This study aimed to develop a solid self-nanoemulsifying drug delivery system (solid-SNEDDS) to enhance the formulation of ketoconazole (KTZ), a BCS Class II drug with poor solubility. Ketoconazole, which is insoluble above pH 3, requires solubilization for effective delivery. This SNEDDS comprises oil, surfactant, and co-surfactant, which spontaneously emulsify in the gastrointestinal tract environment to form nanoemulsions with droplet sizes less than 100 nm. The optimal SNE-vehicle composition of oleic acid, TPGS, and PEG 400 at a 10:80:10 weight ratio was determined based on the smallest droplet size achieved. This composition was used to prepare liquid SNEDDS containing ketoconazole. The droplet size and polydispersity index (PDI) of the resulting liquid SNEDDS were analyzed. Subsequently, solid-SNEDDS was fabricated using a spray-drying method with solidifying carriers such as silicon dioxide, crospovidone, and magnesium alumetasilicate. The physicochemical properties of the solid-SNEDDS were characterized by scanning electron microscopy and powder X-ray diffraction, and its solubility, droplet size, and PDI were evaluated. In particular, the solid-SNEDDS containing ketoconazole and crospovidone in a 2:1 weight ratio exhibited significantly enhanced solubility, highlighting its potential for improved medication adherence and dissolution rates.

This study aims to prepare a colloidal silica-containing powder to enhance the solubility and dissolution rate of rivaroxaban using a self-nanoemulsifying drug delivery system (SNEDDS). We investigate the impact of colloidal silica on a nanoemulsion system for preparing powdered SNEDDS. The liquid SNEDDS comprises 30/20/50 (w/w/w) Peceol/ Cremophor RH40/Tween 80, which results in the formation of the smallest droplets. Three powdered SNEDDS formulations are prepared by suspending the liquid SNEDDS formulation using colloidal silica and spray drying. The powdered SNEDDS prepared with liquid SNEDDS and colloidal silica at a ratio of 1/0.5 (w/w) exhibits the highest water solubility (0.94 ± 0.62 vs. 26.70 ± 1.81 μg/mL) and dissolution rate (38.4 ± 3.6 vs. 85.5 ± 3.4%, 45 min) when compared to the drug alone. Morphologically, the liquid SNEDDS is adsorbed onto colloidal silica and forms smaller particles. In conclusion, an SNEDDS containing rivaroxaban, prepared using colloidal silica, facilitates the creation of a nanoemulsion and enhances the water solubility of rivaroxaban. Accordingly, this technology holds significant potential for commercialization.

The objective of this study is to assess the impact of spray drying conditions on medium-chain triglyceride (MCT) loading, solubility, and release of an MCT-loaded solid self-emulsifying system in a water-insoluble oily substance. MCT-loaded solid self-emulsifying systems are prepared by spray drying with SDS and calcium silicate. The effects of inlet temperature (60, 80, or 100oC) and feed solution composition (0, 10, 50, 90, or 100% ethanol) on physicochemical properties of MCT-loaded solid self-emulsifying systems are studied. The inlet temperature significantly affects the water solubility of MCT. Moreover, the feed solution composition significantly affects water solubility, release rate, and MCT loading. The MCT-loaded solid self-emulsifying system obtained at 60oC using 90% ethanol feed solution shows the best physicochemical properties among the synthesized products and exhibits better water solubility (4.43 ± 0.44 vs. 0 μg/mL) and release (94.4 ± 1.6 vs. 32.8 ± 7.4%, 60 min) than a commercial product. Furthermore, the MCT-loaded solid self-emulsifying system shows an excellent emulsion droplet size (approximately 230 nm).

