Honey bee plays an important role in pollinating plants. Recently, however, declines in honey bee populations have been reported in many countries, and pesticides have been pointed out as one of the factors contributing to honey bee loss. To determine the effects of pesticides on honey bee behavior, we investigated the homing ability of honey bee exposed to four pesticides (acetamiprid, imidacloprid, fenitrothion, and carbaryl). In addition, the changes in expression levels of genes associated with ‘learning and memory’ (cGMP-dependent protein kinase foraging, Kruppel homolog 1, Adenlyate cyclase 3, Early growth response protein 1, Hormone receptor 38) were examined after pesticide treatment in forager bee. The four pesticides tested in this study generally reduced the homing ability of foragers. In the examination of gene expression, learning and memory-related genes were induced by the exposure to acetamiprid, imidacloprid, and carbaryl, whereas fenitrothion decreased the expression of these genes in honey bee. Although further studies are needed, this suggests that pesticides may have negative effects on honey bee behavior and behavior-related gene expression.

This study investigated the effects of multisensory memory strategies of pairing visual and aural learning strategies of aural lexical advance organizers (LAO) and read-alouds on 146 Korean high school students learning the meaning and pronunciation of 18 unfamiliar English words. In this quasi-experimental design, the control group learned the words on a single mode of written LAO and silent reading as opposed to two treatment groups of aural LAO and silent reading, and of aural LAO and read-alouds, respectively. The effects were tested three times via pre-, post-(immediately after learning), and delayed (30 days later) tests. The immediate and long-term effects were examined by detecting the differences across the three groups in post- and delayed-tests by one-way ANOVA, and the retention of effects was examined by paired t-tests in each group across the three tests. The results indicated that pairing aural LAO and read-aloud strategies was most effective in learning and retention of both vocabulary meaning and pronunciation.

This study aimed to investigate the effect of visual input enhancement (VIE) on the comprehension of reading texts and the learning of two grammatical forms: English relative clauses and articles. Individual learners’ working memory (WM) capacity was also tested to explore its impact on the effectiveness of VIE. A total of 48 Korean college learners of English were assigned into three groups: (a) relative group receiving VIE on relative clauses (b) article group receiving VIE on articles, and (c) a control group receiving no VIE. Results showed that VIE did not have any negative effect on the learners’ reading comprehension. Rather, it had positive effects on the learning of the two grammatical forms. According to the findings, VIE on relative clauses enhanced the learners’ receptive knowledge of the grammatical form, whereas VIE on articles enhanced the learners’ productive knowledge of the form. There was a potential link between the effectiveness of VIE and the learners’ working memory processing ability. Pedagogical implications are also discussed based on these findings.

게임을 포함한 가상환경 및 현실의 문제를 해결하기 위한 현대의 강화학습에서는 근사 함수로써 인공신경망을 사용한다. 하지만 이는 통계 기반이기 때문에 대량의 데이터가 필요해서 시뮬레이터가 없는 경우는 사용 및 적용에 애로가 있다. 이때문에 인공신경망은 아직 일상에서 자주 접할 수가 없는데, 대부분의 환경은 시뮬레이터를 만들기 힘들거나 데이터와 보상은 희소하기 때문이다. 이에 메모리 구조를 활용해서 적은 데이터와 희소한 보상을 가진 환경에서 빠른 학습을 할 수 있는 모델을 만들었다. 실험에서는 기존의 policy gradient와 메모리를 기반으로 open AI CartPole 문제에 도전했다. 이때 이득을 평가하는 함수인 Advantage function을 메모리구조를 변형하여 구현하였다. 이후 실험에 서 모델의 학습 시 편차가 커서 평균적으로는 저조한 성적을 보였다. 하지만 다른 알고리즘과의 학습 속도 비교를 통해 100회 이내의 작은 에피소드 내에서 상위 10개, 5개의 성적이 타 알고리즘들 보다 더 높은 점수를 획득한 것을 확인하였다. 결론적으로 연구를 통해 메모리구조를 사용하는 방법이 적은 데이터에 효과적일수 있다는 가능성을 발견했으며, 향후에는 학습의 편차를 줄이는 기술들에 대한 연구가 필요하다.

