The gaming industry is experiencing rapid growth due to recent advances in technology. Game engines such as Unity and Unreal are being actively utilized. These game engines offer a variety of plugins to naturally extend the functionality of the engine. Among them, innovations in 3D graphics technology have made game characters more expressive and enhanced the user experience. However, traditional 3D modeling approaches can sometimes bring limitations and challenges. In particular there are problems with the representation of fine details when utilizing general photos through AI scanning. This paper aims to overcome these difficulties by designing and implementing a game 3D character generation framework using Stable Diffusion. By improving the creation process by utilizing concept art images without hairstyles, it enables fast and efficient character creation. The application of this framework allows for faster and more consistent character creation with fewer steps in the creation process and helps game developers to adapt characters to the engine more easily and quickly. In addition, we verified the effectiveness and scalability of the 3D game character data generated by Stable Diffusion by checking the animation behavior in the game engine.

The effect of oxidation time on the characteristics and mechanical properties of spent nuclear fuel cladding was investigated using Raman spectroscopy, tube rupture test, and tensile test. As oxidation time increased, the Raman peak associated with the tetragonal zirconium oxide phase diminished and merged with the Raman peak associated with the monoclinic zirconium oxide phase near 333 cm−1. Additionally, the other tetragonal zirconium oxide phase peak at 380 cm−1 decreased after 100 d of oxidation, whereas the zirconium monoclinic oxide peak became the dominant peak. The oxidation time had no effect on the tube rupture pressure of the oxidized zirconium alloy tube. However, the yield and tensile stresses of the oxidized nuclear fuel cladding tube decreased after 100 d of oxidation. The results of the scanning electron microscopy and transmission electron microscopy were represented with the in-situ Raman analysis result for the oxide characteristics generated on the cladding of spent nuclear fuel.

Spirodelae Herba (SH) and Perilla Frutescens (PF) extracts have been widely used in clinical practice with various disorders for thousands of years. There are some reports regarding the anticancer effects of SH and PF each by each, but their mixture have not been investigated and their mechanisms also have not been clear. The purpose of the present study was to investigate the anticancer mechanisms and their effects of the mixture of SH and PF extracts on head and neck cancer cell line. Head and neck carcinoma KB cells were treated with SH, PF and their mixture. Anticancer effects were investigated by searching cancer cell death pathway; apoptosis and autophagy, which have been regarded to be effective and safe methods. Apoptosis, which is termed a programmed cell death, was observed by TUNNEL assay. Autophagy, which is termed a type II programmed cell death, was observed by acridine orange red staining. Additionally, the protein expressions associated with apoptosis and autophagy were detected for their mechanism by western blots. The mixture of SH and PF extracts induced autophagic and apoptotic cell death simultaneously in cancer cells. And 0.4 mg/ml of the mixture with SH and PF extracts down-regulated the expression of mTOR, however, the expressions of ATG5 and LC3-II, which induced autophagy, up-regulated. The mixture of SH and PF extracts also down-regulated the expressions of Bcl-2, but up-regulate the expressions of PARP-1 cleavage, Caspase-9 cleavage, Caspase-3 cleavage and BAX, which induced apoptosis. Taken together, these results suggested that the mixture of SH and PF extracts induce autophagic and apoptotic cell death simultaneously in head and neck cancer cells and it could be used as an alternative for anti-cancer drugs.

Leiomyoma is a Benign tumor that develops in smooth muscles and is known to occur more in women in age between 40s and 50s. The most common site of leiomyoma is uterine (95 %). It occurred in oral region is very rare about 0.065 % and usually developed in upper and lower lips, palatal site, buccal site and tongues. The prognosis of leiomyoma is very positive. The recurrence rate is extremely low to 2 % below. In present study, we report a 78 year old female with a lesion located in temporomandibular joint cavity which was suspected as a malignant tumor. Additionally, this paper reports contains a literature review of oral leiomyoma. Rare location with painless leiomyoma of present case will be considered to be caution.

