Nasopharyngeal stenosis is defined as a morphological transition of narrowing at the nasopharyngeal region. A 2-yearold, castrated male, Korean short hair cat was referred to the animal medical center, Gyeongsang National University. According to clinical signs, diagnostic imaging, and physical examination, nasopharyngeal stenosis was diagnosed. The staphylectomy was performed using a CO2 laser, and there were not any post-operative complications. The patient was discharged in two days. This report describes the case of nasopharyngeal stenosis in cat and represents that laser ablation could be a good option for surgical management of the nasopharyngeal region with a low complication rate.

A 12-year-old, spayed female, Pomeranian dog was referred for limbs stiffness and circling movement. Computed tomography(CT) and magnetic resonance imaging(MRI) revealed a contrast-enhanced space-occupying lesion suggestive of meningioma in the olfactory groove to the right frontal lobe. For a successful and accurate surgery, 3D printing technique for preoperative planning and 3D guide was applied. Surgical excision of the meningioma was successfully performed. The postoperative complications were managed through medical treatment and patient care without the revision surgery.

Consumers' online reviews have become more powerful in the Internet market. Consumers share reviews, post comments and constantly evaluate products online. In previous studies, the analysis of online reviews mainly focused on purchasing products based on consumers' own use experience, but in innovative products, it was difficult to find an analysis of product acceptor's response to product user reviews. In particular, there is no online review study of VR covered in this study. This study not only quantitatively analyzed online reviews of consumers who purchased VR products on Amazon, an online distribution site, but also qualitatively analyzed them through crawling. This study used Amazon's VR product user review, where purchases were confirmed, to select algorithms that are more likely to be matched by predicting a helpful review and presenting a predictive model. In addition, the online review extracted deep text associated with Helpful and conducted topical modeling. As a result, topics related to 1) experience in use, 2) post-product evaluation, 3) product composition and peripherals, 4) immersion, and 5) comfort were highly acceptable to potential inmates. To enhance the acceptability of innovative products through online reviews, it is not just highlighting the product advantages of VR, but also suggests that the link between smartphones and applications can bring in more potential users. Also, interworking with other peripheral devices (speakers or screens) can be predicted as a way to increase the acceptability of VR products. From a marketing perspective, this study has found targeted topics that help consumers in pioneering the VR market, which will help potential customers create the services they want.

The aspiration of entrepreneurs to extensively grow their firms has been found to make stronger contribution to economic growth than the entrepreneurship rate in general. Formal and informal institutions shape the business environments in which companies are operating. Thus, they affect entrepreneurs’ beliefs about firm growth. However, prior research gives little attention to the interaction effects of formal and informal institutions on entrepreneurial growth aspiration.

파기스탄은 중국과 공식 외교관계를 맺은 첫번째 이슬람 국가이다, 양국의 전통적 우호관계 및 “전천후 전략적 협력 동반자관계”는 중-파 경제회랑에 외교적으로 기여해 왔고, 지역 협력에도 기여해 왔다. 하지만, 근래 파기스탄의 포퓰리즘은 양국의 경제무역협력 및 인문교류의 걸림돌이 되고 있다. 본 논문은 우선 질적으로 국내외 학술계가 포퓰리즘에 관한 문헌을 정리하였다, 그리고 양적으로 BDP 데이터분석 소프트웨어를 통해 국내외 학계의 포퓰리즘 관련 문헌을 시각화분석(Visualization)하였다. 또한 시각화가 파기스탄 포퓰리즘에, 또는 중-파 경제회랑에 주는 시사점도 도출하였다. 아직 국내외 학술계가 파기스탄의 포퓰리즘에 크게 주목하지 않고, 포퓰리즘의 정도도 그리 심각하지는 않다. 그러나 파기스탄의 포퓰리즘은 민족성 및 나라의 특수성 때문에 주기적인 발전과정을 거치고 있기 때문에, 중국-파키스탄 경제회랑 등이 지속적으로 심화하는 상황에서는, 향후 파기스탄의 포퓰리즘이 심각해질 수도 있다.

