반려동물은 점차 인간 삶의 중요한 동반자로 자리매김하고 있다. 이에 연구자들은 반려동물 상실과 이에 따른 애도에 주목하고 있다. 반려동물의 상실은 다른 상실과 달리 대개 그 부적응이 오래 지속되는 복합 애도로 나타나는 경우가 많다. 이러한 현상은 사람(vs. 반려동물)과의 관계가 더 중요하다는 사회적 인식에 기인하며, 이는 반려인이 자신의 상실 경험을 타인에게 제대로 이해받지 못한다고 여기게 만드는 일종의 ‘제약’으로 작용한다. 즉, 반려인의 지각된 사회적 제약은 이들의 반려동물 상실에 대한 회복을 저해하고 복합 애도를 유발하는 중요한 원인이 된다는 것이다. 따라서 본 연구는 반려동물의 죽음을 경험한 사람들을 대상으로 지각된 사회적 제약이 초기 상실 이후 적응을 방해함으로 써 그 충격이 복합 애도로 이어지는 과정을 심화시킬 것이라고 가정하였다. 연구 결과, 예상대로 지각된 사회적 제약은 상실의 충격과 복합 애도의 관계를 조절하는 것으로 나타났다. 구체적으로, 반려동물 상실 충격으로 인한 복합 애도는 사회적 제약을 크게 지각할수록 더 강하게 나타나는 경향이 있었다. 본 연구는 반려동물 상실 경험과 애도를 이해하는 데 지각된 사회적 제약이 중요한 역할을 담당함을 보여줌으로써 사회적 인식 변화 및 개선의 필요성을 제안한다.

Dentin hypersensitivity (DH) is defined as short and sharp pain caused by external stimuli such as heat, vaporization, contact, osmotic pressure, and chemical stimulation in a normal tooth, rather than due to disease or tooth damage. Its solution is to block the flow of dentinal fluid by physically blocking the dentinal tubule. Of these treatments, fluoride and oxalate type for hypersensitivity can only have a temporary effect. Resins should be used with a suitable bonding system and they may cause hypersensitivity symptoms after treatment. Overcoming these limitations, there is a need for method that can effectively treat dental hypersensitivity lasting long without any side effects. For this reason, experiments with 200 plant extracts as candidates for dentin hypersensitivity, Buddleja officinalis was considered as a candidate for present study. The purpose of this study is to confirm whether the ethanol extract of Buddleja officinalis is effective to protect enamel and dentin by coating tooth surface and resistance to acid or alkali even after tooth coating.

본 연구의 목적은 대학에서 신입생들을 위한 선후배간 코칭의 효과성을 검증하는 것이며, 구체적으로 코칭 이전과 이후 피코치의 대학생활적응, 진로결정자기효능감, 진로결정수준을 비교하는 것이다. 이를 위해 사전에 코치에게 ‘CMOE 5-STEPS coaching process’에 기반한 코치양성교육을 이수토록 하였다. 신입생 피코치 38명에 대해서는 선후배간 코칭을 시작하기 전 사전검사를 실시하여 진로결정자기효능감, 진로결정수준, 대학생활적응을 측정하였다. 이후 3달 간 코칭 프로그램을 진행한 후에 동일한 사후검사를 실시하여 피코치의 진로결정자기 효능감, 진로결정수준, 대학생활적응을 측정하였다. 그 결과로 첫째, 대학생활적응과 관련하여 피코치의 사회적응은 유의하게 증가하였으나. 대학환경적응은 유의한 차이가 없었다. 둘째, 진로결정자기효능감과 관련하여, 피코치의 직업정보, 목표선택, 미래계획, 문제해결, 자기평가의 모든 하위척도가 유의하게 증가하였다. 셋째, 진로결정수준과 관련하여 확실성은 유의하게 증가하였으나, 미결정성은 유의한 차이가 없었다. 또한 피코치는 코치를 같은 눈높이를 가진 자신만의 정서적 후원자로 인식하고, 진로와 관련된 객관적 정보를 함께 탐색하는 것으로 분석 되었다.

