This study deals with the vibration transmissibility of a vibration isolation device, which is composed of frictional damping and nonlinear softening springs, when its base is harmonically excited. The SCAP method, a type of averaging method, is employed to obtain steady-state responses. The vibration characteristics due to excitation of the base are investigated through the analysis of displacement transmissibility in the steady-state response. In this process, displacement transmissibility for design parameters is analyzed, and the stability of the response is also investigated. The vibration isolation effect due to frictional damping is found to be more effective in the case of the softening spring than in the case of the hardening spring. Additionally, the pattern of the jump phenomenon observed during frequency sweeping, both upward and downward, has been identified.

본 논문에서는 기저 스크리닝 기반 크리깅 모델(BSKM: Basis Screening based Kriging Model) 생성의 정확도를 높이기 위해 페널티 를 적용한 최대 우도 평가 방법(PMLE : Penalized Maximum Likelihood Estimation)에 대해서 소개한다. BSKM에서 사용하는 기저함 수의 최대 차수와 종류는 그 중요도에 따라서 결정하게 되며, 이때 중요도의 지표는 기저함수에 대한 교차 검증 오차(CVE : Cross Validation Error)로 택한다. 크리깅 모델(KM : Kriging Model) 구성시 최적의 기저함수 조합은 우선 최대 기저함수 차수를 선택하고 개별 기저함수의 중요도를 평가를 하게 된다. 최적 기저함수 조합은 크리깅 모델의 CVE가 최소가 될 때까지 개별 기저함수의 중요도 가 높은 순으로 기저함수를 하나씩 추가하며 찾는다. 이 과정에서 KM은 반복적으로 생성해야 하며, 동시에 데이터 사이의 상관관계 를 나타내는 하이퍼 매개변수(Hyper-parameters)도 최대 우도 평가방법을 통해 계산하여야 한다. 하이퍼 매개변수의 값에 따라 선택 되는 최적의 기저함수 조합이 달라지기 때문에 KM의 정확도에 막대한 영향을 미치게 된다. 정확한 하이퍼 매개변수를 계산하기 위해 서 PMLE 방법을 적용하였으며, Branin-Hoo 함수 문제에 적용하여 BSKM 의 정확성이 개선될 수 있음을 확인하였다.

최근 우리는 Hg2+에 대한 높은 선택성을 가지며 Hg2+와 결합하여 밝은 녹색 형광을 보이는 tetraphenylethylene-bis(thiophen-2-ylmethyl)amine (TPE-BTA)의 착화합물(TPE-BTA-2Hg2+)의 구조를 밝혀내기 위해 시 간 의존적(time-dependent, TD) 밀도 함수 이론(DFT)을 이용하였다. 그러나 우리는 이 과정 속에서 Hg2+ 이온에 대한 모든 전자(all electron, AE) basis set인 x2c-TZVPPall만이 실험 스펙트럼에 가까운 흡수 및 형광 스펙트럼을 성공적으 로 재현한다는 것을 발견했다. 많이 알려져 있는 effective core potential (ECP) 기반인 LANL2DZ는 형광스펙트럼 계산 과 관련된 들뜬 상태의 구조 최적화 계산을 모두 실패했으며 또한, LANL2DZ는 첫 번째 들뜬 상태의 최적화 과정에서 너무 작은 형광 에너지를 제공했다. 이때 LANL2DZ는 리간드와 Hg2+ 사이의 거리가 증가함에 따라 빠르게 감소하는 HOMO-LUMO gap을 제공하는 반면, x2c-TZVPPall은 점진적으로 감소하는 안정적인 HOMO-LUMO gap을 보여줬다. 우리는 적어도 Hg2+ 이온을 포함하는 착화합물 시스템에서 ECP에서 발생하는 기하학적 문제들을 피하기 위해서는 모 든 전자 기본 세트를 사용하거나 새로운 ECP를 만들어야 된다고 조심스럽게 제안한다.

