Potentillae Chinensis Herba 추출물의 항산화 효능 평가를 위해 DPPH 자유라디칼 소거 활성 과 ABTS 양이온 라디칼 활성 평가를 시행하였다. 세포 실험에서 항염증 평가를 위해 호흡기 점막 상피세 포 NCI,H292와 RAW264.7 세포 대상으로 항염증 효능을 평가하였다. 그 결과, DPPH 자유라디칼 소거 활성과 ABTS 양이온 라디칼 활성 모두 농도 의존적으로 항산화 활성이 증가하는 것으로 나타났다. 세포 MTT 분석 결과, 각 농도 100 μg/ml로 처리한 경우 NCI-H292 세포의 생존율이 70% 미만으로 감소하 였고, 이후 실험은 50 μg/ml로 진행하였다. 항염증 효능 평가에서는 NO생성, TNF-α, IL-1β, PGE2가 감소하였고, COX-2도 50 μg/ml에서 유의하게 감소하였다. Potentillae Chinensis Herba 추출물과 생물 전환 추출물의 뮤신 단백질 발현은 MUC5AC 발현이 유의하게 감소하는 것으로 관찰되었다. 이상의 결과 는 Potentillae Chinensis Herba의 호흡기 점액 단백질 발현을 도와 염증을 억제하는 기능성 소재로 활용하 는데 가치가 있음을 알 수 있다.

본 연구는 만성질환으로 외래서비스를 이용하는 환자를 대상으로 의 료기관 유형별 의료서비스 이용 경험을 조사하고, 만성질환자의 건강 결과를 실증적으로 비교 분석하여, 만성질환 관리의 효과적인 중재방안 마련에 기초자료를 제공하고자 시도되었다. 본 연구의 자료수집은 2023년 7월 1일부터 7월 31일까지 고혈압과 당뇨병 진단으로 보건소 와 의원, 종합병원의 외래서비스를 이용하고 있는 대상자 167명에게 면담을 통한 구조화된 설문지를 작성하여 자료를 수집하였고, 수집된 자료는 SPSS 통계프로그램을 이용하여 분석하였다. 연구 결과 고령의 취약계층은 의료기관 중 의원을 가장 많이 이용하고 있었고, 의료기관 유형별 이용경험의 결과는 의원이 가장 부정적이었다. 그러나 만성질환 관련 건강 결과는 의료기관 유형별로 유의한 차이가 없었다. 그러므로 보건소는 특히 취약계층 환자들의 보건의료 요구를 중시하고 공공보건 서비스를 효율적으로 제공해야 하며, 의원의 만성질환 관리 역량의 강 화를 위한 다양한 중재 방안 마련과 함께 국가 시범사업의 적극적 참 여를 유도할 수 있는 정책이 수립되어야 할 것이다.

목적: 국민건강영양조사 제7기(2016-2018) 원시자료를 이용하여 황반변성에 영향을 줄 수 있는 만성질환을 파악 하고자 수행되었다. 방법 : 국민건강영양조사 제7기(2016-2018) 자료 중 40세 이상의 성인 중에 황반변성 진단여부에 응답한 4,356명의 대상으로 만성질환과의 관계를 분석하였으며, p<0.05인 경우 유의한 것으로 판단하였다. 결과 : 황반변성은 연령에 따라 유병률이 높아졌는데, 연령과 관계된 만성질환 중 심근경색증에서만 유의한 결 과를 얻을 수 있었다. 또한, 심근경색증의 위험요인인 이상지질혈증과 이상지질혈증을 일으키는 고콜레스테롤혈증 도 황반변성과 관계가 있는 것으로 나타났다. 결론 : 황반변성은 연령과 관련된 만성질환 중 심근경색증, 이상지질혈증, 고콜레스테롤혈증과 관련이 있음을 확인하였다.

The petroleum refinery industry handles a variety of complex chemical substances and employs a large number of people around the world. According to previous research, diseases caused by exposure to chemicals were quite common among workers in refineries until the 1980s. More recently, it is unusual for oil refinery workers to suffer from these serious diseases. The objective of this study was to identify the occurrence level of general diseases and any differences in lifestyle habits of workers in refineries in Korea compared with the general population. In this study, we used the results of health examinations from 2014 for workers at a large oil refinery in South Korea. In addition, based on the results of KNHANES from 2014 as representative of the population, hypertension, diabetes, anemia, hyperlipidemia, liver function abnormality, and kidney function abnormality were calculated using the standardized incidence rate. Hypertension showed a low result with an SIR of less than 1, but a high result in the case of abnormal liver function. The workers’ occurrence rates of hypertension, hyperlipidemia, kidney dysfunction, and anemia were lower than those of ordinary salaried employees. however, their occurrence rate for abnormal liver function was markedly higher. In lifestyle habits, the smoking rate of workers was low while the alcohol consumption rate was quite high. This study has improved the understanding of the health status of workers in a large oil refinery in Korea, and has shown the impact of lifestyle habits related to the work environment on chronic diseases.

