Metastatic tumors in oral cavity are rare, where their prognoses are considered to be extremely poor. Unless recognizing its primary origin, pathologic diagnoses for metastatic cancer have been troublesome for oral pathologists. This retrograde analysis was aimed at providing practical suggestion for the diagnoses of metastatic cancers to oral and maxillofacial region. We reviewed 20 patients diagnosed as metastatic cancers to oral cavity from 1991 to 2007. The patients were classified according to their clinical and histologic findings. We also reviewed 19 patients of mucoepidermoid carcinoma and 16 patients of adenoid cystic carcinoma to compare with those of metastatic cancers. Immunohistochemical staining for CK 5/6, CK 17, TTF-1, CEA was performed for differential diagnosis. Histologically, 20 cases compromised 11 cases of adenocarcinoma, 5 cases of undifferentiated carcinoma, 3 cases of squamous cell carcinoma, and one papillary carcinoma. The lung was the most common site for primary site (5/20), followed by the breast (2/20). In metastatic adenocarcinoma, TTF-1 positive cases were one lung cancer and a rectal cancer, and carcinomas from breast and rectum showed CK5/6 positive reaction. CEA was expressed in gastric and rectal carcinomas. In 19 cases of mucoepidermoid carcinoma, 13 cases (68.4%) are CK5/6 (+). In 16 cases of adenoid cystic carcinoma, 11 cases (68.8%) showed the positive reaction for CK5/6. TTF-1 is an antibody to show high sensitivity and specificity for lung adenocarcinoma, therefore, TTF-1 is helpful to make a diagnosis of metastatic adenocarcinomas from lung. Adenocarcinomas originated from salivary glands show high CK5/6 expression, but metastatic adenocarcinomas, except of those from breast and rectum, show no CK5/6 expression, lending support that CK5/6 may be useful to differentiate metastatic adenocarcinomas from carcinomas of salivary gland origin.

The objectives of this study were to investigate the relationship between fear-avoidance beliefs and functional status in individuals suffering from low back pain, and to identify factors that influence on fear-avoidance beliefs, functional status and pain. A cross-sectional study included 214 individuals with low back pain. Each of subjects completed a fear-avoidance beliefs questionnaire (FABQ) which divided into two subscales, FABQ for physical activity (FABQ-PA) and FABQ for work(FABQ-W), Oswestry disability index (ODI) and numeric pain rating scale (NPRS). Individuals with radiating pain were significantly higher in FABQ-PA, FABQ-total, and ODI scores than with no radiation pain (p<.05). Individuals who had received surgery were significantly higher in FABQ-PA, FABQ-total, ODI and NPRS scores when compared with individuals who had not received it (p<.05). And individuals with taking medication were significantly higher in all variables (FABQ-PA, FABQ-W, FABQ-total ODI and NPRS) than individuals not taking medication (p<.05). In correlation analysis. age appeared to be significantly correlated with FABQ-PA, FABQ-total and ODI scores (p<.05), and all variables was significantly correlated with each other (p<.01). These findings indicate that individuals suffering from low back pain have psychosocial problems such as fear-avoidance beliefs as well as functional status and pain. Fear-avoidance beliefs may contribute to aggravate physical symptoms, and therefore it should be carefully considered for the management of individuals with low back pain.

In this study, the stress-strain response and the cracking behaviors of ITO film on a PET substrate are investigated. The cracking behaviors of ITO thin films deposited on a thermoplastic semi-crystalline polymer developed for flexible display applications was investigated by means of tensile experiments equipped with an electrical measurement apparatus and an in-situ optical microscope. Electrical resistance increased gradually in the elastic-to-plastic transition region of the stress strain curves and cracks formed. Numerous cracks were found in this region, and the increase of the resistance was linked to the cracking of ITO thin films. Upon loading, the initial cracks perpendicular to the tensile axis were observed at about 1% of the total strain. They propagated to the entire sample width as the strain increased. The spacing between the horizontal cracks is thought to be determined by the fracture strength and the thickness of the ITO film as well as by the interfacial strength between the ITO and PET. The effect of the strain rate on the cracking behavior was also investigated. The crack density increased as the strain increased. The spacing between the horizontal cracks (perpendicular to the stress axis) increased as the strain rate decreased. The increase of the crack density as the strain rate decreased can be attributed to the higher fraction of the plastic strain to the total strain at a given total strain. The higher critical strain for the onset of the increase in the resistance and the crack initiation of the ITO/PET with a thinner ITO film (300 ohms/sq.) suggests a higher strength of the thinner ITO film.

