The objective of this study was to produce a nutrient delivery system (NDS) using sialic acid extracted from edible bird’s nest (EBN), which improves brain function in patients with Alzheimer’s disease and Parkinson’s disease, by affinity bead technology (ABT). The inhibitory activity of acetylcholinesterase (AChE) and pyramidal cells in the dentate gyrus of the hippocampus were analyzed to investigate the effect of a sialic acid NDS on Alzheimer’s disease. Also, the effect of a sialic acid NDS on Parkinson’s disease was evaluated by rota-rod test and pole test in an animal model. Among the groups treated with donepezil, EBN, and sialic acid NDS, the AChE activity was the lowest in the sialic acid NDS-treated group. The results of the hippocampus analysis of the rat model confirmed that the sialic acid NDS inhibited amyloid-beta accumulation depending upon the concentration. Also, the sialic acid NDS group showed more improvement in motor deterioration than the1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- induced group in both the rota-rod test and pole test. Therefore, the sialic acid NDS had an effect of protecting not only Alzheimer’s disease by inhibiting AChE and amyloid-beta accumulation, but Parkinson’s disease by preventing neurotoxicity induced by MPTP.

We investigate the effects of Yb2O3 and calcium aluminosilicate (CAS) glass as sintering additives on the sintering behavior of AlN. The AlN specimens are sintered at temperatures between 1700oC and 1900oC for 2 h in a nitrogen atmosphere. When the Yb2O3 content is low (within 3 wt.%), an isolated shape of secondary phase is observed at the AlN grain boundary. In contrast, when 3 wt.% Yb2O3 and 1 wt.% CAS glass are added, a continuous secondary phase is formed at the AlN grain boundary. The thermal conductivity decreases when the CAS glass is added, but the sintering density does not decrease. In particular, when 10 wt.% Yb2O3 and 1 wt.% CAS glass are added to AlN, the flexural strength is the highest, at 463 MPa. These results are considered to be influenced by changes in the microstructure of the secondary phase of AlN.

본 연구는 북방수염하늘소 성충이 집합-성 페로몬 트랩에 유인되는 시기를 명확하게 규명하기 위해 수행하였다. 또한 집합-성 페로몬에 유 인된 개체의 난황 성숙도를 조사하여 집합-성 페로몬 트랩에 유인되지 않은 개체와 비교하였다. 이를 위해 홍릉시험림 내 망실 안에 유인제인 집합-성 페로몬을 매단 다중깔때기트랩과 집합-성 페로몬을 매달지 않은 다중깔때기 트랩을 각각 1개씩 배치하고, 우화망실에서 채집한 북방수염하 늘소 성충을 우화시기별(우화 직후, 후식 1일차, 후식 7일차, 후식 10일 경과 후 교미)로 그룹화한 후 트랩이 배치된 망실 안에 방사하여 트랩에 포획 여부를 조사하였다. 각각의 시기별로 80개체(20개체씩 4반복)를 대상으로 실험하여 총 320개체를 망실 내에 방사하였다. 조사 결과, 우화 후 7일 동안 섭식한 개체들의 유인 포획률이 가장 높았으며, 교미 후에는 유인 포획률이 급격히 낮아지는 경향이었다. 또한 집합-성 페로몬이 있는 경 우에만 후식 7일차 그룹의 유인 포획률만 통계적으로 유의미한 차이를 보였다. 성별에 따른 유인 포획률의 경우, 암컷이 수컷에 비해 많이 포획되긴 하였으나, 암컷과 수컷 간의 유인 포획률 차이는 없는 것으로 확인되었다. 우화 직후와 후식 1일차에는 모든 개체에서 난황이 미성숙한 상태였으나, 후식 7일차와 교미 후에는 모든 개체에서 성숙한 난황을 확인할 수 있었다. 따라서 페로몬트랩은 우화 후 초기에 후식을 통한 소나무재선충 전파가 가능하므로 소나무재선충병의 확산 억제를 막기에는 제한적일 가능성이 있다. 반면, 성적으로 성숙한 성충을 포획하고, 야외 발생을 조사 하는 등으로는 활용 가능성이 있을 것이다.

