The multicolored Asian ladybird beetle, Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae), is common to a wide range of natural and agricultural habitats. Applications of gamma irradiation minimized the losses of stored food and the death or failure of emergence in larval and pupal stages. On the other hand, degrade toxin waste as one of alternative to chemical pesticide for both quarantine and sprout control purposes of storage crop pest. So, we have investigated whether gamma irradiation exposed to eggs, lava, pupa and adults of H. axyridis. It may be affected the emergence, fertility, fecundity, development period and sex ratio of H. axyridis. Some changes of physiological characteristics may be applied to more efficient agents as biological control of several aphids. Insects were exposed to gamma irradiation from 0 to 500 Gy of 60Co depended on their developmental stages. The results showed that the first instar, eggs, third instar, pupae, and adults were more sensitive in order of irradiation dose. And fecundity and fertility of female adults were significantly decreased with increasing gamma irradiation dose at all tested individuals.

Amelobl astic carcinoma(AC) is a maJignant coun terpart of ameloblastoma. histologically characteri zed by amelobJastomatolls feature with obviollS cytologic a typi a . AC is a r are malignant tumor with poten t iaJ of metastasis‘ asssllmed to occur far less tha n 1% of ameloblastoma . Nearly 80% of ACs have been reported to occur in the mandibJ e. The allthors reviewed 5 cases of AC in Department of Oral PathoJogy. SeouJ National University from 2005 to 2007 clini copathologically according to age, sex. location and clinical findings. They occllrred at the age from 46 to 75 years wi th average age of 60 Four cases occurred in male and 1 in female‘ showing prediJ ection for ma le‘ While four cases occu rred in the maxilla , including 3 cases in the maxillary molar area and 1 in the maxiJJ a ry premola l‘ a rea, only 1 case occurred in the mandibJe. AC showing predorninance in the maxilla over t he ma ndible in our cases in contrast to other case reviews. Three patients presented painful large oral lllcer at the time of admi ssion, a nd other 2 patients presented swol1en mass around the gingivae and alveoJar bone While the clini cal impression of 3 patients were ma lignant tllmor, other 2 patients were amelboJastoma and nicotine stomatitis. The dllration of symptoms before final diagnosis has ranged from 4 months to 2 years Radiogr a phicalJy they showed poorly demarcated radiolucent lesion with irreg비 ar bony destruction. Resected tumors were measured as 6.0X4.5x4.0cm‘ 0‘ 7xO.5xO.3cm, 5.0 x 4.5 X5.0cm. 0.8xO.6 XO.5cm, and 5cm diametel mass respecti vely. Microscopically lymph node metastasis was confirmed in 1 case, but not in others . The tumors showed basic histologic featu re of ameloblastoma with apparent cytologic atypia sllch as pleomol‘ phism‘ hyper chromatism and atypical ffiJ tOSIS Individua l neoplastic cells displayed wide va riations from case to case‘ showing c lear cells with faint PAS positive granules‘ isolated round cells with abundant cytoplasm. s quamoid ceJls and polygonaJ cell s . [mmunohis toc hemical survey was done in 2 cases. all of which showed positivity to pan-cytoker atin a ntibody and p53 a ntibody‘ but negativity to HMB-45, S-100, and SMA One case recurred twice during 2 yeal's after surgery. But 3 cases showed no evidence of recurrence and metastas is. lt seems to us t hat AC have the potential of metastasis and reCllrrence.

Epithelial-mesenchymal transition(EMT) plays a pivotal role in the convers ion of earl y s tage tumors into invasive malignancies‘ and has been shown to be regulated hy the transcri ptional factor. Snail. Recent ly‘ actlvatlon of the phosphatidylinositol 3' kinase (PI3K)/따<:T axis is emerging as a centra l feature of EMT‘ However. it is unclear whether the phosphorylation of AKT regulate the expl'ession of s nail in ora l cancer cell underwent EMT. T。 investigate a role of p-AKT in EMT, we assessed the effects of inhibi ting p-AK1' activity in oral squamous can cer cells(KOSCC-25B) using PIAs, structurally modified phosphatidyli nositol ether lipid analogues(P1As) . PIAs de creased phosphorylation of c-Jun N-terrninal Kinase(JNK) and increased phosphorylation of glycogen synthase kinase 3beta(GSK-3beta). Inhibition of p-AKT ir빼ce d down regulation of Snail and Twist. but Sip1 regulated independent of p-AKT inhibition. Also inhibi tion of p-AKT dec reased cell migration and invas ion. Therefore our results implicate that p-AKT may contribute to the translocalization of sna il in the EMT associated with canceJ cell rnigration and invasion

