Purpose: To develop a tool for measuring peripheral intravenous catheter insertion performance. Methods: This was a cross-sectional descriptive study. Initial items were generated using existing guidelines and tools, and 19 experts assessed content validity. Data were collected from a tertiary hospital in D city from January 17, 2018, to October 20, 2019. The data of 365 nurses were used for principal component analysis with orthogonal rotation. Concurrent validity was confirmed using Pearson’s correlation between the developed tool and the nursing career period. Reliability was confirmed after evaluating internal consistency. Results: Initially, 16 items were generated, but three items were deleted in content validation. A two-factor solution was preferred in exploratory factor analysis and explained 48.2% of the variance. The two factors were named “point of care” and “follow-up care,” respectively. The tool’s reliability is .87. Conclusion: The developed tool was valid and reliable. It is composed of 13 items and can be used quickly and easily. Therefore, it can be utilized for the education and training of novice nurses and the self-reflection of experienced nurses. In addition, it will be useful to review the catheterization process in common clinical settings.

It is well documented that giant cells can be observed in some types of odontogenic tumors such as central odontogenic tumor and dentinogenic ghost cell tumor. However, the presence of stromal giant cells has only rarely been reported in ameloblastoma, although being the most common epithelial odontogenic tumor. In this study, we present a novel case of peripheral ameloblastoma associated with peripheral giant cell granuloma arising in the mandibular alveolar mucosa of a 65-year-old male patient. The possible pathogenesis of this combined lesion will be discussed, in addition to the review of previous reports of ameloblastoma accompanied by stromal giant cells.

We investigated the effect of moderate- and high-intensity resistance training on hippocampal neurotrophic factors and peripheral CCL11 levels in high-fat diet (HFD)-induced obese mice. C57/black male mice received a 4 weeks diet of normal (control, CON; n = 9) or a high-fat diet (HF; n = 27) to induce obesity. Thereafter, the HF group was subdivided equally into the HF, HF + moderate-intensity exercise (HFME), and HF + high-intensity exercise (HFHE) groups (n = 9, respectively), and mice were subjected to ladder-climbing exercise for 8 weeks. The hippocampal brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels were significantly lower in the HF group than in the CON group (p < 0.05). In addition, in the HFME and HFHE groups were significantly higher than in the HF group (p < 0.05). The peripheral CCL11 levels were significantly higher in the HF group than in the CON group (p < 0.05). In addition, in the HFME and HFHE groups were significantly lower than in the HF group (p < 0.05). However, there was no significant difference according to the exercise intensity among the groups. Collectively, these results suggest that obesity can induce down-regulation of neurotrophic factors and inhibition of neurogenesis. In contrast, regardless of exercise intensity, resistance training may have a positive effect on improving brain function by inducing increased expression of neurotrophic factors.

The objective of this study was to investigate the dynamic neural mobilization program on the changes in muscle activity and nerve conduction velocity (NVC) in stroke patients. The participants were sampled and randomly divided into experimental group I (n=12) who underwent arm neural mobilization and experimental group II (n=13) who underwent arm dynamic neural mobilization. As the pretest, peripheral NVC of the radial, median, and ulnar nerves were measured using the Viking Quest; the biceps brachii, brachioradialis, flexor carpi radialis, and extensor carpi radialis activities were measured with sEMG. Each intervention program consisted of 10 trials per set and three sets per session. The intervention programs were performed once daily for four weeks (four days/week). Posttest measurements were taken equally as the pretest measurements. Significant differences in peripheral NVC in all sections of the radial and median nerves and wristbelow elbow and below elbow-above elbow areas of the ulnar nerve, as well as in muscle activity of all muscles except the biceps brachii. These findings indicate that dynamic neural mobilization was effective in increasing peripheral NVC and altering the muscle activity.

The honey bee soluble acetylcholinesterase 1 (AmAChE1) is overexpressed under the overwintering and brood rearing-suppressed conditions. To investigate the role of AmAChE1 in regulating acetylcholine (ACh) titer, ACh concentrations in both the head (central nervous system) and abdomen (peripheral nervous system) were analyzed. ACh titer was significantly lower in both tissues of worker bees under the overwintering and brood rearing-suppressed conditions compared to control bees. Interestingly, the expression levels of choline acetyltransferase (AmChAT) and molecular marker genes of immune systems were significantly reduced in honey bee head under the same conditions. Taken together, ACh titer appears to be reduced via a cooperative interaction of the AmAChE1 overexpression and AmChAT underexpression and to be linked to reduced inmmune responses under the overwintering and brood rearing-suppressed conditions. The roles of AmAChE1 (with little catalytic activity) and AmChAT in the ACh homeostasis and signaling was discussed in the contexts of immune response and longevity regulation in honey bees.

