목적: 제 5기 국민건강영양조사(2011년, 2012년) 자료를 기반으로 우리나라 나이관련황반변성(age-related macular degeneration)과 비타민과 무기질의 섭취의 상관성을 분석하였다. 방법: 국민건강영양조사 제 5기 과정 중 2011, 2012년도 조사대상자 중 건강 검진, 안과 검진과 영양검진 조사를 받은 45세 이상 성인을 대상으로 나이관련황반변성과 비타민, 무기질섭취량의 상관성을 분석하였다. 나이관련황반변성의 연관성은 교차분석과 카이제곱 검정으로 분석하고, 위험비(odds ratio)는 로지스틱 회귀분석으로 구하고 유의수준은 0.05 이하로 하였다. 결과: 국민건강영양조사를 받은 45세 이상의 한국인 6,219명 중 나이관련황반변성 유병률은 9.6%로 나타 났다. 초기 나이관련황반변성은 비타민 A, B1, B2, B3 및 C와 칼슘, 인, 철, 나트륨, 칼륨의 섭취와 상관성이 있었으며, 비타민 B3 섭취량이 평균 미만인 경우는 평균이상인 경우보다 초기 나이관련황반변성의 발생 위험이 1.35배(95% 신뢰구간:1.03~1.78) 높았다. 나이관련황반변성 말기 환자 군에서는 칼륨과 비타민 B2 섭취량이 평균보다 적으면 유병률이 높았으며, 칼륨 섭취량이 평균 미만인 경우는 발병 위험이 4.3배(95% 신뢰구간:1.76~10.59) 높았다. 결론: 비타민과 무기질의 섭취는 나이관련황반변성의 발병 위험과 병의 진행을 억제하는 것으로 사료된다.

목적: 한국 폐경기 여성에서 호르몬 관련 요인과 건성안의 연관성에 대하여 알아보고자 하였다. 방법: 본 인구 기반 단면 연구는 제5기 국민건강영양조사(2010-2012)를 완료한 총 4,586명의 폐경기 여성을 대상으로 복합표본설계 프로시저를 구성하여 분석을 시행하였다. 폐경기 여성을 대상으로 건성안 유병 률을 산출하였고, 공변량을 보정한 다중 로지스틱 회귀분석을 시행하여 내생적 및 외생적 호르몬 관련요인 과 건성안의 연관성을 평가하였다. 결과: 폐경기 여성에서 건성안의 가중된 유병률은 14.2%(95% 신뢰구간: 13.0－15.8)이었다. 사회 인구학 적 요인, 건강행태 요인, 동반질환을 보정한 후에도 경구피임약을 23개월 이상 복용한 경우 건성안 발생 위 험이 1.47배(95% 신뢰구간: 1.03－2.09) 증가하였으며, 여성호르몬제를 36개월 이상 복용한 경우 건성안 발생 위험이 1.70배(95% 신뢰구간: 1.17－2.47) 증가하였다. 결론: 한국 폐경기 여성에서 장기간의 경구피임약과 여성호르몬제의 복용은 건성안의 위험을 유의하게 증가시켰다.

In commercial vehicles. the pulsation noise when the power steering operating is the major item to make the complain for users. If this noise have related to vibration characteristics in steering system's parts or assembly, it makes the problem in vehicle quality. Recently, the users demand the high quality in commercial vehicles, and we must identified the relevance between the pulsation noise and the vibration characteristics. After the identification, we can design the power steering system for satisfaction the user’s needs. Finally, the identification of relevance in pulsation noise for analysing the vibration characteristics will be suggested advanced power steering system.

The objectives of this study were to investigate the effects of PM10 and O3 concentration on the symptoms of allergic diseases. The questionnaire was used to determine whether or not symptoms of allergic diseases were present from September to October 2012. The air pollution concentration data used was the corresponding point CEM (continuous emission monitoring) data. The average concentration of PM10 was 56.09 μg/m3 in the control area, and the concentration in the exposed area was 40.44 μg/m3. In the two areas, concentration of O3 was 28.73 ppb and 28.74 ppb, respectively. The total average concentrations of PM10 and O3 were 45.66 μg/m3 and 28.73 ppb in the Gwangyang area. The rate of asthma diagnosis was higher in the control area (9.6%) than in the exposed area (4.1%), but the rate of allergy eye disease was higher in the exposed area (23.9%) than in the control area (16.5%). There was a significant difference in the symptoms of some allergic diseases when the relative concentration of PM10 and O3 were high and low.

