The present study aims to examine vocabulary analysis programs suitable for English textbook authorization in the amended version of the national curriculum. The analysis of WordLister 2002, a conventional vocabulary analysis software, reveals that it fails to meet the needs necessary to authorize textbooks in terms of user-friendliness and limited uses of the vocabulary analysis output. The design of WordLister 2002 is too complicated to be used without special training. While it provides useful information on new vocabulary, it fails to provide information in comparison with the existing research on vocabulary. NLPtools, on the other hand, applies corpus analysis techniques to the analysis of textbook vocabulary. In this program, texts in the textbook are seen as a corpus. Another characteristic is that NLPtools employs analysis methods based on dictionaries. It is found that NLPtools processes special characters in the text, so that the user does not need to process them by using specified input codes as in WordLister 2002. Wordlister 2002 requires its user to register a number of words in the process of vocabulary analysis, whereas the user with NLPtools does not need to register words as its built-in dictionary has a wide range of information on words. NLPtools also provides its users with functions, by which they can get and analyze the information they need. With these advantages over the conventional software, it is suggested that NLPtools can be used as a vocabulary analysis program for textbook authorization in the amended curriculum.

The Korean Astronomical Data Center(KADC) in Korea Astronomy and Space Science Institute(KASI) has developed a database of astronomical journals published by the Korean Astronomical Society and the Korean Space Science Society. It consists of all bibliographic records of the Journal of the Korean Astronomical Society(JKAS), Publication of the Korean Astronomical Society(PKAS), and Journal of Astronomy & Space Sciences(JASS). The KADC provides useful search functions in the search page such as search criterion of bibcode, publication date, author names, title words, or abstract words. The journal name is one of the search criterion in which more than one journal can be designated at the same time. The criterion of author name is provided bilingually: English or Korean. The abstract and full text can be downloaded as PDF files. It is also possible to search papers related to a specific research topic published in Korean astronomical journals, provided by the KADC, which often cannot be found the worldwide, Astrophysics Data System(ADS) services. The KADC will become basic infrastructure for the systematic construction of bibliographic records, and hence, make the society of Korean astronomers more interactive and collaborative.

본 논문에서는 MPEG-7 서술자 (descriptor) 들을 이용하여 바이오 동영상들의 특징을 분석하고， 각 서술자별 검색 효율을 비교한다. 바이오 동영상 검색을 위해 MPEG-7의 칼라 (color) ，텍스쳐 (texture) 그리고，모션 (motion) 서술자들을 이용하여 바이오 동영상들로부터 특정 값을 추출하고， 추출된 원소들의 분산과，가설 검증을 이용하여 바이오 동영상의 특징을 분석하였으며，바이오 동영상 검색에 효율적인 소틀을 찾을 수 있었다. 또한 검색 실험을 통하여 각 서술자들의 바이오 동영상에 대한 검색 효율을 비교하였으며，끝으로 서술자들의 적용 가능 여부를 확인하였다.

구조물의 진동 자료를 이용하는 유전알고리즘(GA) 기반 손상검색기법에 있어, 사용되는 모드 특징의 선택은 손상검색 결과의 정확도를 높이는데 중요하다. 본 연구의 목적은 고유진동수와 모드변형에너지를 이용하여 손상검색의 정확도를 높이는 것이다. 이와 같은 연구 목적을 달성하기 위하여 다음과 같은 연구를 수행하였다. 먼저, 모드 변형에너지를 유도하고 고유진동수와 모드변형에너지를 이용하는 새로운 GA 기반 손상검색기법을 제안하였다. 다음으로 제안된 기법의 효율성을 검증하기 위하여 양단 자유보의 손상시나리오를 제시하고, 손상시나리오에 따른 진동모드 실험을 실시하였다. 마지막으로 실험 자료를 바탕으로 제안된 기법과 기존의 고유진동수와 모드형상을 이용하는 기법으로 손상검색을 실시하여 결과를 비교하였다.