Bropirimine, a class of antineoplastic agents, is known as one of the potent immunomodulators and is currently under clinical development for the treatment of cancer. However, the effect of bropirimine on the cow remains unknown as a therapeutics agent. In this experiment, the effect of bropirimine in the peripheral blood mononuclear cells (PBMCs) stimulated by lipopolysaccharide (LPS) or concanavalin-A (Con-A) was examined. Jugular venous blood was collected from Korean Hanwoo calves and PBMCs were isolated. It was used to study the effect of bropirimine upon stimulation with LPS or Con-A for 72 hours. The expression pro-inflammatory cytokines like Tumor Necrosis Factor α (TNF-α) and Interferon γ (IFN-γ) were confirmed. Bropirimine significantly inhibited LPS- or Con-A-induced TNF-α and Con-A-induced IFN-γ in dose-dependent manner. Furthermore, Bropirimine inhibited TNF-α and Con-A mRNA expression at the transcription level. These results clearly indicated that bropirimine inhibited LPS or Con-A stimulated up-regulation of proinflammatory cytokines in a dose-dependent manner without conspicuous cytotoxicity. The bropirimine has potential to protect cow from LPS or Con-A induced endotoxin shock, possibly through inhibition of the production of proinflammatory cytokines. It suggesting that bropirimine may be a novel therapeutic agent for the prevention of inflammatory diseases. This result revealed specific features of the immune responses depending on the bropirimine compound and would help to knowledge of bovine immunity.

To promote global trade governance, both central and peripheral reforms occur in multilateral and regional trade agreements. The central reforms are suggested to enhance the WTO’s efficiency in trade negotiations by engaging in ‘mini-multilateral’ negotiations and soft law-making or to expand its current advantage in dispute settlement by extending its dispute jurisdiction to investor-state disputes or trade disputes arising from PTAs. The peripheral reforms develop in two different routes; one is rule-based and is carried out by high-standard PTAs, and the other is relation-based and is exemplified by “the Belt and Road” Initiative proposed by China. While peripheral reform fragments international law, various methods of multilateralizing regionalism are suggested, such as the incorporation of the third-party most-favoured-nation clause, the simplification of the rules of origin, and the construction of multilateral agreements through the ‘building blocs’ of PTAs. Most of these reforms make achievements to some extent, although they also have deficiencies.

In the present study, we investigated the role of peripheral ionotropic receptors in artemin-induced thermal hyperalgesia in the orofacial area. Male Sprague-Dawley rats weighting 230 to 280 g were used in the study. Under anesthesia, a polyethylene tube was implanted in the subcutaneous area of the vibrissa pad, which enabled drug-injection. After subcutaneous injection of artemin, changes in air-puff thresholds and head withdrawal latency time were evaluated. Subcutaneous injection of artemin (0.5 or 1 μg) produced significant thermal hyperalgesia in a dose-dependent manner. However, subcutaneous injection of artemin showed no effect on air-puff thresholds. IRTX (4 μg), a TRPV1 receptor antagonist, D-AP5 (40 or 80 μg), an NMDA receptor antagonist, or NBQX (20 or 40 μg), an AMPA receptor antagonist, was injected subcutaneously 10 min prior to the artemin injection. Pretreatment with IRTX and D-AP5 significantly inhibited the artemin-induced thermal hyperalgesia. In contrast, pretreatment with both doses of NBQX showed no effect on artemin-induced thermal hyperalgesia. Moreover, pretreatment with H-89, a PKA inhibitor, and chelerythrine, a PKC inhibitor, decreased the artemin-induced thermal hyperalgesia. These results suggested that artemin-induced thermal hyperalgesia is mediated by the sensitized peripheral TRPV1 and NMDA receptor via activation of protein kinases.

