Texts and icons are used to deliver the safety and health information on pesticide labels. This study surveyed the standards or guidelines regarding the presentation formats of texts and icons used in pesticides. Also, the text and icon formats being used in the 50 pesticide products in Korea were investigated in the aspects of size, font (texts only), color. From the guideline survey, it was found that while the guidelines for the text fonts and colors in pesticides were suggested, there was no detailed guidelines about the text size. For the icon presentation, it was regulated that the icon size for the pesticides should be larger than 7mm×7mm, and this size was equivalent to the size when the reading distance of 28 ㎝ was applied to other two guidelines. From the sample survey of the 50 pesticides, it was found that the small text size being used in the 50 pesticides was 1mm (3pt), and this size was considered to be very difficult to be read, particularly by old people. The minimum size of the texts for the toxicity of the pesticide, the very important safety information, was found to be 1.5 mm, which is considered to be very uncomfortable to be read. The size of icons were varied from 2 to 12 mm, and the total average size was 4.6 mm. The 149 icons from a total 187 icons (80%) were smaller than the icon presentation guideline (7mm×7mm), and the reason for the small icon size might be the small area of the label of the pesticides. Thus, more detailed guidelines for the text size and more practical guidelines for the size of icons are required.

This study surveyed the reading discomforts and the reasons for discomfortable reading of the safety and health information (texts and icons) presented on the agricultural vehicles/machines, pesticides, fertilizers, and feeds. Eighty seven people residing in rural area participated in the survey interview. Questionnaire survey showed that the most discomfortable product in reading the texts was pesticides. Forty three (49%) among participants had very-discomfortable or discomfortable in reading the texts used in the label of pesticides, and the main reason for the discomfort was small text size. The reading discomforts in reading the texts (varied from 4 point to 19 point and presented in 50 cm reading distance) showed different pattern according to the age groups. Three age groups (50s, 60s and older than 70s) showed a similar discomfort pattern, but different from the group of 30s and 40s. Forty four people (51%) had a problem in understanding the meaning of the icons and the main reasons were the small size and the difficulty in inferring the meaning of the icons. Thus, the more detailed and practical guidelines for the presentation format, particularly about the text heights and the size of icons, are required. Also, more comprehensive research is needed to investigate the readability and legibility of texts and icons.

This paper presents the economic validity with the cost/benefit analysis on establishing R&D Supreme Academy. To evaluate the profitability of R&D Supreme Academy, willingness to pay (WTP) is measured by contingent valuation method (CVM) and then the net present value (NPV), internal rate of return (IRR) and benefit/cost ratio(BCR) are calculated. The results of economic evaluation verified that the establishment of R&D Supreme Academy is timely and effective in an economic perspective.

본 연구는 김치건조분말을 제조하는 과정에서 김치의 발효과정과 건조 전후에서 나타나는 향기성분의 변화를 조사하고, β-cyclodextrin의 첨가로 인한 향기성분 포집효과를 검증하고자 GC-MS를 이용하여 분석실험을 실시하였다. 김치를 제조하여 20oC에서 발효시켰을 때, 초기 2일째는 dimethyl sulfide와 carbon disulfide가 생성되었고, 7일이 경과하였을 때, dimethyl disulfide, methyl 2-propenyl disulfide, allyl methyl sulfide, and di-2-propenyl disulfide의 황화합물이 주된 향기성분으로 검출되었다. 본 김치시료를 감압건조 하였을 때, 11개 화합물이 검출되지 않았고 dimethyl sulfide, acetaldehyde and methanethiol를 주로 포함하는 13개 화합물이 잔류하였다. 건조공정 중에서 김치 향기성분의 손실을 최소화하고자 0.25-1.0% 농도의 β-cyclodextrin을 건조보조제로 첨가하였을 때, 향기성분의 포집효과에 의해 건조 김치분말에 잔류하는 향기성분의 함량이 평균 3% 증가하였다. 본 연구결과로 볼 때 cyclodextrin은 건조 김치분말 제조공정뿐만 아니라 건조식품제조에서 건조보조제로 효과적으로 사용할 수 있을 것으로 보인다.

This study develops reeducation programs to satisfy needs conducted by the analyses of potential customers and present R&D education programs. The results of this study were derived using the data collected from 200 R&D researchers and control managers occupied in research centers. By analyses of the survey, results showed that the professional R&D reeducation institution and specialized education programs according to career and position were needed. To bring solution of the researcher's reeducation, the establishment of R&D Supreme Academy is essential for effective human resource development and management in R&D.