The efficiency to detect mutagenicity of the system using a specific locus mutation of Bombyx mori was examined and improved. In the system, mutagenicity could be detected by the egg colour manifested by the pe and/or re genes, which is a kind of recessive visible mutation of the insect. Among tested four mutagens, MMC had specially high sensitivity in the oocytes of silkworm and EMS had in the spermatozoa. PCB and dioxin showed a positive effect in both the oocytes and spermatozoa. In a consequence of sensitivity of mutagen by mating number of male moth of B. mori, treated mutagen, there was no difference between one mating - and three mating - male moth in sensitivity of mutagen. Sun3ho, B. mori variety, which showed high sensitivity to mutagens was improved in the major characteristics by crossing of C5 and N12.

We collected eleven large astronomical catalogues, which include 2MASS, USNO B1.0, GSC 2 catalogues and so on. Most of these catalogues are the frequently used by astronomers for all sorts of applications. But the researches are faced with the problem of accessing these databases because these catalogues contain from tens millions up to thousands of millions of records. So we developed a web application system to manage these large catalogues, the main purpose of the web application is to allow a powerful and efficient querying activity on these catalogues through internet by using a simple web interface. User could retrieve the query result in variety of formats including plain text, HTML, Microsoft Excel format (XLS), and VOTable. Furthermore, user also could display and analyze result graphically by using a powerful interactive visualization tools named VOPlot which was developed by the Virtual Observatory-India (VOI) project.

The First Generation Digitized Sky Survey (DSS-I) is a collection of digitized photographic atlases of the night sky taken from the Palomar Observatory (northen sky) and the Anglo-Australian Observatory (southern sky). DSS-I is widely used by the astronomical community for a number of applications including object cross-identification and astrometry. However, accessing and retrieving the actual images are nontrivial owing to the huge size (> 60 GB) of the dataset. To facilitate retrieval process of DSS-I data for the public, Korean Astronomical Data Center (KADC) developed a web application that provides not only data retrieval but also visualization functions. The web application consists of several modules developed using Java Applet, Jave Servlet, and JaveServer Pages (JSP) technologies. It allows users to retrieve images efficiently in various formats such as FITS, JPEG, GIF, and TIFF, and also offers an interactive visulization tool, ImgViewer, for displaying/analyzing FITS images. To use the web application, users require a Java-enabled web browser.

Rhus verniciflura of the Anacardiaceae family well known as the lacquer tree has been used not only as a material for coating with sap but as a herbal medicine for thousands of years. However, it has been limited access to application as a food additive because urushiol compounds are able to cause irritation, inflammation or blistering of the skin to mammalian. So, in previous study, we investigated as a new approach to effect of mushroom sp.(12 species) on urushiol contents in the stem bark of Rhus verniciflua and found that some mushroom species were able to decrease urushiol contents by 93 to 97%. And detoxified Rhus verniciflua had some functional effect for antioxidative, antihyperlipidemic, nitrite scavenging, ACE(angiotensin converting enzyme) or tyrosinase inhibitory effect. Also, detoxified Rhus verniciflua was evaluated for TH(tyrosine hydroxylase), related to Parkinson's disease, enhancement in pc12 cells or rat brain region, and for cytotoxicity against cancer cells. The TH gene expression was increased in a dose, time-dependant fashion from the both pc12 cells and rat brain. THIR( Immunoreactive) neurons in the rat midbrain were generated and cell body of it was increased from the observation throughout immnohistochemistry. Cytotoxicity for cancer cells (T24, Saos) was significantly increased, as dose or time increase, whereas, for the normal cell line (NIH3T3) was not effected.