강유위(1858-1927)는 서방열강의 중국침략으로 중국이 반식민지 반봉건사회로 전락하고 중 국 민족이 생존위기에 직면하였을 때 대동사회를 구상하였다. 그는 당시 중국사회를 “끝없이 푸른 하늘과 넓은 대지는 큰 도살장이며 감옥일 따름”(대동서·甲部)이라고 생각하였다. 그 리하여 모두가 행복하고 괴로움이 없는 세상을 꿈꾸었는데, 그것이 바로 대동사회이다. 강유 위의 대동사상은 동서양 사상의 결합으로 이루어졌는데, 특히 공자의 대동사상, 공양삼세설, 인(仁)사상 등과 서구의 천부인권론과 공상적 사회주의 등의 영향을 크게 받았다. 이렇게 형 성된 그의 공상적 사회주의는 유가사상을 통한 사회주의의 공고화를 도모하는 중국사회주의 의 현대화를 이룩하는 데 사상적 초석으로 작용하였다.

음모론은 모든 국가와 사회에서 발생하고 있으며, 한국사회에서도 정치적 사건에 대한 음모론이 지속적으로 발생하고 있다. 음모론은 사회현상의 근본적인 발생 원인에 대해 공식적 원임규명에 대해 특정한 개인이나 집단에 의해 의도적으로 원인규명에 이의를 제기하면서 반발하는 현상을 말한다. 음모론은 국가와 정부의 사건에 대한 원인규명에 저항하여 신뢰성에 반발하면서 저항하여 타격을 주는 것이다. 한국사회에서 음모론은 주로 정치적 사건에서 발생하였는데, 정치적 사건에 대한 음모론은 정치권력을 안정화시키려는 세력과 정치권력을 교체하려는 보수와 진보의 작용과 반작용의 형태로 나타나고 있다. 장준하 사망사건에 대한 음모론은 집권세력에 저항한 인물의 갑작스런 죽음에 의문을 제기하는 과정에서 발생한 것으로 집권세력의 대한 정당성을 불신하는 측면이 강하였다. 또한 광주민주화운동과 천안함 침몰에 대한 음모론은 전자가 신군부의 정권탈취를 위한 폭력의 정당화, 후자가 남북관계의 단절에 대한 정당화에 근거로 활용되는 것에 대한 국민들의 저항적 성향을 지니고 있다. 한국정치에서 음모론은 각종 선거과 관련하여 활용되는 특성이 강하지만 선거 결과에 직접적이고, 결정적인 영향력을 행사하지는 못하였다. 그렇지만 한국 정치에서 음모론은 정치적 사건의 원인규명에 대한 진위논란에서 음모론의 정 당성 여부에 관계없이 한국사회를 혼란시키는 요인으로 작용하고 있다.

본 연구는 RPS3 유전자의 SNP를 탐색하고 버크셔 돼지 433두에서 RPS3 유전자 SNP와 육질형질과 의 연관성을 규명하였다. SNP 탐색을 위해 버크셔 돼지의 간 조직을 사용하여 RNA-Seq을 수행한 결 과, RPS3의 염색체 451번째 G 서열이 C로 변환되어 arginine에서 serine으로 아미노산이 치환되는 non-synonymous SNP를 확인하였다. 동일한 조건에서 사육된 버크셔 돼지 433두에서 RPS3 SNP의 유전자형을 분석한 결과 major allele은 G이며 minor allele은 C로 확인되었다. RPS3의 유전자형과 육 질형질과의 연관성 분석 결과 공우성 모델에서 등지방두께(Backfat thickness), 가열감량(Cooking loss), 적색도(CIE a), 사후 45분 후 삼겹살과 등심 pH(pH45minB and pH45minL), 지방(Fat)과 단백질 (Protein) 함량 형질에서 유의성을 가졌다. 성별에 따른 RPS3 SNP 유전자형의 육질분석 결과 거세돈 은 단백질 함량에서만 유일하게 유의성이 나타난 반면 암퇘지는 등지방두께를 포함한 7가지의 육질 형 질에서 유의성을 나타나 거세돈 보다 육질 형질과의 연관성이 높은 것으로 확인되었다. 육질형질과 RPS3 SNP를 비교하였을 때, G allele을 가진 유전자형이 C allele에 비해 사후 pH45minB, 사후 pH45minL, 단백질 함량을 증가시키고, 등지방두께, 가열감량, 지방 함량을 감소시키는 것으로 확인하였 다. 따라서 G allele을 가진 돼지가 육질이 더 좋은 것으로 판단된다. 본 연구의 결과를 통해 RPS3의 SNP를 육질이 우수한 돼지고기를 생산하기 위한 분자유전 육종에서 육질 연관 biomaker로 응용 할 수 있을 것으로 사료된다.