Parosteal osteosarcoma, a subtype of juxtacortical osteosarcoma, has a better prognosis compared to central osteosarcoma with a relatively low risk for recurrence and metastasis. Rarely, it can arise synchronously with other malignant tumors. Synchronous malignancies are defined as the occurrence of a second primary malignancy within 6 months of the appearance of the first malignancy. Here in, we introduce a 64-year-old woman who visited the Department of Oral & Maxillofacial Surgery, Yonsei University Dental Hospital with a 2 year history of a whitish verrucous lesion on the palate. She presented an exophytic mass on mandible during the following visits. Histopathologic evaluation revealed a synchronous parosteal osteosarcoma and squamous cell on right mandible and a precancerous verrucous leukoplakia on the palate.

PURPOSES : For large-scale construction, such as a concrete pavement, design and construction are not entirely consistent. If the inconsistency between design and construction is very large, construction quality is significantly degraded, affecting performance life span and driving comfort. The quality of pavement construction is managed according to standards. However, it is difficult to improve construction quality as the standard measures construction quality after construction is completed. Therefore, this study developed a system to measure the construction quality of concrete pavement in real-time and presented the corresponding standards. METHODS : A basic module for simultaneously measuring the width, thickness, and roughness of the concrete pavement was designed. Based on the measurement results of the distance measurement sensor, a calibration method is presented that can remove noise. The system process was developed to measure construction quality based on location and distance data, measured in real-time using GPSs and sensors. The field application experiment was conducted and the results were analyzed. RESULTS : The measurement module is properly designed to be used in concrete pavement construction sites. Noise was removed from the distance measurement sensor results according to the presented calibration method, leaving only the wave of pavement surface irregularities. As a result of applying the system process in the field application, a reasonable level of PRI was observed. CONCLUSIONS : In the past, the width, thickness, and roughness were measured after construction was completed and, if the standard was not met, construction quality control was performed via reconstruction or repair. Through this study, it is expected that the width, thickness, and roughness of the concrete pavement can be measured in real-time and, if the standard is not met, construction quality can be immediately controlled during construction to maintain high quality.

본 연구에서는 두 종류의 도너-억셉터 (D-A) 타입 고분자들을 Stille coupling 반응을 통하여 중합한 뒤, 이들 을 고분자 기반 유기 태양전지의 광활성 층으로 적용하였다. Benzodithiophene 전자 주게와 pyrazinoquinoxaline 전 자 받게를 활용하여 고분자들을 합성하였고, 전자 주게와 전자 받게가 직접 연결된 고분자를 PB-TMPQ 그리고 둘 사 이에 티오펜 π-bridge가 도입된 고분자를 PB-TTMPQ라 각각 명명하였다. 기본적인 화학 구조의 검증과 더불어, 고분 자들의 광학적 및 전기화학적 특성에 대한 분석 또한 실시하였다. 최종적으로 inverted-type 구조의 소자를 이용하여 고분자들의 광전지 특성들을 분석하였으며, PB-TMPQ와 PB-TTMPQ의 전력변환 효율은 각각 1.01%로 0.83%로 관측 되었다. 따라서, π-bridge의 도입이 pyrazinoquinoxaline 기반 고분자의 광전지 특성을 큰 영향을 미친다는 것이 확인 되었으며, 이러한 결과는 향후 pyrazinoquinoxaline 기반 고분자의 구조-물성 간 상관관계 연구에 활용될 수 있을 것 이다.

This paper proposes an outlier detection model based on machine learning that can diagnose the presence or absence of major engine parts through unsupervised learning analysis of main engine big data of a ship. Engine big data of the ship was collected for more than seven months, and expert knowledge and correlation analysis were performed to select features that are closely related to the operation of the main engine. For unsupervised learning analysis, ensemble model wherein many predictive models are strategically combined to increase the model performance, is used for anomaly detection. As a result, the proposed model successfully detected the anomalous engine status from the normal status. To validate our approach, clustering analysis was conducted to find out the different patterns of anomalies the anomalous point. By examining distribution of each cluster, we could successfully find the patterns of anomalies.

