According to enhancement of roles and functions of enterprises’ distribution centers, recent trend of distribution centers are specialization and diversification which have generated lots of new distribution center building or expansion of the existing ones and led attention on stock transfer importance in case of distribution center relocation. This thesis is a study for how to reduce stock transfer leadtime in order to minimize business risk and how to increase inventory accuracy when stock ownership is transferred in case of distribution center relocation, and to provide inventory accuracy management methods and inventory in/out management types, detailed definition to evaluate level for inventory accuracy management and pros/cons by inventory in/out management type assuming ‘the higher inventory accuracy before stock transfer, the shorter stock transfer leadtime when distribution center is relocated'. This thesis provides detailed procedure to secure an absolute stock transfer leadtime and process to confirm hugh inventory accuracy by stakeholders which should be sloved by Task Force Team for stock transfer in case of distribution center relocation.

The investigation on the lightweight of automobiles has been underway in commercial vehicles as well as passenger cars due to global warming and strengthening of European emission standards. In this study, the V-arm were developed for lightweight parts using aluminum alloy instead of steel with high pressure die casting processing. This study has focused on lightweight adaptive concept design. Several models of V-arm were designed and analyzed for the fluidity and solidification. V-arm was produced with ADC12 by high pressure die-casting process. The mechanical properties of developed V-arm were measured; such as tensile strength, elongation, shear strength, and durability. The possibility of mass production with the light weight aluminum V-arm substitute from the steel. The weight was reduced about 38% from 16kg to 9.98kg. The productivity was improved with decreasing the process from 8 to 5 by All-in-0ne process using high pressure die-casting.

In this study, the extrusion process of 6xxx series aluminum cast alloy for high speed train interior or exterior parts are developed. For casting, selection of optimum alloying elements, dissolution technology, de-gassing process, production of molds conforming to the conditions of use, development of casting process control technology for various shapes and materials are performed for the development of high-quality, high strength aluminum alloys. The development of more high farmable extruded aluminum casting alloys for interior or exterior materials has been the scope of this study. The extruded die design was performed for the 6063, 6061 and 6N01 alloy profiles and extrusion test was executed. From these results, the extrusion conditions such as extrusion pressure following as billet temperature and materials were carefully examined.

본 연구의 목적은 지역아동센터 정의와 발전배경을 살펴보고, 지역아동센터의 변천사에서 태동기, 발전기, 성장기, 정착기를 알아봄으로 지역아동센터 역사를 알아보았다. 태동기 1990년 이전에는 종교단체, 시민단체의 민간차원에서 공부방으로 시작되었으며, 발전기 1990년~2003년에는 아동복지법의 개정으로 법적인 제도권으로 진입하는 시기이다. 성장기 2004~2008년 전국 지역아동센터 공부방협의회를 발족하였고, 2004년 1월 법제화가 실시되었으며 2008년 지역아동센터 시범평가 실시를 통해 지역아동센터 관리의 질 향상을 꾀하였다. 지역아동센터정착기 2009년~현재 제도권 진입 후 2009년~2011년 지역아동센터 평가도입을 실시하였으며 종사자 역량 강화 교육을 실시하였고, 시설정보시스템 의무 사용으로 아동복지 종합복지 시스템으로 전환했다. 2012~2014년도 지역아동센터 평가센터를 설치 후 3년 주기의 평가지표를 구축하였다. 평가2기는 2015~2017년으로 진입평가와 심화평가로 분리하여 평가위원의 교차평가를 실시하였다. 평가 3기는 2018~2020년으로 중앙평가 운영위원회를 도입하고, 평가지표에 시설운영자의 철학을 추가하고 등급을 부여 하여 pass, non-pass시설에 컨설팅을 의무화 하므로 운영비 차별화를 주었다. 따라서 시설에서 바라보는 평가 체계 개선점을 제시함으로 지역아동센터 평가의 요소를 제고하는데 의의가 있다.