This study was conducted to evaluate the risk of overweight and obesity in adolescents consuming snacks frequently from 2007~2009, Korean National Health and Nutrition Examination Survey (KNHANES). The subjects (12~14 years: n=523; 15~18 years: n=614) were presented with food frequency questionnaires, and they were classified according to their gender and frequency of snack consumption. In the age group of 12~14 years, boys and girls (boys OR: 1.11, 95% CI: 0.52~2.39, girls OR: 12.45, 95% CI: 2.26~68.51) who consumed yogurt frequently had a higher risk of overweight and obesity at the highest quartile frequency compared with the lowest quartile after adjustments for multiple confounding factors, including age, physical activity, frequency of eating out and snack consumption, and energy intake. In the age group of 15~18 years, girls (OR: 1.01, 95% CI: 0.34~2.99) consuming fried foods had a higher risk of overweight and obesity at the highest quartile frequency compared with the lowest quartile after adjustments for multiple confounding factors, including age, physical activity, frequency of eating out and snack consumption, and energy intake. Thus, we conclude that frequent consumption of yogurt and fried foods increases the risk of overweight and obesity in adolescents. These findings suggest that the risk of overweight and obesity is associated with the frequency of snack consumption.

애플이 삼성을 상대로 특허침해소송을 제기함 에 따라 다양한 특허법적 이슈와 논쟁이 발생하였 다. 특히 미국 연방순회항소법원은 애플이 삼성을 상대로 신청한 임시적 금지명령 및 영구적 금지명 령 사건에서 연관성(nexus) 요건을 제시하면서 금지명령의 판단 요건을 강화하였는데, 기능이 다 수 포함된 제품의 일부분이 특허를 침해한 경우 침해된 특허사항과 특허권자의 판매 감소 또는 시 장점유율 상실과의 연관성이 있어야 금지명령의 판단 기준인 ‘회복할 수 없는 손해’ 요건이 충족된 것으로 볼 수 있다는 것이다. 이러한 연관성 요건 은 특허침해 소송에서의 손해배상액 산정에 관한 원칙인 기여분 할당 법리와 전시장가치법칙과도 연결되는데, 위와 같이 기존의 금지명령에 관한 판단 기준을 강화시킨 미국 법원의 태도 변화는 디자인특허 침해소송에서의 손해배상액 산정에도 영향을 미쳤고, 결국 2016년 12월 6일 미국 연방 대법원은 애플과 삼성의 디자인특허 침해소송에 서 기존의 입장과는 다르게 특허법 제289조의 ‘제조물품’에 제품 구성요소도 포함된다고 보아 제품 전체의 이익만이 아닌 해당 구성요소의 이익 을 기준으로 손해액을 산정할 수 있는 가능성을 열었다. 이처럼 미국 법원은 현 산업구조의 변화 등을 고려하여 종래 특허권자를 강력하게 보호하 던 입장을 바꾸어 침해자에게 과도한 손해배상액 을 부담시키는 것을 제한하는 방향으로 나아가고 있다. 우리나라에서는 제품의 일부분만이 특허를 침해하는 경우 기여도 법리에 따라 전체 제품 중 특허를 침해한 부분의 기여도를 고려하여 손해배 상액을 산정하는 것이 일반적인데, 최근 나타난 미국 판례에 대한 비교법적 연구를 통하여 좀 더 합리적인 손해배상액 산정 기준을 확립할 필요가 있다.

Thus far, there have been many studies focusing on meat quality improvement for Hanwoo (Korean cattle). It is considered that studies on meat quality have been actively conducted because beef consumption has changed from quantity to quality since early 1990's. Moreover, many studies on meat quality using maker assisted selection (MAS) have been conducted. However, there is a need to study quantity of meat in order to enhance the economic effect by genetic diversity and quantity of meat for Hanwoo. Therefore, in order to use a myostatin gene affecting meat quantity among quantitative genes for MAS, this study analyzed the association between genetic variation of myostatin gene in individuals of Hanwoo and carcass traits. Analysis between genotypes and individual phenotypic characteristics was performed by ANOVA using ASREML. Association analysis between these 10 SNPs and phenotypic characteristics (carcass weight, eye muscle area, backfat thickness, marbling score, yield index), and there were significant differences in 5 SNPs. As a result, there were five significant differences. Although all the SNPs did not show significant differences in each trait in this study, some SNPs showed significant differences in each trait. The diversity of myostatin gene was found in Hanwoo.