목 적: 본 연구는 MPC(2-methacryloyloxyethyl phosphorylcholine)와 PEGMA(poly(ethylene glycol) methacrylate) 등의 단량체를 사용한 콘택트렌즈의 물리적 성질을 살펴보고자 한다. 방 법: 시료는 하이드로겔의 기본 단량체인 HEMA(2-hydroxyethyl methacrylate)에 MPC, PEGMA, 그리고 Styrene를 혼합하여 공중합으로 제작하였다. 전체 시료는 중합한 8종의 콘택트렌즈와 시판되는 omafilconA을 사용하였다. HEMA에 MPC와 PEGMA를 혼합한 경우와 HEMA, MPC, PEGMA에 저함수 단 량체인 styrene을 추가한 경우를 비교하였다. 시료의 물리적 성질을 측정하기 위하여 함수율, 굴절률, 접촉 각, 인장강도를 측정하였다. 결 과: 함수율은 HMP시료가 가장 높으며, HS시료는 가장 낮은 값으로 나타났다. HS와 HSP시료의 굴절 률이 높은 값을 가지며 HM과 HMP시료는 낮은 값을 보였다. 인장강도의 경우, omafilcon A가 매우 낮게 나타났으며, HS시료가 높은 값을 나타냈다. 함수율이 증가하면 인장강도는 감소하는 경향성을 보였다. 접촉 각의 경우, HMP시료가 가장 낮아 높은 습윤성을 나타내었으며, HSMP시료는 가장 높은 값을 보여 습윤성 이 낮음을 알 수 있었다. Omafilcon A는 HSMP시료와 비슷한 접촉각을 보임으로써 본 연구에 사용한 8종의 시료와 비교하여 높은 접촉각을 나타내었다. 결 론: MPC와 PEGMA를 동시에 혼합하여 높은 함수율, 낮은 접촉각을 얻을 수 있었다. 본 연구를 통해 MPC와 PEGMA 단량체는 하이드로겔 콘택트렌즈의 습윤성을 개선하는데 기여한다는 것을 알 수 있었다.

This study was conducted to investigate the quality characteristics of the natural dishwashing liquid added with the mixture extracts of Curcuma Longa L. (CL), Morus alba (MA) and Ecklonia cava (EC) at various concentrations. The pH and lightness of the natural dishwashing liquid were reduced by adding the mixture extracts, while the turbidity was increased. The natural dish washing liquid added with mixture extracts was shown to display strong antimicrobial activities against L. monocytogenes compared to that of control. Also, it revealed that antioxidant activity was increased depending on concentrations. However, natural dishwashing liquid added with mixture extracts showed the low detergency efficiency. In sensory evaluation, the natural dishwashing liquid containing CL 0.5%, MA 0.25% and EC 0.25% was preferred than the control and it showed negative result in skin patch test. These results suggest that the addition of CL 0.5%, MA 0.25% and EC 0.25% positively improved the qualities characteristics in the natural dish washing liquid.

The quantity of the fuel gas consumed is trending upwards because it can be easily delivered but isn't deteriorated and doesn't have any environmental pollution. Though there are many advantages to use the fuel gas, it can be hesitated to consume more gas because of its explosiveness and combustibility. So paying more attentions to prevent the fuel gas accidents is required. In this paper, we examine the present situation data about the fuel gas accidents and analyze them statistically using ANOVA. we confirm that there is an acceptable difference between the mean values of accidents classified by the kind of gas, the cause, the type and the place but isn't by month. It is expected that our result can be applied as preliminary data when mapping out a strategy for preventing the fuel gas accidents.

The quantity of the fuel gas consumed are trending upwards because it can be easily delivered but isn't deteriorated and doesn't have any environmental pollution. Though there are many advantages to use the fuel gas, because of its explosiveness and combustibility, it can be hesitate to consume more gas. So paying more attentions to prevent the fuel gas accidents is required. In this paper, we examine the present situation data about the fuel gas accidents and analyze those statistically using ANOVA. we confirm that there is an acceptable difference between the mean values of accidents classified by the kind of gas, the cause, the type and the place but isn't by month. It is expected that our result can be applied as preliminary data when mapping out a strategy for preventing the fuel gas accidents.

As Standards and Specifications of the Saengsik-classes has been established since 2005 by KFDA. The microbial Standards and Specifications of the Saengsik-classes is as follows; no detection in Escherichia coli, colony forming unit less then 1,000/g in Bacillus cereus, colony forming unit less then 100/g in Clostridium perfringens respectively. Contamination levels of Total aerobic bacteria, Escherichia coli,, Bacillus cereus and Clostridium perfringens in Saengsik-classes were monitored. Total aerobic bacteria counts in Saengsik-classes was 1×10¹~5.3×107 cfu/g, for Bacillus cereus 1×10²~9×10² cfu/g, for Clostridium perfringens 1×10¹ cfu/g. Escherichia coli, was not isolated from all Saengsik-classes. Thess results will provide information for introduction of HACCP system to ensure microbial safety of Saengsik-classes.