Green tea polyphenol (–)-epigallocatechin-3-gallate (EGCG) is a potent antioxidant with protective effects against neurotoxicity. However, it is currently unclear whether EGCG protects neuronal cells against radiation-induced damage. Therefore, the objective of this study was to investigate the effects of EGCG on ultraviolet (UV)-induced oxidative stress and apoptosis in PC12 cells. The effects of UV irradiation included apoptotic cell death, which was associated with DNA fragmentation, reactive oxygen species (ROS) production, enhanced caspase-3 and caspase-9 activity, and poly (ADP-ribose) polymerase cleavage. UV irradiation also increased the Bax/Bcl-2 ratio and mitochondrial pathway-associated cytochrome c expression. However, pretreatment with EGCG before UV exposure markedly decreased UV-induced DNA fragmentation and ROS production. Furthermore, the UV irradiationinduced increase in Bax/Bcl-2 ratio, cytochrome c upregulation, and caspase-3 and caspase-9 activation were each ameliorated by EGCG pretreatment. Additionally, EGCG suppressed UV-induced phosphorylation of p38 and rescued UV-downregulated phosphorylation of ERK. Taken together, these results suggest that EGCG prevents UV irradiationinduced apoptosis in PC12 cells by scavenging ROS and inhibiting the mitochondrial pathways known to play a crucial role in apoptosis. In addition, EGCG inhibits UV-induced apoptosis via JNK inactivation and ERK activation in PC12 cells. Thus, EGCG represents a potential neuroprotective agent that could be applied to prevent neuronal cell death induced by UV irradiation.

Dentin hypersensitivity (DH) is defined as short and sharp pain caused by external stimuli such as heat, vaporization, contact, osmotic pressure, and chemical stimulation in a normal tooth, rather than due to disease or tooth damage. Its solution is to block the flow of dentinal fluid by physically blocking the dentinal tubule. Of these treatments, fluoride and oxalate type for hypersensitivity can only have a temporary effect. Resins should be used with a suitable bonding system and they may cause hypersensitivity symptoms after treatment. Overcoming these limitations, there is a need for method that can effectively treat dental hypersensitivity lasting long without any side effects. For this reason, experiments with 200 plant extracts as candidates for dentin hypersensitivity, Buddleja officinalis was considered as a candidate for present study. The purpose of this study is to confirm whether the ethanol extract of Buddleja officinalis is effective to protect enamel and dentin by coating tooth surface and resistance to acid or alkali even after tooth coating.

Sialadenoma papilliferum (SP) is a rare tumor that develops from salivary glands. First described by Abrams and Finck, the tumor shows a papillary form. The most frequent location of this tumor is the palate. In this case, we report a 63 year old man with a lesion located at the right retromolar of the mandible which might have caused bone resorption. Among with this case report, this paper discuss the feature of this rare tumor. The cases were searched from the pubmed website (https://www.ncbi.nlm.nih.gov/pubmed/) using the keyword ‘sialadenoma papilliferum’. Out of total 65 cases 41 patients were male and 19 patients were female. 4 patients were under the age of 20, 4 patients were between 21 and 40, 25 patients were between 41 and 60, 23 patients were between 61 and 80 and 4 patients were over 81 years old. The number of patients with the size of the lesion less than 1cm were 23, 16 patients had the size of 1cm to 2cm and 8 patients lesion were larger than 2cm. 22 lesions were located at the hard palate, 2 were at the soft palate, 6 were at the junction of hard and soft palate, 8 were at the buccal mucosa, 1 was at the upper lip mucosa, 3 were at the retromolar pad, 2 were at the tongue, 4 were at the parotid gland, 2 were at the floor of mouth, 1 was at the faucial pillar, 3 were at the bronchus, 1 was at the esophagus, 2 were at the nasopharynx, 1 was at the nasal septum, 1 was at the lung, 1was at the nasal cavity. In this case the lesion was found at an unusual location and although SP is known to be a benign tumor it may present bone resorption and have malignant characteristics.

