성능을 발휘하지만 화재가 지속됨에 따른 재료특성 변화 또는 성능저하의 위험을 갖는다. 이 연 구는 실물모형 철근 콘크리트 (RC) 보를 활용하여 비재하 화재 실험을 수행하여 화재노출 전후의 콘크리트 및 보강철근의 재료특성을 실험적 으로 분석한 연구이다. 화재실험에 사용된 보는 길이 4 m의 RC 보로서 KS F 2257 화재실험 규격에 따라 시험 체를 제작 및 화재실험을 수행하 였다. 화원의 가력은 ISO 834의 표준화재 곡선을 사용하였으며 보 가열부에서의 온도를 계측하고자 하면 및 측면에 열전대를 설치하였다. 실 험결과, 화재에 노출된 화재 코어 공시체의 경우 약 11 MPa로 약 66%의 강도저하가 발생하였다. 화재에 직접 노출된 철근의 경우 노출되지 않 은 철근에 비해 약 17%에 해당하는 75 MPa의 항복강도 저하를 나타낸 것으로 분석되었다. 철근의 경우 콘크리트라는 내화피복에 의하여 보호 되어 약 4시간의 화재 실험에서도 온도는 한계온도의 최댓값인 649°C를 크게 상회하지 않는 것으로 나타났다.

This study carried out a fire test for the RC beam to investigate fire performance. It includes the analysis for materials strength change of concrete and steel and heat transfer capacity of the concrete beam. Fire curve and standard test method was applied with ISO 834 and KS F 2257, respectively. The result of fire test will be used for parametric study using numerical analysis to verify heat transfer characteristic of RC beam structure.

Up to date, the specifications of construction and maintenance for airport pavement are primarily from ICAO (International Civil Aviation Organization), IATA (International Air Transport Association) or FAA (Federal Aviation Administration). In order to consider circumstances such as rainfall characteristics, this study aims to develop pervious concrete for base course of an airport pavement. Strength characteristic of pervious concrete was investigated with respect to different maximum course aggregate size. When 25mm sized aggregate was used, greatest strength was achieved.