목적 : 본 연구의 목적은 노인 운전자의 운전 적합성을 판별할 수 있는 Drivers 65 Plus에 대한 신뢰도와 타당도 검증을 걸쳐 한국형으로 표준화하기 위함이다. 연구방법 : 번역 검증을 통해 최종 번역본을 완성하고, 도구의 신뢰도와 타당도를 검증하기 위해 65세 이상의 노인 운전자 218명을 대상으로 K-Drivers 65 plus(Korean-Drivers 65 plus)와 K-DBQ(Korean Version-Driver Behavior Questionnaire), MoCA-K(Montreal Cognitive Assessment-Korean version)를 이용한 평가를 진행하였다. 결과 : K-Drivers 65 plus의 신뢰도 검증 결과, 문항들에 대한 내적 신뢰도는 Cronbach's α가 0.575였으며, 검사-재검사 신뢰도는 ICC(Internal Classification Coefficients)가 .95를 나타내었다. 구성타당도를 검증하기 위한 확인적 요인분석에서는 모형 적합도 지수가 NC(Normed Chi-square)=2.954, CFI(Compaative Fit Index)=.806, TLI(Tucker-Lewis Index)=.736, NFI(Normed Fit Index)=.742, RMSEA(Root Mean Square Error of Approximation)=.095로 나타내었다. K-DBQ와 유의한 정적 상관(r=.470, p<.01)이 있는 것으로 확인되었으며, MoCA-K와의 결과에서도 유의한 부적 상관(r=-.495, p<.01)이 확인되었다. 유용성 검증에서는 ROC(Receiver Operating Characteristic) 곡선에서 참조선의 왼쪽 상단에 위치하는 경향을 보였으며, AUC(Area Under Curve)(.726)에서도 적합성을 선별하는데 보통의 정확성을 지니고 있다는 것이 확인되었다. 또한 30.5점(Youden's index=1.002)을 기준으로, 총점이 31점 이상인 경우 위험운전자, 31점 미만인 경우 안전운전자로 선별되었다. 결론 : 본 연구를 통해 K-Drivers 65 plus가 높은 신뢰도와 타당도를 나타내지 못했지만, 개인이 아닌 다수의 노인 운전자를 대상으로 간편하게 제공할 수 있고, 점수 결과를 바탕으로 운전 적합성을 예측하여 운전 사고를 예방할 수 있다는 측면에서 적합한 수준의 자가 운전 평가도구임을 증명할 수 있었다.

목적 : 본 연구는 가정안전 자가 평가도구(Home Safety Self-Assessment Tool: HSSAT)를 번안 후 신뢰도와 타당도를 검증하기 위함에 있다. 연구방법 : HSSAT의 번안을 위하여 번역과 역 번역의 과정을 실시하여 한국어판 가정안전 자가 평가도구 (Korean-translated Version of Home Safety Self-Assessment Tool; K-HSSAT)를 완성하였다. 그 후 내용타당도와 수렴타당도 검증을 실시하였다. 신뢰도 검증을 위하여 내적일치도와 검사-재검사간 신뢰도, 검사자간 신뢰도 검증을 실시하였다. 10명에게 해결책을 적용한 전·후 비교를 실시하였다. 결과 : K-HSSAT의 내용타당도 지수는 .94로 높게 나타나 내용타당도를 수립하였다. 수렴타당도 검증 결 과 K-HSSAT의 총점과 주거환경 위험평가(Checklist for Home Fall Hazard; CHFH)의 각 영역 간 상관계수는 .23~.52의 범위를 보였고 CHFH의 총 4개 영역 모두 의미 있는 양의 상관관계를 보였다 (p<.01). K-HSSAT의 내적일치도 Cronhach's α값은 .89를 나타내었다. 검사-재검사 신뢰도 검증 결 과 9가지 영역 모두 통계적으로 유의미한 상관관계를 나타내었다(p<.01)(p<.05). 검사자간 신뢰도 검증 결과 9가지 영역 모두 통계적으로 유의미한 상관관계를 나타내었다(p<.01). K-HSSAT의 해결책을 제 시하고 전·후 비교한 결과 적용 전 17.40±4.55, 적용 후 12.70±3.26로 통계적으로 유의한 차이를 보였다(p<.01). 결론 : 한국어판 가정안전 자가 평가도구(K-HSSAT)의 타당도와 신뢰도를 검증하였고 가정 낙상환경위 험 평가와 환경적 중재를 위한 다양성을 갖춘 도구임이 입증되었다.

Purpose: This study aimed to compare students’ and examiner’s assessment scores of students’ simulated performance. Methods: For two years, 46 teams of 183 senior nursing students participated in simulated emergency. The examiner assessed the students’ reactions during simulation using the Nursing Competency Scale in Simulation (NCSS). The students assessed their own performance using the same scale after participating in the simulation. Data were analyzed using descriptive statistics, a paired t-test, a one-way ANOVA, a Kruskal-Wallis test, an independent t-test, and a Mann-Whitney U test. Results: The students’ NCSS scores were significantly higher than those of the examiner. The difference of students’ self-rated and examiner’ scores was larger in the lower third group of actual NCSS scores as compared to the difference for those in the upper third group. The students’ self-assessment accuracy improved after exposure to the NCSS, but the change was not significant. Conclusion: The findings can be suggest various strategies to promote more realistic self-appraisals among students.