It is essential to determine a proper earthquake time history as a seismic load in a seismic design for a critical structure. In the code, a seismic load should satisfy a design response spectrum and include the characteristic of a target fault. The characteristic of a fault can be represented by a definition of a type of possible earthquake time history shape that occurred in a target fault. In this paper, the pseudo-basis function is proposed to be used to construct a specific type of earthquake, including the characteristic of a target fault. The pseudo-basis function is derived from analyzing the earthquake time history of specific fault harmonic wavelet transform. To show the feasibility of this method, the proposed method was applied to the faults causing the Gyeong-Ju ML5.8 and Pohang ML5.3 earthquakes.

In this paper, the effect of a dynamic vibration absorber to suppress the response of a base excitation vibration system composed of a cubic nonlinear spring and a friction damper is investigated. And the dynamic absorber consists of a linear spring and a viscose damper. The mathematical models of these systems are governed by second order nonlinear ordinary differential equations. The response characteristics of the system are analyzed using the slowly changing phase and amplitude(SCPA) method, which is one of the averaging methods. As a function of the friction force ratio, It was obtained the locking frequency at which the relative motion starts was obtained, and the regions where the locking occurred. The displacement transmissibility was investigated according to the change of the design parameter, and the optimal design parameters could be found to minimize the displacement transmissibility.

Clothing, as a signsystem, implies many different meanings according to different circumstances. Korean fashion designers’ designs also imply various meanings. Therefore, the purpose of this study is the exploration of Korean fashion designers’ design characteristics through Greimas’ Semiotic Square. As sublimity is the most representative characteristic of modern fashion design, this study discusses the in-depth aesthetic meaning innated in Korean fashion design through the semiotic square proposed by Greimas. To fulfill this goal, Korean fashion designers were sought after on the internet; consequently, four Korean designers became subjects for the analysis. Their collections were analyzed according to predefined criteria adopted and modified from previous studies. Sublimity characteristics were applied to Greimas’ and Floch’s semiotic squares for further interpretation. Results of the study indicate that sublimity, which is typically found in Korean fashion designs, varies depending on different points of view. In terms of culture, this study discovered a relationship of contrariety between sublimity and beauty. This finding opposes the theory of Greimas’ semiotic square, in which sublimity stands as a contradictory of the technician. According to the culture industry theory, suggested by Held, the technician is an implication of sublimity. Through a technician, sublimity may pose as a complementarity or implication of beauty. Finally, sublimity might substitute beauty as well; furthermore, it constitutes practical valorization in the semiotic square of Floch. Moreover, the artist present as a ludic valorization stands as a contradictory, while art, serving as a utopian valorization, enacts as a contrary.

Friction damping is often used as a vibration isolation medium to protect large objects from vibration. In this paper, it is modeled and analyzed a basis-excited nonlinear vibration system with friction damping using the SCPA method, which is one of the averaging methods. The displacement transmissibility and the stability of the steady state response were analyzed seperately for the linear and the non-linear spring systems. The critical frequency at which the relative motion starts was obtained as a function of the friction ratio, and the characteristics of the displacement transmissibility according to the change of the design parameters were investigated. In the case of the nonlinear spring system, the displacement transmissibilities were divided into three types and the motion characteristics were considered. In particular, there was a peculiarity that the displacement transmissibilty curve was separated at specific parameter values.

Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of squamous cell carcinoma arising in various anatomical sites. This article describes a case history of BSCC of the floor of mouth with mandibular involvement, and further discusses the appropriate management of such case with reference to the literature review. A 52-year-old male patient was referred to our clinic from another university hospital. Segmental mandibulectomy with supraomohyoid neck dissection and mandible reconstruction with left fibular free flap under general anesthesia was performed, followed by radiotherapy. Histopathological examination on the tumor lesion revealed features of squamous cell carcinoma with comedo-type necrosis. A diagnosis of BSCC was given by the oral pathology specialist. Basaloid squamous cell carcinoma (BSCC) is a biphasic variant of SCC with both basaloid and squamous cell histology. A recent report showed that there is no significant difference in the prognosis. Due to the lack of accumulated research, close follow-up and continuous research are deemed necessary. Treatment that focuses on the stage of the tumor is appropriate. A periodic follow-up observation is also very important due to the occurrence of distant metastasis to the lungs.