Efforts on the continued increase of local government's fiscal spending related to improving the residential environment are desirable to counter the declining phenomenon of urban decline. At the same time, however, it is also important to know how to operate limited finances more efficiently to improve the residential environment. This study aims to contribute to the rational allocation of fiscal expenditure and the creation of productive results for the improvement of the settlement environment. To this end, this study analyzed the efficiency of financial expenditure related to the improvement of the residential environment in 225 local governments nationwide. The relationship between financial expenditure and residential environmental performance was also measured and the CCR, BCC and SBM models were used to measure efficiency. The analysis showed that most local governments need to scale back their fiscal spending related to improving the government environment. In addition, it was required to prepare feasible spending plans by bench-marking the processes of residential environment improvement projects in areas such as Haman-gun, Jongno-gu, Seoul, and Seocho-gu, which are considered to be under efficient operation.

The highway junctions are the areas where frequent congestion occurs due to a conflict between vehicles entering the main road from the connecting road and vehicles passing through the main road, which is the main target of microscopic and macroscopic traffic flow study. The importance of study on the behavior and the interaction between vehicles at the highway junctions has been emphasized as an essential element of the Cooperation Intelligent Transport System (C-ITS) and Autonomous Vehicle technology. In this study, merging location and time of vehicles in acceleration lane of highway merging area is recorded by aerial videos from drones, and vectormodelling method was developed with merging location (y-axis) and merging time (x-axis). In the vector model, the vector region of the traffic flow is represented by the realistic expressible vector region and the stable entry into the highway. The model is compared with the traffic conditions according to speed, traffic volume, and density in main line and connecting road. This study can be used as a basic data for understanding the behavior of vehicles at the highway junctions and It is expected to be used as an operational indicator for advanced transportation such as lamp metering, C-ITS, and Autonomous Vehicle technology to stable traffic flow on the highway.

The building which are essential for disaster recovery is classified as a special seismic use group. Especially, achievement of seismic performance is very important for the hospital, so the hospital should be able to maintain its function during and right after an earthquake without significant damage on both structural and non-structural elements. Therefore, this study aimed at checking the seismic performance of a hospital building, but which was limited to structural elements. For the goal, a plan with a configuration of general hospitals in Korea was selected and designed by two different seismic-force-resisting systems. In analytical modeling, the shear behavior of the wall was represented by three inelastic properties as well as elastic. Nonlinear dynamic analyses were conducted to evaluate the performance of structural members. The result showed that the performance of shear walls in the hospital buildings was not satisfied regardless of the seismic-force-resisting systems, while the demands on the beams and columns did not exceed the capacities. This is the result of only considering the shear of the wall as the force-controlled action. When the shear of the wall was modeled as inelastic, the walls were yielded in shear, and as the result, the demands for frames were increased. However, the increase did not exceed the capacities of the frames members. Consequently, since the performance of walls is significant to determine the seismic performance of a hospital building, it will be essential to establish a definite method of modeling shear behavior of walls and judging their performance.

The need for eco-friendly building materials such as engineered wood has increased to reduce carbon emissions. Although the range and height of engineered wood buildings are gradually increasing in North America and Europe, engineered wood is mainly used for low-rise residential buildings in Korea. In order to reduce carbon emissions more, therefore, it needs to expand the use of engineered wood by applying it to various buildings with different uses or more stories. With this background, the aim of this study is to investigate the applicability of engineered wood for 9-story office buildings. Since a 9-story building with engineered wood only is not allowed in KBC, an example building has RC ordinary shear walls as the lateral force resisting system while engineered wood is only used for gravity load resisting moment frames. Another example building is also used for comparison where both lateral and gravity load resisting systems are designed by RC. The applicability of engineered wood is investigated by comparing the seismic performance and the amount of carbon emission of both buildings. The result shows that the seismic performance of both buildings was not significantly different while the amount of carbon emission of the engineered wood building was much less then the RC building. Based on this result, engineered wood is sufficiently applicable to 9-story office buildings even though it still needs to pay attention to the shear design of reinforce concrete walls.