The flushing is important to maintain good water quality in water main. It is a technique of using water velocity to remove sediments in water distribution system. The variety of water quality problems can occur in a distribution system, so too can a variety of benefits be gained by system flushing. In order to effectively perform the flushing, the contaminants to be removed to set up and it can be solved, it is necessary to ensure the proper flow rate. In this study, the removal of contaminants present in the inner water pipe attached loose deposits such as fine particles of granular activated carbon, sand and iron corrosion product sought to derive flow rates. Thus, the constant observation of using pilot plant scale water distribution plant for the movement of floating characteristics of particles were assessed.

The purpose of this study were to investigate middle and high school students' food habits and food attitudes, and to assess student's nutrient consumption. A self-administered questionnaire was developed based on review of literature. The questionnaire consisted of three sections (food habits, food attitudes, and food consumption). The questionnaires were distributed to 4,050 students enrolled in 34 middle and high schools located in Seoul, Gyeonggi, and Gyeongnam provinces. A final response rate was 88.2% (3,570) excluding responses that had significant missing data. Data of the food habits and food attitudes were analyzed with descriptive analysis, 2-test, and t-test using SPSS WIN(ver.11.0). The student's self-reported food consumption data was converted into nutrient consumption using conversion factor. Many middle and high school students skipped breakfast and/or dinner. Approximately 29% of the students did not eat vegetables and fruits. Scores of the middle school student's attitudes(19.1) towards foods were significantly higher than those of the high school student's attitudes(18.7)(p〈.001). Student's nutrient intakes were estimated according to the student's self-reported food consumption data. The nutrient intakes were compared with DRIs(Dietary Reference Intakes: DRIs) for their age groups. The result of EAR(Estimated Average Requirement: EAR) cut-point method demonstrated 57.7% of middle school boys, 64.4% of middle school girls, 70.2% of high school boys, and 71.0% of high school girls did not meet EAR for Calcium. Additionally, it showed that 39.0% of middle school boys, 23.7% of middle school girls, 58.4% of high school boys, and 24.4% of high school girls did not consume EAR for Vitamin B1. 25.7% of middle school boys did not meet EAR for Vitamin B2, while 44.4% high school boys did not satisfy EAR for Vitamin B2.

자가통제평가(CSA : Control Self Assessment)는 핵심사업 목적을 달성하는데 개입되는 위험 그리고 그러한 사업위험을 관리하기 위하여 설계된 내부통제를 공식적이고 문서화된 협력적 프로세스에 의하여 검토하기 위하여 사용되는 방법론이다. 현재 많은 기업에서 효과적인 조직통제와 비즈니스 프로세스 개선을 위하여 전문 감사인과 경영인들이 기업지배구조 조직의 강력한 위험관리 도구로서 자가통제평가의 필요성을 강조하고 있다. 자가통제평가는 해당 조직

This study was carried out in order to evaluate the growth promotion effects on tomato crops and to assess the mineral nutrient concentrations of farm-made liquid fertilizers used in organic cultivation in South Korea. We hope that this study will help to develop of a standardized manufacturing technique for these organic liquid fertilizers. We collected 62 farm-made liquid fertilizers made from various raw materials including fish, seaweed, food scraps, plant and crop by-products, and other materials. Two groups of tomato seedlings were treated at different times, one at 20 days and the other at 40 days after sowing. We used both foliar and soil applications. These seedlings were treated using liquid fertilizers at various dilution rates (x1000, x500 and x100). When foliar application was used, seedlings after 20 days had a 20-30% increase in shoot fresh weight with 47-48 fertilizers and seedlings after 40 days had a 20-30% increase in shoot fresh weight with 17-32 fertilizers. When soil application was used, seedlings after 20 days had the same increase in shoot fresh weight with 30-31 fertilizers and seedlings after 40 days also saw the same increase with 6-7 fertilizers. Therefore, our studies showed that application of liquid fertilizers to seedlings 20 days after sowing was most effective and that foliar treatment was more effective than soil treatments. We also observed that the higher the concentrations of fertilizer, particularly when applied twice rather than just once, the higher the rates of growth, which promoted shoot fresh weight more than plant height. Our results imply that mineral nutrients in liquid fertilizers seem to be the probable cause for the growth promotion observed in this study. However, more study is required to determine exactly which mineral nutrients are most effective.