Burial sites are constructed for the purpose of controlling air-born livestock diseases such as avian influenza and foot-and-mouth outbreak. As most of the burial sites are located in the agricultural land use, public concerns are mounting about soil and groundwater contamination. During precipitation events, contaminated baseflows are released from the burial sites into surface waters. Baseflow are therefore required to be managed properly, by monitoring and even by remediation means. We propose each burial sites should be regarded as a point source possibly degrade groundwater, thus be managed in watershed scale for the purpose of surface water quality conservation.

Baswflow is defined as short term discharge through groundwater caused by rainfall events. Impacts of baseflow is significant on water quality especially where pervious agricultural watershed as groundwater is more vulnerable to the contamination. In this study, the Cheongmicheon watershed was subjected to study to assess the impacts of baseflow on surface water quality, where more than 90% of pollutant load is originated from the livestock raising area, and very high probability of surface water contamination due to the baseflow. To estimate nutrient loading cased by baseflow, NI (Numerical Integration) model and LOADEST (LOADing ESTimation) model were used.

Pemphigus is an autoimmune blistering disease characterized by autoantibodies against epidermal adhesion molecules, desmogleins. Pemphigus vulgaris is most common and shows intraepidermal vesicles caused by the breaking apart of epidermal cells, acantholysis. A 65 years old male patient complained of severe mucosa ulceration on his right mandibular retromolar pad area where traumatic injuries occurred during mastication. He also had multifocal round skin ulcerations, less than 7~8mm in diameter and showed habitual onset and disappeared soon. At this time he was anxious about his oral ulceration with a cancer phobia, thereby a biopsy was made to rule out any malignancy in the ulceration. The histology examination showed multifocal suprabasal splits forming vesicles and erosion. The suprabasal splits were linear and parallel to the basal cell layer. The immunostain of IgK was strongly positive in the vesicular fluid as well as the cell membranes of dissociating keratinocytes, and also positive in many plasma cells infiltrated into the subepithelial zone. TNFα, IL‐1, ‐8, ‐28 for the pro‐inflammatory reaction were weakly expressed, while IL‐6 was strongly positive in the acantholytic keratinocytes of vesicle forming area. β‐defensin‐1, ‐2, ‐3 for the innate immunity were diffusely positive in the involved epithelium. The cell survival proteins, pAKT and HSP‐70 were diffusely positive in the epithelium, while the apoptosis protein, PARP was consistently positive in some acantholytic keratinocytes. These findings indicated that the vesicle formation occurred by autoantibody reaction without the activation of pro‐inflammatory and cell‐mediated immune reactions. The lesion was diagnosed pemphigus vulgaris with abrupt onset of epithelial vesicles at the predisposing areas of traumatic injuries by type II hypersenstitive immune reaction.

최근 산림분야를 통해 탄소배출량을 줄이고자하는 노력으로 신규 및 재조림이 주를 이루던 산림정책 패러다임이 산림전용 및 산림황폐화방지를 통한 탄소배출감축(REDD) 활동에 대한 관심으로 집중되고 있다. 이에 따라 REDD 이행 성과 가시화를 위한 단계적 연구가 진행되고 있다. 본 연구는 한국의 16개 시도단위별 산림환경여건을 분류하고, 국제적으로 주요하게 사용되는 6가지 기저선 접근법을 적용하여 국가단위 REDD 프로그램 운영을 위한 최적 기저선 접근법을 도출하였다. 연구결과 일반적으로 HFLD에 대한 탄소배출권 획득량이 낮았으며, 이에 반해 LFMD, LFHD에 대한 획득량은 높게 나타났다. 이에 따라 HFLD 지역은 산지전용을 통한 개발이 더 많은 경제적 이익을 가져올 수 있기 때문에 REDD 이행 기제에 대한 참여 유인이 부족하게 된다. 모든 유형의 산림여건에서 REDD에 대한 참여를 높이기 위한 유인성과 적은 노력으로 많은 양의 탄소배출권을 획득하는 일이 발생하지 않는 실제성이 모두 적절하게 만족스러운 기저선 접근법이 필요하다. 이러한 실제성과 유인성 평가시 Corridor Approach 접근법 선택이 가장 합리적인 것으로 판단되며, 국내 적용시 발생하는 이익분배에 대한 단점을 보완하기 위해 한국형 Corridor Approach 접근법을 개발하였다.