This study examines the construction and management of physical facilities in natural recreational forests that have been created after gaining an understanding of how visitors will use them. It also studies operations tailored for the use of visitors to natural recreation forests. The study presents basic data pertaining to management of natural recreation forests, analyzes the impact of current facilities on visitor satisfaction, and reveals the potential for new programs to be implemented. The independent variables in this study are facilities and program establishment/management and program utilization pertaining to the operation of natural recreation forests. The considered variables include facilities management and facilities requirements categorized by state programs. Program needs were analyzed using correlation. The state of facilities management in natural recreation forests, utilization program implementation, and demand for utilization programs were found to have a positive (+) influence on visitor satisfaction. The results of the rank regression analysis of the influence of the independent variables on visitor satisfaction decreases in the following order: state of facilities management, utilization program implementation, and demand for utilization programs. Visitors to natural recreation forests prefer recreational activities that provide a break from their normal routine, rather than the use of other aggressive utilization programs. Therefore, a higher priority should be given to ensuring appropriate provision of facilities that generate higher visitor satisfaction, as well as their stable management, compared to other utilization programs. Therefore, there are some indications that natural recreation forests of the future will benefit from the development and implementation of an essential set of utilization programs that will have a positive (+) impact on visitor satisfaction.

To prepare the dried Cirsium setidens Nakai appropriate to the gondre-namul, this study investigated the effects of steaming and blanching on its color characteristic, degree of browning, peroxidase activity, rehydration, and preference test. Cirsium setidens Nakai (gondre) was steamed for 5-15 min and blanched in different blanching solutions for 1-5 min, followed by drying at 50oC. The blanching solutions used in this study were water, and 0.5% (w/v) solutions of NaCl, CaCl2, and sodium polyphosphate (SPP). The control was dried without pre-treatment. Relative to the control, the lightness of dried Korean thistle decreased, except for that blanched with NaCl solution, whereas its redness decreased except for that steamed. All treatments exhibited lower yellowness than the control. Also, all treatments revealed a lower degree of browning and peroxidase activity than the control. Rehydration was reduced by pre-treatments of Korean thistle relative to the control. Korean thistle blanched for 1 min with CaCl2 solution exhibited higher points for color, flavor, taste, and overall acceptability than those of the control. Overall, blanching with CaCl2 solution would be an appropriate way of preparing the gondre-namul using dried Korean thistle, accompanying the common way by blanching with NaCl solution.

본 연구는 nano-silica solution(NSS)을 배합수 중량치환방법을 사용한 OPC-slag cement의 특성에 관한 연구이다. 새로운 치환방법은 선행연구들보다 높은 NSS 치환율의 시멘트에 대한 거동을 연구하기 위한 기초 단계이다. NSS는 배합수 중량의 10%, 20%, 30%, 40%, 그리고 50% 치환하였다. 그 결과 역학적 및 미세구조적 특성이 향상되는 결과를 보였다. 이는 두 가지 원인으로 요약된다. 첫 번째는 NSS를 배합수 중량 치환하면 나노 실리카 입자의 균질한 분산작용이 향상된다. 이는 초기 수화작용을 촉진한다. 두 번째는 배합수 보다 밀도가 큰 NSS의 치 환은 w/b를 감소시킨다. 이는 치밀한 수화반응물질을 형성시킨다. 새로운 치환방법은 선행연구에서 밝혀진 분말형 나노 실리카 입자를 사용한 결과와 비교하여 역학적과 미세구조 특성의 저하가 나타나지 않았다. 따라서 본 연구에서 사용한 NSS를 배합수 중량 치환한 방법은 OPC-GGBFS cement의 배합에 적용 가능할 것으로 판단된다.

Patients with type II diabetes mellitus are more susceptible to colorectal cancer (CRC) incidence than non-diabetics. The anti-diabetic drug metformin is most commonly prescribed for the treatment of this disease and has recently shown antitumor effect in preclinical studies. The aberrant mutational activation in the components of RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signaling pathway is very frequently observed in CRC. We previously reported that metformin inhibits the phosphorylation of ERK and BEZ235, a dual inhibitor of PI3K and mTOR, has anti-tumor activity against HCT15 CRC cells harboring mutations of KRAS and PIK3CA. Therefore, we hypothesized that simultaneous inhibition of two pathways by combining metformin with BEZ235 could be more effective in the suppression of proliferation than single agent treatment in HCT15 CRC cells. Here, we investigated the combinatory effect of metformin and BEZ235 on the cell survival in HCT15 CRC cells. Our study shows that both of the two signaling pathways can be blocked by this combinational strategy: metformin suppressed both pathways by inhibiting the phosphorylation of ERK, 4E-BP1 and S6, and BEZ235 suppressed PI3K/AKT/ mTOR pathway by reducing the phosphorylation of 4E-BP1 and S6. This combination treatment synergistically reduced cell viability. The combination index (CI) values ranged from 0.44 to 0.88, indicating synergism for the combination. These results offer a preclinical rationale for the potential therapeutic option for the treatment of CRC.

