본 연구는 황련 추출물을 함유한 에센스가 피부 장벽 강화와 보습에 미치는 영향을 검증하 는데 목적을 두고 있다. 황련 추출물을 함유한 에센스를 22명의 피험자에게 4주간 사용하게 한 후 지정 한 상박 부위의 경피 수분 손실량(g/m²h)과 수분량(A.U.)을 측정하였다. Vapometer를 이용하여 경피 수분 손실량을 측정한 결과 사용 전 14.82±4.01에서 4주 사용 후 11.08±2.55로 나타났고 유의 확률은 p<0.001로 25.27% 유의하게 감소하였다. Corneometer로 측정한 피부 수분량은 사용 전 31.73±8.09에 서 사용 후 46.73±7.45로 나타났고 유의 확률은 p<0.001로 47.26% 증가하였으며 설문을 통한 효능평 가에서 피부 이상 반응 없이 두 항목 모두 100% 개선된 것으로 나타났다. 이와 같은 결과로 황련 에센 스는 피부 장벽 강화와 보습에 효과적인 것으로 확인되었고 이는 향후 황련 추출물의 다양한 활성을 이 용한 화장품 개발에 초석이 될 것으로 기대된다.

The engineered barrier system (EBS) is an indispensable element of a deep geological repository (DGR) designed to prevent the discharge of radioactive materials into the environment. The buffer material is a vital component of the EBS by creating a physical and chemical barrier that prevents the migration of radioactive materials. In the disposal environment, gases can be generated from the corrosion of the canister. When the gas generation rate exceeds the diffusion rate, the buffer material’s performance can deteriorate by the physical damage induced by the increase in pore pressure. Therefore, understanding the EBS’s behavior under gas generation conditions is crucial to guarantee the longterm safety and performance of the DGR. Lab-scale and field-scale experiments have been conducted to examine the stability of the buffer material concerning gas generation and movement by the previous researchers. To evaluate long-term stability for more than 100,000 years, it is essential to assess stability using a numerical model verified by these experiments. This study investigated the effect of interfacial characteristics on the numerical modeling accuracy of experimental simulation while verifying a numerical model through field-scale experimental results. The findings of this study are expected to furnish fundamental data for establishing numerical analysis guidelines for the longterm stability assessment of disposal systems.

본 연구에서는 머위에탄올추출물 (PJE)의 기능성 소재로서의 활용 가능성을 알아보기 위해 UVB로 유도된 Human keratinocyte (HaCaT cell)를 통해 피부장벽과 염증 개선에 대한 활성을 알아보 고자 하였다. DPPH 라디칼 소거능 측정, ABTS+ 라디칼 소거능 측정, Hydrogen peroxide 소거능 측정 을 통해 항산화 효과를 확인한 결과, 1 mg/ml 농도에서 대조군인 ascorbic acid과 비슷한 항산화 효과 를 가지고 있음을 확인하였다. UVB로 유도된 HaCaT 세포의 filaggrin과 aquaporin-3의 생성능의 mRNA의 발현을 확인해본 결과, UVB 자극에 의해 줄어든 발현량이 머위 추출물 처리 시, 농도 의존적 으로 증가하고 있음을 확인하였다. TNF-α와 IL-1β의 mRNA 발현은 UVB 자극에 의해 증가되었으 며 머위 추출물을 처리하였을 때 감소되는 것을 확인할 수 있었다. Migration assay 결과 농도 의존적 으로 피부 각질세포의 증식과 상처의 회복율을 증가시켰음을 확인하였다. 실험결과를 바탕으로 머위가 피부 보습 및 피부장벽 기능을 개선할 수 있는 기능성 소재의 화장품으로 사용될 수 있음을 시사한다.

The purpose of this study was to compare the efficiency of air and oxygen injected into the underwater non-thermal dielectric barrier discharge plasma (DBD plasma) device used to remove five types of antibiotics (tetracycline, doxycycline, oxytetracycline, clindamycin, and erythromycin) artificially contained in the fish farm discharge water. The voltage given to generate DBD plasma was 27.8 kV, and the measurement intervals were 0, 0.5, 1, 2, 4, 8, 16 and 32 minutes. Tetracycline antibiotics significantly decreased in 4 minutes when air was injected and were reduced in 30 seconds when oxygen was injected. After the introduction of air and oxygen at 32 minutes, 78.1% and 95.8% of tetracycline were removed, 77.1% and 96.3% of doxycycline were removed, and 77.1% and 95.5% of oxytetracycline were removed, respectively. In air and oxygen, 59.6% and 83.0% of clindamycin and 53.3% and 74.3% of erythromycin were removed, respectively. The two antibiotics showed lower removal efficiency than tetracyclines. In conclusion, fish farm discharge water contains five different types of antibiotics that can be reduced using underwater DBD plasma, and oxygen gas injection outperformed air in terms of removal efficiency.

