The purpose of this study is to develop and evaluate amorphous spray-dried microparticles (SDM) containing levosulpiride to increase its solubility. SDM are prepared via solvent evaporation using polyvinylpyrrolidone (PVP) as the water-soluble polymer and Cremophor RH40 as the surfactant. The SDM is prepared by varying the amounts of PVP and Cremophor RH40, and its physicochemical properties, solubility, and dissolution are confirmed. All levosulpiride-loaded SDMs converted the crystalline drug into an amorphous form, significantly improving drug solubility and dissolution compared with the drug alone. SDM consisting of drug/PVP/Cremophor RH40 in a weight ratio of 5:10:3, with increased solubility (720 ± 36 vs. 1822 ± 51 μg/mL) and dissolution rate (10.3 ± 2.2 vs. 92.6 ± 6.0%) compared with drug alone, shows potential as a commercial drug for improved oral bioavailability of levosulpiride.

홍잠은 숙잠(熟蠶)을 수증기로 익혀서 인간이 섭취할 수 있도록 제조한 다양한 건강 증진 효과가 있는 천연 건강 식품이다. 현재 표준 제조 방법은 수증기로 찐 홍잠을 보관과 판매의 편의를 위하여 급속 냉동하여 동결 건조를 진행하는 것이다. 그런데, 홍잠을 동결 건조하는 과정은 많 은 시간과 비용을 필요로 하여 홍잠 제품 가격의 인상 요인으로 작용하고 있다. 본 연구에서는 홍잠을 수증기로 찐 후 바로 균질 액으로 제조하여 분무 건조하면 분말 제조 비용을 절감할 수 있음을 발견하였다. 그리고 홍잠 균질 액에 식용 단백질 분해 효소를 첨가하여 분해시킨 후, 단 1회의 분무 건조로 제품을 제조할 수 있는 방법을 개발하였다. 특히 홍잠 균질 액이나 효소 분해 홍잠 균질 액은 바로 액상이나 젤리 형태로 일반 또는 환 자용 특수 의료 용도 식품에 활용이 가능함을 보여주었다. 본 연구에서는 생산비용이 감소된 홍잠의 가공 방법을 제안하며 이는 제품 생성의 단가 를 낮추어 제품의 대중화와 양잠 농가의 연관산업 육성을 불러올 것으로 기대된다.

SiAlON-based ceramics are some of the most typical ceramic materials used as cutting tools for HRSA(Heat Resistant Super-Alloys). SiAlON can be fabricated using ceramic processing, such as mixing, granulation, compaction, and sintering. Spray drying is a widely-used method for producing a granular powder of controlled morphology and size with flowability. In this study, we report a systematic investigation aimed at optimizing spherical granule morphology by controlling spray-drying parameters such as gas flow and feed rate. Before spray drying, the viscosities of the raw material slurries were also optimized with the amount of dispersant added.

소금은 인체에서 생리작용을 위한 필수적인 물질 중 하나로, 염화나트륨(NaCl)을 주성분으로 한다. 그러나 구성 성 분인 나트륨의 과잉 섭취는 고혈압, 뇌졸중 등 심혈관질환과 골다공증의 발생률을 증가시키는 것으로 알려져, 건강유 지 및 삶의 질 향상을 위하여 나트륨 저감화를 위한 연구가 진행되고 있다. 따라서 본 연구에서는 운반체의 역할을 할 수 있는 maltodextrin을 NaCl에 적용하여 제조한 NaCl-maltodextrin 복합체를 쌀튀기의 시즈닝에 적용하여 짠맛의 증진 효과 및 나트륨 저감화 효과를 확인하고자 수행되었다. NaCl와 maltodextrin을 2:1(w/w)로 혼합한 후, 이의 20%의 수용액을 분무건조하여 NaCl-maltodextrin 복합체를 제조하였다. 분무건조 시 inlet temperature (130-170℃)와 atomizing pressure (6-22 × 10 kPa)를 각각 다르게 적용하였으며, 이 때 blower는 0.6 m 3 /min이었다. 제조한 NaCl-maltodextrin 복 합체의 외관 관찰 및 주사형 전자 현미경을 사용하여 하여 NaCl-maltodextrin 복합체 입자의 크기를 측정하였다. 또한 로터리쿠커를 사용하여 복합체를 양념한 쌀튀기를 제조하였고, 관능검사를 진행하여 NaCl-maltodextrin 복합체의 짠맛 의 저감화 효과를 확인하고자 하였다. NaCl-maltodextrin 복합체의 입자 크기 측정 결과, 분무건조 시의 inlet temperature 에 따른 차이는 나타나지 않았으나, atomizing pressure가 높아질수록 입자의 크기가 감소하였다. 양념한 쌀튀기의 관 능검사 결과 160℃의 inlet temperature와 22 × 10의 kPa atomizing pressure의 조건으로 제조한 NaCl-maltodextrin 복합체 로 양념한 시료의 짠맛이 가장 강한 것을 확인하였다. 가장 작은 NaCl-maltodextrin 복합체 입자 크기가 가장 강한 짠 맛을 나타냄에 따라 NaCl-maltodextrin 복합체가 혀와 접촉할 수 있는 표면적이 증가한 것에 기인한 것으로 판단된다. 이에 따라, 분무건조를 이용하여 제조한 NaCl-maltodextrin 복합체의 짠맛 증진 효과를 확인하였으며, 입자의 크기가 작을수록 더욱 효과적일 것으로 기대되었다.

