Cardiovascular disease remains a leading global cause of mortality, demanding effective prevention and management. This systematic review explores the impact of lycopene, prevalent in various fruits, on cardiovascular health. Thirteen randomized and controlled trials were analyzed, involving 385 participants with cardiovascular risk factors. Notable findings included significant blood pressure reductions, particularly among hypertensive individuals, and favorable alterations in lipid profiles. Lycopene interventions also demonstrated potential in mitigating oxidative stress and inflammation markers. While these findings show promise, more rigorously designed studies are essential to determine optimal dosages and durations for precise cardiovascular benefits. In conclusion, lycopene shows potential in managing cardiovascular risk factors, and its role in blood pressure regulation, lipid profile improvement, and antioxidant and anti-inflammatory effects is encouraging. Nonetheless, further research is warranted to provide definitive guidance on integrating lycopene to enhance cardiovascular health.

This study was designed to evaluate antihyperglycemic and antihyperlipidemic effects of ethanol extracts of Taraxacum mongolicum (T.m.) on streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley rats were randomly assigned to five groups: normal (NC), STZ-control (DC), and three experimental groups. Diabetes was induced in Sprague-Dawley rats with a single intravenous injection [45 mg/kg body weight (b.w.)] of STZ. An ethanol extract of T.m. was orally given to diabetic rats for 14 days. Three experimental groups were additionally treated with T.m. extract at doses of 1 g/kg b.w./day for T.m.-1, 2 g/kg b.w./day for T.m.-2, and 3 g/kg b.w./day for T.m.-3. Oral administration of T.m.-2 significantly increased their body weights. T.m.-1 and T.m.-2 significantly decreased aspartate aminotransferase (AST) levels than DC. T.m.-1 and T.m.-2 group significantly decreased blood glucose levels. Total cholesterol, triglycerides, and free fatty acids were significantly decreased whereas high-density lipoprotein cholesterol was significantly increased in groups treated with T.m. extract than those in the DC group. These results support the fact that administration of T.m. extract can reduce hyperglycemia and hyperlipidemia risk in diabetic rats.

This study was to confirm the effect of supplementation of superjami bran extract on lipid and antioxidant metabolism. Twenty-five subjects were recruited, and divided into Superjami group (n=12), and Placebo group (n=13) random assignment. Among the groups, the Superjami group took a Superjami bran extract (2 g/2 capsule/day), and the Placebo group took dextrin (2 g/2 capsule/day), for 12 weeks. As a result of the experiment, concentrations of TG, TC, and HDL-C in the blood, were significantly lower than those in the control group, and HDL-C was significantly higher. AI and HTR also showed positive values. Leptin did not differ significantly, but as a result of adipectin, the Superjami group displayed a higher value, compared to the Placebo group, and LAR also had significantly lower value. Antioxidant results showed that GPx, CAT, and RGLU, were significantly higher before as well as after intakes of the Superjami group, and significantly higher levels of the Superjami group, compared to the Placebo group. AOPP showed significantly lower values for the Superjami group, compared to the Placebo group. So, based on this study, ingestion of Superjami bran extract is effective in improving blood lipid concentrations as well as inflammatory substances, and has positive effects relative to increasing antioxidant activity.

본 연구는 비만여대생을 대상으로 섭식제한(DG), 유산소운동(EG), 섭식제한과 유산소운동 (DEG) 그룹으로 나누어 체중, 비만의 개선, 혈중지질성분 및 대사성위험요인에 미치는 영향을 분석하였다. 실험은 8주간 주 5회 실시하였으며, DG는 1일 에너지 섭취열량을 300㎉를 제한하였고, EG는 런닝 머신을 이용하여 300㎉를 소비시켰으며, DEG는 각각 150㎉를 제한과 소비시켰다. 결과, 신체조성의 경우 DG에서는 체중(p<.011), BMI(p<.008)가 감소하였고, EG와 DEG에서는 체중(p<.044, p<.017), 체지방량(p<.047, p<.018), BMI(p<.03, p<.008), 체지방률(p<.036, p<.015), WHR(p<.049, p<.027)이 유의하게 감소하였다. 혈중지질성분은 DG에서 HDL-C(p<.028), EG에서 TG(p<.038), DEG에서는 TC(p<.014), LDL-C(p<.007)에서 유의하게 감소하였다. 대사성위험요인은 DG에서 HOMA-IR (p<.035), leptin(p<.007), EG에서 FBG(p<.043), leptin(p<.003), DEG에서 FBG(p<.014), insulin (p<.005), HOMA-IR(p<.005), leptin(p<.016), resistin(p<.040)에서 유의한 차이가 나타났다. 따라서 본 연구의 결과로부터 비만여대생들이 섭식제한, 유산소운동의 단독처치보다 섭식제한과 유산소운동을 병행 하는 것이 신체조성, 혈중지질성분, 대사성위험요인의 개선에 가장 효과가 있을 것으로 판단된다.

