A variety of microorganisms are contained in the groundwater and surrounding environment at the depth of a deep geological repository, and could adversely affect the integrity and/or safety of the facility under certain thermal, hydraulic and chemical conditions. In particular, microbial activity (in the buffer and backfill) around the canister can cause corrosion of the canister through sulfide production by sulfate-reducing bacteria (SRB), and subsequently promote radionuclide release through the corroded part. Namely, this phenomenon is important in a perspective of performance assessment since it will have an impact on the post-closure exposure dose in the biosphere by accelerating radionuclide leakage into the near-field due to deterioration of the canister integrity In Finland, the performance assessment on microbial activity in buffer, backfill, and plug was performed for the licensing. However, in Korea, researches relevant to microbial activity are only in the early stage as of now. Accordingly, in this study, we draw initial considerations for the performance assessment on the phenomenon in the domestic facility based on review results for the methodology carried out as part of operating license application (i.e. SC-OLA). Studies on the performance assessment of microbial activity in Finland were mainly performed: (a) to investigate complex interactions among microorganisms in the repository by analyzing both indigenous and exogenous microorganisms through drilling, geological and geochemical analysis, (b) to identify microbial interactions at the buffer, backfill, and host rock interface for specific microorganisms that may affect activity of other microorganisms and integrity of the repository, (c) to analyze canister corrosion caused by microbial activity, particularly sulfide production by SRB, and (d) to characterize microbial illitization of montmorillonite that could affect permeability, hydraulic conductivity, and structural integrity of the repository. From reviewing studies above, it is judged that studies labelled as (b) through (d) are applicable to the performance assessment of microbial activity for the domestic facility regardless of specific conditions in Korea. However, for study labelled as (a), the following data on reflecting domestic conditions should be additionally obtained: (1) radionuclide inventory and temperature in spent nuclear fuel, (2) swelling pressure and organic carbon content of bentonite, and (3) size, shape, and gas composition of pores in bentonite. Results of this study could be directly applied to the design and performance assessment for buffer and backfill components, provided that input data specific to the domestic disposal facility is prepared for the assessment required.

EBV-positive mucocutaneous ulcer (EBVMCU) is an indolent, superficial lymphoproliferative disorder that occurs in either iatrogenic or age-associated immunocompromised patients with latent Epstein-Barr virus (EBV) infection. Although EBVMCU is histologically similar with other lymphoproliferative disorders, such as EBV-positive diffuse large B cell lymphoma, the diseases are classified as distinct entities by the World Health Organization with different clinical manifestations, prognosis, and genetic profiles. EBVMCU commonly shows spontaneous regression by conservative management, reduction or cessation of immunosuppressive treatment, but local progression is possible. Complete remission of disease can be achieved with combination of surgical resection, chemotherapy and local radiation therapy. Herein, we report 2 cases of oral superficial lymphoproliferative disorders arising adjacent to the gnathic bone with striking differences in prognosis and bone involvement. One of the cases induced extensive osteomyelitis in the underlying bone. Furthermore, we discussed the differential diagnosis of EBVMCU and reviewed the former literature.

Malignant melanoma is a highly malignant tumor derived from melanocyte. Malignant melanoma of the oral cavity occurs mainly in the palatine mucosa and the maxillary gingiva in men in their 50s. Malignant melanoma can be divided into pigmented and non-pigmented(amelanotic). Among them, non-pigmented malignant melanoma accounts for 2-8% of all malignant melanomas. Pigmented malignant melanoma is detected through changes in pigmentation, whereas non-pigmented malignant melanoma is characterized by no pattern of color change. In this study, at the initial visit, a malignant lesion was suspected and a biopsy was performed. According to the biopsy results, it was diagnosed as polymorphic sarcoma, but the histological examination performed during the operation revealed that it was amelanotic melanoma. As such, the differential diagnosis is important because there is no clinical change in non-pigmented malignant melanoma. Diseases to be differentially diagnosed when non-pigmented malignant melanoma occurs in the oral cavity include squamous cell carcinoma, lymphoma, sarcoma, inflammation, and osteomyelitis. In this study, we report a case that showed the histopathological characteristics of malignant melanoma without superficial pigmentation.