압력-분배 탈기방식으로 막접촉기를 구성하여 바이오가스 정제를 하였다. 폴리프로필렌(PP) 중공사막 모듈과 물리흡수제를 이용하여 막접촉기 성능 평가를 수행하였다. 실험은 흡수 압력, 가스의 유량, 흡수 온도 및 흡수제의 농도등 다양한 조건에서 수행하였다. 특히 CO2 흡수능이 높은 상용 흡수제인 프로필렌카보네이트(PC)와 물의 혼합흡수제를 사용하여 회수성능이 향상되었다. 탈기 방법이 개선된 압력-분배 탈기방식의 막접촉기는 50% CO2/50% CH4의 바이오가스 모사가스로부터 바이오메탄을 98% CH4 순도와 91%의 회수율로 정제하였다. 따라서 압력-분배 막접촉기를 통해 바이오가스로부터 수송용 바이오메탄의 생산이 가능함을 확인하였다.

Membrane bioreactors (MBRs) have big issue on high aeration energy. In this study, reciprocation of membrane was adapted to mitigate membrane fouling. Inertial force induced by reciprocation removed foulants from membrane surface. Pilot plant with capacity of 1,100 m³/day was operated for 8 months in Singapore. The result showed stable trans membrane pressure (TMP) and low permeate turbidity below 0.1 NTU at 25 LMH. It also showed 60 times less energy consumption than conventional MBR. Low dissolved oxygen in membrane tank resulted in higher nitrogen removal. Long-term reciprocation requires very strong membrane modules. Braid reinforced membrane and its modules were optimized to reciprocation. The evaluation of them after the operation showed there was no change in all their properties.

The new businesses started by the companies usually results in being unsuccessful. The main reasons for that are either aiming targeting wrong customers, unsatisfaction of customers’ requesting quality standards, or taking wrong actions against the competitors in the market. Therefore, companies should aim the targets for the newly developing products based on the fulfilling values for the customers when they start the new businesses, and should take good cares for risk managements at the each step of the new business to prevent the failure in advance. In addition to that, the companies starting new businesses not only need to take the customers attributes (CA) into account, but they also should apply the new technologies as one system to initiate a new business to satisfy the basic wants of the customers. This article suggests the New Product Development Pursuing Model using the Indicative Planning methodology and the Quality Management tools. The New Product Development Pursuing Model would be completed by the following steps as below; 1. Drawing the CTQ (Critical To Quality) for setting up the new product development objectives by : i) using the VOC (Voice Of Customers) obtained by the QFD (Quality Function Deploypment) if the market is mature, ii) applying AHP (Analytic Hierarchy Process) to information in the QIS (Quality Information System) if the market is unmature to get enough need information of the customers. 2. Risk Management in NPD : The NPD pursuing model consisted of the IP (indicative planning) is suggested not by the process of top-down-way mandatory planning process, but by the tools used in the administrative science and economic fields, namely by governance. The companies could apply innovative methodology for new products development processes to fulfil the customers satisfaction in the fields, through the CA (Contingency Approach) of the NPD (New Product Development) process.

In this study, a model was developed to predict for Disinfection By-Products (DBPs) generated in water supply networks and consumer premises, before and after the introduction of advanced water purification facilities. Based on two-way ANOVA, which was carried out to statistically verify the water quality difference in the water supply network according to introduce the advanced water treatment process. The water quality before and after advanced water purification was shown to have a statistically significant difference. A multiple regression model was developed to predict the concentration of DBPs in consumer premises before and after the introduction of advanced water purification facilities. The prediction model developed for the concentration of DBPs accurately simulated the actual measurements, as its coefficients of correlation with the actual measurements were all 0.88 or higher. In addition, the prediction for the period not used in the model development to verify the developed model also showed coefficients of correlation with the actual measurements of 0.96 or higher. As the prediction model developed in this study has an advantage in that the variables that compose the model are relatively simple when compared with those of models developed in previous studies, it is considered highly usable for further study and field application. The methodology proposed in this study and the study findings can be used to meet the level of consumer requirement related to DBPs and to analyze and set the service level when establishing a master plan for development of water supply, and a water supply facility asset management plan.