This study was conducted to investgate the effect of gamma irradiation on the lipid oxidation, olfactory properties, fatty acid isomer and volatile compound profiles of five different oil sources. Three plant oils, canola oil, corn oil and soy oil, and two animal fat, tallow and fish oil, were irradiated with 0, 5, 10, and 20 kGy level of dose by Co-60 as a radiation source. Lipid oxidation parameters, FFA, POV and TBARS, were determined according to the AACC and AOCS method. Olfactory property of irradiated oil sources was analyzed using electronic nose (FOX3000, AlphaMOS Co., France) with 12 metal oxide sensors and the result was interpreted using principle component analysis program. Fatty acid isomer profiles and volatile compound profiles of irradiated oils were also measured by GC and GC-MS, respectively. Although the free fatty acid level of oil were the highest by high dose level (20 kGy) of irradiation, changes of both TBARS and POV values by gamma irradiation were varied between oil sources and irradiation level of dose. Electronic nose analysis showed a distinct difference among dose levels of irradiation. Although there was no new volatile compound produced by gamma irradiation, amounts of each volatile compounds were increased by irradiation. Only cis isomer, 9c12c15c of linolenic acid was dose-dependently decreased as irradiation level increased but there was no difference among other isomer profiles of linoleic acid and linolenic acid by gamma irradiation. This study showed that changes in physico-chemical properties of both plant and animal oil were remarkable by gamma irradiation. Therefore, a further study should be needed to scrutinize the interaction among lipid oxidation, production of volatile compounds and off-flavor, and isomerization of fatty acid by gamma-irradiation.

This study was conducted to examine the correlation among meals variety, obesity index, blood pressure, and lipid profiles of Korean adults. A total of 308 adults(men 124, women 184) measured the anthropometric characteristics, blood pressure, dietary intake using 24-hour recall method, and serum lipid profile. The average ages of the study subjects were 50.9 yrs in men and 51.4 yrs in women. The average height, weight and BMI were 166.3 cm, 68.4 kg, 24.7 kg/cm2 in men and 154.3 cm, 59.8 kg, 25.0 kg/cm2 in women, respectively. The numbers of food items in meal of men and women were 14.1, 15.9 for breakfast, 15.7, 15.9 for lunch, 14.7, 14.1 for dinner, respectively. The numbers of dish items in meal of men and women were 4.0, 4.3 for breakfast, 4.3, 4.3 for lunch, 4.2, 3.9 for dinner, respectively. The average blood pressure, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and atherogenic index were 126.6/76.0 mmHg, 181.0 mg/dL, 157.7 mg/dL, 40.9 mg/dL, 108.6 mg/dL, 3.5 in men and 123.2/73.6 mmHg, 185.0 mg/dL, 137.3 mg/dL, 44.8 mg/dL, 112.7 mg/dL, 3.2 in women, respectively. The total cholesterol was negatively correlated to the number of food item for lunch(p〈0.05). Therefore, more systematic studies to investigate the meal variety roles of blood lipids in meals of adults were required.

This study was performed to investigate the effect of Lycii fructus beer on serum lipid profiles and antioxidant activity in rat Sprague-Dawley (SD) rats weighting about 190g were divided into the following 5 groups ; distillate water (Control), 5% ethanol in distillate water (Ethanol), commercial beer (CB), Lycii fructus beer (LFB) and 5% alcohol red wine diluted with distillate water (RW). Body weight, total food intake, FER and percent organ (liver, kidney) weight per body weight were not significantly changed by Lycii fructus beer drinking. After 6 weeks, serum total cholesterol, triglyceride and HDL cholesterol level were not significantly different. But, Lycii fructus beer intake tended to decrease serum triglyceride level and atherogenic index. Also, GOT and GPT levels were expressed lower than Ethanol group. There was not significantly different in hepatic glutatiione (GSH) content and glutathione-S-transferase (GST) activities among 5 groups. Lipid peroxidation in the hepatic was decreased by Lycii fructus beer intake. The results demonstrated that Lycii fructus beer was potential and effective antioxidant that can protect the decrease associated with alcohol.