Telangiectatic osteosarcoma(TAEOS) is a rare subtype of osteosarcoma(OS) composed of blood-filled or empty cystic architecture simulating aneurysmal bone cyst. TAEOSs account for 2-12% of all OSs. TAEOSs mostly develop around knee and proximal humerus, but TAEOSs of the jaws are rare. To the best of my knowledge, this is the fourth case of primary TAEOS affecting the jaws. A 36-year-old female who had been previously diagnosed osteosarcoma by biopsy reported with a chief complaint of throbbing and swelling of the right mandible. The patient received neoadjuvant chemotherapy followed by hemi-mandibulectomy. After surgery, patient received adjuvant chemotherapy. The patient is free of disease for 6 months after surgery. TAEOSs are mimicking other benign entities, such as aneurysmal bone cyst and central giant cell granuloma. Thus, careful diagnosis through thorough radiographic and histopathologic evaluation is important to establish a treatment plan, prognosis, prediction and management strategy.

Pancreatic acinar cell carcinoma (ACC) is a rare neoplasm accounting less than 1% of malignant pancreatic tumors. A 47-year-old male patient visited the emergency room with epigastric pain. Computed tomography or magnetic resonance imaging revealed a 4.7-cm heterogeneously enhanced solid and cystic mass with internal necrosis located in the head of the pancreas. Radiological diagnosis was borderline malignancy such as neuroendocrine tumor or solid pseudopapillary neoplasm. Two months later, the necrotic mass in the pancreas head had grown up to 11 cm, compressing the duodenum, superior mesenteric vein, and proximal transverse colon. Pylorus preserving pancreatoduodenectomy with segmental resection of transverse colon was performed. Histopathological examination revealed that the tumor was pancreatic ACC. The patient recovered without any complication and was doing well without recurrence for 12 months after surgery.

Sarcomatous transformation of fibrous dysplasia (FD) is rare and can occur in patients with McCune-Albright syndrome (MAS). To date, there have been several cases of malignant transformation of FD in the craniofacial area of patients with MAS. Here, we report an additional case of secondary osteosarcoma arising from FD in the mandible of a 41-year-old woman with MAS. The patient complained of rapid swelling in the right facial area, which was initially misdiagnosed as soft tissue sarcoma at another hospital. After neoadjuvant concurrent chemoradiotherapy resulting in poor response, the lesion was surgically resected in our hospital, and the final diagnosis of secondary osteosarcoma was rendered. Currently, post-operative adjuvant chemotherapy is in progress. As a result of our review of 17 reported cases showing malignant transformation in FD/MAS, the M/F ratio was 1:1.1, and the median age at onset of malignancy was 28.6 years. The most commonly affected site was the craniofacial bones (n=13; 76%), and the most common histopathologic type of malignancy was osteosarcoma (n=14; 82%). More than half of the patients (8/15; 53.3%) died within 1 year, mainly due to lung metastasis (6/8; 75%). Taken together, since MAS patients with malignant transformation of FD have a relatively poor prognosis, accurate diagnosis based on histopathologic findings as well as clinical and radiographic information is important to select optimal treatment.

Central odontogenic fibroma (COF) is an uncommon slow growing benign neoplasm that is derived from the mesenchymal tissue. Differential diagnoses include fibrous dysplasia, calcifying odontogenic cyst, and central ossifying fibroma. Clinically, the lesion shows expansion of cortical bone. Radiologically, unilocular or multilocular lesion with well-defined borders is found. Histologically, fibroblastic tissues with bundle of collagens including inactive odontogenic epithelium can be observed. In this case report, a 45-year-old male with central odontogenic fibroma of the maxilla is examined. The lesion was surgically removed without any postoperative complications. In order to diagnose the disease properly, histopathologic analysis was performed.