Learning and memory are essential for animals like honey bee, in which foragers leave their nest to collect food and then successfully learn to navigate back to colony. Chronic environmental exposure of neoniconitiod highly affect pollinators like honey bee. We investigated the effect of neonicotinoid, thiacloprid and imidacloprid on learning, memory and mortality of pollen foragers based on their toxicity level. Individual Pollen foragers Apis mellifera were trained using a proboscis extension proboscis. We used three treatments: 50% sugar solution, 50% sugar contaminated thiacloprid and imidacloprid as unconditioned stimulus and 2M 1-nonanol as conditioned stimulus. Our result shows that there is no significant difference between control and thiacloprid treatment both in learning and mortality of honey bee. But we found difference in memory between subjects exposed to control and thiacloprid contamination. Whereas imidacloprid contamination significantly lowered learning, eradicate memory retention and higher mortality of honey bee. Even thiacloprid and imidacloprid are in the same chemical class of Neonicotinoid insecticides, their toxic level would be different resulting in differential ecological impact to honey bee colony.

목적 : 본 연구의 목적은 얼굴-이름 연상학습을 통해 오차배제훈련이 경도 치매노인의 얼굴-이름기억과 기억 효능감의 향상에 효과가 있는지 알아보기 위함이다. 연구방법 : 연구 대상은 3명의 치매로 진단받은 노인이었고, 연구 설계는 개별사례 실험 연구(single subject experimental research design)중 ABA’ 설계를 사용하였다. 독립변수는 얼굴-이름 연상 학습에 시간차회상 훈련(Spaced Retrieval; SR)을 병행한 오차배제훈련(Errorless Learning; EL)이었다. 종속변수는 얼굴-이름 회상성공률과 실생활에서 얼굴-이름 기억 수준, 한국판 기억평가검사(Korean version of Memory Assessment Scale; K-MAS)의 얼굴즉각 기억과 얼굴지연 기억, 기억 효능감을 측정하였다. 결과 : 오차배제훈련 후 모든 대상자의 얼굴-이름 회상성공률과 실생활에서 얼굴-이름 기억 수준, 얼굴지연 기억, 기억 효능감이 향상되었다. 재기초선 종료 4주 후 치료유지 효과를 측정한 결과 모든 대상자의 향상된 얼굴-이름 회상성공률과 실생활에서 얼굴-이름 기억 수준, 기억 효능감은 유지되었다. 결론 : 본 연구결과를 기반하여 오차배제훈련이 경도 치매 노인의 얼굴-이름기억과 기억 효능감에 효과적인 중재임을 알 수 있었다.

This study investigates the effects of working memory capacity (WMC) and the types of vocabulary learning, i.e., explicit vs. implicit, on the acquisition of English multi-word verbs. For this purpose, a total of 60 middle school students, divided into two groups (control and experimental), participated in the study. The participants in the control group were taught multi-word verbs in a traditional and explicit manner, whereas the participants in the experimental group were exposed to multi-word verbs with short passages. The results manifested that both of the instructional styles had positive effects on the learners’ acquisition of multi-word verbs in the short-term. Although there was not a significant interaction between WMC and the overall scores on the immediate post-test, according to the scores on the gap-fill tasks which tested learners’ productive knowledge, there were significant differences between the low-WMC and high-WMC groups. High-WMC students learned more target multi-word verbs than low-WMC students on average. The results also showed that WMC and the two different learning types did not affect the students’ acquisition of multi-word verbs in the long-term. Further, the interaction effect between WMC and learning type in the long-term was not significant.