The Manchester Driver Behavior Questionnaire (DBQ) is the most commonly used frameworks for investigating the relationship between self-reported driving behavior and accident involvement. After Reason et al. introduced DBQ, there were many studies replicating the research of Reason et al. in many countries. There was, however, no study replication of the Reason's research in Korea. The aim of this study is to replicate the distinction among errors, lapses and violations, and to evaluate the relationship of these behaviors with road traffic accidents on Korean drivers. 223 Korean drivers completed the Korean version of original DBQ with questions regarding background information, such as age, gender, annual mileage and accident involvement. Participants answered self-assessment questions, also. Factor analysis revealed three factors like Reason et al. The three factors were dangerous errors, violations and relatively harmless errors.

아무리 좋은 그래픽과 뛰어난 엔진 성능과, 독창적인 아이디어, 그리고 마케팅 능력을 가진 게임이라 할지라도 게임이 밸런스가 잡히지 않은 게임이라면 아무런 소용이 없다. 이를 알고 있는 게임 개발자들은 밸런스에 많은 노력을 기울이지만 명확한 기준 없이 수많은 테스트를 통해 결과를 얻는다. 본 논문에서는 기존의 테스트를 통한 게임의 밸런스를 수정하는 방법을 개량하여 시간과 자원을 아낄 수 있는 방안에 대해 고찰하였다. 특히 MMORPG 게임에서 유저들이 가장 많이 사용하게 되는 스킬을 가지고 밸런스 방법에 대해 접근 하며 각각의 가지고 있는 특징들을 가치로 부여함으로써 스킬의 파라미터를 조율하고 이를 통해 캐릭터들 간의 밸런스도 좀 더 효과적으로 할 수 있도록 유도하는 방법론에 대해 제안하고자 한다. 본 연구 결과를 활용하면 객관적인 자료를 토대로 효율적이고 체계적인 밸런스가 가능하다.

  In this paper, we described the existing methodology of product safety analysis and proposed a Petri-nets based method to analyze product safety systematically. The proposed method can be used to find the defects of hardware/software and the error of hu

This research was designed to investigate changes of growth factors and bone matrix proteins during the bone healing processes using immunohistochemistry and in situ hybridization. Especially this study was focused on the changes of bone matrix and growth factors around the titanium implant. Threaded implants were introduced into the long bone of tibia. Time dependent changes of several bone associated protein and and its mRNAs were observed. Proteins investigated in this study are collagen, osteonectin(ON), osteopontin(OPN), osteocalcin(OC). Expression of the proteins were measured using immunohistochemistry. VEGF and ON were measured using in situ hybridization, and northen blot technique. Bone regeneration were observed as early as the third day of experiment. Matrix proteins and growth factors observed around implant were identical to the proteins observed in the control group. The expression of the ON, OC and VEGF were observed mainly in the osteoblast-like cell on the surface of new bone around the implant and the cells lining the margin of bone defect apart from the implant. The observation may not result from direct osteoconducting activities of titanium but by passive adsorption of extracellular factors which has bone inducing capacities. These passive adsorption results in the immobilization of the growth factors and consequent prolongation of the activities.

ISPARC (Secreted protein acidic and rich in cysteine) is detected in the bone stroma during wound-healing process. To understand the roles of SPARC in bony wound-healing process, SPARC cDNA were synthesized from rat calvarial osteoblast culture, and SPARC protein was synthesized from the cDNA. To observe the effects of SPARC protein on the differentiation of osteoblasts, bony defect were made on rat tibia, and the distributions of bone matrix related proteins and SPARC were investigated using immunohistochemistry. In the rat osteoblastic culture using untreated plastic surface, Collagen-SPARC treated surface presented higher protein synthesis than untreated surface or only collagen treated surface. SPARC synthesis in the bony defect of rat tibia was augmented by introducing SPARC to the bony defect. SPARC synthesis were increased from the center of the defect compared to the control. SPARC synthesis in cells of the center of the defect was increased and maintained for 14 days. We could conclude that SPARC introduction may affect the early bone matrix formation, including SPARC, and mineralization in bony wound healing process.