Barrier effect model developed by CRIEPI is used for the estimation of rate of radioactive material release from a transport cask submerged in the ocean. If the containment boundary of cask is broken in an accident during maritime transportation, the sea water comes into the cask cavity and the leaching of radioactive material occurs. If the release of radioactive material thorough the opening of the containment boundary of cask is less than the leaching rate of the radioactive material inside the cask, then the release rate is controlled by the saturation limit of the sea water inside the cask cavity. In this study, the release rate estimation using the barrier effect model is compared with the model used in other codes, such as MARINRAD. And by parameter study, important factors that affect the releaser rate are identified and prioritized. It is shown that the gap generated in the containment boundary is the key parameter that determine the release rate of the radioactive material and the leaching rate is the dominant parameter to determine the saturation time of the cavity sea water.

노화가 진행될수록 활성산소종으로 인하여 피부 보습은 떨어지고 피부 장벽은 붕괴되어 피부 가 손상된다. 본 연구에서는 인천 동막 해변에 서식하는 염생식물인 갯끈풀(Spartina anglica; SAE)과 갯메꽃(Calystegia soldanella; CSE)을 70% 에탄올(EtOH)로 추출하여 피부 보습 및 피부 장벽 기능 강화에 대한 효능을 평가하였다. 이 추출물들에 대한 피부 각질형성세포(HaCaT cell) 에서 세포독성을 WST-8 assay를 이용하여, 세포 생존율이 90% 이상을 보이는 농도를 선별하 여 추가 실험을 진행하였다. ABTS 라디칼 소거능을 통해 항산화 효과를 확인한 결과, SAE와 CSE는 높은 라디칼 소거능을 보였다. 피부 보습과 관련된 인자들인 filaggrin (FGL), aquaporin 3 (AQP3), hyaluronan synthase 2 (HAS2)과 피부 장벽 기능과 연관 있는 transglutaminase 1 (TGM1) 과 involucrin (INV)의 유전자 수준에서의 발현 변화를 측정한 결과, SAE에 의해 AQP3, HAS2, TGM1의 발현이 증가하였으나, CSE는 변화가 없는 것을 확인할 수 있었다. SAE에 의한 세포 내 신호전달 경로를 확인하기 위해 western blot 분석을 수행하였다. Extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase의 활성이 SAE에 의하여 상향 조절되었음을 확인하였다. 이러한 결과는 갯끈풀 추출물이 피부 보습 및 피 부 장벽 기능 강화를 위한 화장품의 기능성 소재로 사용될 수 있음을 시사한다.

본 연구는 PFEG(글루코실세라마이드 4.0% 함유)가 저미네랄 특수사료(HR-AD)를 섭취시킨 헤어리스 마우스에서 발생하는 피부장벽 붕괴에 대한 억제작용이 있는지를 확인하고자 하였다. 4주간의 투여를 통해 정상군(Rabo MR Stock)과 비교하여 대조군(HR-AD)에서는 경피 수분 손실량(TEWL)이 서서히 상승하여 피부장벽기능의 붕괴가 발생함과 동시에 표피 수분량 및 각층 수분량도 서서히 저하되는 것이 확인되었다. 육안적으로는 깊은 주름 형성이 확인되었으며 조직학적 소견에서는 표피의 비후와 각화 항진이 확인되었다. 그러나 PFEG를 섭취시킨 시험군에서는 대조군에서 유발되는 피부장벽기능 붕괴에 대한 억제 효과가 확인되었다. 즉, 글루코실세라마이드 0.01% 배합군 및 0.1% 배합군에서는 섭취 시작 2주일째 이후 야기되는 TEWL 상승을 완전히 억제하였다. 또한, 저하되는 표피 수분량, 각층 수분량에 대해서도 유의하게 억제하여 피부 보습 기능을 유지하고 있었다. 육안적으로도 깊은 주름 형성은 억제되었으며, 조직학적인 검토에서도 표피의 비후나 각화 항진은 확인되지 않았다. 이러한 결과는 HR- 1 마우스의 피부 세라마이드 생산 개선에 기인한 결과라고 예상된다. 즉, HR-AD 섭취에 의해 HR-1 마우스는 세라마이드를 포함한 피부 지질의 함량 및 구성에 이상이 생기고, 피부 수분량이 급격히 줄어들어 피부 보습 능력이 저하된다. 그런데 PFEG의 혼합 투여는 손상된 피부의 세라마이드 함량 및 구성을 정상과 가깝게 만들어, 대조군에서 나타나는 증상의 발현을 억제하는 것으로 판단된다. 이상의 결과로부터 PFEG의 섭취는 피부장벽기능의 손상으로 발생하는 다양한 피부 수분 손실을 억제함으로써 피부 보습 개선에 우수한 효능이 있음을 알 수 있었다. 따라서 PFEG가 피부 보습에 도움을 주는 건강기능성 원료로서 이용 가능성이 높음을 확인할 수 있다.