To investigate the in vivo cognitive effects of syringic acid(SA), Y-maze and passive avoidance tests were performed in amyloid-β(Aβ)-induced cytotoxicity. Learning and memory impairment by Aβ neurotoxicity was partially recovered in Institute of Cancer Research(ICR) mice orally administered SA(10mg/kg of body weight). The SA treated group showed an inhibitory effect on acetylcholinesterase(AChE) that was extracted from mice brain tissue after in vivo tests. Aβ-induced oxidative stress was also examined by malondialdehyde(MDA) and 2',7,-dichlorofluorescein diacetate(DCF-DA) assays, and lipid peroxidation of brain homogenates and cellular oxidative stress were reduced by SA. In cell viability assays using 3-[4,5-dimethythiazol-2-yl]-2,5-diphenyl tetrazolium bromide(MTT), lactate dehydrogenase(LDH) leakage, and caspase 3/7 activity, the SA treated group showed relatively effective protection against Aβ-induced neurotoxicity compared to the others. Consequently, these results suggest that SA in black soybean seed coat extract might improve cognitive function because of its neuronal cell protective effects against oxidative stress and the inhibitory effect of AChE as a cholinergic enzyme.

그동안 학습과 기억이 과거의 경험에 의해 구성된다는 측면이 강조되어왔으나, 최근의 연구들은 이들 인지과정이 미래의 보상물을 최대화하는 목표를 달성하기 위해 이루어짐을 조명하였다. 본 개관 논문은 이와 관련된 연구를 소개하고 목표지향적 학습과 기억에 대하여 논의하고자 한다. 먼저 강화 학습에서 내적 모형 기반 학습, 즉 상위 차원의 목표를 달성하기 위해 즉각적인 보상을 가져오지 않음에도 불구하고 특정한 행동을 취하는 과정이 이루어지고, 또한 직접적 강화를 받지 않은 대상으로의 일반화 및 유추가 일어나 미래의 적응적 행동을 가져옴을 보여준 연구들을 소개한다. 또한 위와 같은 목표지향적 학습 과정의 신경학적 기제를 탐색한 연구들을 개관하고, 선조체의 도파민 신호를 기반으로 한 과정이 기억 과정에 역시 영향을 미칠 수 있음을 논의한다. 특히, 기억이 과거의 경험을 모두 동일한 수준으로 부호화하고 인출하는 과정이 아니라, 상위 수준의 목표에 맞춘 의사결정과정의 결과임을 보여주는 연구들을 소개한다. 이러한 연구들은 미래에 얻게 될 보상 정보가 역향적으로 현재의 인지처리에 영향을 줄 수 있음을 시사한다.

학습자의 학습 스트레스 수준(stress level)과 금전적 보상(monetary rewards)의 제시 시점 차이가 장, 단기 기억수행에 미치는 영향을 알아보았다. 지연-파지 효과(delay-retention effect)에서는 지연 보상 (delayed reward)이 기억의 공고화(consolidation) 과정을 촉진시켜 결과적으로 장기 기억 수행을 향상시키게 된다고 주장한다. 본 연구에서는 지연 보상과 즉시 보상(immediate reward)이 학습 스트레스가 높고, 낮은 맥락의 차이에 따라 기억 수행에 미치는 영향력이 다를 것이라 예상하였다. 따라서 학습 맥락을 학습 스트레스가 높고, 낮은 두 조건으로 나누고, 보상 조건과 기억의 인출 시점을 구분하여 실험하였다. 보상 조건은 보상 제시 시점(5초 후 제시, 바로 제시)과 보상의 유무(500원, 0원)를 구분하였고, 기억 검사는 바로 인출하는 경우와 기억 공고화 과정을 거치고 일주일 후 인출하는 경우로 나누었다. 실험 결과 지연 보상은 장기 기억에 이점 효과가 있었고, 즉시 보상은 단기 기억에만 이점 효과가 나타났다. 이러한 보상의 기억 이점 효과는 스트레스가 높은 학습 맥락에서만 관찰되었다. 본 결과는 학습자가 지각하는 학습 스트레스 수준이 높을수록 보상에 대한 민감도가 높으며, 학습 후 즉시 보상 보다 지연 보상이 기억 공고화 과정에서 기억을 촉진시키는 역할을 수행하여 결과적으로 장기 기억력을 향상시킴을 시사한다.