Adenoid cystic carcinoma(ACC) is one of the most common malignant tumors of minor salivary glands and can also arise in a variety of sites in the head and neck including the major salivary glands, the esophagus, the lacrimal glands. ACC shows slow but relentless growth, so it shows long-term recurrence. The various reports about prognostic factors which influence the recurrence pattern are introduced but the reports about prognostic factors are rare in Korean adenoid cystic carcinoma patients. We examined 40 ACC patients who finally diagnosed at Department of Oral Pathology, Seoul National University Dental Hospital. Clinicopathologic and immunohistochemical features were reviewed and factors correlated with recurrence and survival were analyzed. The 5-year survival rate of T3,T4 stage was 31.2%, while that of the T1,T2 stage was 88.2%, and the difference 5-year survival and T stage was statistically significant. The rate of local recurrence was 20% and the rate of distant metastasis was 27.5%. Mean recurrence time were 4.8 years and 5.2 years. There was no significant difference between age, sex, T stage, TNM stage, histologic type and recurrence. But the high T stage and the solid type recurred more frequently. There was no significant difference between recurrence rate, 5-year survival rate and Ki-67, MVD expression. But the higher expression of Ki-67, MVD show the higher recurrence rate and the lower 5-year survival rate

본 연구는 각종 매설관의 경계조건에 따른 동적 거동에 대한 연구이다. 축방향 및 축직각방향에 대한 거동을 조사하였다. 매설관은 탄성기초 위에 놓인 보요소로 모형화하였고, 지진파는 정현파 형태의 지반 변위로 적용하였다. 매설관의 고유진동수와 모드 형태 그리고 매개변수의 영향을 조사하기 위해 자유 진동에 대한 해석을 수행했다. 그리고 지반진동에 대한 거동을 조사하기 위해 자유진동 해석을 통해 얻어진 고유진동수와 모드 형태를 이용하여 강제 진동에 대한수식을 유도하였다. 자유 진동시 매설관의 고유진동수에 가장 큰 영향을 미치는 것은 지반 강성과 매설관의 길이였다. 지반진동의 전파방향과 전파속도 그리고 진동수에 대한 콘크리트관, 강관, FRP관의 동적거동을 연구하였고 그 결과를 비교하였으며 다양한 단부경계조건에 대한 동적거동해석을 통해 매설관의 종류와 단부경계조건에 따른 최대 변형률 발생지점을 산정하였다.

본 논문은 경기 서부 서해안 산업밸트의 지역혁신체제 구축을 위한 정책적 연구이다. 먼저 서해안 산업밸트의 현황분석 및 SWOT분석을 통해 문제점을 파악하였고, 경쟁력분석을 통해 전략산업 및 발전모델을 도출하였다. 서해안 산업밸트의 혁신체제 기본방향과 이 체제에 의해 견인되는 정량적 목표를 설정함으로써 지역혁신체제의 안을 구상하였다. 마지막으로 9대 핵심 전략 실천과제를 설정함으로써 서해안 산업밸트가 성공적인 혁신체제로 도약할 수 있는 대안을 제시하였다.

Alterations in cell surface receptors and adhesion molecules which regulate cell-cell and cell-matrix interactions have been 뻐plicated in tumor processes. In order to investigate the effect of integrin expression on the invasiveness of oral sqllamous cell carcinoma, integ띠1 expression in the celllines such as SCC-4, SCC-9, SCC-15, and SCC-25 was analyzed, and the comparison between cell adhesion assay towards extracellular matrix proteins and in vitro invasion assay following inhibition of the functional domain of the integrins using blocking antibodies against the specific integrins 낀 nd Arg-Gly-Asp (RGD) peptide were carried out. The expression of integrin a 2, a 3, a 6 was detected in all oral squamous cell carcinoma celllines. In contrast, the expression of a vß6 integrin is detected in SCC-4 and SCC-9, not in SCC-1 5 and SCC-25. 까1e adhesion of SCC-4 cell line to collagen 1, laminin, and fibronectin was significantly reducecl by σeatment with a 3-, a 6-, and a vß6-blocking antibody, respectively (p (0.05). 꺼.1e invasion of SCC-4 cell line throllgh Matrigel was significantly reduced by treatment with v 6-blocking antibody and RGD pepticle (p(0.05). These results sllggested that specifìc integrins play an in1portant role in the process of adhesion and invasion of oral squamous cell carcinoma cells and the expression of a vß6 integrin is believed to the enhance its invasivene잃.