In this study, microbial investigation is accomplished for 554 Jeot-kal samples (102 of Jeot-kal, 448 of Seasoned Jeot-kal and 4 of Sik-khe, respectively) that corresponds with Coliform-bacteria, Escherichia coli, Aerobic live bacteria as hygienic indicator microorganisms, and Staphylococcus aureus, Vibrio parahaemolyticus as Food-borne pathogenic microorganisms. Based on the methods in Korea Food Code, reliable data are obtained as follows; in 31.9% rate of the samples, Coliform bacteria are verified in the extent of 0~20,000 CFU/g as 2.3 logCFU/g. Especially, Seasoned Jeot-kal (37.7%, 2.3 logCFU/g) are detected to 6 and 2 folds higher than those of Jeot-kal, 5.9% and 1.4 logCFU/g. Likewise, Escherichia coli is detected from 9 samples only in Seasoned Jeot-kal, that includes seasoned squid, seasoned octopus, seasoned roe of pollack, seasoned large-eyed herring and seasoned hairtail. Aerobic live bacteria are also detected in the range of 0~8.9 × 108 CFU/g. Against salinity, E. coli are detected in samples only less than 10% salinity. Concomitantly, aerobic live bacteria count is decreased to 5.5~3.6 log CFU/g upon the salinity is increased up to 25%. However, S. aureus and V. parahaemolyticus are not detected in 554 samples, presumptively referring Jeot-kal products are somehow free from such food-borne pathogens. As the results above, we deliberately consider that the sanitary control in Jeot-kal, which be necessarily fermented- as well as non-microbially inactivated should be ensured in near future and also suggest an effectual microbial standard corresponding to the Negativity in E. coli for Jeot-kal products.

골다공증 치료제로 이용되고 있는 hPTH는 체내의 혈중 칼슘 농도를 조절하는 인간의 부갑상선 호르몬이다. 본 연구에서는 hPTH를 효율적으로 생산하는 돼지세포를 구축하고자 다양한 retrovirus vector를 이용하였는데 다음과 같은 결과를 관찰하였다. 1) hPTH 유전자의 전이를 확인하기 위해 RT-PCR을 수행한 결과, 형질전환된 모든 돼지세포에서 420 bp의 hPTH에 해당하는 단편을 확인할 수 있었으며, WPRE가 도입되지 않은 실험군보다 WPRE서열이 도입된 실험군에서 더 강한 밴드를 확인하였다. 2) ECLIA 측정 결과 hPTH 유전자가 도입된 모든 세포에서 hPTH가 생성되었으며, 특히 Tet-On system에서는 doxycycline을 처리한 실험군에서 hPTH의 발현이 유도되었음을 확인하였다. 또한 RT-PCR과 ECLIA을 수행하여 hPTH의 도입 여부와 단백질 생산을 비교한 결과, WPRE 서열이 hPTH 유전자의 downstream 위치에 도입된 실험군에서 가장 많은 단백질이 생산됨을 확인할 수 있었다.

In order to investigate bacterial sanitary condition of fish and shellfish, we examined the normal flora in the 25 species of commercial fish and shellfish, and also proportional change of normal flora by storage period and temperature. Isolated 334 were isolated in the normal fish and shellfish and predominant genera were Pseudomonas (25.2%), Staphylococcus (10%), Acinetobacter (7.2%), Vibrio (6.9%), Micrococcus (5.4%), Aeromonas (5.2%), and Enterobacter (5.2%). In accordance with storage period and temperature, Pseudomonas grew on high ratio at 10℃ steadily, but Proteus had increased proportionally at 20℃ and 30℃. Additionally, Citrobacter, Moganella, and Pasteuralla had increasd, while Achromobacter, Acinetobacter, Yeast, and Micrococcus had decreased by period.