Extranodal intraoral Hodgkin lymphoma is not common. We report the case of a 78-year-old male patient with ulcer of the mandibular oral mucosa that was not cured for about 3 weeks. In biopsy and histopathologic examination, it was found to be extranodal intraoral Hodgkin lymphoma. Early diagnosis of oral lesions led to early detection of lesions of the opposite neck lymph node in an additional PET-CT scan. We report this case and review relevant literature.

Acinic cell carcinoma is a well-differentiated, low-grade tumor that accounts for 1-3% of salivary gland tumors. Among the variant of acinic cell carcinoma, papillary cystic variant of acinic cell carcinoma is much more rare and it is known to be difficult to diagnose and has a poor prognosis. In this paper, we report a case of 58 - year - old man diagnosed as papillary cystic variant of acinic cell carcinoma and the characteristics of the lesion by integrating the recent cases of papillary cystic variant of acinic cell carcinoma. This study emphasizes the need for long-term studies and further investigation of papillary cystic variants of acinic cell carcinoma.

The occurrence of atypical lipomatous tumor of the head and neck is rare, and clinical and histologically differential diagnosis of the tumor is needed for other similar diseases. Herein we report atypical lipomatous tumor arising in neck area. And literature review was done. Complete excision with negative margins followed by long-term follow-up is recommended as the treatment of choice for these uncommon entities.

The aim of this study was to examine the effects and the sensitivity of antifungal therapy for patients with oral candidiasis and to investigate the relationship among the signs & symptoms of patients and the ratio change of Candida species to antifungal therapy. Candida fungus culture test with ChromeIDTM Candida agar (CAN2) was carried out more than twice for 10 patients who visited Oral Medicine department of Chonnam National University Dental Hospital during the period from Dec. 2015 to Aug. 2016. After culturing the smear sample before and after antifungal therapy in ChromeIDTM Candida agar (CAN2), the number of colonies was counted to compare. Patients were divided into 5 group according to the therapeutic effects of the antifungal agents used: 1) high susceptibility to nystatin, 2) low susceptibility to nystatin, 3) high susceptibility to fluzonazole, 4) low susceptibility to fluzonazole, and 5) increased ratio of new Candida species. Although nystatin is used as first-line therapy in oral candidiasis, it is desirable to use fluconazole if patients had a history of the low sensitivity to nystatin or chemotherapy. Even if the patient's symptoms and signs are improved, there is a possibility of oral candidiasis recurring, so that clinicians should be careful during the treatment with antifungal agents.

The purpose of this study is to analyze the distribution of Candida species in patients with oral disease and clarify the distinction of Candida culture test according to its isolation technique. 75 samples was isolated from 42 patients who visited Chonnam National University Dental Hospital due to oral disease from December 2015 to August 2016. For isolating the candida sampling, saliva sampling and oral swabbing were used. Acquired sampling was cultured in CHROMagar Candida Culture Medium, which indicates the candida species as color. Of the 42 patients, C. albicans was the most frequently isolated species in 39 patients. For 17 patients out of 21 who underwent saliva sampling and oral swabbing simultaneously, oral swabbing was quantitatively underestimated comparing to saliva sampling. 12 samples in 21 samples having particular Candida species were not isolated by oral swabbing. Considering the possibility of fungal infection in various oral disease, it is recommended to perform not only oral swabbing but saliva sampling when isolating Candida.

Composite resins are developed as restorative materials to improve esthetics and mechanical properties. To improve the physical properties of resin material, resin filler have to be added. However, no imaging method is adopted for resin filler distribution. Optical coherence tomography (OCT) is a optical imaging technique to delineate microscopic structures within biological tissue. The OCT application to dental composites resin and its filler is not described yet. So, this new and advanced optical method is needed for clinical application for evaluation of dental composite resin. To analyze the spatial distribution of dental composite resin and to evaluate the resin restoration in cavity, frequency domain optical coherence tomography (FD-OCT) was used for their analysis. Resin restored tooth was prepared. For morphological observation, serially sectioned teeth, conventional X-ray taking and micro computed-tomography (CT) images were compared with OCT images. The experiment has done to evaluate the success of the resin restoration using 3 dimensional structure OCT image. In this research, OCT is evaluated as a new technique to image resin restoration. The evaluation of resin restored tooth was performed by OCT. Inappropriate restoration such as marginal adaptation, large porosities, internal integrity and poor contour could be detected. Resin filler also could be checked by OCT. The distribution, number, regularity and size of resin filler can be differentiated from several commercial products. Considering the characteristics of the OCT, it can be used to evaluate the defects of resin restoration, resin filler distribution, and internal integrity between resin material and tooth structure. The OCT can be considered to be a new and advanced method for the evaluation of resin restorations.