This study aimed to investigate the various biological activities of Geranium thunbergii such as antimicrobial activity and protective effect against oxidative damage. To evaluate its antioxidant and antimicrobial activities, we first performed methanol extraction; this methanol extract was further partitioned using various solvents. And then, its antioxidant activity was measured using various assays including total phenolic content and protection against oxidative DNA damage, and antimicrobial activities were examined using minimum inhibiting concentration (MIC) test, and paper disc method. In addition, high-performance liquid chromatography was performed to analyze the major chemical components of ethyl acetate fraction. The G. thunbergii fraction with ethyl acetate exhibited higher antioxidant and antimicrobial activities than the other fractions. The results showed that G. thunbergii ethyl acetate fraction at 50 μg/mL had strong DPPH and ABTS radical scavenging activities of 80.88% and 80.12%, respectively. In addition, the ethyl acetate fraction protected DNA from the oxidative damage induced by ferrous ion and hydroxyl radicals and showed high antimicrobial activity with diameter of inhibition zones ranging from 13.33 to 15.67 mm. High-performance liquid chromatography analysis revealed the major phenolic compounds of G. thunbergii to be ellagic acid and gallic acid. These results suggest that G. thunbergii might protect DNA against oxidative stress induced by reactive oxygen species and can be utilized as a natural source of antioxidant and antimicrobial agent in the food industry.

신선한 곤드레를 메탄올로 침지 추출하여 얻어진 추출물 에 대해 n-hexane, EtOAc 및 n-BuOH로 극성별 순차 용매 분획을 실시하였고, 얻어진 결과물에 대하여 DPPH와 ABTS+ radical 소거능 및 최종당화물 생성 저해활성을 평가 하였다. 먼저 DPPH 라디칼 소거활성은 페놀성 화합물의 함량이 상대적으로 높은 n-BuOH 가용부에서 IC50값이 24.3±1.7 μg/mL 으로 우수한 DPPH 라디칼 소거능을 확인하였고, 곤드레 추출물에 존재하는 페놀성 화합물과 라디 칼 소거능과의 연관성을 시사하였다. 또한 ABTS+ 라디칼 소거능은 EtOAc 및 n-BuOH 분획층물의 IC50값은 각각 69.5±2.6 μg/mL, 25.0±3.3 μg/mL의 라디칼 소거활성이 확인 되었고, 우수한 라디칼 소거 활성물질의 존재가 시사되었 다. 또한, 최종당화물 생성 저해활성을 측정한 결과, n-BuOH 가용분획에서 IC50값이 46.0±1.5 μg/mL로 높은 생 성저해활성을 나타내었으며, 이는 positive control인 aminoguanidine의 IC50값인 90.2±3.2 μg/mL과 비교해볼 때 우수한 활성이었으며, 다양한 화합물이 공존하는 추출물 상태의 시료를 단일물질로 정제할 경우 더욱 우수한 효능의 화합물이 존재할 가능성을 시사하였다. 향후 이들 활성물 질 동정을 통한 활성물질의 구조 결정 및 활성 기작에 대한 연구가 필요하며 본 연구결과는 천연물 유래의 라디칼 소거 능 및 AGEs 생성 저해능을 가지는 새로운 천연 기능성소재 발굴을 위한 기초자료로 활용가능하리라 사료된다.

단풍취를 70% 에탄올로 침지 추출하여 얻어진 추출물에 대해 n-hexane, EtOAc 및n-BuOH로 순차 용매 분획하였고,얻어진 결과물에 대하여 DPPH와 ABTS+ radical 소거능및 α-glucosidase 저해활성을 평가하였다. DPPH 라디칼 소거능은 페놀성 화합물의 함량이 상대적으로 높은 EtOAc층에서 IC50 값이 23.4±0.3 mg/mL으로 강한 DPPH 라디칼 소거능을 확인하였고, 단풍취 추출물에 존재하는 페놀성 화합물과 라디칼 소거능과의 연관성을 시사하였다. 또한 ABTS+ 라디칼 소거능은 EtOAc층의 IC50 값이 19.9±2.3mg/mL, n-BuOH층이 IC50 값이 23.4±0.3 mg/mL의 우수한라디칼 소거활성이 확인 되었고, 강한 활성물질의 존재가 시사되었다. 또한, α-glucosidase 저해활성을 측정한 결과, 강한 ABTS+ 라디칼 소거능을 나타낸 EtOAc 층의 IC50은 103.4±1.0 mg/mL의 저해활성을 나타내었으며 이는 positive control인 acarbose에 비해 우수한 활성이었으며, 추출물 상태의 시료를 단일물질로 정제할 경우 더욱 강한 효능의 화합물이 존재할 가능성을 시사하였다. 향후 이들 활성물질 동정을 통한 활성 기작에 대한 연구가 필요하며 본 연구결과는 보다 우수한 라디칼 소거능 및 α-glucosidase 저해능을 가지는 새로운 기능성 식품소재 발굴을 위한 기초자료로활용가능하리라 사료된다.

