An 81-years-old woman presented multiple mucosa ulcers with a chief complaint of pain during wearing the lower denture. She had been wearing upper and lower complete dentures for five months, and received multiple drugs for the treatment of angina pectoris, constipation, neurosis, hypertension and arthritis (calcium channel blockers, furosemide, captopril, nonsteroidal anti-inflammatory agents and penicillamine, respectively), but no history of immune-diseases and viral infection symptom. The present lesion was primarily diagnosed as traumatic ulcer, candidiasis and lichen planus in the clinical observation, thereby conservatively treated with denture relining, antifungal agent, and steroidal agent. However, the ulcer lesion was not healed for two months and rather increased in size. With the diagnosis of viral infection the immunohistochemical (IHC) staining of IL28 and E6, and polymerase chain reaction (PCR) using herpes simplex virus (HSV)-1 primer sets was done but entirely showed negative reaction. Therefore, with the patient’s medical history and IHC findings exhibiting strong positive reaction of CD3 and CD28, but rare/weak reaction of NFkB, CD20, IgK and p38, the ulcer lesion was finally diagnosed as drug-induced pemphigoid ulceration which was not an inflammatory granulomatous lesion but related to the retrogressive acantholytic degeneration of epithelial cells caused by multiple drug abuse.

The aim of this study was to evaluate the anti-inlfammatory effects of glycyrrhiza glabra Linne extract on ulcerative colitis induced by 3% dextran sulfate sodium in mice. The experimental animals were divided into six groups: control(normal), DSS-induced colitis(control), 1㎎/㎏, 10㎎/㎏, and 100㎎/㎏ of glycyrrhiza glabra Linne extract, and 150㎎/㎏5-aminosalicylic acid(5-ASA)(positive control). We evaluated the pathological disease activity index(DAI), change in weight, colon mucosa damage and myeloperoxidase(MPO) in colon mucosa. Treatment with 10㎎/㎏ and 100㎎/㎏ of glycyrrhiza glabra Linne extract led to significant loss of body weight, the decrease of MPO activity and clinical symptoms such as DAI and histological change. In particular, 100㎎/㎏ Glycyrrhiza glabra Linne extract led to markedlygreater improvement than 150㎎/㎏ 5-ASA treatment. These results suggest that glycyrrhiza glabra mediated anti-inflammatory action on colorectal sites may be a useful therapeutic approach to ulcerative colitis.

Foot ulceration results in substantial morbidity in patients with peripheral neuropathy. The purpose of this study was to find the relationship of plantar foot pressures during walking to plantar ulceration in patients with Hansen's disease. The subjects were recuruited from two Welfare Clinic for Hansen's disease in Wonju and Uiwang city. Ten subjects (5 females, 5 males) with plantar ulceration and a mean age of 63 years were evaluated in this study. The mean duration of Hansen's disease in these subjects was 30 years. Plantar pressures were measured during self-selected comfortable walking speed by using MatScan system. Three subjects had plantar ulceration under the first metatarsal head. Five subjects had plantar ulceration under the second and third metatarsal head. Two subjects had plantar ulcers under the fifth metatarsal head. Eight of 10 subjects had plantar ulceration at highest pressure point that measured during walking. This result suggests that the abnormal high plantar pressure could be related factor to plantar ulceration in patients with Hansen's disease. Also the foot pressure measurement may be useful to evaluate the risk of plantar ulceration in patients with Hansen's disease.

본 연구는 보행주기 동안 정상인과 당뇨병성 족부궤양 환자의 족관절 운동역학적 변수와 족관절 근육들의 근활성도에 차이가 있는지 알아보기 위하여 실시하였다. 본 연구의 대상자는 당뇨병성 족부궤양이 있는 환자 9명(남자: 6명, 여자: 3명)과 성, 연령, 체중으로 짝짓기(matching)시킨 대조군 9명이었다. 3차원 동작분석기, 힘판, 표면 근전도를 이용하여, 보행주기 동안 족관절의 관절가동범위, 모멘트(moment), 일률(power), 그리고 내측가자

Propolis, a natural resinous compound collected from honey bees, contains many biochemical constituents and has been used in traditional medicines as early as 300 B.C. Recently, it has been reported to possess many biological activities such as antibacterial, antiviral, fungicidal, local anaesthetic, immunostimulating, antiinflammatory and free radical scavenging properties. This study was performed to investigate the pharmacological effects of the propolis extract and fractions on the gastric lesion and ulcer. The ethanol extract was fractionated with hexane, toluene and ethyl acetate. Followed by bioassay on antigastric and antiulcer activity. Propolis ethanol extracts(500, 750, 1,000, 1,500 and 2,000 mg/kg) showed the protective effect on HCl ethanol-induced gastric lesion and the antisecretory effect against Shay's gastric secretion in pylorus-ligated rats in a dose related manner. In the animal models of HCl ethanol, aspirin-induced gastric lesion and Shads gastric secretion, the hexane and toluene fraction of propolis significantly reduced the length of gastric lesion and the acid secretion. These data showed that the gastric protective effects of propolis might result from reduction of acid secretion through the inactivation of H^+/K^+ATPase activity.