This study aimed to indentify single nucleotide polymorphisms (SNPs) in exon region of the glycerol-3-phosphate dehydrogenase 1 (GPD1) gene and to evaluate their associations with meat yield and quality traits in Hanwoo (Korean cattle). Two SNP markers, g.2766C>T and g.5105A>G were identified in the exons 5 and 8, respectively. Genotyping of the two SNPs was carried out using PCR-RFLP analysis in 309 Hanwoo steers to evaluate their associations with meat yield and quality traits. As a result, g.2766C>T in exon 5 was significantly associated with carcass weight (CW) and marbling score (MS). Animals with the CC genotype of g.2766C>T had heavier CW than those with the CA or AA genotype. Animals with the CC genotype of g.2766C>T also had higher MS than those with the CA or AA genotype. Additive effect was also observed with CW and MS traits. We constructed haplotypes by linkage disequilibrium analysis and analyzed association between haplotypes and meat yield and quality traits. Haplotype of GPD1 gene was associated with CW. As a result, animals with CA haplotype had heavier CW than TG haplotype. These findings suggest that the SNPs of bovine GPD1 gene may be a useful molecular marker for selection of meat yield and quality traits in Hanwoo.

For evaluating the boar semen quality, sperm motility is an important parameter because the movement of sperm indicates active metabolism, membrane integrity and fertilizing capacity. Phospholipase C zeta (PLCz) is important enzyme in spermatogenesis, but the effect has not been confirmed in pigs yet. Therefore, this study was aimed to analyze their association with sperm motility and kinematic characteristics. DNA samples from 124 Duroc pigs with records of sperm motility and kinematic characteristics [total motile spermatozoa (MOT), curvilinear velocity (VCL), straight-line velocity (VSL), the ratio between VSL and VCL (LIN), amplitude of lateral head displacement (ALH)] were subjected. A SNP in non-coding region of PLCz g.158 A > C was associated with MOT (p < 0.05), VCL (p < 0.01), LIN (p < 0.01) and ALH (p < 0.05) in Duroc population. Therefore, we suggest that the intron region of the porcine PLCz gene may be used as a molecular marker for Duroc boar semen quality, although its functional effect was not defined yet. Whether the association is due to the candidate gene or not require further verification. Thus, it will be of interest to continue association studies in the regions surrounding those genes.

For evaluating the boar semen quality, sperm motility (MOT) is an important parameter because the movement of spermatozoa indicates active metabolism, membrane integrity and fertilizing capacity. Estrogen receptors 2(ESR2) is involved in estrogen related apoptosis in cell cycle spermatogenesis, but their functions have not been confirmed in pig until now. Therefore, this study was conducted to analyze their association with sperm motility and kinematic characteristics. DNA samples from 105 Duroc pigs with records of semen motility and kinematic characteristics [Total motile spermatozoa (MOT), Curvilinear velocity(VCL), Straight-line velocity(VSL), the ratio between VSL and VCL(LIN), Amplitude of Lateral Head displacement(ALH)] were analyzed. A SNP in coding region of ESR2 g.35547A > G in exon 5 was associated with MOT (p < 0.05) in Duroc population. Therefore, we suggest that the porcine ESR2 gene may be used as a molecular marker for Duroc boar semen quality, although its functional effects were not defined yet. These results might shed new light on the roles of ESR2 in spermatogenesis as candidate gene for boar fertility, but still the lack of association across populations should be considered.

