인삼을 야생에서 재배한 산양삼(cultivated wild Panax ginseng, CWPG)은 여러 논문에서 인삼보다 전반적으로 높은 Ginsenoside 함량을 갖는다고 보고되었다. 그러나 이미 널리 알려져 있는 인삼이나 홍삼과는 달리 산양삼에 대한 연구는 미비하다. 본 연구의 목적은 산양삼의 유효성분 증진을 위하여 다양한 종류의 산을 상압 및 초고압 조건에서 처리하여 산처리 산양삼을 제조하고 그 진세노사이드 및 항산화 특성을 연구하는 것이다. 시료로 사용한 산양삼의 일반 성분은 수분 함량 84.38 %, 조지방 0.94 %, 조단백 10.51 %, 조회분 3.51 %로 나타났다. 산 처리를 위해 1M 아세트산 (Acetic-CWPG), 0.5 M 아스코르브산 (Ascorbic-CWPG), 0.5 M 시트르산 (Citric-CWPG), 0.5 M 옥살산 (Oxalic-CWPG) 및 0.2 M 염산 (HCl - CWPG)이 사용되었으며, control은 증류수를 사용하였다. 상압 산처리의 경우 CWPG 건조중량의 10 배에 상당하는 산 용액을 첨가하여 산양삼과 함께 분쇄한 후 산 처리 반응은 실온에서 15 분간 반응시켰으며, 초고압 처리의 경우 분쇄한 산-산양삼 시료를 파우치에 넣고 밀봉한 후 상온에서 15분간 초고압 처리를 진행하였다. 두 시료 모두 반응이 끝난 후 2 M NaOH를 사용하여 pH 4.75로 중화시켰다. 추출은 70 % 에탄올을 사용하여 수행하였다 Ginsenoside profile 및 함량은 high performance liquid chromatography (HPLC)를 사용하여 분석되었다. 처리 시료의 항산화능을 측정하기 위해 Total phenolic contents, Total flavonoid content’s 및 DPPH radical 소거능을 측정하였다. 상압에서 처리된 산양삼의 경우 산의 종류에 관계없이 Ginsenoside profile에 특별한 변화가 나타나지 않았다. 550MPa에서 처리된 시료의 경우 acetic acid와 citric acid로 처리된 산양삼은 control과 비슷한 profile을 나타낸 반면 HCl과 oxalic acid로 처리된 산양삼은 major ginsenoside가 급격히 감소하였다. 초고압-산 처리가 major ginsenoside를 가수분해하여 minor ginsenoside 형성하는 것으로 생각된다. 상압에서 산 처리된 시료들은 TP 및 DPPH radical 소거능이 증가하는 경향성을 보였다. 하지만 홍삼 처리와 같은 가열처리에 비해 그 변화가 매우 미미하였다. TF의 경우 감소하는 경향을 나타냈다. 초고압-산 처리의 경우 상압처리와 비슷한 경향성을 나타냈지만 전체적으로 낮은 함량 및 활성을 나타냈다. 산양삼의 상압 및 초고압 산 처리를 통한 유효성분의 증대는 산양삼을 이용한 고부가가치 식품의 국내 및 세계 시장을 개척 및 확대하기 위하여 본 연구의 진행이 중요한 역할을 할 것으로 기대된다.