본 연구는 스트레스에 의해 발생하는 위궤양에 대한 Opuntia dillenii Haw.(선인장)의 효과를 관찰하고자 시행되었다. 실험동물로는 Sprague-Dawley계 수컷 흰쥐 48마리를 사용하였며, 대조군(CO)과 3개의 투여군(E-1, E-2, E-3)으로 나누어 1996년 7월 29일부 1996년 8월 25일까지 4주간 실험을 수행하였다. Opuntia dillenii Saw.(선인장)는 1일 1회 경구투여하였으며, 각각 30 mg/kg BW(E-1) 및 120 Mg/kg BW(E-3)의 농도를 투여하였다. 결과느 s다음과 같다. 1. 체육은 전 군에 걸쳐서 고르게 증가되었으며, 특히 실험시작 후 13일째 체중증가량은 대조군에 비하여 Opuntia dillenii Haw.(선인장)를 투여한 실험군 실험군에서 유의한 차이는 관찰되지 않았다. 4. Alcian bule staining을 통한 위점액량 산출 결과 Opuntia dillenii Haw.(선인장)를 투여한 실험군이 대조군에 비해 전 농도에서 점액량이 높게 나타났으며, 실험군 E-1군은 유의하게 높았고(p<0.05), 실험군 E-2의 경우 그 증가가 현저하였다(p<0.01). 이로서 Opuntia dillenii Haw.(선인장)가 위의 점액생성을 촉진시키거나 위에 보호막을 형성함으로서 위궤양 발생저하에 기여하는 것으로 보여진다. 5. shear rate 11.25, 45.0, 90.0 및 225.0 sec^(-1)에서 전혈점도 및 혈장점도를 측정한 결과 모든 shear rate에서 C군>E-3군>E-1군>E-2군의 경향성을 보였다. E-1(30 mg/kg BW)군의 전혈점도는 대조군에 비하여 shear rate 11.25, 45.0 sec^(-1)에서는 매우 유의하게 감소하였고(p<0.01), shear rate 90.0, 225.0 sec^(-1)에서도 유의하게 감소되었다(p<0.05). E-2(60 mg/kg BW)군의 전혈점도는 대조군에 비하여 매우 유의하게 감소하였고(p<0.01). E-3(120 mg/kg BW)군의 전혈점도는 대조군에 비하여 shear rate 11.25 sec^(-1)에서 매우 유의하게 감소되었고 (p<0.01), shear rate 45.0, 225.0 sec^(-1)에서도 유의하게 감소되었다(p<0.5). 동일한 shear rate에서의 혈장점도는, E-1(30 mg/kg BW)군은 대조군에 비해서 shear rate 90.0 sec^(-1)에서 유의하게 감소되었다(p<0.05). E-2(60 mg/kg BW)군의 혈장점도는 대조군에 비해 shear rate 90.0, 225.0 sec^(-1)에서 유의하게 감소되었다(p<0.05). E-3(120 mg/kg BW)군은 대조군에 비해 전 shear rate에서 모두 감소하였으나 유의한 차이는 보이지 않았다. 이러한 결과로부터 Opuntia dillenii Haw.(선인장)가 스트레스하에서 발생하는 위의 미세혈관 협류흐름장애를 개선시켜 위게양 발생저하에 기여하는 것으로 보여진다. 6. 전 실험군의 위를 조사한 결과 출혈을 동바한 궤양이 형성되었음을 관찰할 수 있었다. Opuntia dillenii Haw.(선인장)투여군에서는 대조군에 비해서 궤양의 면적과 깊이가 다소 적은 경향을 나타내었다. 7. 위조직에 대한 병리조직학적 검사를 시행한 결과 Opuntia dillenii Haw.(선인장)을 투여한 실험군에 비하여 대조군의 궤양이 매우 심함을 관찰할 수 있었고, E-2군의 경우 궤양이 경미한 정도였다. 8. 위궤양의 지표로 사용한 pH, 위점액량, 전혈점도, 혈장점도, 조직병리학적소견 등을 종합한 결과, Opuntia dillenii Haw.(선인장)를 투여한 실험군이 대조군에 비해서 항궤양효과가 있는 것으로 나타났으며, 치료양의 2배를 투여한 E-2(60 mg/kg BW)군에서 효과가 가장 뛰어났다.