Purpose : To investigate correlations between ocular components and corneal aberration according to comeal topographic pattems. Methods : 100 subjects (127 eyes) whose corrected visual acuity is 20/20 or better participated in this study. Ocular components. comeal topography and comeal aberration were measured. Results : Round type was 25%. oval type was 17%. symmetric bow tie type was 15%. asymmetric bow tie type was 26%, irregular type was 17% in classified by corneal topographic patterns. There were significant correlations between 1st coma aberration and refraclive error. between corneal power and total astigmatism. spherical aberration(total. 1st. 2nd and 3rd). There was significant correlations between comeal eccentricity and 2nd astigmatism. There were significant correlations between corneal astigmatism and astigrnatism(total. 1st and 3rd). Refractive error. comeal astigmatism and comeal aberration were the highest value in round type among the 5 different comeal topographic patterns. Corneal power was the highest value in oval type. but corneal eccentricity was the highest value in symmetric bow tie type. Conclusions : lt is considered that this data can be used as basic information for further studies regarding effecls of comeal pattern and aberration on the qualily of vision.

본 연구는 항암, 항균, 항산화 등의 기능을 나타내는 식물성 플라보노이드인 naringin이 암컷 SD rat의 지질대사와 혈액 생화학적 지표에 미치는 영향을 살펴보기 위해 수행되었다. 실험은 5주령의 암컷 SD rat를 대상으로 일주일에 3번, 총 5주 동안 naringin을 경구투여하여 지질대사와 항혈전능에 미치는 영향을 비교 분석하였으며, 실험군은 대조군(non naringin group), 저용량 naringin 투여군(0.2 g/kg), 고용량 naringin 투여군(0.5 g/kg)으로 구분하였다. 실험결과 랫드의 체중증가량과 상대장기중량에서는 통계학적으로 유의적인 변화가 관찰되지 않았다. 체중증가량에서 3주차 이후에 용량에 비례하지는 않지만 대조군에 비하여 naringin 투여군의 체중 증가율이 적은 것을 관찰 할 수 있었다. 사료섭취량과 체중증가량을 이용하여 각 군의 5주간 식이효율을 구해보았을 때, 군간에 통계학적으로 유의적인 차이는 없었으며, 장기와 조직의 상대장기중량은 간을 비롯하여 신장, 비장 모두 naringin 투여군과 대조군 간에 통계학적으로 유의적인 차이가 없었다. 혈청 중 Triglyceride, free fatty acid, total lipid, glucose의 수치는 대조군에 비해 naringin 투여군에서 유의적으로 감소하였다. 혈청 total cholesterol과 HDL-cholesterol의 수치를 이용한 Atherogenic index 즉, 동맥경화지수는 대조군에 비하여 고용량군이 유의적으로 감소하였다. 항혈전능 실험결과에서는 고용량 naringin 투여군이 대조군에 비해 유의적으로 높은 수치가 관찰되었다. 이상의 결과를 종합해 볼때 암컷 SD rat에서 naringin은 체중감소에 대한 효과는 관찰되지 않았지만, 지질저하 효과, 항산화 효과 등의 면에서 모두 우수하였다. 따라서 우리나라에서 자생하는 천연물 소재에 널리 분포된 naringin은 고혈압과 당뇨병에 효능이 있는 것으로 추측되며 동맥경화에도 효과가 있는 것으로 보여 건강기능 식품 소재로 이용될 수 있는 적절한 물질이라 판단된다.

to malignant transformation. Oral leukoplakia is a common premalignant lesion in oral mucosa and the incidence of cancer progression into SCC has been reported to be 0~43%. The genetic alterations of oncogenes, tumor suppressor genes and DNA repair genes occur during carcinogenesis. In order to evaluate the role of epithelial cells in the early stage of carcinogenesis, we analyzed the alterations of genetic heterogeneity in epithelial cells of oral leukoplakia samples, using Laser capture microdissection(LCM). The incidence rate of microsatellite instability(MSI) and loss of heterozygosity(LOH) were analysed from the DNA of epithelial cells from 16 leukoplakia samples using adjacent fibroblasts as a normal control. In this study, LOH was found in epithelial cells of all 16 cases of leukoplakias while MSI has been observed in 3 cases. Interestingly, the fibroblasts showed LOH and MSI in some cases, which was confirmed by DNA sequencing. Taken together, this study showed that leukoplakia has multiple genetic alterations in fibroblasts as well as in epithelial cells, suggesting that interaction between epithelial cells and fibroblasts might be involved in the early step of carcinogenesis.