인삼을 야생에서 재배한 산양삼 (cultivated wild Panax ginseng, CWPG)은 여러 논문에서 인삼보다 전반적으로 높은 Ginsenoside 함량을 갖는다고 보고되었다. 그러나 이미 널리 알려져 있는 인삼이나 홍삼과는 달리 산양삼에 대한 연구는 미비하다. 산양삼을 팽화 처리하여 유효성분을 증가시키는 실험을 수행하였다. 본 연구의 목적은 산양삼을 여러 수분함량과 압력조건으로 팽화산양삼을 제조하고 특성을 조사하는데 있다. 샘플로 사용한 산양삼의 일반 성분은 수분함량 78.04 %, 조지방 0.83 %, 조단백 8.77 %, 조회분 5.04 %로 나타났다. 최적의 팽화 조건을 설정하기 위해 50 °C에서 건조하여 각각 8 %, 10 %, 14 %의 수분함량으로 조절하였다. 압력 조건은 7 kgf/cm2 (686 kPa), 8 kgf/cm2 (784 kPa), 9 kgf/cm2 (882 kPa), 10 kgf/cm2 (980 kPa)의 압력에서 팽화 처리하였다. 총 12개의 팽화 산양삼시료와 팽화 하지 않은 산양삼 총 13가지를 분석하였다. 추출은 70 % EtOH를 이용하여 상온에서 추출하였다. 105 °C에서 건조하여 추출수율을 계산하였고, 수포화 n-부탄올을 이용하여 조사포닌 분석과 HPLC분석을 하였다. Carbazole - sulfuric acid 방법을 이용하여 산성 다당체를 분석하였다. 추출수율과 조사포닌 함량은 팽화 압력 증가에 따라 모든 수분함량에서 감소하였다. 수분함량에 따라서는 추출수율은 큰 차이가 없었고 조사포닌 함량은 8%에서 가장 높게 나타났다. HPLC분석결과 팽화 처리에 따라서 Minor ginsenoside인 Ginsenoside Rg3, compound K의 함량이 증가하였고, Ginsenoside Rh2, Rg2의 경우 일정하게 유지되었다. Ginsenoside Rg1, Re, Rf, Rb1, Rb2, Rc, Rd는 팽화 처리에 의해 급격하게 감소하였고, 팽화압력 증가 시 감소하는 모습이 나타났다. 팽화 처리에 의해서 증가한 Ginsenoside Rg3, Compound K는 항암, 항산화 효과 및 항 염증 활성이 보고되었다. 팽화 처리에 의해 생리활성이 높은 성분으로 변환되는 것은 기존의 논문에서의 결과와 일치하는 것으로 나타났다. 산양삼의 일반 특성과 팽화 처리를 통한 유효성분의 증대는 산양삼을 이용한 고부 가가치식품의 국내 및 세계 시장을 개척 및 확대하기 위하여 본 연구의 진행이 중요한 역할을 할 것으로 기대된다.

목적 : 본 연구는 국내 실정에 적합한 보조공학 적용과 적용 이후의 과정을 일괄적이고 객관적으로 평가할 수 있는 평가도구를 개발하는데 목적을 두고 있다. 연구방법 : 선행연구 검토와 전문가 사전 조사, 전문가 조사, 내용타당도 조사를 통해 국내 실정에 맞는 보조공학 만족도 평가요소를 추출하였다. 추출된 평가요소의 타당도와 신뢰도 분석을 위해 탐색적 요인분석과 내적일치도 신뢰도를 확인하였다. 결과 : 선행연구 검토와 전문가 사전조사, 전문가 조사, 내용타당도 조사를 통하여 최종적으로 ‘보조공학기구’, ‘보조공학서비스’, ‘일상생활’ 3개의 평가항목 및 17개의 평가요소를 추출하여 확정하였다. 17개의 평가요소를 토대로 보조공학기구를 사용하는 장애인 190명을 대상으로 탐색적 요인분석을 실시하여 D1(가격)의 평가요소를 제외하고, 총 16개의 평가요소를 도출하였다. 16개의 평가요소의 내적일치도 신뢰도 분석을 통하여 Cronbach’s α값이 .908로 나타났으며, 항목이 삭제된 경우의 Cronbach’s α값이 .777~.871로 나타났다. 결론 : 최종 한국형 보조공학 만족도 평가도구를 구성하는 3개의 평가항목과 16개의 평가요소 개발을 완성하였다. 앞으로 개발한 평가도구의 추가적인 수렴타당도, 공인타당도 및 검사-재검사 신뢰도연구가 요구된다. 본 평가도구는 국내 보조공학 및 작업치료 분야에서 보조공학 성과 기초자료로 사용될 수 있을 것으로 기대한다.

The purpose of this study was to compare the ring lock type knee-ankle-foot orthosis (KAFO) with newly developed 4-bar linkage KAFO on the gait characteristics of persons with poliomyelitis clinically. This 4-bar linkage is the stance control type KAFO which provide the stability during stance phase and knee flexion during swing phase. Two subjects participated in this study voluntarily. We provided the customized 4-bar linkage KAFO then asked the subjects to walk in level surface and stairs under the two different KAFO conditions. The characteristics of gait in the persons with poliomyelitis were evaluated using a 3D motion analysis system and force plate. Additionally 6 minute walk test for physiological cost index were conducted using pulse oximeter to measure the energy consumption. In the results of this study, the differences of 4-bar linkage KAFO compared with ring lock type KAFO are as follows: (1) Walking speed, stride length, and step length on level increased in subjects, (2) The gait symmetry was improved by generated knee flexion and decreased pelvic external rotation on level and stairs walking, (3) Decreased vertical excursion of center of mass and pelvic elevation during swing phase was decreased on level, (4) Knee extension moment, hip flexion moment, hip and knee internal rotation moment of non-braced limb were decreased on level walking, (5) Walking speed in 6-minute walk test was increased and physiological cost index was decreased. These findings indicate that 4-bar linkage KAFO compared with ring lock type KAFO is effective in enhancing pattern, endurance, and energy consumption in level surface and stairs walking.