Cholesterol granuloma(CG) occurs frequently in association with chronic middle ear diseases. pa rti cul arly dis eases in the mastoid antrum a nd ai r cells of the tempora l bone. and much less frequent ly in paranasal sinuses, It occurs f1'eq uentJy seconda1'Y to massive hemor1'hage of oral and pal'aol'aJ cysts, Howeve1'. It has nevel' been I'eported to OCCUI' solely wi thout any association of pl'eexisting lesion in the mandibJe We expel'ienced development of unusuaJ cholestel'ol granuloma in the mandible, Seventy year old female pl'e sented diffuse ha1'd swelling on the left mandibular a rea with Iymphadenopathy in the left cer vical Iymph node Radi og1'aphic exarnination showed a well circumsc ribed multi locular radiolucency resembling soap bubble appeara nce with tooth di s placement and root resorption‘ leading to the radiogrphic imp1'ession of dentigerous cyst 0 1' 。dontogenic cys t or amelobJas toma, CT showed bucco-lingua lly undul ating expansi le lesion with co rticated ma l'gin from the left posterior mandibular bocly to the anterior ramus. including #46, #47 ancl #43. and the mass containing in the lesion showed s lightly lower a ttenuation than muscJe leading to the impression of ameloblastoma, The mass aftel' surgical excis ion composed of 3 sac like structures, measuring 4,1 cm, 1, 3cm ancl 1.4cm in diame ter respectively, One sac was t ightl y a ttached to the #46. l'eRembling dentigerous cyst, Mi croscopic examination showed a large numbel' of c h이 es te rol clefts in association with hemol'rhage, hemosiderin pigments and fO l'eign body giant cells, There was no evidence of cyst 0 1' other lesions, CG should be taken into diffe l'enti a l diagnosis in addition to odontogenic cysts and tumors when radiographica lly well ci rcumscribed multilocuJal' radiolucent lesion occurs

Although a number of molecules have been implicated in the metastasis of oral squamous cell carcinoma (OSCC) , the precise molecular mechanisms that deterrnine the direction of rnigration and invasiveness of OSCC cells into the lymph nodes remain unclear, Chemokines are a superfarnily of small structurally related heparin- binding proteins‘ which have been identified as attractants that control the rnigration of leukocytes‘ especia lly during imrnune and inflammatory reactlOns Moreover, recent studies have demonstrated that several types 。f cancer express chemokine receptor‘s and use chemokines to metastasize to the target organ, However, there h ave been few reports on biological behaviors by downregulation 0 1' CXCR-4 in ora l cancel‘ cells We tried to screen several OSCC cell lines in order to obtain a suitable cell line model which had the cha ract eris tic of the constitutive ly expressed state of CXCR• 4 Of the several OSCC cell lines, only KOSCC-25B showed the high expression of CXCR-4 in both RT-PCR and Western blot analysis, siRNA-CXCR-4 infected subclones of KOSCC-25B(Si, 3‘ Si 1이 showed downregulation of CXCR-4 expression as expected‘ At serum-free co ndi tion‘ Si.3 s ubclone s ignif icantly decreased cell proliferations at 24 h and 48h and Si, lO subclone significant ly dec reased cell proliferations at 24 h Si ,3 clone dec reased to 67 ,4% and Si,lO clone to 65 ,5% in comparison to vector infected cells These data suggest that the downregulation of CXCR-4 expression could induce anti-rnigratory and ant i- rni g ratory effect