Paeoniae Radix has been used as a traditional medicine for various diseases including hepatic disease. However, the inhibitory effect of Paeoniae Radix on intestinal inflammation has not been fully understood yet. The aim of this study was to evaluate the effect of Paeoniae Radix on colitis induced by dextran sulfate sodium in mice. To investigate the protective effects of Paeoniae Radix, the colitis mice were induced by drinking water containing 5% dextran sulfate sodium for 7 days. Mice were randomized into groups receiving Paeoniae Radix (100 ㎎/㎏), sulfasalazine (150 ㎎/㎏) as a positive control, or water as a negative control. We evaluated the effects of Paeoniae Radix on clinical signs induced by dextran sulfate sodium, measuring weight loss, colon length, and disease activity index. Additionally, to find a possible explanation for the anti-inflammatory effects of Paeoniae Radix, we evaluated the effects of Paeoniae Radix on the interleukin-6 and cyclooxygenase-2 levels in colitis tissue. The results indicated that mice treated with dextran sulfate sodium showed measurable clinical signs, including weight loss and reduced colon length. However, Paeoniae Radix treatment significantly improved the weight loss and disease activity index as clinical symptoms. Moreover, Paeoniae Radix inhibited the interleukin-6 and cyclooxygenase-2 expression levels in colon tissues treated with dextran sulfate sodium. Taken together, the findings of this study suggest that Paeoniae Radix may be useful for treating intestinal inflammation, including ulcerative colitis.

본 연구는 산약(Dioscorea Rhizoma)이 급성 위궤양을 유발 한 흰쥐의 위장 장애에 미치는 효과를 조사하였다. 산약 분말사 료를 섭이한 실험군과 산약 분말액을 투여한 실험군의 궤양성 출혈은 1 일 이상 진행되었으나 시간이 경과함에 따라 서서히 호 전되었으며, 특히 산약즙을 처리한 실험군의 경우 급성 위궤양 유발직후에 국소적인 위점막 울혈만이 관찰되었다. 또한 산약 분말액과 산약즙을 투여한 실험군에서는 급성 위괘양 유발 후 증가되는 gastrin과 histamine의 농도가 감소되어 산약이 위산 의 과다 분비를 억제하는 것으로 조사되었으며, 산약을 투여한 모든 실험군에서 과도한 지질과산화물의 생성이 감소되었다. 이와 더불어 산약의 투여는 급성 위궤양에 의해 급격하게 증가 된 SOD와 GPX의 활성을 감소시키는 반면, CAT의 활성은 높여 주어 조직 내 항산화효소 활성을 정상 수준으로 회복시켜주는 것으로 나타났다. 따라서 산약은 급성 위궤양에 의한 위 조직의 손상을 감소시키고 혈장 성분과 항산화효소의 활성을 정상수준 으로 회복시켜 위궤양으로부터 위장기능을 개선하는데 높은 효 과가 있을 것으로 사료된다.

The association of colorectal cancer with ulcerative colitis (UC) is well-recognized. However, not much is known regarding the increased risk of extra-intestinal malignancies with UC. Several studies have revealed that patients with UC are at in-creased risk of hepatobiliary cancer, nonmelanoma skin cancer, and myeloid leukemia. A 41-year-old man was diagnosed with UC in 1993 and had three relapses over the next three years. Six months after the fourth remission, he developed pan-cytopenia and was diagnosed with acute promyelocytic leukemia (APL). He achieved complete remissions of APL through chemotherapies, and, since then, no recurrences of APL and UC were observed.

We previously examined extracts, isolated from Scutellaria baicalensis (SB), chemical mediators, and IgE by mesenteric lymph node (MLN) lymphocytes in rats. The present study was to evaluate the effects of extracts of SB on the MLN lymphocytes function of mice given orally by 20 mg/kg for 2 weeks with dextran sulfate sodium (DS)-induced colitis. Results show that IgE levels in MLN lymphocytes was low, while IgA was high, in mice given SB compared to that fed water. Concentrations of Inteferon-γ and interleukin (IL)-2 of T cells by concanavalin A treatment was significantly higher in the SB fed group than the normal group. Activation-induced IL-4 and IL-10 secretion was lower in SB fed mice compared control mice after DS-induced colitis. These results suggested that SB suppresses the inflammation in DS-induced colitis through the modulation of Th1/Th2 balance to down-regulate TH2 response in MLN lymphocytes.

유백피 물 추출물의 위궤양치료 효과를 확인하기 위하여 여러 비율의 농도로 rat에 대한 투여량을 조절하면서 Shay, aspirin 및 Indomethacin으로 유도된 위궤양에 대하여 실험하였던 바 유백피의 물 추출물을 각기 500 및 1000mg/kg을 투여하였을 때 항궤양 효과가 유의성 있게 농도 의존적으로 증가하였으며 Shay궤양이나 aspirin유발 궤양보다도 indomethacin유발 궤양의 경우에 더욱 항궤양 효과가 좋았다.