BMP-2 is a well-known TGF-beta related growth factor, having a significant role in bone and cartilage formation. It has been employed to promote bone formation in some clinical trials, and to differentiate mesenchymal stem cells into osteoblasts. However, it is difficult to obtain this protein in its soluble and active form. hBMP-2 is expressed as an inclusion body in the bacterial system. To continuously supply hBMP-2 for research, we optimized the refolding of recombinant hBMP-2 expressed in E. coli, and established an efficient method by using detergent and alkali. Using a heparin column, the recombinant hBMP-2 was purified with the correct refolding. Although combinatorial refolding remarkably enhanced the solubility of the inclusion body, a higher yield of active dimer form of hBMP-2 was obtained from one-step refolding with detergent. The refolded recombinant hBMP-2 induced alkaline phosphatase activity in mouse myoblasts, at ED50 of 300-480ng/ml. Furthermore, the expressions of osteogenic markers were upregulated in hPDLSCs and hDPSCs. Therefore, using the process described in this study, the refolded hBMP-2 might be cost-effectively useful for various differentiation experiments in a laboratory.

본 연구는 마이크로파 저온진공건조 기술을 이용하여 고효율 인삼개발을 하고자 하였다. 홍삼 제조 공정에서 증삼 후 60-70℃에서 24시간 동안 건조하고 다시 40℃에서 72시간동안 건조한 열풍 건 조 홍삼과 증삼 후 마이크로파 저온진공건조기에서 900 watt, 2.45 MHz, 50 mmHg 조건으로 5시간동 안 건조하고 다시 750 mmHg로 2시간동안 건조한 홍삼으로 조직 관찰, 관능평가, 진세노사이드 및 조 사포닌 함량 변화 등을 비교하였다. 그 결과, 마이크로파 저온진공 홍삼은 색도가 밝은 색으로, 표면적 은 다공성 조직으로 변화하였으며, 향미를 높이고 쓴 맛을 크게 감소시킴과 동시에 단 맛을 증가시켜 종합적인 선호도를 높였다. 또한, 단시간에 진세노사이드 Rg1과 Rb1 함량을 열풍 건조 홍삼에 비해 1시 간대에서 약 6배, 8배가 증가되었으나, Rg3 함량에서는 큰 차이가 나타나지 않았다. 마지막으로 조사포 닌 함량은 10-20분대부터 크게 증가하여 이후 지속적으로 높은 함량이 나타났다. 이와 같은 결과를 종 합해보면, 마이크로파 저온진공홍삼은 열풍 건조 홍삼에 비해 다공성 조직 변화를 통해 단시간에 진세노 사이드 및 조사포닌에 대한 추출 수율을 높이고 향미와 식감을 개선시켜 홍삼에 대한 선호도를 높일 수 있음을 확인되었다.

현재의 역삼투막 담수화는 전체 담수화 시장의 60%정도를 점유하고 있으며, 향후 2020년에는 70%까지 증가할 것으로 예상되고 있다. 역삼투막 공정의 Cost는 전처리 공정, 멤브레인 배치, 원수 및 최종 생산수의 요구수질 조건 등에 따라 다르므로, 설계에서 운영에 소요되는 모든 비용 구성을 이해하는 것이 중요하다. 대부분 전력비와 시설투자 비용에 80% 이상이며, 운영/유지보수에 20% 정도 차지한다. 당사에서는 역삼투막 전력비저감 및 고효율 전처리 개발과 운영/유지비용을 줄이기 위한 기술개발을 하고 있다. 또한 탈황 폐수처리를 위한 증발 무방류(Zero Liquid Discharge) 공정에 역삼투막(RO) 또는 정삼투막(FO) 공정을 결합하여 증발기의 용량을 줄여 열/전기에너지를 저감하는 공정 연구와 저염분 처리를 위한 전기화학 탈염 공정(CDI) 연구 개발을 수행하고 있다.