Epithelial myoepithelial carcinoma(EMC) is an uncommon malignant sali va ry gland neoplasm, compri sing about 1% 。f salivar y gland neoplasms, They are histologically composed 01' biphasic cell s such as myoepithelial cells and ductal cells EMC occurs predominantly in the major salivary glands, par t icularly in the par otid gland, They have been reported to occur onJy 10-15% in t he intraoral minor salivary glands, The authors experi enced 4 cases of EMC in Department of Oral Pathology in Seoul National University Dental Hospital from 1995 to 2007‘ and reported them with revi ew of li terature, They occurred at the age [rom 34 to 75 years with average age of 54, Three cases occurred in f'emale and 1 in male, showing predominant occurrence in female, Al I of them occurred in the f100r of mouth Three patients presented localized swollen mass at the time of admission, One patient manifested pain with surface n ecrotic ulcer, and others did not complain any symptoms, The duration of symptoms before diagnosis has ranged f rom three mont hs to 2 years in our cases Microscopically, they growed in double layered ductal structure composed 。f' ductal cells of the inner luminal layer which showed positive immunohistochemical reaction to cytokeratin and rnyoepithelial cells 01' the outer peripheral layer identifi ed by the positive reactivity to S-100 and srnooth muscle ac tin antibody, They did not show perinem al invasion‘ but invasíve growth into adjacent tissue, AII of them did not show in vasion into t he underlying bOl1e While 3 pat ients were treated with total excision of tω110 1' mass wi thout n。 evidence of recurrence a ncl metastasis, a 75 year old patient gave up receiving t reatment at the t irne of diagnos is, and then died 01' the cancer 5 years after init ial diagnosis, It seems that EMC of the intraoral minor salivary gland is a tumor 01' low grade malignancy with low potent ial of recurrence and metastasis

예수 그리스도의 지상명령 (마 28:18-20, 막 16:15, 눅 24:47, 요 20:21, 행 1:8)은 인류의 구원을 위하여 생명의 복음을 땅 끝까지 증거 하라는 것이다. 이 기독교의 복음은 우리를 위해서 십자가에 돌아가시 고 삼일 만에 죽은 자 가운데서 부활하신 예수 그리스도이시다. 수천 년의 기독교 역사는 이 복음을 증거 하는 역사였다. 이 동일하고 고유 한 복음은 인류의 다양한 문화 속에서 증거 되어 왔다. 히브리, 희랍/ 로마 문화 속에서 기록된 이 복음은 절대로 변할 수 없는 진리이다. 그러나 그것을 받아드리는 인간의 문화는 항상 변화하고 있으며 지역 별로 다양하다. 본 연구는 이 동일한 생명의 복음을 다양한 문화 속에 서 어떻게 효과적으로 증거 할 수 있을지에 관하여 살펴본다. 이미 조지 헌터가 주장한 바와 같이 아리스토텔레스의 수사학은 기 독교 복음의 효과적인 증거를 위하여 크게 기여할 수 있다. 아리스토 텔레스는 커뮤니케이션의 목적을 설득으로 이해하였다. 그에 의하면, 청중은 세 가지 방법에 의하여 설득 당할 수 있다. 첫째, 그들은 메시 지를 전하는 화자의 인격에 의하여 많은 영향을 받으며 화자의 신뢰성 을 통하여 설득 당할 수 있다. 둘째, 그들은 메시지 자체의 논리성에 의하여 설득 당 할 수 있다. 메시지는 연역적으로도 전개될 수 있으며 귀납적으로도 전개될 수 있다. 셋째, 그들은 자신들의 감정의 변화에 의하여 설득 당할 수 있다. 메시지가 강렬하게 청중의 감정을 움직일 때 그들은 설득 당하며 의지를 갖고 화자가 주장하는 바를 실천할 수 있다. 기독교 선교에 있어서 화자는 교차문화적 선교사이다. 교차문화적 상황 속에서 선교사가 복음을 전할 때 그/녀는 예수 그리스도를 본 받 아 성육신적으로 복음을 증거 해야 한다. 그렇게 하기 위해, 선교사는 자신이 섬기기 위해 부름을 받은 해당 문화를 존중하고 그 문화 속에 사는 토착민을 사랑해야 한다. 민족적, 문화적 우월감을 버리고 그들 과 함께 거하면서 복음을 전할 때 그들과 일치를 이룰 수 있으며 그 일치 속에서 성육신적 사역을 감당할 수 있다. 선교사가 전하는 유일 한 복음은 구원의 기쁜 소식이다. 이 생명의 기쁜 소식을 받아드리는 자는 살고 거부하면 죽는다. 그러나 이 복음의 메시지는 청중이 알아 듣기 쉽고 분명하게 제시되어야 한다. 이 복음의 메시지는 토착민은 물론 토착민이 구성하고 사는 사회를 변화시킨다. 따라서 이 복음은 화자중심이 아니라 청자중심으로 전해져야 한다. 선교사는 자신의 문 화적 형태-교단적 그리고 교리적 특징-를 받아드리라고 토착민에게 강 요할 것이 아니라 순수한 복음을 그들의 문화적 형태를 통하여 받아드 리도록 격려해야 한다. 교차문화적 상황 속에서 효과적인 복음증거는 기독교의 토착화를 요구한다. 기독교의 토착화는 궁극적으로 토착화를 통하여 선교지에 하나님의 나라를 확장하는 것이다. 이 하나님의 나라는 선교지에 토착 적 교회들이 세워질 때 이루어지며 확장된다. 건전한 토착화는 복음 과 문화 사이에서 균형을 유지하면서 복음을 문화적 형태를 빌려 의미 있게 전하되 복음의 진정한 의미를 상실하지 않도록 성령과 성경의 안 내를 받는 노력을 요구한다. 효과적인 교차문화적 복음증거는 토착민 의 문화적 형태를 통하여 복음의 의미를 더욱 분명하게 증거하는 것을 목표로 한다. 이와 같이 현대 기독교의 교차문화적 복음증거가 아리스토텔레스의 수사학에 기초하여 그의 설득 모드를 활용한다면 보다 효과적인 복음 증거를 기대할 수 있다. 커뮤니케이션의 삼대요소인 화자, 메시지, 그 리고 청자가 구성되어야 의사소통이 가능하듯이 교차문화적 선교에 있 어서도 선교사, 메시지, 그리고 토착민이 준비되어야 복음증거가 가능 하다. 화자로서 선교사는 종으로서의 인격을 갖추고 섬길 때, 예수 그리스도가 중심이 되는 메시지는 의미가 분명하도록 논리적으로 제시 될 때, 그리고 청자인 토착민이 메시지를 자신의 언어와 문화적 형태를 통하여 들으며 감정을 포함하여 전인격적으로 하나님을 만날 때 진정 한 회심이 일어나며 사회가 아울러 변화한다. 그리고 변화된 토착민들 이 중심이 되어 토착적 교회가 세워진다. 이 토착적 교회들이 선교지 여러 곳에 세워질 때, 하나님의 나라는 확장되며 “여호와의 영광을 인 정하는 것” (합 2:14) 이 세상에 가득할 것이다.