We investigated the effects of Acorus gramineus water extract on the blood lipid levels in high fat diet-fed obese male mice. We divided thirty-five C57BL/6 mice into 5 groups: normal group, control group, and groups treated with Acorus gramineus water extract at concentrations of 20, 100, and 500 ㎎/㎏. We inoculated Acorus gramineus water extract per orally once a day for 6 weeks respectively. The results revealed that Acorus gramineus water extracts had positive effects on the total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels.

Onion (Allium cepa L.) is one of the richest sources of flavonoids in human diet. Onion peel contains over 20times more quercetin than onion flesh. In this study, we studied the effects of onion peel water extract (OPE) on the bloodlipid profiles in mice. The onion peel extracts was extracted with hot water. The experimental groups were divided with 3groups (n=6) of ICR male mice: normal diet+distilled water (NC), high-fat diet+distilled water (HF), high-fatdiet+onion peel water extract 20㎎/㎏ (OPE-20). The oral administration was conducted daily. The experimental periodwas 7 weeks. Onion peel water extract showed higher concentration of polyphenol gallic acid and anti-oxidant trolox equiv-alent than the ethanol extract. The body weight gain and food efficiency ratio was significantly lower in the OPE-20 group ascompared with HF group (p<0.05). The epididymal fat and retroperitoneal fat showed significantly lower weights and sizesin the OPE-20 group as compared with HF group (p<0.05). The serum levels of total cholesterol, LDL cholesterol and trig-lyceride were significantly lower in the OPE-20 group as compared with HF group (p<0.05). The OPE-20 group showedhigher HDL cholesterol concentration than HF group (p<0.05). Atherogenic index was ignificantly lower in as comparedwith HF group (p<0.05). The serum levels of glucose, GOT and GPT were significantly lower in the OPE-20 group as com-pared with HF group (p<0.05). In these results, we suggests that onion peel water extracts supplementation can reduces theserum lipid components and improves the lipid metabolism in hyperlipidemic mice induced with a high-fat diet.

우장지버섯 균사체 배양액으로 발효시킨 초산발효액 (AJA: pH 3.2, acidity 2.0, brix degree 3.2)이 streptozotocin으로 유발한 당뇨쥐의 혈당과 혈청지질에 미치는 영향을 조사하였다. 실험용 식이는 AIN-76 diet를 기본으로 하여 조제하였으며 실험동물은 5주령의 평균체중이 인 Sprague-Dawly계 흰쥐를 사용하여 정상대조군(NC), 당뇨 대조군(DM), 당뇨유발 후 체중 100 g당 AJA 1/2 희

본 연구는 혀의 분얼최성기의 관수스트레스 시 탁도(청수, 반탁수, 탁수) 및 관수시간에 따라 반응하는 단백질, 지방산 조성 및 지질과산화(malodialdehyde)를 정량하여 관수에 따른 생육장해 및 그 작용기작을 구명하여, 관수에 따른 생화학적 대사의 기초자료를 제공하고자 실시되었다. 관수스트레스에 의해 가용성단백질은 약 20%가 감소하였다. 특히 탁도가 높고 관수시간이 경과할수록 급격히 감소하였으며, 관수 36시간부터 감소량이 크게 나타났다. 단백질 전기영 동패턴은 관수스트레스에 따라 생성이나 소멸한 펩타이드는 없었으나 약 53Kd부위의 폴리펩타이드는 관수초기부터 함량이 증가하였고, 약 28Kd는 48시간, 54시간에서만 함량이 증가하였다. 관수스트레스에 의한 지질의 과산화정도는 약 150%가 증가하였고, 탁도처리에서 청수와 반탁수간의 차이는 작은 경향이었지만, 관수 60시간에서 약 160-180%가 증가하였다. 그러나 탁수에서는 관수초기부터 malondialdehyde함량이 높았고, 36시간이후부터는 약 190-200%로 급격히 증가하였다. Catalase는 탁도가 높고 처리시간이 경과할수록 활성은 급격히 증가하였다. 관수 48시간을 기준으로 catalase 활성변화가 크게 나타났다. 지방산조성의 변화는 포화지방산의 조성비율은 증가하고 불포화지방산은 감소하였다. 특히 불포화지방산 중 monounsaturated은 증가하였고 polyunsaturated의 상대적인 조성비율은 감소하였다. Double bond index는 탁도가 높을수록 관수기간이 경과할수록 감소폭은 커서 불포화정도가 떨어짐을 나타냈다.