We report the effect of Standard Clean-1 (SC-1) cleaning to remove residual Ti layers after silicidation to prevent Al diffusion into Si wafer for Ti Schottky barrier diodes (Ti-SBD). Regardless of SC-1 cleaning, the presence of oxygen atoms is confirmed by Auger electron spectroscopy (AES) depth profile analysis between Al and Ti-silicide layers. Al atoms at the interface of Ti-silicide and Si wafer are detected, when the SC-1 cleaning is not conducted after rapid thermal annealing. On the other hand, Al atoms are not found at the interface of Ti-SBD after executing SC-1 cleaning. Al diffusion into the interface between Ti-silicide and Si wafer may be caused by thermal stress at the Ti-silicide layer. The difference of the thermal expansion coefficients of Ti and Ti-silicide gives rise to thermal stress at the interface during the Al layer deposition and sintering processes. Although a longer sintering time is conducted for Ti-SBD, the Al atoms do not diffuse into the surface of the Si wafer. Therefore, the removal of the Ti layer by the SC-1 cleaning can prevent Al diffusion for Ti-SBD.

The root of Codonopsis lanceolata has been used in traditional medicine. This study was conducted to confirm the comparative effect of ethanol solvent extraction (CLE) and supercritical carbon dioxide extraction (CLS) of C. lanceolata roots. CLS had higher antioxidant than CLE. For supercritical co-solvent modified carbon dioxide extraction (CLS), it were extracted at 250 bar 50℃ 150 min at a flow rate of ethyl alcohol 3 mL/min for 90min. In addition, CLS inhibited the adipocyte differentiation of 3T3-L1 cells. When treated with the extract at a concentration of 100 μg/mL, the Wnt/β-catenin pathway reporter luciferase activity of HEK 293-TOP cells increased approximately by 3-folds compared to that of the untreated control group. Also, the treatment by CLS (50 μg/mL) showed a significant increase of involucrin expression. These results indicate that supercritical carbon dioxide extract of C. lanceolatamay serve as a cosmeceutical agent for improving skin barrier function and the treatment of obesity.

본 연구의 목적은 퇴직을 앞둔 중장년 근로자의 나이차별인식이 퇴직 후 경력준비에 미치는 영향을 확인하는 것이다. 또한 나이차별인식과 퇴직 후 경력준비의 관계에서 업무장애의 매개효과를 검증하고, 다집단 분석을 통해 업무장애와 퇴직 후 경력준비의 관계에서 고용형태(즉, 정규직 및 비정규직)의 조절 효과를 검증하였다. 다양한 국내 기업에 종사하고 있는 중장년 근로자 372명의 설문을 분석한 결과, 나이 차별인식은 업무장애와 퇴직 후 경력준비에 영향을 미치는 것으로 나타났다. 업무장애는 퇴직 후 경력준비에 부정적인 영향을 끼쳤으며, 매개효과 검증결과 나이차별인식은 업무장애를 통해 퇴직 후 경력준비 에 유의미한 간접 효과를 보이는 것으로 나타났다. 고용형태로 구분한 다집단 분석 결과, 업무장애와 퇴직 후 경력준비 경로에서 고용형태에 따른 유의미한 차이가 발견되었는데, 비정규직 근로자는 정규직 근로 자보다 업무장애를 겪을 경우 퇴직 후 경력준비에 더 어려움을 느끼는 것으로 나타났다. 연구 결과를 바 탕으로 중장년 근로자의 퇴직 후 경력준비에 대한 시사점과 후속 연구를 제안하였다.

SiC-based composite materials with light weight, high durability, and high-temperature stability have been actively studied for use in aerospace and defense applications. Moreover, environmental barrier coating (EBC) technologies using oxide-based ceramic materials have been studied to prevent chemical deterioration at a high temperature of 1300℃ or higher. In this study, an ytterbium silicate material, which has recently been actively studied as an environmental barrier coating because of its high-temperature chemical stability, is fabricated on a sintered SiC substrate. Yb2O3 and SiO2 are used as the raw starting materials to form ytterbium disilicate (Yb2Si2O7). Suspension plasma spraying is applied as the coating method. The effect of the mixing method on the particle size and distribution, which affect the coating formation behavior, is investigated using a scanning electron microscope (SEM), an energy dispersive spectrometer (EDS), and X-ray diffraction (XRD) analysis. It is found that the originally designed compounds are not effectively formed because of the refinement and vaporization of the raw material particles, i.e., SiO2, and the formation of a porous coating structure. By changing the coating parameters such as the deposition distance, it is found that a denser coating structure can be formed at a closer deposition distance.