Cluster-of-differentiation antigen 9 (CD9) gene expressed in the male germ line stem cells is crucial for sperm–egg fusion, and was therefore selected as a candidate gene to investigate Duroc boar semen motility and kinematic characteristics. This study was performed to investigatetheir association with semen motility and kinematic characteristics. DNA samples from 96 Duroc pigs with records of sperm motility and kinematic characteristics [Total motile spermatozoa (MOT, 82.27±5.58), Curvilinear velocity(VCL, 68.37±14.58), Straight-line velocity(VSL, 29.06±6.58), the ratio between VSL and VCL(LIN, 47.36±8.42), Amplitude of Lateral Head displacement(ALH, 2.88±0.70)] were used in present study. A single nucleotide polymorphism (g.358A>T) in intron 6 was associated with MOT, VCL, VAP and ALH in Duroc population (p<0.05). Therefore, we suggest that the porcine CD9 may be used as a molecular marker for Duroc boar semen quality, although its functional effect was not clear yet. These results will improve the understanding of the functions of the CD9 in spermatogenesis within the reproductive tracts, and will shed light on CD9 as a candidate gene in the selection of good sperm quality boars.

Although chemical fertilizers have a quick effect and broad applicability to agricultural fields, they have caused many problems like increasing soil acidity or decreasing soil organic matters. Environmental-friendly agriculture has been attempted in various ways such as organic agriculture, natural farming, low input and sustainable agriculture. The common interest of all environmental-friendly systems is to decrease burden to agricultural environment by low input of agricultural labor and materials. This study was conducted to estimate overwintering capacity and genetic distance among Chinese Milk Vetch (Astragalus sinicus, CMV) collections based on morphological characteristics and AFLP (Amplified fragment length polymorphism) analysis. Furthermore, the effect of CMV as green manure was observed in mix-cultured paddy fields with rice, sesame and sweet-potato. An another objective of this study was also to compare the pattern of weed occurrence in paddy fields with or without CMV and different rice transplanting times. The CMV collected from Paju district in central region of Korea was successively occurring through self-reseeding without artificial management. However, there was no noticeable difference in growth habit between Paju native CMV and introduced CMV from China which is currently used in farm fields. On the basis of multi-dimensional scaling and tree analyses, there are no significant difference of agricultural growth characteristics among Paju and chinese collections only excepting leaf angle and root length. The flowering time of Gurye collection was fast for 1 week as compared to other collections. AFLP that was commonly used for plant classfication, was applied to exam the genetic variation of CMV collections. Total 579 PCR products and 336 polymorphic fragments were generated using 8 primer pairs.

The KLF(Kruppel-like factors) are transcriptional regulators that including the C2H2 zinc-finger motif and regulation of cell growth, cell differentiation, and development. In this study, mRNA and total DNA was extracted from the meat around the backbone of 130 cattle that has economic traits score. The KLF11 gene was act on the center of the main pathway in associated with the development and growth of cells and the fat metabolism. Genetic polymorphism was detected by DNA sequencing. A total of four SNPs(G9047A, C9104G, G9131A, C9170T) were identified in exon 4 regions, statistical association analysis revealed that the G9131A polymorphism were significantly associated with marbling score. The real time quantitative PCR to investigated gene and miRNA expression patterns and identify the relation of economic trait in Korean Native Beef Cattle. Gene expression level linked to KLF11 genes was investigated by determining its association and variation with the economic traits in Korean Native Beef Cattle. The increment of KLF11 gene expresstion level is resulted in increasing marbling score(MS). We found that expression profile of KLF gene and mir-494 was contrast tendency because the lower expression ratio of gene was the higher marbling score rating was when we analyzed expression profile ofKLF gene and mir-494. Therefore, this result has useful in improvement of livestock in Korean cattle.

To identify the cause of the error and maintain the health of system, an administrator usually analyzes event log data since it contains useful information to infer the cause of the error. However, because today’s systems are huge and complex, it is almost impossible for administrators to manually analyze event log files to identify the cause of an error. In particular, as OpenStack, which is being widely used as cloud management system, operates with various service modules being linked to multiple servers, it is hard to access each node and analyze event log messages for each service module in the case of an error. For this, in this paper, we propose a novel message-based log analysis method that enables the administrator to find the cause of an error quickly. Specifically, the proposed method 1) consolidates event log data generated from system level and application service level, 2) clusters the consolidated data based on messages, and 3) analyzes interrelations among message groups in order to promptly identify the cause of a system error. This study has great significance in the following three aspects. First, the root cause of the error can be identified by collecting event logs of both system level and application service level and analyzing interrelations among the logs. Second, administrators do not need to classify messages for training since unsupervised learning of event log messages is applied. Third, using Dynamic Time Warping, an algorithm for measuring similarity of dynamic patterns over time increases accuracy of analysis on patterns generated from distributed system in which time synchronization is not exactly consistent.