With the introduction of the video display terminal (VDT), the efficiency and productivity of work has improved. However, VDT syndrome is threatening the health of workers as a side effect of prolonged use of a VDT. Among various VDT syndromes, the musculoskeletal disorder, especially, the cumulative trauma disorder (CTD) is the common research topic related with upper extremities function. The aim of this study was to investigate the effect of the wrist-hand orthosis (WHO) on fatigue in middle deltoid, anterior deltoid, serratus anterior, and upper trapezius during one-hour computer keyboard typing. Twelve healthy subjects participated in this study. Surface electromyography was used to assess the localized muscle fatigue (LMF), and the LMF was calculated at 10 minutes, 20 minutes, 40 minutes, and 60 minutes in each muscle, with and without the WHO. Data were analyzed by paired t-test with a level of significance of .05. The results of this study are as follows: 1) At 10 minutes, the LMF decreased significantly with applied WHO in the middle deltoid, anterior deltoid, and upper trapezius (p=.001, p=.026, p=.019, respectively). 2) As the computer keyboard typing period increased, there were no significant LMF differences, except for the upper trapezius. Therefore, it can be concluded that the WHO can be applied to decrease the LMF for the initial 10 minute period in the middle deltoid, anterior deltoid, and upper trapezius' but that the long term effect of WHO in reducing the LMF was proven only in upper trapezius during continued computer keyboard typing.

목적 : 본 연구는 정상성인남성의 마시기 동작을 표면근전도와 삼차원 동작 분석기를 통하여 상지 움직임에 대한 계량적(운동형상학: kinematics, 근활성도: muscle activity) 자료를 수집하여 마시기 과제 수행 시 운동 패턴과 전략에 대해서 알아보고자 하였다. 연구방법 : 연구 대상자는 건강한 20대 젊은 남성 30명을 대상으로, 삼차원동작분석기(VICON MX System)와 근전도기(MP-100)를 이용하여 마시는 동작의 관절가동범위, 속도, 근활성도를 측정하였다. 결과 : 물 마시기 수행 중 컵을 잡는 동안 어깨에서 최대 내전과 팔꿈치의 최대 신전이 나타났고, 마시는 동안 어깨에서는 최대 굴곡 및 외전이 팔꿈치에서는 최대 굴곡이 나타났다. 뻗기 단계에서 각 관절의 각도 변화에 대해 피어슨상관계수(pearson product-moment correlation coefficient)를 이용한 결과 어깨와 팔꿈치사이에서 (r=-.904), 어깨와 손목사이에서(r=.722), 팔꿈치와 손목사이에서(r=-.700)로 통계학적으로 유의한 상관관계를 나타냈다(p<.05). 입으로 가져오기 단계에서는 위쪽등세모근(7.31%)과 위팔두갈래근(1.60%)이 가장 높은 활성도를 보였고, 정리하기, 마시기, 뻗기 단계에서 각각 위팔세갈래근(.43%), 중간어깨세모근(1.33%), 긴노쪽손목폄근(2.20%)에서 활성도가 높게 나타났다. 결론 : 본 연구는 작업치료사가 중추신경계 및 근 골격계 환자의 치료 계획 및 치료 전략을 설정 시 적용 될 수 있으며, 또한 치료적 중재 후 상지 움직임 향상에 대한 평가의 기초자료로 이용 될 수 있을 것이라고 사료 된다.