In patients with acute cerebral infarction, taranscranial ultrasonography is helpful in assessing blood flow, but in some patients, failure to detect cerebral blood flow through the temporal window is an important problem in expansion of clinical indications for transcranial ultrasonography. This study was performed between May 2016 and September 2016 in patients admitted to the neurology department of Chosun University Hospital with cerebral infarction and underwent transcranial ultrasonography and brain magnetic resonance image. Of the 129 patients, 47 were female (36.4%). The mean age of the patients was 80.7±8.0 years. Fifty patients (38.8%) did not showed any blood flow signal due to poor temporal window. The mean age of patients with temporal window failure (83.8±6.0 years) was significantly higher than without temporal window failure (78.7±8.5), and the temporal window failure was significantly higher in women. In conclusion, temporal window failure was more common in elderly and women in this study. In addition to temporal bone thickness and heterogeneity of temporal bone due to osteoporosis, hyperlipidemia may also be associated with temporal window failure and future prospective studies will be needed.

Many traditional designs and products can be seen to be out of step with modern society. While being marginalized from the contemporary market for this reason, they are highly regarded in terms of their historical and traditional values embedded in ways of life in the particular community over time and transmitted from generation to generation. This paper aims to explore cultural significance embodied in such designs and products and clarify its meaning and interpretation for people today who make and/or use them. This will help craft makers and designers better understand what to bear in mind while trying to revitalize them without losing its essential meaning and value. Employing an in-depth case study method, 11-day field research was undertaken to explore traditional designs and products in New Mexico, USA as a successful example of well-sustained and thriving art and craft culture acknowledged both locally and internationally. Based on key informant interviews and site visits, research findings are discussed mainly around three areas: traditional crafts, artisans and place. Based on the analysis of research findings, key success factors of traditional designs and products in Santa Fe are discussed, from which implications for important elements that consist of cultural significance attached to the products can be drawn.

게임 개발에 있어서 사용자와 게임간의 상호작용은 중요한 요인이다. 본 논문은 슈팅게임에서의 Leaderboard UI에 대해 고찰하고 Leaderboard UI의 유무 및 제공하는 빈도에 따른 사용자의 수행수준에 대하여 연구한다. 본 연구를 위해 3인칭 슈팅 게임을 개발하였으며 80명의 대학생을 대상으로 실험을 진행하였다. 실험결과에 대해 T-test 분석 기법을 활용하여 그 통계적 의미를 분석하였다. 최종적으로 사용자의 수행수준 향상을 위해서는 Leaderboard의 유무 및 제공 빈도보다는 사용자의 게임 경험이 더 큰 요인이며 유의미한 차이를 발생시킨다는 결론을 얻었다.

Bacterial meningitis is an uncommon complication of pituitary macroadenoma. Bacterial meningitis can occur in patients with pituitary macroadenoma who have received sphenoidal surgery or had cerebrospinal fluid (CSF) rhinorrhea. A 62-year-old male visited our hospital for headache and fever. Brain magnetic resonance imaging showed a pituitary macroadenoma. CSF study revealed acute bacterial meningitis. Intravenous antibiotics and hydrocortisone replacement therapy were started, and lead to good clinical outcome. Bacterial meningitis should be considered in patients with a pituitary macroadenoma who present with meningitis symptoms, even though in the absence of rhinorrhea or surgical history.

UV 뿐 아니라 가시광선, 적외선에 의해 발생된 열로 인해 피부 온도 상승, MMP-1의 증가에 따른 피부 노화가 진행된다. 따라서 열에 의한 노화에서 피부 온도 조절은 노화 억제에 중요한 핵심 요소이다. 일시적인 수용체 전위 통로인 TRPM8은 멘솔 수용체(CMR1)로써 25 ℃ 이하의 온도에서 활성화되고 시원한 감각을 발생시키는 냉 수용체로 보고되어 있다. TRPM8 조절을 통해 시원한 감각과 피부 온도를 조절하는 연구가 활발히 진행되고 있다. 본 연구에서는 천연물인 영지버섯을 이용하여 냉 수용체인 TRPM8 발현에 어떠한 영향을 주는지 확인하였다. 영지버섯추출물 및 용매 분획물의 TRPM8 발현에 대한 영향을 측정한 결과, 영지버섯추출물, n-hexane 분획물 및 water 분획물에서 농도의존적으로 TRPM8 발현이 증가함을 확인하였 다. Hex 분획물에서 유효성분을 찾고자 크로마토그래피를 실시하여 1개의 화합물을 분리하였으며 1H 및 13C NMR spectrum 분석을 통하여 화학구조를 동정하였다. 분리된 화합물은 에르고스테롤로 TRPM8 발현 증가에 효과가 있음을 확인하였다. 결과를 토대로, 영지버섯추출물 및 에르고스테롤은 화장품 분야에서 새로운 쿨링 소재로서 개발가능성이 있다고 사료된다.