본 연구에서는 상백피의 소화효소 저해활성과 3T3-L1 전지방세포의 분화 억제능을 기반으로 항비만 효능소재로 서의 활용가능성을 평가하였다. 상백피의 에탄올 추출물 (MRE)은 α-amylase와 α-glucosidase, pancreatic lipase를 활 용한 소화효소 저해활성 평가 실험에서 각각 7.86±0.36, 0.12±0.03, 7.93±0.11 mg/mL 의 IC50 값을 보이며 우수한 억제 활성을 나타냈다. 또한 3T3-L1 전지방세포를 활용한 세포분화억제효능실험에서 MRE 처리군의 세포내 지방 축 적율은 농도 의존적으로 감소되었다. 상백피의 항비만 작 용 기전을 구명하기 위하여 adipogenesis 및 lipogenesis와 관련된 유전자 발현양상을 분석한 결과, 상백피 추출물 처 리군에서는 생체내 지방대사 조절에 중요한 역할을 하는 FAS와 ACC 뿐 아니라 adipogenesis와 lipogenesis와 관련된 주요 전사요소인 PPARγ와 C/EBPα, SREBP-1c의 유전자 발현이 현저하게 억제되었다. qRT-PCR 분석 결과, 상백피 추출물의 anti-adipogenesis 효능은 전사단계에서의 관련 유 전자 발현억제에 기인한다고 판단되었다. 본 실험결과 상 백피 추출물은 전지방세포의 분화와 세포내 지질합성을 저해하고 비만과 관련 된 소화효소에 대한 저해활성을 나타 내었다. 이러한 결과를 기반으로 상백피의 비만 예방 소재 로서의 잠재적인 가능성을 확인하였다.

본 연구는 섬더덕의 항비만 효능과 지질대사 개선효과를 알아보기 위해 C57BL/6J 4주령의 마우스에게 고지방식이를 9주간 급여하여 비만을 유발한 후 섬더덕 추출물을 첨가한 식이를 5주간 먹여 실험하였다. 체중은 고지방식이군에서 유의적으로 증가하였으며, 섬더덕 추출물을 먹인 마우스에서 유의적인 감소를 하였다. 식이효율 결과 또한 섬더덕 추출물을 공급한 군이 고지방식이군보다 통계적으로 유의하게 낮은 것으로 나타났다. 장기 및 지방무게에서도 고지방식이군에서 무게가 증가한 것을 확인하였고, 섬더덕 추출물을 공급한 군에서 장기 및 지방의 무게가 전반적으로 감소한 것을 알 수 있었다. 혈장을 이용한 중성지방, 총콜레스테롤, 고밀도콜레스테롤을 측정한 결과 섬더덕 추출물을 공급한 군에서 중성지방과 총콜레스테롤은 유의적으로 감소하였고, 고밀도콜레스테롤은 유의적으로 증가함을 확인 할 수 있었다. 동맥경화 지수와 심혈관계 위험도 지수는 감소된 것을 확인할 수 있었다. Western blot을 통해 지방관련 단백질 발현양상을 본 결과 지방분해에 관여하는 PPAR α의 경우 섬더덕 추출물을 급여함으로써 발현양이 증가하였으며, 지방생성 관련 단백질인 SREBP-1, FAS, ACC의 경우 고지방식이군과 비교 시, 섬더덕 추출물을 공급한 군에서 억제되었다. 이상의 결과로 섬더덕 추출물의 섭취는 체중 감소와 더불어 혈장 지질수준 개선에도 도움을 줄 수 있음을 제시하였다.