좁은 수로에 관한 국제해상충돌방지규칙상의 서술은 모든 구체적 상황을 포괄하여 명시하지 않으므로, 실제 항법 적용상 다툼이 발생할 수 있다. 예컨대, 좁은 수로를 항행하고 있는 선박과 수로에 진입하려는 선박이 서로 횡단하는 상황에서 좁은 수로의 항법이 적용될 것인지에 대한 의문이 발생한다. 2015년 발생했던 The “Alexandria 1” and “Ever Smart” Case에 대한 영국법원의 판결은, 이 문제의 보편적인 해결 방안, 즉 좁은 수로상에 있는 선박에게는 좁은 수로의 항법만이 적용되어야 마땅하다는 결론을 제시하였다는 점에서 큰 의의가 있다. 다른 한편, 2017년 발생했던 “한림페리9호·민호호 충돌사건”에 대한 대전 고등법원의 판단은 외관상 영국법원과 크게 다르지 않지만 논증구조는 판이하며, 향후의 지침이 되는 판결을 내리지 못한 것으로 보인다. 본 논문에서는 상기 판결들에서 좁은 수로 인근에서 발생한 선박 간 횡단 상태에 있어 좁은 수로의 항법 적용을 정당화하는 과정이 어떻게 달랐는지 법적 논증이론의 관점에서 검토한다. 한국법원과 영국법원은 유사한 결론에 도달하 였지만, 한국법원은 논증상 합리적인 근거를 제시하지 못하였다는 점에서 정당화 맥락의 부족함이 지적된다. 이러한 논의의 목적은 특수한 상황에서 어떤 항법 적용이 옳은지를 밝히는 것이 아니라, 판결의 바람직한 근거 제시 방향에 대해 제언함에 있다.

With few reported cases, cystic hygroma is known to occur mainly in patients under the age of two years. Cystic hygroma can eventuate in any area; however, it mostly occurs in the cervicofacial area. If cystic hygroma occurs in this area, then the lesion may be related to the vital structures. Therefore, a complete surgical resection may be impossible and difficult to perform. This incident affects the high recurrence rate of cystic hygroma. The purpose of this report is to present a case of cystic hygroma occurring on the left side of the neck of a 47-year-old male patient as well as a review of literatures.

Mucinous adenocarcinoma (MAC) refers to a malignant neoplasm that belongs to a subtype of adenocarcinoma which produces mucin. The World Health Organization has classified MAC as a tumor of salivary gland origin and it is extremely rare. Therefore, its characteristics are not well-known. This study reports a case of MAC of minor salivary gland origin, which occurred in the oral commissure of an 82-year-old female patient, and a systematic review on existing cases of MAC of salivary origin. Based on the study’s findings, it is safe to assume that the occurrence of lymph node metastasis is an important factor in determining the prognosis of patients with MAC.

Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease, KFD) is a benign self-limiting lesion that can self-heal when no severe symptoms are present. KFD resembles tuberculous lymphadenitis and malignant lymphoma. Thus, early differential diagnosis will minimize unnecessary evaluation and treatment. Histological examination of a lymph node biopsy or fine needle aspiration could be a reliable method for KFD diagnosis. This study reports a case of histiocytic necrotizing lymphadenitis of the right cervical lymph node in a 52-year-old female patient. According to the fine needle aspiration biopsy result, the patient was diagnosed with Kikuchi-Fujimoto disease and treated with prednisolone (15 mg/day). After treatment, there was no recurrence or adverse event.

Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Being pleomorphic, its histologic characteristics can be considerably varied, showing epithelial (ductal and non-ductal) cells and mesenchyme-like tissues (chondroid, myxoid, and osseous). Here, we present a rare case of a 76-year-old female presenting with a 2.0 cm PA with an epidermoid cyst of minor salivary glands on the soft palate.

Pseudosarcomatous fibromatosis (PSF), also known as nodular fasciitis and pseudosarcomatous fasciitis, is a rare, benign proliferation of fibroblasts and myofibroblasts. It is often misdiagnosed as sarcoma because of its characteristic rapid progression, leading to unnecessary and aggressive surgery. Here we report a case of PSF found in the masseter muscle in a 26-year-old female. The mass that could be misdiagnosed because of its rapid growth characteristics was surgically excised by an intraoral approach and diagnosed as PSF by histopathologic examinations.