본 연구는 하퇴의지 착용자와 정상 성인간의 시간-거리, 운동형상학 변수를 조사하고 비교하기 위하여 실시하였다. 연구 대상자는 외상으로 인한 하퇴 절단자로서 내골격식 하퇴의지를 착용하고 독립적으로 보행이 가능한 20명과 연령, 신장으로 짝짓기한 대조군(matched control group) 20명이 참여하였다. 보행분석은 Vicon Clinical Manager Software (VCM)를 내장한 PC에 5개의 카메라가 연결되어 있는 Vicon 512

The purposes of establishing accreditation standards for the occupational therapy program are to assure the quality of the program and to assist in the development of the program. Accreditation serves the public as accredited programs modify their requirements to reflect changes in knowledge and practice generally accepted in the field. To students, accreditation provides an assurance that the educational activities of an accredited program have been found to be satisfactory, and therefore meet the needs of students. Also it assists in the transfer of credits between institutions, or in the admission of students to advanced degrees through the general acceptance of credits among accredited institutions when the performance of the students has been satisfactory and the credits to be transferred are appropriate to the receiving institution. The occupational therapy programs benefit from accreditation through the stimulus provided for self-evaluation and self-directed program improvement and strengthening of program self-evaluation by the review and counsel provided through the accrediting agency. At the same time, this process enhances the reputation of an accredited program because of public regard for accreditation. Lastly, the profession of occupational therapy can be strengthened by contributing to the unity of the professions in an activity directed at improving professional preparation and professional practice.

This study was conducted to investigate the status and the life satisfaction of amputees from July 9, 2001 to August 18, 2001. Questionnaire survey was collected from lower extremity amputees using the services of prosthetic and orthotic centers in five Veterans Hospitals (Seoul, Busan, Gwangju, Daeku, and Daejun), Seoul Tehlin prosthetic and orthotic center, Chunan prosthetic and orthotic center, and Junju Lee Ganga rehabilitation institute. Amputees were grouped as trans-tibial amputees, trans-femoral amputees, and bilateral amputees based on amputation level. Demographic and social characteristics, performance of social role, and factors influencing life satisfaction revealed findings as follows: 1) The number of subjects voluntarily participated in the study was 113 (109 men, 4 women), and the mean age of subjects was 53.65 years (age range=22-74 years). 2) The time of amputation was at their second decade mostly (72.6%), and the most common etiology of amputation was trauma (91.2%). 3) The most common type of amputation was trans-tibial amputation (59.3%). Subjects who were employed was 68.1% before amputation and 47.8% after amputation. Subject had income regardless of being employed or unemployed after amputation. 4) No significant difference was found between the scores of social role and the scores of life satisfaction in three groups(p<0.05). 5) The significant factors on life satisfaction was income status and occupational role among variables(p<0.05).

Activities of daily living (ADL) and instrumental activities of daily living (I-ADL) are tasks of self-care, functional mobility, functional communication, home management, and community living that enable an individual to achieve personal independence. The purpose of this study were to investigate the effect of factors on ADL in stroke patients and to identify the relationship between the function of upper extremities and ability of ADL. Thirty-one stroke patients participated in this study. The results of this study were as follows: 1) There were significant functional gains between admission and discharge on the MFT score, dexterity, and the motor FIM(p<0.01). 2) There were moderate correlation between MFT score of the non-affected side and motor FIM score at discharge(r=0.499, p<0.01) and high negative correlation between dexterity of non-affected hand and motor FIM score at discharge(r=-0.704, p<0.01). 3) There was a significant difference on motor FIM score among academic background groups (p<0.01). 4) There was no significant difference on motor FIM score among caregiver groups (p<0.01). 5) Four factors were found. one factor comprised dexterity of non-affected hand at admission and discharge and duration of treatment. Two factor comprised MFT of non-affected side at admission and discharge and academic background. Three factor comprised MFT of affected side at admission and discharge and caregiver. Four factor comprised sex and affected side.

The purpose of this study was to compare the static pressure, dynamic pressure, dynamic pressure-time integral, relative impulse, and contact time between the sound lower limb and amputated lower limb in trans-tibial amputee subjects using Parotec system. Seventeen trans-tibial amputee subjects wearing endoskeletal trans-tibial prosthesis voluntarily participated in this study. The results were as follows: 1) In static standing condition, there were significantly higher static pressure in sound lower limb insole sensor of 10, 14, 15, 18, 19, 23, and 24 and in amputated lower limb insole sensor of 9, 12, and 16 (p<.05). 2) In dynamic gait condition, there were significantly higher dynamic pressure in sound lower limb insole sensor of 2, 18, 22, 23, and 24 and in amputated lower limb insole sensor of 5, 9, 10, 11, 12, 14, 15, and 16 (p<.05). 3) In dynamic gait condition, there were significantly higher pressure-time integral in sound lower limb insole sensor of 2, 4, 18, 19, 20, 21, 23, and 24 and in amputated lower limb insole sensor of 5, 11, 12, and 15 (p<.05). 4) In dynamic gait condition, there were significantly higher relative impulse in sound lower limb insole sensor of 18, 19, 20, 22, 23, and 24 and in amputated lower limb insole sensor of 5, 9, 10, 11, 12, and 15 (p<.05). 5) In dynamic gait condition, there was significantly higher percentage of contact time in push off phase of sound lower limb and in support phase of amputated lower limb (p<.05). These results suggest that trans-tibial amputee subjects had characteristics of shortened push off phase due to unutilized forefoot and of lengthened support phase with higher pressure in the midfoot.