This study aimed at investigating the gene expression profile in basal ganglia of hexa-valence chromium exposed rat based on cDNA array analysis. For cDNA array, Sprague-Dawley male rats (300 ± 25 g) were administrated with 15 mg/kg B.W/day of potassium dichromate by gavage (0.3 ml) dissolved in saline for 10 days (n=5). For dose-related gene expression analysis, rats were administrated with 0, 1, 5 mg/kg B.W/day of potassium dichromate for 10 days. Control rats were administrated with equal volume of saline (n=5). For cDNA array analysis, RNA samples were extracted from brain tissue and reverse-transcribed in the presence of [α³²P]-dATP. Membrane sets of the Atlas array II and Toxicology array kits were hybridized with cDNA probe sets. RT-PCR and Northern blot hybridization methods were employed for validation and assessment of the dose-related gene expression profile, respectively. Among the 2352 cDNAs, 43 genes showed significant (>two-fold) changes in expression. 22 genes were up-regulated and 21 genes were down-regulated in the 15 mg/kg B.W/day hexa-valence chromium treated group than control. According to the Northern blot hybridization analysis, heat shock protein 47, neurodegeneration associated protein 1 and pituitary specific growth factor 1a genes were up-regulated, but Gamma-aminobutyl-acid a1 subunit, neuroligin2, brain calcium-transporting plasma membrane type ATPase genes were down-regulated even in the low-dose of hexa-valence chromium exposed group (1 mg/kg B.W/day) than control. Genes that detected in this study may be closely related to the hexa-valence chromium-induced neurotoxicity in the rat basal ganglia and addition study of these genes can give some more useful information about the neuro-toxic mechanism by hexa-valence chromium.

53 years old female showed repeated ulceration of labial gingival mucosa at upper and lower anterior teeth, which was a partly desquamated and erythematous lesion. The lesion was slightly extended into vestibule and buccal mucosa in oral cavity, but the similar lesion was not found in other organs by medical inspection. The incisional biopsy including the border of the ulcerated mucosa and normal mucosa showed a severely inflamed mucosa, of which epithelium was gradually detached from the underlying conective tissue, so that it was diagnosed as a mucous membrane pemphigoid (MMP) pathologically. The epithelium was thinned, almost lost its rete pegs, and the basement membrane was completely distorted by the epithelial detachement. The inflammatory cell infiltration was mainly composed of small round cells and plasma cells. Immunohistochemistry was performed to know the expression of pathogenetic proteins using antisera of Igk, E-cadherin, laminin a5, elafin, and eIF5A. The basement membrane at the epithelial detachment was condensely positive for Igk, and the involved epithelium became atrophic but showed consistently positive reaction of matrix proteins and protein translation factor, i.e., E-cadherin, laminin a5, elafin, and eIF5A similar to the adjacent normal mucosa continuous to the MMP lesion. The Igk was also diffusely deposited on the basement membrane of nearby normal mucosa. Many plasma cells infiltrated around the lesion were strongly positive for Igk in their cytoplasms. Therefore, we suggest that the MMP be characterized by the deposition of Igk on the basement membrane of the detached epithelium in the absence of no other pathognomic changes of molecular events.