In this study, we investigate the effect of the diffusion barrier and substrate temperature on the length of carbon nanotubes. For synthesizing vertically aligned carbon nanotubes, thermal chemical vapor deposition is used and a substrate with a catalytic layer and a buffer layer is prepared using an e-beam evaporator. The length of the carbon nanotubes synthesized on the catalytic layer/diffusion barrier on the silicon substrate is longer than that without a diffusion barrier because the diffusion barrier prevents generation of silicon carbide from the diffusion of carbon atoms into the silicon substrate. The deposition temperature of the catalyst and alumina are varied from room temperature to 150°C, 200°C, and 250°C. On increasing the substrate temperature on depositing the buffer layer on the silicon substrate, shorter carbon nanotubes are obtained owing to the increased bonding force between the buffer layer and silicon substrate. The reason why different lengths of carbon nanotubes are obtained is that the higher bonding force between the buffer layer and the substrate layer prevents uniformity of catalytic islands for synthesizing carbon nanotubes.

In this study, using the surface dielectric barrier discharge (DBD) produced at atmospheric pressure to improve the physiological activities of quercetin was investigated. Quercetin (at 200 ppm) was treated using air DBD with an input power of 250 W. The tyrosinase inhibition effect and total phenolic content of quercetin increased from 38.96 to 91.58% and from 134.53 to 152.93 ppm, respectively, after 20 min of plasma treatment. The antioxidant activity of quercetin treated for 20 min in the lipid models was higher than that of quercetin treated for 0, 5, and 10 min. Furthermore, plasma-treated quercetin exhibited antimicrobial activity against Listeria monocytogenes, Salmonella Typhimurium, and Staphylococcus aureus, whereas activity was not shown in the control. Structural modifications of the quercetin molecule induced by plasma might be responsible for the improvements in its physiological activity. These results indicate that DBD plasma could be used to enhance the physiological activity of quercetin for various applications in food.

PURPOSES: The purpose of this study is to evaluate the effect of the quiet pavement on reducing a barrier height by using a prediction tool called SoundPLAN. METHODS: Firstly, the prediction was carried out to evaluate the difference in the maximum noise level at a building facade between the normal and the quiet pavements without a barrier. After calculating the noise reduction effect by the quiet pavement, a comparable barrier height to obtain the same noise reduction effect with it was predicted according to designable factors including road-building distance(10 m, 20 m, 40 m) and road-barrier distance(5 m, 10 m, 20 m, 30 m). RESULTS: The result showed that within the considered designable factors, the maximum barrier height was 37 m, 52 m, and 55 m to have the same noise reduction effect by the quiet pavement reducing 1 dBA, 3 dBA , and 5 dBA, respectively. It was evaluated that the barrier height increased with the increase of the road-building and road-barrier distances. To simulate the real situation in urban areas and to evaluate the combined effect of the normal/quiet pavement and barrier, the barrier height was fixed as 6 m. It was predicted that the noise level would reduce to as low as 0.2 dBA by the combination of normal pavement and barrier. On the other hand, the combination of the quiet pavement and barrier reduced 1.2 dBA, 3.2 dBA, and 5.2 dBA, respectively, for quiet pavement reducing 1 dBA, 3 dBA, and 5 dBA. CONCLUSIONS: A guideline needs to be suggested to select appropriate noise abatement schemes by considering factors such as the roadbuilding and road-barrier distances.

This study analysed impact of service quality on customer satisfaction and loyalty in the take-out coffee shop. The switching barrier was also studied as a moderating effect. Particularly, this study focused on relationships between customer loyalty and switching barriers. A lot of previous studies interest only in customers satisfaction. This study also analysed relationships among service quality, customer satisfaction, switching barriers and brand loyalty. Eventually, service quality significantly affects customer satisfaction, moderating effects, brand loyalty and marketing performance. SERVQUAL model which was established by PZB (1988) was used as a service quality factors. The impact on customer satisfaction was analysed using multiple regression analysis. Simple regression analysis was used to find effects of customer satisfaction and customer loyalty. Additional factors of switching barriers was classified based on previous studies. Hierarchical multiple regression analysis was used to find factors of customer loyalty among switching barriers. In the result, we can find that the importance of tangibles, responsiveness in service quality factors and contract cost, search cost and continuous cost in moderating effects.