Metastatic spread to cervical lymph nodes(LNs) is a major determinant of outcome in oral squamous cell carcinoma (SCC). To provide an useful method for the detection of lymph node micrometastases, we fulfilled the histopathological examination and reverse transcriptase polymerase chain reaction(RT-PCR) using the paraffin-embedded LNs of oral SCC patients. In this study, 78 LNs from 12 patients with primary oral SCC were analyzed. Metastases in the regional LNs were evaluated by RT-PCR for squamous cell carcinoma antigen(SCCA) and cytokeratin 5(CK5). Detectability of metastatic LNs by RT-PCR was compared with histopathological examination. Of 78 LNs, CK5 and SCCA mRNA were detected in 32(41.0%) and 8(10.3%), respectively. Histopathologically, 10(12.8%) of 78 LNs were positive. CK5 mRNA was detected in all 10 histopathologically positive LNs. In contrast, SCCA mRNA was detected in 5 of 10 histopathologically positive LNs. These findings suggest that genetic diagnosis by RT-PCR based on CK5 mRNA expression may be sensitive and clinically useful technique to detect the presence of metastatic carcinoma cells in regional lymph nodes of oral SCC.

The adenomatoid odontogenic tumor(AOT) is a benign tumor of odontogenic epithelium characterized by slow but progressive growth and rare recurrence. Tumor growth may cause displacement of teeth rather than root resorption. The AOT appears in 3 clinicotopographic variants such as follicular, extrafollicular, and peripheral. The follicular AOT mimics a dentigerous or follicular cyst and the extrafollicular cyst does a residual cyst, globulo-maxillary cyst and lateral periodontal cyst. Although over 750 cases of AOT were reported in the literature, clinicopathologic parameters of AOT in Koreans has not been investigated. 22 cases of AOT were retrieved from the files of the department of Oral Pathology, Seoul National University Dental Hospital and their clinicopathologic findings were reviewed. The central type accounts for 95%, 72% of which are follicular. The follicular and extrafollicular varients together are more commonly found in the maxilla than in the mandible with a ratio of 4.5:1. Age distribution showed that 59% of AOTs were diagnosed in the second decade of life, and mean age was 18.5 years. The female to male ratio was 3.4:1. All variants of AOT showed identical histologic features.

Odontogenic ghost cell tumor (OGCT) is considered as a neoplastic counterpart of the calcifying odontogenic cyst (COC). β-catenin mutations have been described in COC suggesting a critical role in its histogenesis. In this study, we report a patient with OGCT contains a missense mutation on codon 3 (ACT -> TCT). Immunohistochemistry showed nuclear, cytoplasmic, and membranous accumulation of β-catenin in the tumor cells. TUNEL assay showed positive signals in nucleated cells adjacent to the ghost cells. Our data suggest that β-catenin plays an important role in the tumorigenesis of OGCT. OGCT may developed by improper differentiation process coordinated by WNT signaling pathway. Further studies are needed to determine a genotypic/phenotypic characteristics of ghost cell containing odontogenic lesions.

In order to obtain novel genes related to the human craniofacial development, molecular cloning and sequencing, and in situ hybridization using craniofacial tissue sections were performed and followed by protein structure simulation. Totally 231 clones were obtained from the subtracted craniofacial tissue cDNA library of human embryo. Random cloning using the non-redundant clones from the craniofacial tissue of human embryo was done and obtained 398 clones from the premade human chondrocyte cDNA library. Their partial sequence data showed that 214 clones of subtracted cDNA library of craniofacial tissue were still non-redundant in Genebank search. And 20 clones among 498 clones of premade chondrocyte cDNA library were known to be undefined genes. Through in situ hybridization screening in the craniofacial tissue sections of 10 weeks old human embryo 36 clones were found to be positive in specific tissues. Depending on the cell types of sirnilar developmental origin, the positive reactions could be divided into five groups. Among the 20 clones of undefined genes from human chondrocyte cDNA library, 7 clones showed characteristic positive reaction in human cartilage tissue by in situ hybridization. From the simulated protein structure, motif analysis and in situ hybridization studies for the 7 undefined clones, Ch89, Ch96, Ch129, Ch285 clones may function in the outer space of the cell constituting a part of matrix protein complex, and Ch276 as a transmembrane protein which might partic ipate in matrix calcification around chondrocytes. Ch153 is a kind of antirnicrobial protein also acting as an inflammation mediator, and Ch334 clone is a zinc finger protein, of which expression increases in human adult tissues We presume these novel genes from human chondrocytes may provide a new path of chondrocyte development and functions of human craniofacial tissues