확장 B-스플라인 기저함수(extended B-spline basis functions)을 이용한 레벨셋 기반의 위상 형상 최적설계 기법을 정상 상태의 열전도 문제에 대하여 개발하였다. 본 해석법은 레벨셋으로 결정된 영역 안쪽만 고려하여 해석을 수행하게 되므로 열전달 문제에서 생길 수 있는 영역 바깥부분 영향을 제거할 수 있다. 설계민감도 해석으로부터 결정되는 법선속도를 활용하여 헤밀턴-자코비 방정식의 해를 구하게 되며, 주어진 체적조건 하에서 열 컴플라이언스(thermal compliance)가 최소가 되는 방향으로 최적의 형상을 결정할 수 있다. 형상 설계민감도를 정확하게 얻기 위해서는 레벨셋 함수와 B-스플라인 함수를 이용하여 수직 단위 벡터와 형상의 곡률을 정확히 결정하며, 위상 설계민감도를 통해 최적화과정 동안 필요한 위치와 시점에서 위상의 변화를 주는 홀을 쉽게 생성할 수 있다.

A case of a distinctive variety of basalαd squamous cell carcinoma (B8CC) of the floor of mouth is described Histologic evaluation of the tumor showed lobules and aggregates of medium-sized basaloid cells with distinctive periph eral palisading and focal areas of comedo- necrosis. This appearance together with microcystic spaces simulated that of an adenoid cystic carcinoma. Accompanying epithelial dysplasia of the overlying mucosa was found. Immunohistochemistry of the tumor revealed diffuse strong expression for cytokeratin AE1/3, focally positive for Epithelial Membrane Antigen in the inner cells of tubular structures However, CEA, 8-100, smooth muscle actin, and vimentin were negative. The histologic differential diagnosis considered were adenoid cystic carcinoma and adenosquamous cell carcinoma Immunohistochemistry and awareness of this unusual pattern of B8CC will facilitate the correct diagnosis being reached.

위상최적화기법을 이용하여 보의 기본고유진동수 최대화문제를 수행하였다. 도입된 위상최적화기법은 구조물의 모드형상에 의해서 발생되는 모드변형에너지를 바탕으로 한다. 최소화하고자하는 모드변형에너지를 목적함수로 하고 구조물의 초기부피를 제약함수로 채택하였다. 최적정기준법을 바탕으로 한 크기조절알고리듬을 유한요소내부에 존재하는 셀의 빈공간의 크기를 조절하기 위해 도입하였다. 세 가지의 다른 경계조건을 가지는 보를 이용하여 자유진동모드형상에 저항하는 보의 최적위상을 조사하였다. 수치해석결과로부터 도입된 위상최적화기법을 이용하여 도출한 보의 최적위상은 초기구조물에 비해 저차의 자유진동수가 크게 증가하는 것으로 나타났으며 특히 모드변형에너지를 이용하는 위상최적화의 경우에는 구조물의 기본진동수를 최대화하는데 매우 효과적인 것으로 나타났다.

This study was designed to determine the effects of different widths in the base of support (BOS) on trunk and lower extremity muscle activation during upper extremity exercise. Twenty-seven healthy male subjects volunteered for this study. Exercises were performed for a total of 10 trials with a load of 10 repetitions maximum (10 RM) for each of the various widths of BOS (10 cm, 32 cm, 45 cm). The width of a BOS is the distance between each medial malleoli when a subject was in a comfortable standing position. Electromyography was used to determine muscle activation. Surface bipolar electrodes were applied over the tibialis anterior, medial gastrocnemius, biceps femoris, rectus femoris, gluteus maximus, upper rectus abdominis, and elector spinae muscle. Electromyographic (EMG) root mean square (RMS) signal intensity was normalized to 5 seconds of EMG obtained with a maximal voluntary isometric contraction (MVIC). The data were analyzed by atwo-factor analysis of variance (ANOVA) with repeated-measures () and Bonferroni post hoc test. The results were as follows: (1) There were significant differences in the width of the BOS (p=.006). (2) The post hoc test showed significant differences with the BOS between 10 cm and 32 cm, between 10 cm and 45 cm and between 32 cm and 35 cm (p=.008, p=.003, p=.011). (3) There was no interaction with the BOS and muscle. (p=.438) There were no significant differences in the muscle activation (p=.215).