Unlike somatic cells mitosis, germ cell meiosis consists of two consecutive rounds of divisions that segregate homologous chromosomes and sister chromatids, respectively. The meiotic oocyte is characterized by an absence of centrioles and asymmetric divisions. Centriolin is a relatively novel centriolar protein that functions in mitotic cell cycle progression and cytokinesis. Here, we explored the function of centriolin in meiosis and showed that it was localized to meiotic spindles, and concentrated at the spindle poles and midbody during oocyte meiotic maturation. Unexpectedly, knockdown of centriolin in oocytes with either siRNA or Morpholino micro-injection, did not affect meiotic spindle organization, cell cycle progression, or cytokinesis (as indicated by polar body emission), but led to a failure of peripheral meiotic spindle migration; and symmetric division or large polar body emission. These data suggest that, unlike in mitotic cells, the centriolar protein centriolin does not regulate cytokinesis, but plays an important role in regulating asymmetric division of meiotic oocytes.

Behavioral responses to the sex pheromone blends rely on genetically designed hardwired olfactory pathways, including precise detection of the specific pheromone compounds and sophisticated signal processes in the brain to interpret correct pheromone mixture information. Owing to minimized association of individual variation and acquired traits from learning in sex pheromone communication, behavioral assays can be very useful tool for understanding each step in the olfactory system. To investigate interactions between peripheral and central pathways in shaping olfactory perception, we used antennal imaginal disc transplants between phylogenetically close two heliothine moth species Heliothis virescens and Heliothis subflexa. In behavioral tests, the response patterns of the male transplants were distinct from any of normal males of either species. Neurophysiological analyses of olfactory receptor neurons in the antenna and projection neurons in the brain also supported the behavioral dissimilarities between the transplants and normal animals. Results will be discussed in light of the functional roles and developmental significances of peripheral and central olfactory pathways in pheromone communication system.

In photobiophysics, biophoton means a kind of biological energy which enhances most metabolisms of the body. To investigate the immuno-enhancing effects of biophoton energy projector (BEP) producing light energy, pigs were irradiated with BEP for 8 weeks. Swine peripheral blood mononuclear cells (sPBMCs) were isolated from the blood of irradiated pigs. In this study, the antigen uptake and mitochondrial membrane potential of sPBMCs were measured by flow cytometric analysis. The irradiation of BEP increased the antigen uptake of sPBMCs. For functional analysis, the production of Bordetella bronchiseptica-specific IgG, measured using antigen-specific ELISA, was increased during the period of BEP irradiation. Taken together, the results suggest that the irradiation of BEP has immune-enhancing effects on sPBMCs.

Peripheral ameloblastoma, a rare and unusual variant of odontogenic tumor, representing 1% of all ameloblastomas. The extraosseous location is the peculiar feature of this type of tumor, which is otherwise similar to the classical ameloblastoma. This paper describes a case of peripheral ameloblastoma in a 43-year-old female affecting the left retromolar pad area of the mandible which was clinically diagnosed as a pyogenic granuloma. Histologically, the tumor showed of follicular ameloblastoma in continuity with a surface oral epithelium.

Dentinogenic ghost cell tumor (DGCT) is a rare neoplasm, representing 1.9% to 2.1% of all odontogenic tumors. Peripheral DGCT is a rare tumor with only 25 cases previously described in the English literature. The majority of cases have been reported to occur in the anterior part of the jaws. A rare case of peripheral DGCT is reported, located in the lingual side of the anterior mandible of a 68-year-old man. The patient presented a pedunculated painless growth of 1.5cm in diameter. Radiographically, no bone involvement was found. The lesion was excised and histologically characterized by islands of epithelial cells showing ameloblastoma-like features within fibrous background tissue. Dysplasic dentin and ghost cells with calcifications were frequently observed. Areas showing a connection between tumor cells and the overlying mucosa were also identified.