The basic instrument for oral hygiene is toothbrush. Many patents that are announced to enhance efficiency and convenience by changing shape and using new material. There are also patents regarding its various functions. This study, the purpose of study, was surveyed the toothbrush patents from 2005 to 2014. The patent search was done in site 'kipris' using keyword ‘toothbrush’. Among sorts of administrative measure, enrollment and extinction patents was searched, followed by classified patents into its shape, materials, function and electronic toothbrush. For the patents with function, detailed analysis was done. Total numbers of toothbrush patents decreased in 2006 to 2008, lowest in 2008, and steadily increased to 2014. The patents regarding shape was outnumbered material. Shape and material patents could be divided by handle portion and head portion patents, which patents of head portion is more than handle portion. The patents of function could be classified into certain situation or combinate functions to its natural function. Function patents increase with the ratio of total patents. For brush patents, they have a tendence of increase. In addition, from a shape and function, toothbrush patents going to be more variable. It choose small quantity batch production. From a shape of toothbrush, patents regarding head portion are going to increase. And it has a tendency to change the shape rather than the development of materials for efficiency of toothbrushing. Electronic toothbrush will be placed certain position, however, conventional toothbrush also will place large portion by estimating patent number and there be more progressive. Some patents will catch popularity like combination of brush and paste, replacement of brush head, attraction for toothbrushing, and hygiene tooth brush. Also disposable toothbrush and portable toothbrush are getting popularity along with social phenomenon.

Along with toothbrushes, toothpaste has been used for a long time to improve the personal oral hygiene. Toothpaste was firstly introduced to Korea through as a form of powder by the Japanese company Lion Corporation in 1889 and in 1954, the LakHee Chemistry company released Korea’ s first ever tube type cream toothpaste called lucky toothpaste, and afterwards we got to where we are today in terms of toothpaste. As a variety of products are released and customer choices become more diverse, there needs to be a development of toothpaste that can fulfill customers’ needs and requests. Therefore, this study analyzes toothpastes and related patents submitted to the Patent Office from 1962 to June 2015, thereby examining the changes in toothpaste development trends up to the present day. This study was searched using the keyword ‘toothpaste’ in the patent, utility model search engine at Kipris(www.kipris.or.kr), a patent search site, and categorized a total of 2,465 patents, which excluded those rejected by the Patent Office and those unrelated to toothpaste, using titles, full texts of publications and announcements. Research results showed that in the past, from 1960 to 1989, patents related to toothpaste containers took up the highest ratio of 35%. However, after 1990, patents pertaining to toothpaste composites and functionality made up the highest percentage of 54%, and from 2010 to 2015, it occupied 72% of the whole; therefore, we analyzed in detail the patents related to composites and functionality. Taking a look at the objectives and effects of patents having to do with composites and functionality, we found out that from 1964 to June 2015, patents related to Base, a basic component of toothpaste, and those having to do with periodontal disease took up the highest percentages of 25% each, and from 2010~2015 in particular, patents concerning periodontal diseases were submitted 3% more than those about Base. Composites aiming to prevent and treat periodontal diseases can be divided into four different categories, based on components; among those, there were a total of 171 (57%) patents related to living organism and herbal medicine extracts, 107 (36%) patents using compounds, 16 (5%) patents using bamboo salt as well as salt, and 5 (2%) patents using mineral components such as gold, silver. Looking at these investigation results, it can be thought that with the increasing development of toothpaste related to periodontal diseases, there’ s a great amount of interest about toothpaste of effective periodontal disease prevention and treatment purposes. Along with this, we thought that research about how effective periodontal disease toothpastes actually are is also necessary.