구조물의 응답에 대한 잔류변위의 영향을 평가하기 위하여, 초기 잔류변형이 있는 상태에서 작용하는 설계지진에 대한 좌굴방지 가새골조(BRBF)와 특수 모멘트골조(SMRF)의 응답을 평가하였다. 초기 잔류변형은 구조물에 두 가지 방법으로 적용하였다. 첫 번째 방법은 첫 지진에 대하여 구조물이 정지 상태에 도달한 이후 같은 크기의 지진을 적용하는 것이다. 두 번째 방법은 소요 잔류층간 변형이 발생할 때까지 일방향으로 가력한 다음 지진하중을 적용하였다. 해석결과에 따르면 초기 잔류층간변위는 BRBF와 SMRF의 응답에 큰 영향을 주었다. SMRF 시스템보다 BRBF의 응답이 초기 잔류변형에 크게 의존하였다. 그러므로 지진발생 이후 보수비용을 최소화하기 위하여 잔류층간변위를 줄이는 것이 필요하다.

Eight Bacillus thuringiensis strains activated against mosquito larva were compared their characterization. Spherical-shaped parasporal inclusion of B. thuringiensis subsp. tohokuensis CAB167 was observed by phase-contrast microscopy and scanning electron microscopy. LC₅₀ values of B. thuringiensis subsp. tohokuensis CAB167 against Culex pipiens molestus, Culex pipiens pallens, and Aedes aegyti were 173, 190 and 580 ng/㎖, respectively. B. thuringiensis subsp. tohokuensis CAB167 had a parasporal inclusion containing 4 major protein components, for example, 135, 80, 49 and 28-kDa by SDS-PAGE. Otherwise, after trypsin digestion of parasporal inclusion, SDS-PAGE was showed new protease-resistant peptides at 72 and 63-kDa. Activated toxins of isolated CAB167 were different from other reference strains on a serological by immuno-diffusion test.

The purpose of this study is to examine three bird-watching science museums near the Yellow-sea area. The two museums on the construction are located in Chungnam province and the other is located in Chunnam province which are already operated for several years to now. The bird-watching science museum is similar to conventional science museum in terms of exhibiting objects, but in detail the bird-watching science museum is specialized in bird-watching and study it's ecology. So the sight should be near the place where the bird can be seen easily and the building should be built in ecological way. Now establishing museum in local area as a community development is pretty popular in Korea. as tourism purpose. But the main purpose of bird-watching museum should be educational and cultural way and next tourism. So in this study I tried to pick designing point of architecture and exhibition of bird-watching museum.

This study examines public accountability of terrestrial broadcasters, especially KBS, MBC and SBS, in Korea, Public accountability understand a new role for public broadcasters in context of changing media environment, and is responsibility in return for the privilege of public channels. Theoretically there is close relationship between public accountability and public interest, which based on the public broadcasting system in tradition. Public accountability is a response to public ownership, public funds and public channel, and therefore includes not only public program service, public control system and active service for the audience. In practice, it can not be given to all free channels the same accountability, but different. For example, KBS has very strict public accountability, because it is based on public characteristics for ownership, financing and free channel. On the other hand belongs to the public accountability SBSs basically public service for audience included public program service. But it is very impotent for all public channels to survive in the future.

Growth behavior of InGaN/GaN self-assembled quantum dots (QDs) was investigated with respect to different growth parameters in low pressure metalorganic chemical vapor deposition. Locally formed examples of three dimensional InGaN islands were confirmed from the surface observation image with increasing indium source ratio and growth time. The InGaN/GaN QDs were formed in Stranski-Krastanow (SK) growth mode by the continuous supply of metalorganic (MO) sources, whereas they were formed in the Volmer-Weber (V-W) growth mode by the periodic interruption of the MO sources. High density InGaN QDs with 1~2nm height and 40~50nm diameter were formed by the S-K growth mode. Dome shape InGaN dots with 200~400nm diameter were formed by the V-W growth mode. InN content in InGaN QDs was estimated to be reduced with the increase of growth temperature. A strong peak between 420-460 nm (2.96-2.70 eV) was observed for the InGaN QDs grown by S-K growth mode in photoluminescence spectrum together with the GaN buffer layer peak at 362.2 nm (3.41 eV).

본 논문에서는 중 약진 지역에서 중력 저항시스템인 중간 모멘트골조로 설계된 3층, 6층 RE 플랫플레이트 구조물을 KBC 2005를 만족하도록 RC구조물에 강판과 가새/ BRB 등의 보강방법을 적용하여 보강하고, 내진성능을 평가하여 보강 효과를 검증하였다. 비탄성 정적해석과 동적해석 결과에 따르면 내진 보강된 구조물은 강도와 강성이 크게 향상된 것으로 나타났다 특히 기둥을 철판으로 보강한 경우 슬래브를 철판으로 보강하여 조기 뚫림 전단파괴를 방지함으로써 강도를 크게 향상할 수 있다. BRB로 보강된 구조물은 Brace로 보강된 구조물보다 다소 연성적 거동을 보였으며, 그 효과는 3층 모델에서 현저하게 나타났다.