Extranodal intraoral Hodgkin lymphoma is not common. We report the case of a 78-year-old male patient with ulcer of the mandibular oral mucosa that was not cured for about 3 weeks. In biopsy and histopathologic examination, it was found to be extranodal intraoral Hodgkin lymphoma. Early diagnosis of oral lesions led to early detection of lesions of the opposite neck lymph node in an additional PET-CT scan. We report this case and review relevant literature.

최근 벤처캐피털의 운영 펀드 규모의 지속적 증가에 따라 투자 심사역의 업무 도 대폭 증가하고 있다. 그러나 투자 판단은 심사역의 역량에 따라 많은 차이를 보이고 있다. 이에 본 연구는 ‘벤처 투자 실무 평가 지표’에 대한 후속 연구로서 투자 심사 평가 지표의 유 효성을 검증하고자 하였다. 연구는 먼저 평가 지표를 표준화한 후, 100개 벤처 기업을 대상으 로 t-검증을 실시한 결과, 투자 심사 평가 지표들은 유의미하였고 정성 평가 지표의 유효성 역시 약 85%의 적중률을 보였다. 따라서 본 연구결과가 향후 벤처기업 투자 의사 결정력 제 고에 나름 기여할 수 있을 것으로 사료된다.

Canalicular adenoma is an uncommon, benign salivary gland tumor. It has a significant predilection for occurrence in the minor salivary glands, with most cases occurring in the upper lip, followed by the buccal mucosa and palate. Rarely, canalicular adenoma can involve the major salivary glands, such as the parotid gland. Only a small number of cases of canalicular adenoma of the parotid gland have been reported in the literature. We report a rare case of canalicular adenoma on the left parotid gland of an 81-year-old man, and present a review of the literature.

국내의 강력사건은 헬기·경비함정을 이용, 즉각적인 대응 및 처리를 할 수 있으나, 공해상 원양어선에서의 강력사건 대응은 지리적 원거리로 인한 자연적 한계가 있고, 국내법 및 국제법적 판단이 필요하다. 즉, 선박의 국적, 발생해역의 법적 지위, 가해자 또는 피해자의 국적 등을 감안하여 대한민국이 형사관할권을 행사할 수 있는지를 판단해야하며, 이러한 자연적인 문제와 함께 외국에서 해 양경찰이 실효적으로 경찰력을 발동할 수 있는가의 문제가 있다. 본 논문에서는 최근에 발생한 803광현호를 중심으로 관할권, 피의자 신병처리, 선상살인 사건의 근본 원인을 분석하여 향후 유사사례 발생 시 신속한 수사를 위한 제도적 개선방안을 제시하고자 한다.

This article aims to introduce and critically analyze the jurisprudence and its application in the UPP case in South Korea with reference to the ECtHR case law. In this controversial case, the CCK decided to dissolve the UPP and, without any basis in positive law, disqualify five National Assembly members affiliated with it. It is argued that when the CCK attempted to articulate the principle of proportionality that the ECtHR case law has firmly developed in this field and to apply it to this case, standards governing the dissolution of political parties were distorted at least in two ways. First, it substituted ‘social need’ for “pressing social need.” Second, it deliberately omitted the requirement of ‘sufficient imminence.’ In addition, the reasoning of the majority of eight justices based upon the rule of evidence in civil proceedings can also be criticized for being too abrupt to be justified in this highly controversial case of constitutional importance.

Oral hyperpigmentation is common in patients older 40 years. But lesions in a newborn are unusual and congenital melanotic macule of the tongue has rarely been reported. A 2-month-old infant with 3 pigmented lesion on the right side of the dorsal tongue was evaluated. They were brown black but not homogeneous in color, smooth, nonblanchable, and nonpalpable, with irregular margins. We recommend excisional biopsy under general anesthesia because of possibility of malignancy, but parents refuse invasive procedure. On a following-up examination of the child at the age of 1 year, the pigmented lesions were unchanged. We report a case of congenital melanotic macules on the tongue and a review of literature about the lesion.