Magnetic nanoparticles have a significant impact on the development of basic sciences and nanomedical, electronic, optical, and biotech industries. The development of magnetic structures with size homogeneity, magnetization, and particle dispersibility due to high-quality process development can broaden their utilization for separation analysis, structural color optics using surface modification, and energy/catalysts. In addition, magnetic nanoparticles simultaneously exhibit two properties: magnetic and plasmon resonance, which can be self-assembled and can improve signal sensitivity through plasmon resonance. This paper reports typical examples of the synthesis and properties of various magnetic nanoparticles, especially magnetoplasmonic nanoparticles developed in our laboratory over the past decade, and their optical, electrochemical, energy/catalytic, and bio-applications. In addition, the future value of magnetoplasmonic nanoparticles can be reevaluated by comparing them with that reported in the literature.

In the recent business environment, risks related to product safety problems are increasing. These are arising from various factors such as increasing product and production complexity, supply chain diversification, enhanced PL (product liability) law and strengthening regulations of the government. Accordingly, ISO (international organization for standardization) published standards of PSMS (product safety management system) for suppliers such as ISO 10377 and ISO 10393. Meanwhile, the ISO 9001 QMS (quality management system) was revised in 2015, and it has established itself as an effective tool that can consistently meet the various requirements of stakeholders and promote customer satisfaction. This study aims to suggest an integration framework of QMS and PSMS based on the recent ISO international standards. To this end, firstly, the relationship between QMS and PSMS is studied based on the quality and product safety definitions, PDCA (plan-do-check-act) cycle and risk-based thinking. Secondly, the requirements of ISO 10377 and ISO 9001 are compared and classified as the common and ISO 10377 specific requirements. Finally, integration steps of two systems are suggested and guidelines that can systemize the integrated requirements are presented in the aspect of processes and documentation. This study is expected to be used as a guideline that helps companies those have already acquired QMS certification to build an international-level product safety management system early.

The ISO 9000 Quality Management System(QMS) standard is an effective tool that can consistently meet the various requirements of stakeholders and promote customer satisfaction management. However, in the recent business environment, not only quality issues but also risks in various other areas are increasing. In particular, risks related to product safety problems which are arised from product convergence, diversification of methods of production and globalization of supply chain pose a great threat to the sustainability of companies. Accordingly, ISO published standards of Product Safety Management System(PSMS) for suppliers such as ISO 10377 and ISO 10393. This study aims to suggest an integration framework of QMS and PSMS based on ISO international standards. To this end, the relationship of QMS and PSMS are analyzed and the requirements of the both systems are integrated based on the Plan-Do-Check-Act(PDCA) cycle and risk-based thinking. In addition, guidelines that can systemize the integrated requirements are presented in the aspect of processes and documentation. This study is expected to be used as a guideline that helps companies that have already acquired QMS certification to build an international level product safety management system early.

동물들은 항상성 유지를 위해서 지방에 축적된 에너지의 양을 판단하고 섭식량을 조절한다고 알려져 있으나 그 조절 메카니즘은 아직 확실히 알려져있지 않다. 본 연구에서는 노랑초파리로 지방세포에서 섭식조절과 관련된 유전자를 찾기 위해 mRNA의 과발현을 이용한 1차 스크리닝(screening)과 RNAi를 이용한 2차 스크리닝을 수행하여 지방세포에서 발현하는 유전자 purple이 섭식조절과 관련이 있다는 것을 확인하였다. 유전자 purple은 조효소인 tetrahydrobiopterin (BH4)의 생합성에 관여하는 유전자인데, 연구결과 BH4생합성에 관련된 다른 유전자인 Punch와 Sepiapterin Reductase (Sptr) 뿐만 아니라 BH4도 섭식행동을 조절하는데에 관여한다는 것을 밝혀냈다. 흥미로운 사실은 Punch와 purple은 지방에서 발현되어야 하는 반면 Sptr은 뇌에서 발현되어 섭식행동을 조절한다는 사실이다. 추가연구를 통해 BH4가 섭식에 관련된 뉴런인 neuropeptide F (NPF)을 억제하여 섭식억제가 이루어지는 사실을 확인하였다. 본 연구는 새로운 유형의 섭식억제제 개발에 기초적인 정보를 제공할 것으로 보인다.