Background: Pain Neuroscience Education (PNE) is an educational approach that deals with the physiology of the nervous system as well as the pain system and refers to educating patients with chronic musculoskeletal disorders such as chronic back pain. Objectives: This study examined the effects of pain neuroscience education on patients with low back pain. Design: Systematic review. Methods: Electronic bibliographic databases of a regional information sharing system (RISS) and PubMed were searched to identify randomized controlled studies. In the final outcome, 43 publications were identified, and 13 studies met the inclusion criteria. Results: There were a total of 13 pain-related studies, including 11 studies using NPRS (VAS) and 2 studies using other pain measurement instruments. In NPRS, the effect size was 0.683, which had a medium effect size. In Roland morris disability questionnaire (RMDQ), the effect size was 0.544, which had a medium effect size. In Oswestry disability index (ODI), the effect size was 0.951, indicating a large effect size, but the confidence interval could not be obtained because there was only one study. Conclusion: Pain neuroscience education has positive effects on low back pain and disability index in related patients.

A strain of Amphidinium species was established from samples collected from the intertidal zone of a sandy beach of Jeju Island, Korea. Its cells were 13.0-15.0 μm in length and 10.0-13.0 μm in width. Its cell shape was round or oval and dorsoventrally flat. A pyrenoid was located in the center of the cell and a nucleus was posteriorly located. Its epicone was small and left-deflecting. Its cingulum had V-shape on the ventral side, forming a ventral ridge and extending to the sulcus. Polygonal amphiesmal vesicles and ring-shaped body scales not described previous were observed on the surface of the cell. Its morphological features were consistent with those of previously described Amphidinium fijiense. Phylogeny based on ITS region and LSU rDNA sequences revealed that this Amphidinium isolate was clearly clustered with other A. fijiense strains, but separated from other Amphidinium species. These results indicate that this Amphidinium isolate is A. fijiense. This study reports its presence for the first time in the intertidal zone of a sandy beach of Jeju Island, Korea.

Soft magnetic powder materials are used throughout industries such as motors and power converters. When manufacturing Fe-based soft magnetic composites, the size and shape of the soft magnetic powder and the microstructure in the powder are closely related to the magnetic properties. In this study, Fe-Si-Al-P alloy powders were manufactured using various manufacturing process parameter sets, and the process parameters of the vacuum induction melt gas atomization process were set as melt temperature, atomization gas pressure, and gas flow rate. Process variable data that records are converted into 6 types of data for each powder recovery section. Process variable data that recorded minute changes were converted into 6 types of data and used as input variables. As output variables, a total of 6 types were designated by measuring the particle size, flowability, apparent density, and sphericity of the manufactured powders according to the process variable conditions. The sensitivity of the input and output variables was analyzed through the Pearson correlation coefficient, and a total of 6 powder characteristics were analyzed by artificial neural network model. The prediction results were compared with the results through linear regression analysis and response surface methodology, respectively.

Foot-and-mouth disease (FMD) is a very deadly and highly contagious disease that occurs in various cloven-hoofed animals. Korea imports vaccines including non-vaccinated serotype for the vaccine bank. The two company vaccines imported from 2019 to 2021 were evaluated through multiple tests based on national standard assay. SN titers for the vaccine of company A were more than 1.5 log10, those of company B vaccine in the geometric mean were at least 1.72. All imported vaccines exceeded the evaluation criteria, and the potency of each vaccine was above its own company standard. Stockpiled vaccines for emergency may help to control non-vaccinated serotypes of FMD outbreak nationally.

Subunit vaccines are being developed as a potential therapy for preventing microbial pathogen infection. In this study, the immunogenicity of recombinant Brucella (B.) abortus Fe/Mn superoxide dismutase (rFe/Mn SOD) protein as a subunit vaccine against B. abortus was investigated in BALB/c mice model. Brucella Fe/Mn SOD gene was cloned into a pcold-TF DNA vector. The bacterial recombinant protein was expressed using the Escherichia coli DH5α strain with a size of 82.50 kDa. The western blotting assay showed that rFe/Mn SOD reacted with Brucella-positive serum, indicating the potential immunoreactivity of this recombinant protein. After the second and third vaccinations, the peripheral CD4+ T cell population was increased significantly in the rFe/Mn SOD-immunized mice group compared to the PBS control group. Moreover, immunization of this recombinant protein increased the CD4+ T cell population from the first vaccination to the third vaccination. Meanwhile, the CD8+ T cells were slightly enhanced after the second vaccination compared to the first vaccination and compared to control groups. Fourteen days after the bacterial infection, the splenomegaly and the number of bacteria in the spleen were evaluated. The result showed that both rFe/Mn SOD and positive control RB51 decreased the bacterial replication in the spleen and the splenomegaly compared to control groups. Altogether, these results suggested that rFe/Mn SOD could induce host immunity against B. abortus infection.