Biomimetic apatite deposition behaviors and mechanical performance for as-rolled and annealed Ni-Ti plates were investigated . A good biomimetic apatite formation and excellent mechanical performance of Ni-Ti suggests that Ni-Ti can be an excellent candidate material as orthopedic implants.

We fabricated Bi-2212/ composite superconductors and evaluated the effects of the powder mixing method and melting temperature on their microstructure and superconducting properties. The Bi-2212 powders were mixed with by hand-mixing (HM) and planetary ball milling (PBM) and then the powder mixtures were melted at , solidified, and annealed. We found that the powder mixture prepared by PBM was finer and more homogeneously mixed than that prepared by HM, resulting in more homogeneous microstructure and smaller and second phases after annealing.

The pretreatment for substrate was carried out in change of gun pressure of bar using wet blasting. The size of powder was about . As the results, the surface roughness of cemented carbide substrate was improved with increment of gun pressure of wet blasting. A new surface layer was formed and Co particles were uniformly distributed over the entire surface after pretreatment. The adhesion of the pretreated substrate in same PVD-TiAlN film was improved and in approximately shown the best adhesion value.

Biomimetic apatite deposition behaviors on Zr-1Nb and Ti-6Al-4V plate with various surface conditions were examined. Both alloys were polished with abrasive papers to have different roughness and some of them were treated in NaOH before exposition in simulated body fluid. NaOH treatment was found to enhance the deposition rate of apatite on Ti-6Al-4V significantly. On the other hand, the deposition rate of Zr-1Nb was not influenced by NaOH treatment. Without NaOH treatment, the polished Zr-1Nb with abrasive paper was found to induce more apatite nucleation than the polished Zr-6Al-4V.

The microstructure of the extruded Al-20Si bars showed a homogeneous distribution of eutectic Si and primary Si particles embedded in the Al matrix. The grain size of α-Al varied from 150 to 600 nm and the size of the eutectic Si and primary Si in the extruded bars was about 100 - 200 nm. The room temperature tensile strength of the alloy with a powder size <26μm was 322 MPa, while for the coarser powder (45-106μm) it was 230 MPa. With decreasing powder size from 45-106μm to <26μm, the specific wear of all the alloys decreased significantly at all sliding speeds due to the higher strength achieved by ultrafine-grained constituent phases. The fracture mechanism of failure in tension testing and wear testing was also studied.