This study compared the lifestyle patterns, dietary patterns, and health care practices of Korean middle-aged people by household type, and ultimately analyzed their relationship with different risk factors for the prevalence and severity of metabolic syndrome. We analyzed the data from 4,755 subjects who were from 40 to 64 years old, and gathered our sample from participants of the Korea National Health and Nutrition Examination Survey from 2013 to 2015. Our results showed that single-person households had lower economic income levels, lower subjective health statuses, and higher levels of food instability than households with two or more individuals. The incidence of metabolic syndrome was 1.64 times higher in single-person households than in households with two or more individuals. After adjusting for potential confounding factors (sex, age, education, household income, smoking status, health status, and dietary factors), single-person households showed 1.75 times higher hypertriglyceridemia ORs than non-single-person households. In the conclusion of our study, we suggest that middle-aged people in single-person households may be at greater risk for metabolic syndrome and hypertriglyceridemia.

The purpose of this study was to investigate the current status of chronic diseases according to obesity in the elderly older than age 65 using data from the 7th Korea National Health and Nutrition Examination Survey (2016~2018). The subjects of the survey were 3,245 elderly older than age 65 who participated in the health survey and nutrition survey, 45.8% of the subjects were males and 54.2% of the subjects were female. 37.5% of all the elderly were obese, and the females (42.4%) were more obese than the males (31.8%) (p<0.001). Diabetes, hypertension, and hypertriglyceridemia had a similar prevalence of 24.6%, 63.0%, and 12.7% in males and females, respectively. Hypercholesterolemia was higher in the elderly females (44.2%) than in the elderly males (24.9%) (p<0.001). Through the logistic regression analysis, it was found that the prevalence of chronic diseases was higher in obesity than normal in elderly males and females (p<0.001). The total food intake increased from ‘under weight’ to ‘obesity’ in males (p<0.01) and females (p<0.001). In the case of the elderly males, the higher the degree of obesity, the higher the energy intake (p<0.05), and ‘pre-obesity’ consumed the most energy in elderly females. As a result of this study, the higher the obesity rate of the elderly, the higher the prevalence of chronic diseases.

The aim of this study was to examine the association between egg consumption and the risk of chronic disease in Korean adult females using the 2013 Korea National Health and Nutrition Examination Survey. A total of 1,230 subjects aged 40~64 were classified into the 4 groups according to the number of egg consumed per week: <1, 1~2.9, 3~5, ≥5.1 As egg consumption increased, the intake of energy, protein, fiber, cholesterol, calcium, potassium, riboflavin, and vitamin C increased. The percentage of the subjects with lower intake of energy, protein, calcium, iron, vitamin A, riboflavin, niacin, and vitamin C than the estimated average requirement in the <1 group were the highest among the groups. The blood lipid profile including total cholesterol and LDL-cholesterol was not significantly different among the 4 egg groups. The higher egg consumption was inversely related to a lower odds ratio of metabolic syndrome, hypertriglycemia, hyperglycemia, hypoHDL-cholesterolemia, and hypertension. This result indicates that egg consumption does not elevate the plasma cholesterol level and has a beneficial effect of decreasing the risk of chronic disease. (175)

Purpose: The purpose of this study was to understand the lived experience of a main caregiver, in charge of a family member with a severe chronic disease. Methods: The participants of this study were 13 main caregivers, who have a family member with a severe chronic disease. The data were analyzed through the phenomenological research method. Results: This research concluded with: one core theme, five theme clusters and 13 themes. The one core theme was: ‘My Life is Not Mine.’ The five theme clusters include: ‘The Dark Days Ahead, of What We Do,’ ‘Serious Pressure,’ ‘My Body is Broken (caregivers),’ ‘Overcoming,’ and finally ‘Endless, Long and Long tunnel.’ Conclusion: We must emphasize to a main caregiver of a chronic disease patient, to the fact that their life should be theirs, not the patients. In addition, we need to be attentive of their well-being, as well as the chronic disease Patients, and sensitively responsive to their problems.