The present study was carried out to establish an animal model, displaying long-term learning and memory dysfunction, since single intracerebroventricular (icv) injection of amyloid β peptide (Aβ) causes a short-term memory impairment. Male ICR mice were fed a high-cholesterol diet (HCD) containing 3% cholesterol, 1% corn oil and 0.5% cholic acid, and 1 week later, icv injected with Aβ_1-42 (5 μg/head). Learning/ memory function was assessed via passive avoidance performances 1 day and 2, 4, and 6 weeks after Aβ_1-42 injection, in addition to blood biochemical analyses for lipid profiles and hepatic function. Total cholesterol, lowdensity lipoproteins and hepatic dysfunction parameters markedly increased, while high-density lipoproteins were reduced following HCD feeding. Whereas single injection of Aβ induced temporary memory loss 1 day after administration, exhibiting full recovery after 2 weeks, Aβ treatment in combination with HCD feeding lasted the learning/memory impairment up to 6 weeks. Therefore, it is suggested that hypercholesterolemia augments Aβ-induced memory loss, and that Aβ injection plus HCD feeding could be a long-term memorydeficit model suitable for long-term treatment with drugs or stem cells.

This study aims at investigating the effects of phonological short-term memory (PSTM), learning styles, and oral repetition on middle school students" learning of English vocabulary. Two groups had different treatments (semantic learning and oral repetition) and vocabulary learning was assessed in spelling, meaning, and production twice, immediately after the learning sessions and two weeks thereafter. The results reveal that oral repetition and the PSTM capacity affected the vocabulary learning significantly, but not learning styles. The students with a higher PSTM capacity learned significantly more words but didn"t remember them better for a longer period than those with a lower PSTM capacity. No clear effects of learning styles were noted, while the PSTM capacity of auditory learners was higher than that of visual learners. The oral repetition group learned significantly more words than those who did only semantic learning, which suggests the usefulness of oral repetition in learning new vocabulary.

Background: A critical features of Alzheimer’s disease (AD) is cognitive dysfunction, which partly arises from decreased in acetylcholine levels. AD afftected brains are characterized by extensive oxidative stress, which is thought to be primarily induced by the amyloid beta (Aβ) peptide. In a previous study, Cinnamomum loureiroi tincture inhibited acetylcholinesterase (AchE) activity. That study identified AChE inhibitor in the C. loureiroi extract. Furthermore, the C. loureiroi extract enhanced memory in a trimethyltin (TMT)-induced model of cognitive dysfunction, as assessed via two behavioral tests. Rosa laevigata extract protected against oxidative stress-induced cytotoxicity. Administrating R. laevigata extracts to mice significantly reversed Aβ-induced learning and memory impairment, as shown in behavioral tests. Methods and Results: We conducted behavioral to examine the synergistic effects of C. loureiroi and R. laevigata extracts in inhibiting AChE and counteracting TMT-induced learning and memory losses. We also performed biochemical assays. The biochemical results showed a relationship between increased oxidative stress and cholinergic neurons damage in TMT-treated mice. Conclusions: A diet containing C. loureiroi and R. laevigata extracts ameliorated learning and memory impairments in the Y-maze and passive avoidance tests, and exerted synergistic inhibitory effect against AChE and lipid peroxidation.

All living organisms use memory and oblivion algorithms considering the estimated lifetime and the changes in the ambient environment. Because of the expected lifetime of a bridge is similar to the human’s one, if a bridge uses the same algorithm of human memory, the abnormal responses of the structure can be easily detected. This paper introduces unfamiliarity index (UFI) that calculated from the FFT results of the short term timeline acceleration responses. If this algorithm, which can detect an abnormal behavior from the maximum constant signal, is used to the terminal sensors of an structure, more accurate safety control criteria will be prepared efficiently.