The purpose of this study was to investigate the effect of donning of a hard insole in patients with hallux valgus. Fourteen subjects were selected from patient with foot pain at Lee Chang-Heon Foot Clinic from August 4, 2000 to September 15, 2000. The hallux valgus angle and the first-second intermetatarsal angle were radiographically measured before and after donning the hard insole. Based on these two kinds of angles, a mild hallux valgus deformity group was characterized by the hallux valgus angle of less than 20 degrees, and a moderate hallux valgus deformity group was characterized by the hallux valgus angle of 20 to 40 degrees. After three weeks with the hard insole donned, the foot angles of the patients with hallux valgus were measured again. The data were analyzed by Wilcoxon signed ranks test, and the following results were obtained: 1) After the trial, both mild hallux valgus deformity group and moderate hallux valgus deformity group demonstrated that the hallux valgus angles were significantly decreased. 2) After the trial, mild hallux valgus deformity group demonstrated that the first-second intermetatarsal angle was significantly decreased. 3) After the trial, moderate hallux valgus deformity group demonstrated that the first-second intermetatarsal angle was not significantly decreased. The above findings revealed that according to donning hard insole, the hallux valgus angles of mild and moderate hallux valgus deformity groups and the first-second intermetatarsal angle of mild hallux valgus deformity group were significantly decreased. The results of this study have some limitation for generalization due to the limited number of subjects. Further studies are needed to evaluate the effect of hard insole on hallux valgus with more precise laboratory equipments and measurements in patients with hallux valgus.

To determine an operational condition of an adhesion-type oil skimmer, it is important to estimate the withdrawal rate for a given driving velocity of the skimmer and material properties of the oil. As a theoretical model for this problem the formation of an oil film on a vertically driven flat plate is investigated. The previous steady-state analysis made in the field of coating industry are reviewed. These studies have been made under the assumptions of small Reynolds and capillary number, which is adequate for coating process but not for oil skimming. An alternative analysis based on the linear stability theory is made. Comparisons with the experimental results reveal that the stability analysis gives a correct estimation of the withdrawal rate for high capillary number at which the previous theory losses its validity.

The potential of nitrogen mineralization was studied by applying organic fertilizer to soil and incubating at 25℃ for 28 weeks. The organic fertilizers used in this experiment were oil-cake (CF-Ⅰ, CF-Ⅱ) and amino acid fertilizer (AAF-Ⅰ, AAF- Ⅱ). Accumulated mineralized nitrogen (N) fits the frist-order kinetics during incubation. The N mineralization potential (No) for organic fertilizers treated soil was highest at AAF-Ⅱ treatment with a value of 27.71 N mg/100g, then followed by CF-Ⅱ, AAF-Ⅰ, CF-Ⅰ. The pure N mineralization potential (N0 treatment - N0 control) for CF-Ⅰ, CF-Ⅱ, AAF-Ⅰ, AAF-Ⅱ were 2.55, 5.83, 3.66, 8.57 N mg/ 100g, respectively. The amount of N mineralized from organic fertilizers applied soil ranged from 46% to 61% of the total N content in organic fertilizer. The half-life (t1/2) of organic nitrogen in soil treated with oil-cake and amino acid fertilizer was 17-21 days. Therefore, half of nitrogen contained in oil-cake and amino acid fertilizer was mineralized after 3 weeks application.

만능성 인간 배아줄기세포로부터 확립된 신경줄기세포 또는 신경전구세포는 퇴행성 신경질환 세포치료제로 이용될 수 있는 다양한 종류의 신경세포로 분화 유도될 수 있다. 하지만, 인간 배아줄기세포로부터 신경세포를 생산하기 위한 기술은 아직 많은 장애를 가지고 있다. 인간 배아줄기세포 유래 신경전구세포에서 특징적으로 나타나는 신경관 유사로제트에 대한 이해는 인간 배아줄기세포 신경 분화의 효율을 높이는데 유용한 정보를 제공할 것으로 사료된다. 일반적으로 신경로제트