The incidence of ischemic stroke increases with age due to improvements in health care and living conditions. With increasing proportion of old age, the proportion of old age is rapid expansion in acute ischemic stroke patients. Young and old age groups in acute ischemic stroke patients have different risk factors and clinical features. But, many patients of old age are excluded from active treatment like thrombolysis due to hemorrhagic transformation, poorer clinical outcome etc. So we studied clinical features, risk factor, outcome in ≧80 years old patients compared with <80 years. We enrolled 1,445 patients, who diagnosed acute ischemic stroke in Chosun university hospital, from January 2013 to December 2015. Patients were divided into two groups: ≧80 years versus <80 years. We compared with two groups about risk factors, stroke subtypes, thrombolysis, complications in hospital, initial National Institutes of Health Stroke Scale (NIHSS) score, prognosis. Of the total 172 patients, 54(31.4%) patients were 80 years or older. Symptomatic hemorrhage and asymptomatic hemorrhage was not different between both groups [over 79 years patients: 4/54 (7.4%) vs. under 80 years patients: 10/118 (8.5%), p>0.302], [16.7% vs. 17.7%, p>0.701]. There were no difference in mortality and favorable prognosis at 3 months later between both groups [over 79 years patients: 5/54 (9.3%) vs. under 80 years patients: 5/118 (4.2%), p=0.290], [over 79 years patients: 13/ 21 (24.1%) vs. under 80 years patients: 56/86 (47.5%), p=0.803]. There was difference in early neurological improvement rate(improvement > NIHSS 3) and degree of improvement (NIHSS at discharge - NIHSS at admission) were significant[over 79 years patients: 24/54 (44.4%) vs. under 80 years patients: 77/118 (65.8%), p=0.012], [2.69 vs 5.55, p=0.017]. Intracranial hemorrhage(symptomatic and asymptomatic) and favorable prognosis are not different significantly between two groups. Elderly patients is not a absolute contraindication for intravenous thrombolysis. For intravenous thrombolysis in elderly ischemic stroke patients, we need more study to exclude the poor prognostic factors and to consider of gain of patients.

For patients suffering from acute ischemic stroke from cerebral artery occlusion, reperfusion is necessary to save the ischemic penumbra. Therefore, early and complete recanalization of an occluded artery is the main therapeutic goal of acute ischemic stroke. Among the many advances in management of acute ischemic stroke, thrombolysis with intravenous (IV) tissue plasminogen activator (t-PA) within 4.5 hours after symptom onset has been the only approved pharmacological therapy. However, IV t-PA has many limitations in clinical practice, low eligible patients and low recanalization rates, particularly in cases of larger proximal artery occlusions. In addition, there are many complications, including symptomatic intracranial hemorrhage (approximately 6%). In contrast, higher recanalization rates and an extended therapeutic time window have been reported for intra-arterial (IA) thrombolysis. According to studies until 2013, no studies proving the advantages of IA thrombolysis have been reported. However it was reported that studies in 2015 showed its possibility. Therefore, the purpose of this article is to cast a light on failures of previous studies, and try to assess the differences with studies in 2015. In addition, crucial points for successful IA thrombolysis will be discussed.

Guillain-Barré syndrome can be classified with several subtypes along with the union of each symptom. Autoimmune mechanism is accepted for pathogenesis. It is often difficult to predict the causative antibodies of the various types of Guillain- Barré syndrome, because there are considerable mismatches of causative antibody to clinical phenotype as well as phenotype or antibody heterogeneities. We investigated the clinical characteristics of the patients with positivity of anti-gangliosides antibody in the serum. Nineteen patients were enrolled who showed the positivity of anti-GM1 antibody, anti-GQ1b antibody and anti-GD1b antibody, who had visited the department of neurology of Chosun University Hospital. We classified the three patient groups; 8 patients had positivity for anti-GM1 antibody, 10 patients for anti-GQ1b antibody and 8 patients for GD1b antibody. The result of statistical analysis showed no clinical difference within the groups. Therefore, prediction of causative autoantibody can be risky when we considered only the symptoms and course of disease of Guillain-Barré syndrome.