cording to histopathological characteristics. One is composite tumor, and the other is collision tumor. Composite tumor is a lesion showing the combined histopathological characteristics of two or more previously recognized tumor and/or cysts of different categories. Two constituent parts are mixed with each other, and histological transition is often observed. On the other hand, collision tumor is a lesion showing the independent histopathological characteristics of two or more previously recognized tumor and/or cysts of different categories. Two constituent parts are separated each other by connective tissue, and histological transition is not observed. Their origin is still unclear. In this study, a collision tumor was reported. 77-year old woman was referred to CNUH with a neck mass in right submandibular area. Incisional biopsy was carried out, and the patient was diagnosed as collision tumor of squamous cell carcinoma and neurofibroma. After reviewing studies reporting collision tumor from head and neck area, formation of a collision tumor was most frequent from a cervical area and average age is 59.6. A collision tumor commonly lead to misdiagnosis, and the prognosis is not always transparent. The variety symptom of collision tumor has to be kept in mind in the diagnosis and treatment of the lesions in head and neck area.

Odontogenic cyst and odontogenic tumor shares developmental source. However, they have different histopathologic features, and they are classified respectively. Odontogenic cyst and tumor can share same physical region. It is called a hybrid lesion, a lesion showing the combined histopathological characteristics of two or more previously recognized odontogenic tumor and/or cysts of different categories. In this study, a hybrid lesion was researched. 61-year old man was referred to our department with a multilocular radiolucency in right mandibular angle. Incisional biopsy was carried out, and the patient was diagnosed with ameloblastoma. Odontogenic keratocyst was found with the tumor, and it was thought to be evolved via neoplastic transformation from lining epithelium of the keratocyst. After reviewing studies reporting hybrid lesions from odontogenic cyst and tumor, formation of a hybrid lesion was most frequent from a dentigerous cyst and an adenomatoid odontogenic tumor. A hybrid lesion commonly lead to misdiagnosis, and the prognosis is not always transparent. The close relationship between the odontogenic cyst and tumor has to be kept in mind in the diagnosis and treatment of the lesions in maxillofacial area.

We present a case of intraparotid plexiform neurofibroma in a 7-year-old man. The lesion was determined as plexiform neuroma in histopathological findings, but final diagnosis was plexiform neurofibroma considering his familiy history of neurofibromatosis and café au lait spots on his body. Currently we are executing follow-up after removing the tumor with surgery. Plexiform neurofibroma can develope at any point along a nerve and spread out either just under the skin or deeper in the body. According to the literature, the most common site of plexiform neurofibroma is mouth and face in the head and neck region. Also, plexiform neurofibroma occurs at 8.8-year-old in neurofibromatosis typeⅠ patient with familial history. Because of interlacing with adjacent normal tissue and the invasive nature we have difficult resecting the mass completely. So when the tumor turns symptomatic or disfiguring leading to an aesthetic problem, surgery had better be undertaken.

Proper oral hygiene is required to maintain oral health and prevent oral disease. Toothbrushing is central to proper oral hygiene. Mechanical tooth cleaning is the mainstay of plaque control. A variety of toothbrushing techniques have been developed and evaluated for their efficacy. However, these evaluations are subjective. To adequately evaluate toothbrushing objectively, a novel toothbrushing monitoring system was developed. The system involves user-monitored brushing patterns including toothbrush motions using a 3-axis gyroscope, 3-axis accelerometer, 3-axis magnetic sensor, one load-cell and Bluetooth devices. To confirm the efficacy of this toothbrushing monitoring system, eight periodontist performed tooth brushing in a dental model, and their brushing motion was monitored and recorded, and evaluated by statistical means. The proposed monitoring system can be used to aid dental care personnel in toothbrushing instruction.