목적: 코로나19의 상황에서 대학생을 대상으로 스마트폰을 포함한 디지털기기의 사용이 눈과 근육뼈대계 통증에 미치는 영향을 알아보고자 하였다. 방법: 2022년 11월 온라인 설문조사에 응답한 대학생 156명의 자료를 분석하였다. 설문은 대상자의 일반적 특성을 포함하여 코로나19 대유행 동안 디지털기기의 사용시간과 종류, 컴퓨터시각증후군(computer vision syndrome, CVS) 16항목, 그리고 근육뼈대계 관련 11문항으로 구성하였다. CVS의 빈도는 0~2점, 강도는 1~2점으로 평가하였고, 근육뼈대계 통증은 약한 증상, 경도, 그리고 심한 증상으로 구분하여 3점 척도로 평가하여 총점을 산출하였다. 결과: 일일 평균 디지털기기의 사용은 7.97±3.46시간으로 온라인 수업을 위해 노트북(47.4%), 태블릿(33.3%), 데스크톱(12.2%), 그리고 스마트폰(7.1%)을 사용하였다. 매일 규칙적으로 운동하는 경우는 대상자의 22.4% 이었다. 컴퓨터시각증후군 관련 증상은 건조감이 가장 높은 점수를 보였고, 근육뼈대계 항목은 목 통증이 가장 심했다. 디지털기 기의 사용시간이 증가할수록 몸통(목, 등, 허리)과 전체 근육뼈대 통증이 심해졌고, 노트북이나 스마트폰을 이용해서 온라인 수업을 듣는 경우에는 데스크톱을 사용하는 경우와 비교해 상지통증 점수가 높게 나타났다. 매일 규칙적인 운동을 하는 경우에는 하지 않는 경우에 비해 컴퓨터시각증후군과 근육뼈대 통증의 통증이 작았다. 결론 : 디지털기기의 장시간 사용과 온라인 수업 동안에 사용하는 기기의 종류는 눈과 근육뼈대계 통증에 영향 을 미쳤다. 본 연구결과를 통해 이러한 환경에서 향후 눈과 근육뼈대계의 융합적인 연구와 관리가 함께 필요함을 알 수 있었다.

The oxygen evolution reaction (OER) is very sluggish compared to the hydrogen evolution reaction (HER). Considering this difference is essential when designing and developing a cost-effective and facile synthesis method for a catalyst that can effectively perform OER activity. The material should possess a high surface area and more active sites. Considering these points, in this work we successfully synthesized sheets of cobalt phosphate hydrate (CP) and sulphurated cobalt phosphate hydrate (CPS) material, using simple successive ionic layered adsorption and reaction (SILAR) methods followed by sulfurization. The CP and CPS electrodes exhibited overpotentials of 279 mV with a Tafel slope of 212 mV dec1 and 381 mV with a Tafel slope of 212 mV dec1, respectively. The superior performance after sulfurization is attributed to the intrinsic activity of the deposited well-aligned nanosheet structures, which provided a substantial number of electrochemically active surface sites, speeded electron transfer, and at the same time improved the diffusion of the electrolyte.

Kori-1, the nuclear power plants in South Korea, first started operation in April 1978 and was suspended permanently in 2017. The saturation rate time of spent nuclear fuel generated by major nuclear power plants operating in Korea are getting closer. If we fail to dispose spent nuclear fuel, which is equivalent to high-level radioactive waste, the nuclear power plants will have to be shutdown. High-level radioactive waste is permanently disposed through a deep geological disposal system because it contains long-term half-life nuclides and emits high energy. To select the deep geological disposal site and construct the disposal facilities, it is necessary to establish appropriate regulatory policies accordingly. The status of database construction in OECD-NEA, NRC, SITEX, and IAEA, which provides safety regulations for deep geological disposal system, stipulates each requirement for dismantling nuclear power plants. However, details such as specific figures are not specified, and guidelines for the disposal of high-level radioactive wastes are not clearly distinguished. In Korea, the CYPRUS program, an integrated database system, has been developed to support comprehensive performance evaluation for high-level waste disposal. However, due to several difficult situations, maintenance and upgrades have not been performed, so the research results exist only in the form of raw data and the new research results have not been reflected. Other than that, there is no preemptive basis for regulating the deep geological disposal system. With real-time database, we can develop a regulatory system for the domestic deep disposal system by systematically analyzing the regulatory condition and regulatory case data of international organizations and foreign leading countries. The database system processed and stored primary data collected from nuclear safety reports and other related data. In addition, we used relational database and designed table to maximize time and space efficiency. It is provided in the form of a web service so that multiple users can easily find the data they want at the same time. Based on these technologies, this study established a database system by analyzing the legal systems, regulatory standards, and cases of major foreign leading countries such as Sweden, Finland, the United States, and Japan. This database aims to organize data for each safety case component and further prepare a safety regulatory framework for each stage of development of disposal facilities suitable for the domestic environment.