This study was conducted to investigate the risk of chronic disease as predicted by abdominal obesity in Korean adult females. Data on 2,738 adult females aged 40~64 yrs was obtained from the 2013~2014 Korean National Health Nutrition Examination Survey. The subjects were divided into normal (n=1,835), abdominal obesity (AO, n=73), and BMI-diagnosed abdominal obesity (BMI-AO, n=505) groups based on the NCEP-ATP III guidelines and by applying the KSSO definition regarding waist circumference. Triglyceride blood levels, fasting blood sugar levels, systolic blood pressure, and diastolic blood pressure were higher in the AO and BMI-AO groups than in the normal group. The HDL-cholesterol levels of subjects in the two abdominal groups were lower as compared to those of subjects in the normal group. The mean adequacy ratio was lower among subjects in the AO and BMI-AO groups than among those in the normal group. Moreover, the NAR and INQ scores of some micro-nutrients in both of the abdominal obesity groups were lower than those in the normal group. Both the AO and BMI-AO groups showed significantly higher risks of hypertriglycemia, hyperglycemia, hypertension, hypoHDL-cholesterolemia, and metabolic syndrome than were shown by the normal group. Notably, as compared to the normal group, the AO group showed higher risk of hypercholesterolemia, hyperLDL-cholesterolemia, hypertriglycemia, and metabolic syndrome than did the BMI-AO group. This finding suggests that it is essential to develop prevention programs including programs for those with abdominal obesity despite their having a BMI within the normal range.

The purpose of this study was to compare the validity of obesity indices among the body mass index (BMI), waist circumference (WC), and body fat percentage (BF%), and to determine which is the most useful index to predict the risk of chronic diseases of elderly people. This study was conducted as a cross-sectional study at welfare centers in Seoul. The total number of subjects was 261 (68 men and 193 women) with age ≥60 years. The distribution of obesity using 3 obesity indices in the subjects with hypertension, diabetes, or arthritis was BF%>WC>BMI in elderly men and WC>BF%>BMI in elderly women. In elderly women, odds ratios (ORs) for hypertension in BMI and WC quartiles were significantly increased in quartile 2 and 3 (p<0.05). The ORs for hypertension, hyperlipidemia, and arthritis in BF% quartiles were significantly increased in quartile 3 and 4 (p<0.05). The BF% was sensitive obesity index for predicting the occurrence of chronic disease in men, and the WC was sensitive index in women. Our results suggested maintaining BMI less than 23.5 kg/m2, WC less than 82 cm, and BF less than 35% in order to prevent chronic diseases in elderly women.

목적 : 도시와 농촌 간 만성질환이 있는 65세 이상의 노인을 대상으로 일반적 특성에 따른 신체활동 실천율과 신체활동에 따른 삶의 질 차이를 알아보고자 한다. 연구방법 : 만성질환을 갖고 있는 65세 이상 노인 1,039명을 연구 대상으로 하였다. 신체활동으로는 걷기, 유연성 운동,근력 운동을 조사하였고, 삶의 질은 EQ-5D (Euroqol-5 dimension)를 사용하여 삶의 질에 대한 자료를 수집하여 분석하였다. 결과 : 신체활동 실천율은 도시의 경우 연령, 성별, 배우자, 주택유형, 소득수준, 교육수준에 따라 유의한 차이를 보였고, 농촌의 경우 주택유형과 교육수준에 따라 유의한 차이를 보였다. 삶의 질에서, 도시의 경우는 걷기, 유연성 운동, 근력 운동을 실천 한 군의 운동능력, 자기관리, 일상생활활동, 통증/불편 영역에서 유의한 차이를 보였고, 농촌의 경우는 걷기를 실천 한 군의 운동능력에서 유의한 차이를 보였다. 결론 : 도시와 농촌 모두 만성질환 노인의 신체활동 실천율은 낮은 편이었고, 특히 도시보다 농촌에 거주하는 만성질환 노인의 신체활동 실천율이 더욱 낮게 나타났다. 만성질환노인의 신체적 기능을 높이고, 삶의 질에 긍정적인 영향을 미칠 수 있는 신체활동의 중요성에 대한 인식이 필요하다.

본 연구는 영상의 노이즈 감소를 위한 복합필터 제안과 간 초음파영상에서 노이즈 제거를 통한 영상품질의 향상으로 정확한 영상 해석에 도움을 주고자 하였다. 실험은 ATS-539 다목적용 초음파팬텀을 이용하여 Gaussian blurring filter, Sharpening filter, Median filter의 조합으로 상위 7개의 복합필터를 선정하고 이를 간 초음파영상에 적용하였다. 그 결과 상위 7개 복합필터 적용하였을 때 SNR, CNR, MSR 값이 모두 증가하는 것으로 나타났다. 이 중 복합필터 1과 2가 가장 높은 값을 나타내었다. 또한 PSNR 30 dB이상, SSIM 1에 가까운 결과값을 나타내어 영상의 손실률이 적음을 알 수 있었다. 따라서 본 연구에서 제안한 복합필터의 적절한 적용은 정확한 영상의 판독과 해석에 도움을 줄 수 있을 것이다.