In this study, we fabricated Nd2Fe14B hard magnetic powders with various sizes via spray drying combined with reduction-diffusion process. Spray drying is widely used to produce nearly spherical particles that are relatively homogeneous. Thus, the precursor particles were prepared by spray drying using the aqueous solution containing Nd salts, Fe salts and boric acid with the target stoichiometric composition of Nd2Fe14B. The mean particle sizes of the spray-dried powders are in the range from one to seven micrometer, which are adjusted by controlling the concentra- tions of precursor solutions. After debinding the as-prepared precursor particles, ball milling was also conducted to con- trol the particle sizes of Nd-Fe-B oxide powders. The resulting particles with different sizes were subjected to subsequent treatments including hydrogen reduction, Ca reduction and washing for CaO removal. The size effect of Nd-Fe-B oxide particles on the formation of Nd2Fe14B phase and magnetic properties was investigated.

Hollow silica spheres were prepared by spray drying of precursor solution of colloidal silica. The precursor solution is composed of 10-20 nm colloidal silica dispersed in a water or ethanol-water mixture solvent with additives of tris hydroxymethyl aminomethane. The effect of pH and concentrations of the precursor and additives on the formation of hollow sphere particles was studied. The spray drying process parameters of the precursor feeding rate, inlet temperature, and gas flow rate are controlled to produce the hollow spherical silica. The mixed solvent of ethanol and water was preferred because it improved the hollowness of the spheres better than plain water did. It was possible to obtain hollow silica from high concentration of 14.3 wt% silica precursor with pH 3. The thermal conductivity and total solar reflectivity of the hollow silica sample was measured and compared with those values of other commercial insulating fillers of glass beads and TiO2 for applications of insulating paint, in which the glass beads are representative of the low thermal conductive fillers and the TiO2 is representative of infrared reflective fillers. The thermal conductivity of hollow silica was comparable to that of the glass beads and the total solar reflectivity was higher than that of TiO2.

In the present study, the focus is on the effect of cobalt oxide powder in the carbothermal reduction of the titanium-cobalt-oxygen based oxide powder by solid carbon for the optimizing synthesis process of ultra fine TiC/Co composite powder. The titanium-cobalt-oxygen based oxide powder was prepared by the combination of the spray drying and desalting processes using the titanium dioxide powder and cobalt nitrate as the raw materials. The titanium-cobalt-oxygen based oxide powder was mixed with carbon black, and then this mixture was carbothermally reduced under flowing argon atmosphere. Changes in the phase structure and thermal gravity of the mixture during carbothermal reduction were analysed using XRD and TGA. Titanium-cobalt-oxygen based oxide powder desalted at had a mixture of . And the one desalted at had a mixture of . In the case of the former powder, the reduction of cobalt oxide powder in the titanium-cobalt-oxygen based oxide powder occurred at lower temperature than the latter one. However, the carbothermal reduction of titanium dioxide powder in the titanium-cobalt-oxygen based oxide powder with a mixture of occurred at higher temperature than the one with a mixture of . And also, the former powder showed a lower TiC formation ability than the latter one.

In the present study, the focus is on the analysis of carbothermal reduction of the titanium-cobalt-oxygen based oxide powder by solid carbon for the optimizing synthesis process of ultra fined TiC/Co composite powder. The titanium-cobalt-oxygen based oxide powder was prepared by the combination of the spray drying and desalting processes using the titanium dioxide powder and cobalt nitrate as the raw materials. The titanium-cobalt-oxygen based oxide powder was mixed with carbon black, and then this mixture was carbothermally reduced under a flowing argon atmosphere. The changes in the phase structure and thermal gravity of the mixture during carbothermal reduction were analysed using XRD and TGA. The synthesized titanium-cobalt-oxygen based oxide powder has a mixture of and . This oxide powder was transformed to a mixed state of titanium car-bide and cobalt by solid carbon through four steps of carbothermal reduction steps with increasing temperature; reduction of to and Co, reduction of , to the magneli phase(, n>3), reduction of the mag-neli phase(, n>3) to the (2n3) phases, and reduction and carburization of the (2n3) phases to titanium carbide.

The Indium Tin Oxide(ITO) nano powders were prepared by spray drying and heat treatment process. The liquid solution dissolved Indium and Tin salts was first spray dried to prepare chemically homogeneous recursor powders at the optimum spray drying conditions. Subsequently, the precursor powders were subjected to eat treatment process. The nano size ITO powders was synthesized from the previous precursor powders and the npuities also were decreased with increasing heat treatment temperature. Furthermore, the lattice parameter of TO nano powders was increased by doping Tin into Indium with increasing heat treatment temperature. The par icle size of the resultant ITO powders was about 20∼50nm and chemical composition was composed of In:Sn =86:10 wt.％ at 80.

The magnetic Nd-Fe-B powders were prepared by a thermochemical method, consisting of the processes of spray-drying, debinding, milling, H-reduction, Ca-reduction, and washing. The optimum process conditions were studied by microstructural and thermal analysis. The resultant Nd-Fe-B powder was spherical with the size of 1 . Effects of the process parameters of each step on the microstructure of the powders were investigated, and their magnetic properties were evaluated