This study analyzed the nutritional composition properties of soybeans and the antioxidants, isoflavones, organic acids, and volatile flavor compounds of fermented black soybean products (FBSP). After 24 hours of fermentation, the range of water uptake ratio was 129.00-131.30%, respectively. Total polyphenols content and DPPH and ABTS radical scavenging activity were higher in Cheongja-3 FBSP, flavonoids in Socheongja, while DPPH and ABTS radical scavenging activities were similar in Cheongja-3 FBSP. Isoflavone contents of aglycones (daidzein, genistein, and glycitein) in Cheongja-4 FBSP increased up to 41.97 μg/g. The rank order of primary organic acids was citric acid > fumaric acid > acetic acid > lactic acid, with Cheongja-3 FBSP being the highest. This study identified a total of 34 volatile aroma-compounds, including seven alcohols, seven acids, seven ketones, five phenols, two esters, one furan, four pyrazines, and one miscellaneous. The result could be applied to determine the suitability of cultivars and the quality of the process used for fermented soybean products.

When kimchi is frozen and thawed, the amount of lactic acid bacteria (LAB) and yeast is usually reduced by more than 2 logs, and its texture including its crispness and hardness are changed significantly. As a possible means to minimize these problems, various freezing (direct freezer with -25, -40, and -60oC and plate freezer with -40oC) and thawing methods (radio frequency (RF) thawing, plate thawing, and room temperature thawing) were investigated in terms of the amount of LAB and texture of kimchi. From the use of plate freezing and plate thawing, the amount of LAB of white cabbage kimchi could be maintained by more than 10% of its initial amount while that for red cabbage kimchi could be maintained by more than the initial amount. Pretreatment with trehalose (19 oBrix soluble solid content) to salted Chinese cabbage could maintain kimchi’s hardness and crispness. In order to maintain the texture and the amount of LAB in kimchi, the use of the plate freezer (-40oC) and the plate thawing (20oC) seemed to be effective with the assistance of trehalose.

This study was conducted to secure basic information for corn processing by comparing the quality characteristics according to maize cultivars and kernel types (dent, intermediate, flint-like). As a result of analyzing 15 cultivars, a range of measurements were observed: 100-kernel weight, 22.89~35.63 g; moisture, 7.57~8.42%; crude protein, 8.46~11.45%; crude lipids, 3.26~4.83%; Hunter’s L-value, 83.70~86.79; a-value, 2.61~5.49; b-value, 22.01~28.15; and total carotenoids, 6.74~17.07 μg/g. Significance among the cultivars was shown in all quality characteristics (p<0.001), but the significance among the kernel types was found only in crude protein (p<0.005), crude fat (p<0.001), and Hunter’s L-value (p<0.05). The hardness of maize was decreased proportionally to the soaking time for all maize cultivars (p<0.001). In particular, with the same soaking time for different kernel types, the hardness difference was shown in the order of flint-like > dent ≒ intermediate. It was confirmed that the decrease in the hardness of flint-like kernel of close to that of hard-type starch was slowed compare dent and intermediate kernels. So it is expected the some characteristic of kernel types will contribute to the appropriate customized use of the developed cultivars.

The enamel powders used traditionally in Korea are produced by a ball-milling process. Because of their irregular shapes, enamel powders exhibit poor flowability. Therefore, polygonal enamel powders are only used for handmade cloisonné crafts. In order to industrialize or automate the process of cloisonné crafts, it is essential to control the size and shape of the powder. In this study, the flowability of the enamel powders was improved using the spheroidization process, which employs the RF plasma treatment. In addition, a simple grid structure and logo were successfully produced using the additive manufacturing process (powder bed fusion), which utilizes spherical enamel powders. The additive manufacturing technology of spherical enamel powders is expected to be widely used in the field of cloisonné crafting in the future.

In this paper, we proposed an auto-encoder model of observation-wise linear transformation to reduce the dimensionality of data. While nonlinear models can reduce the dimensionality more effectively than linear models, such as the principal component analysis, the non-linear methods can hardly provide a simple linear relationship between the original and the dimensionally reduced data. The proposed model overcomes this difficulty while maintaining the effectiveness of the dimensionality reduction. We assessed the proposed model and compared with PCA and a typical auto-encoder model in terms of the loss function and the degree of reconstruction of the original data. By applying the proposed method to a public data of MNIST and Fashion-MNIST, we showed the effectiveness in the dimensionality reduction and relationship between the original data to the reduced data.