목 적: 근시성 각막굴절교정 수술안에서 각막 중심부 및 주변부의 비구면도를 정시안과 비교하고 수술전 등가구면굴절력과의 상관성을 관찰하고자 하였다. 방 법: 근시성 각막굴절교정수술을 받고 정시상태가 된 135안(평균 23.49±2.5세, 범위 20~29세)과 정시 안 40안(평균 22.50±1.7세, 범위 20~25세)을 대상으로 Pentacam (Oculus Inc., Germany) 각막형태 검사 기기를 사용하여 각막 6 mm, 7 mm, 8 mm, 9 mm, 10 mm 영역의 비구면계수 Q값을 측정하였고, 수술안은 수술 전 등가구면굴절력이 -6.00 D 미만은 수술안 그룹 1(평균 -4.41±1.09 D, 범위 -1.25~-5.58 D)과 -6.00 D 이상은 수술안 그룹 2(평균 -7.12±0.95 D, 범위 -6.00~-9.00 D)로 분류하여 비교 분석하였다. 결 과: 정시안의 비구면계수 Q값은 모든 각막 영역에서 negative 값으로 영역에 따라 -0.34±0.12(6 mm 영역)에서 -0.52±0.09(10 mm 영역)로 주변부 영역으로 갈수록 negative 값은 더 커졌고, 수직경선이 수평 경선보다 더 큰 negative 값을 보였다. 그러나, 근시성 각막굴절교정 수술안의 비구면계수 Q값은 모든 각막 영역에서 positive 값으로 영역에 따라 0.84±0.43(6 mm 영역)에서 0.09±0.30(10 mm 영역)으로 주변부로 갈수록 positive 값이 감소하였으며, 각막의 8 mm 영역까지는 수직경선이 수평경선보다 positive 값이 더 컸지만, 9 mm와 10 mm 영역에서는 수평경선이 수직경선보다 positive 값이 더 크게 나타났다. 비구면계수 Q값은 각막의 6 mm, 7 mm, 8 mm 영역에서 수술 전 등가구면굴절력과 높은 상관성을 보였다(각각, R=-0.725, R=-0.744, R=-0.713, p=0.000). 결 론: 근시성 굴절교정 수술안의 각막형상은 prolate 형태에서 oblate 형태로 변화되며 비구면계수 Q값 은 negative 값에서 positive 값으로 변하고, 각막의 경선에 따른 비구면 계수도 정시안과 다른 양상을 보였 다. 이와 같은 각막형상의 변화는 안광학적 시기능 변화의 예측과 근시성 각막굴절교정 수술안을 위한 시력 교정용 콘택트렌즈 설계 및 피팅에 필요한 기초자료를 제공할 것으로 사료된다

The lack of media in teaching grammar to university students and the problems faced by students in learning grammar motivates the researcher to do research and development in developing the media. The media which is concerned with peripheral verb phrases (participial phrases, gerund phrases, and infinitive phrases) are designed by considering the importance of keeping both form (structures of peripheral verb phrases) and content (the context in the sentences). In this case, the researcher usesacounterbalanced approach as the base to develop the media into counterbalanced based multimedia on peripheral verb phrases. The aim of this study focuses on the way to design counterbalanced based multimedia (simulation, drill, and evaluation) on peripheral verb phrases in teaching grammar validly, practically, and effectively. By adapting the Borg and Gall model of development, the researcher analyzed the concepts of related theories and needs to create the media based on the counterbalanced approach. Expert appraisals are needed to validate the media. In developing it, the researcher tested the media in two sessions of field tests. They covered preliminary field test and main field test. The investigation of both tests showed that the media are valid, practical, and effective to use in teaching grammar. In the last step the researcher disseminated the products to the grammar lecturers to use the media in their teaching. However, a further level of discussion of grammar topics is required to further develop a greater variety of teaching materials. To sum up, the researcher demonstrated that counterbalanced based multimedia can be validly, practically, and effectively designed to teach grammar.

Olfactory sensitivity exhibits daily fluctuations. Several studies have suggested that the olfactory system in insects is modulated by both biogenic amines and neuropeptides. However, molecular and neural mechanisms underlying olfactory modulation in the periphery remain unclear since neuronal circuits regulating olfactory sensitivity have not been identified. Here, we investigated the structure and function of these signaling pathways in the peripheral olfactory system of the American cockroach, Periplaneta americana, utilizing in situ hybridization, qRT-PCR, and electrophysiological approaches. We showed that tachykinin was co-localized with the octopamine receptor in antennal neurons located near the antennal nerves. In addition, the tachykinin receptor was found to be expressed in most of the olfactory receptor neurons in antennae. Functionally, the effects direct injection of tachykinin peptides, dsRNAs of tachykinin, tachykinin receptors, and octopamine receptors provided further support for the view that both octopamine and tachykinin modulate olfactory sensitivity. Taken together, these findings demonstrated that octopamine and tachykinin in antennal neurons are olfactory regulators in the periphery. We propose here the hypothesis that octopamine released from neurons in the brain regulates the release of tachykinin from the octopamine receptor neurons in antennae, which in turn modulates the olfactory sensitivity of olfactory receptor neurons, which house tachykinin receptors.